NO944517L - Kvarternært nitrogenholdige fosfonatforbindelser for behandling av unormal kalsium- og fosfatmetabolisme - Google Patents

Kvarternært nitrogenholdige fosfonatforbindelser for behandling av unormal kalsium- og fosfatmetabolisme

Info

Publication number
NO944517L
NO944517L NO944517A NO944517A NO944517L NO 944517 L NO944517 L NO 944517L NO 944517 A NO944517 A NO 944517A NO 944517 A NO944517 A NO 944517A NO 944517 L NO944517 L NO 944517L
Authority
NO
Norway
Prior art keywords
present
treatment
quaternary nitrogen
phosphate metabolism
abnormal calcium
Prior art date
Application number
NO944517A
Other languages
English (en)
Other versions
NO944517D0 (no
Inventor
Frank H Ebetino
Susan Mary Kaas
Marion David Francis
Original Assignee
Procter & Gamble Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/052,694 external-priority patent/US5753634A/en
Application filed by Procter & Gamble Pharma filed Critical Procter & Gamble Pharma
Publication of NO944517D0 publication Critical patent/NO944517D0/no
Publication of NO944517L publication Critical patent/NO944517L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen vedrører et kvaternært nitrogenholdig mettet eller umettet monocyklisk og bicyklisk ringholdig fosfonat og farmasøytisk tålbare salter og estere derav, med struktur (I). Oppfinnelsen vedrører videre farmasøytiske preparater inne- holdende en sikker og effektiv mengde av en forbindelse i samsvar med oppfinnelsen, og farmasøytisk tålbare hjelpestof- fer. Endelig vedrører oppfinnelsen fremgangsmåter for behandling eller forebygging av patologiske tilstander karakterisert ved unormal kalsium- og fosfatmetabolisme i mennesker eller andre pattedyr. Fremgangsmåten omfatter tilførsel til et menneske eller annet pattedyr som behøver slik behandling av en sikker og effektiv mengde av en for- bindelse eller preparat i samsvar med oppfinnelsen.
NO944517A 1992-05-29 1994-11-25 Kvarternært nitrogenholdige fosfonatforbindelser for behandling av unormal kalsium- og fosfatmetabolisme NO944517L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89148792A 1992-05-29 1992-05-29
US08/052,694 US5753634A (en) 1992-05-29 1993-04-30 Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
PCT/US1993/005044 WO1993024499A1 (en) 1992-05-29 1993-05-27 Quaternary nitrogen-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism

Publications (2)

Publication Number Publication Date
NO944517D0 NO944517D0 (no) 1994-11-25
NO944517L true NO944517L (no) 1995-01-30

Family

ID=26730951

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944517A NO944517L (no) 1992-05-29 1994-11-25 Kvarternært nitrogenholdige fosfonatforbindelser for behandling av unormal kalsium- og fosfatmetabolisme

Country Status (21)

Country Link
EP (1) EP0643716B1 (no)
JP (1) JPH07507321A (no)
CN (1) CN1043424C (no)
AT (1) ATE187456T1 (no)
AU (1) AU663394B2 (no)
CA (1) CA2136821C (no)
CZ (1) CZ296094A3 (no)
DE (1) DE69327240T2 (no)
DK (1) DK0643716T3 (no)
ES (1) ES2139013T3 (no)
FI (1) FI945597A (no)
GR (1) GR3032452T3 (no)
HK (1) HK1014000A1 (no)
HU (1) HUT69698A (no)
IL (1) IL105836A (no)
MX (1) MX9303248A (no)
NO (1) NO944517L (no)
NZ (1) NZ253542A (no)
PT (1) PT643716E (no)
SK (1) SK144794A3 (no)
WO (1) WO1993024499A1 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5753633A (en) * 1997-04-11 1998-05-19 Colgate-Palmolive Company Method of inhibiting bone resorption
US8676882B2 (en) 2007-02-27 2014-03-18 Sony Corporation System and method for preloading content segments to client devices in an electronic network
US7781418B2 (en) * 2006-12-14 2010-08-24 Isis Innovation Ltd. Composition for treating bone disorders
WO2011147038A1 (en) 2010-05-28 2011-12-01 The Royal Institution For The Advancement Of Learning/Mcgill University Heterocyclyl-pyridinyl-based biphosphonic acid, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
US9290526B2 (en) 2010-05-28 2016-03-22 The Royal Institution For The Advancement Of Learning/Mcgill University Heterocyclyl-pyridinyl-based biphosphonic acid, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
US4687768A (en) * 1984-12-21 1987-08-18 The Procter & Gamble Company Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism
DE4011777A1 (de) * 1989-04-14 1990-10-18 Ciba Geigy Ag N-trisubstituierte aminoalkandiphosphonsaeuren

Also Published As

Publication number Publication date
NO944517D0 (no) 1994-11-25
DE69327240T2 (de) 2000-07-20
GR3032452T3 (en) 2000-05-31
EP0643716A1 (en) 1995-03-22
CN1085909A (zh) 1994-04-27
CA2136821C (en) 1999-06-15
EP0643716B1 (en) 1999-12-08
ATE187456T1 (de) 1999-12-15
IL105836A0 (en) 1993-09-22
FI945597A (fi) 1995-01-25
NZ253542A (en) 1997-01-29
DK0643716T3 (da) 2000-03-27
AU4394693A (en) 1993-12-30
SK144794A3 (en) 1995-08-09
CN1043424C (zh) 1999-05-19
HK1014000A1 (en) 1999-09-17
JPH07507321A (ja) 1995-08-10
FI945597A0 (fi) 1994-11-28
AU663394B2 (en) 1995-10-05
MX9303248A (es) 1994-05-31
CA2136821A1 (en) 1993-12-09
WO1993024499A1 (en) 1993-12-09
IL105836A (en) 1999-11-30
DE69327240D1 (de) 2000-01-13
HU9403410D0 (en) 1995-02-28
PT643716E (pt) 2000-05-31
CZ296094A3 (en) 1995-09-13
HUT69698A (en) 1995-09-28
ES2139013T3 (es) 2000-02-01

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