NO942535L - Halogenation using halogen decay reagent - Google Patents

Halogenation using halogen decay reagent

Info

Publication number
NO942535L
NO942535L NO942535A NO942535A NO942535L NO 942535 L NO942535 L NO 942535L NO 942535 A NO942535 A NO 942535A NO 942535 A NO942535 A NO 942535A NO 942535 L NO942535 L NO 942535L
Authority
NO
Norway
Prior art keywords
halogen
reagent
halogenation
decay
steroid
Prior art date
Application number
NO942535A
Other languages
Norwegian (no)
Other versions
NO942535D0 (en
Inventor
Neil Howard Baine
Donald Nathaniel Kline
Richard Eric Mewsahw
Franklin Fell Owings
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO942535L publication Critical patent/NO942535L/en
Publication of NO942535D0 publication Critical patent/NO942535D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group

Abstract

Oppfinnelsen tilveiebringer en forbedret fremgangsmåte for fremstilling av et halogenert steroid dien. Fremgangsmå- ten innbefatter samtidig omdannelse av det steroide 3-on til 3-halogen og 17-karboksylsyre til 17-karboksamid i en enkel reaksjon, uten isolering av et mellomprodukt. Fremgangsmåten utføres ved omsetning av det steroide utgangsmateriale med et halogen-Vilsmeier-reagens.The invention provides an improved process for the preparation of a halogenated steroid diene. The process involves simultaneous conversion of the steroid 3-one to 3-halogen and 17-carboxylic acid to 17-carboxamide in a simple reaction, without isolation of an intermediate. The process is carried out by reacting the steroid starting material with a halogen-Vilsmeier reagent.

NO942535A 1992-01-06 1994-07-05 Halogenation using halogen decay reagent NO942535D0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81717992A 1992-01-06 1992-01-06
US94134892A 1992-09-04 1992-09-04
PCT/US1993/000079 WO1993014106A1 (en) 1992-01-06 1993-01-06 Halogenation using halo-vilsmeier reagent

Publications (2)

Publication Number Publication Date
NO942535L true NO942535L (en) 1994-07-05
NO942535D0 NO942535D0 (en) 1994-07-05

Family

ID=27124147

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942535A NO942535D0 (en) 1992-01-06 1994-07-05 Halogenation using halogen decay reagent

Country Status (23)

Country Link
EP (1) EP0643723A4 (en)
JP (1) JPH07505138A (en)
KR (1) KR940703849A (en)
CN (1) CN1077201A (en)
AP (1) AP370A (en)
AU (1) AU666167B2 (en)
BG (1) BG98887A (en)
BR (1) BR9305786A (en)
CA (1) CA2127272A1 (en)
CZ (1) CZ161994A3 (en)
FI (1) FI943214A (en)
HU (1) HUT68273A (en)
IL (1) IL104302A (en)
MA (1) MA22761A1 (en)
MX (1) MX9300025A (en)
NO (1) NO942535D0 (en)
NZ (1) NZ246788A (en)
OA (1) OA09961A (en)
RU (1) RU94038223A (en)
SI (1) SI9300006A (en)
SK (1) SK80094A3 (en)
TW (1) TW300226B (en)
WO (1) WO1993014106A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
US5683995A (en) * 1992-11-18 1997-11-04 Smithkline Beecham Corporation 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
NZ552106A (en) 2004-06-08 2010-11-26 Univ Temple Heteroaryl sulfones and sulfonamides and therapeutic uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA883034B (en) * 1987-04-29 1989-03-29 Smithkline Beckman Corp Steroid 5-alpha-reductase inhibitors

Also Published As

Publication number Publication date
TW300226B (en) 1997-03-11
OA09961A (en) 1995-12-11
BR9305786A (en) 1997-02-18
IL104302A (en) 1998-02-22
MA22761A1 (en) 1993-10-01
RU94038223A (en) 1997-04-20
HUT68273A (en) 1995-06-28
FI943214A0 (en) 1994-07-05
SK80094A3 (en) 1994-12-07
JPH07505138A (en) 1995-06-08
AU3434893A (en) 1993-08-03
MX9300025A (en) 1994-01-31
KR940703849A (en) 1994-12-12
AP9300473A0 (en) 1993-01-31
IL104302A0 (en) 1993-05-13
AP370A (en) 1994-11-10
WO1993014106A1 (en) 1993-07-22
EP0643723A1 (en) 1995-03-22
CZ161994A3 (en) 1995-03-15
CA2127272A1 (en) 1993-07-22
CN1077201A (en) 1993-10-13
EP0643723A4 (en) 1995-05-10
AU666167B2 (en) 1996-02-01
NO942535D0 (en) 1994-07-05
BG98887A (en) 1995-05-31
NZ246788A (en) 1996-11-26
FI943214A (en) 1994-07-05
HU9402030D0 (en) 1994-09-28
SI9300006A (en) 1993-09-30

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