NO942310L - Middel for undertrykkelse av infiltrering av eosinofiler - Google Patents

Middel for undertrykkelse av infiltrering av eosinofiler

Info

Publication number
NO942310L
NO942310L NO942310A NO942310A NO942310L NO 942310 L NO942310 L NO 942310L NO 942310 A NO942310 A NO 942310A NO 942310 A NO942310 A NO 942310A NO 942310 L NO942310 L NO 942310L
Authority
NO
Norway
Prior art keywords
denotes
eosinophils
infiltration
independently represent
lower alkyl
Prior art date
Application number
NO942310A
Other languages
English (en)
Other versions
NO942310D0 (no
Inventor
Katsuhiro Shibayama
Naoki Hirayama
Tetsuya Katou
Shu Matsumoto
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of NO942310D0 publication Critical patent/NO942310D0/no
Publication of NO942310L publication Critical patent/NO942310L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Et middel for undertrykkelse av infiltrering av eosinofiler omfat- tende som en effektiv bestanddel et trisyklisk triazoloderivat som sterkt undertrykker infiltrering av eosino- filer i inflammatoriske regioner, er beskrevet. Midlet for undertrykkelse av infiltrering av eosinofiler ifølge foreliggende oppfinnelse omfatter som en effektiv bestanddel et trisyklisk triazoloderivat av formel (I): N.N /CH2) u >(W), C ; 3,X^-N N¿A¿N YT^Z (D [hvori R1 betegner hydrogen, lavere alkyl, C3-C5-sykloalkyl eller substitu- ert eller ikke-substituert aryl; R2 og R3 betegner uavhengig hydrogen, lavere alkyl, lavere alkoksy eller halogen; W betegner C=O eller CR4R5 (hvori R4 og R5 uavhengig betegner hydrogen eller lavere alkyl); A betegner C^-Cs-rett- kjedet eller forgrenet, mettet eller umettet alkylen (forutsatt at det kan inneholde ett eller flere hetero- atomer); l betegner O til 2, n betegner l til 3, .._._._ betegner erikeltbinding eller dobbeltbinding; Y betegner N eller C; Z betegner C(B)ArlAr2 (hvori B betegner hydrogen, hydroksy eller metoksy. Ar1 og Ar2 betegner uavhengig hydrogen eller substituert eller ikke- substituert aryl), CAr*Ar2 (hvori Ar1 og Ar2 har samme betydning som nevnt oven- for), 0-CHAr'Ar2 (hvori Ar1 og Ar2 har samme betydning som nevnt ovenfor) eller en kondensert, aromatisk ring] eller et farmasøytisk akseptabelt salt derav.
NO942310A 1992-10-20 1994-06-17 Middel for undertrykkelse av infiltrering av eosinofiler NO942310L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28165392 1992-10-20
PCT/JP1993/001492 WO1994008581A1 (en) 1992-10-20 1993-10-18 Eosinophil infiltration inhibitor

Publications (2)

Publication Number Publication Date
NO942310D0 NO942310D0 (no) 1994-06-17
NO942310L true NO942310L (no) 1994-08-19

Family

ID=17642105

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942310A NO942310L (no) 1992-10-20 1994-06-17 Middel for undertrykkelse av infiltrering av eosinofiler

Country Status (11)

Country Link
US (1) US5478823A (no)
EP (1) EP0617961A4 (no)
JP (1) JP3163631B2 (no)
KR (1) KR100293684B1 (no)
CN (1) CN1068201C (no)
AU (1) AU671865B2 (no)
CA (1) CA2126217A1 (no)
FI (1) FI942962A (no)
NO (1) NO942310L (no)
TW (1) TW272127B (no)
WO (1) WO1994008581A1 (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
US6492364B1 (en) * 1998-12-04 2002-12-10 Toray Industries, Inc. Triazolo and derivatives as chemokine inhibitors
TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action
US20040127501A1 (en) * 2002-09-24 2004-07-01 Zhengming Chen Therapeutic agents useful for treating pain

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS494478B1 (no) * 1970-11-09 1974-02-01
JPS529198B2 (no) * 1972-04-25 1977-03-14
CN1033327C (zh) * 1991-04-23 1996-11-20 东丽株式会社 三环三唑并衍生物的制造方法
CA2086112A1 (en) * 1991-04-23 1992-10-24 Katsuhiro Shibayama Tricyclic triazolo derivatives, processes for producing the same and uses of the same

Also Published As

Publication number Publication date
CA2126217A1 (en) 1994-04-28
KR100293684B1 (ko) 2001-09-17
TW272127B (no) 1996-03-11
AU5156793A (en) 1994-05-09
WO1994008581A1 (en) 1994-04-28
EP0617961A4 (en) 1995-03-29
CN1068201C (zh) 2001-07-11
FI942962A (fi) 1994-08-19
EP0617961A1 (en) 1994-10-05
FI942962A0 (fi) 1994-06-20
NO942310D0 (no) 1994-06-17
US5478823A (en) 1995-12-26
CN1095594A (zh) 1994-11-30
JP3163631B2 (ja) 2001-05-08
AU671865B2 (en) 1996-09-12

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