NO942301L - Imidazoquinazoline Compounds and Their Preparation and Use - Google Patents
Imidazoquinazoline Compounds and Their Preparation and UseInfo
- Publication number
- NO942301L NO942301L NO942301A NO942301A NO942301L NO 942301 L NO942301 L NO 942301L NO 942301 A NO942301 A NO 942301A NO 942301 A NO942301 A NO 942301A NO 942301 L NO942301 L NO 942301L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- alkoxyalkyl
- alkoxy
- substituted
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Imidazokinazolinforbindelser med. formel (I). hvor Q er (a), (b), (c) eller (d),-COeller -CN; hvorer H, alkyl,. usubstituert eller substituert sykloalkyl, alkoksy, alkoksyalkyl eller CF;. er alkyl;oger uavhengig av. hverandre H, alkyl som eventuelt er. substituert, sykloalkyl, hydroksyalkyl,. alkoksy, alkoksyalkyl, alkoksykarbonyl-alkyl, formylalkyl eller et acetal. derav, eller Rog Rdanner sammen med. N-atomet en syklisk aminogruppe med 4-6 medlemmer, hvor ett eller flere av karbonatomene i ringsystemet kan være byttet ut med N, 0 eller S, sulfinyl, sulfonyl eller karbonyl eller et acetal derav, idet hvert av disse ring-systemene eventuelt er substituert;. ,, Roger uavhengig av hverandre H, OH, halogen, CF, N0, NH, CN, alkyl, alkenyl, alkynyl, alkoksy, alkoksyalkyl eller alkoksykarbonyl. Forbindelsene kan anvendes i psyko-farmasøytiske preparater som anti-konvulsjonsmidler, anxiolytika, hypnotika, antipsykotika eller anti-emetika, for forbedring av den kognitive funksjon av hjernen hos pattedyr, eller som benzodiazepin-antagonister.Imidazoquinazoline compounds with. formula (I). wherein Q is (a), (b), (c) or (d), -CO or -CN; where H, alkyl,. unsubstituted or substituted cycloalkyl, alkoxy, alkoxyalkyl or CF;. is alkyl; and independent of. each other H, alkyl which is optionally. substituted, cycloalkyl, hydroxyalkyl,. alkoxy, alkoxyalkyl, alkoxycarbonylalkyl, formylalkyl or an acetal. hence, or Rog Rdanner together with. The N atom a cyclic amino group with 4-6 members, where one or more of the carbon atoms in the ring system can be replaced by N, 0 or S, sulfinyl, sulfonyl or carbonyl or an acetal thereof, each of these ring systems possibly being substituted;. ,, Roger independently of each other H, OH, halogen, CF, N0, NH, CN, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl or alkoxycarbonyl. The compounds can be used in psycho-pharmaceutical preparations such as anticonvulsants, anxiolytics, hypnotics, antipsychotics or antiemetics, for improving the cognitive function of the brain in mammals, or as benzodiazepine antagonists.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK912042A DK204291D0 (en) | 1991-12-20 | 1991-12-20 | HETEROCYCLIC RELATIONSHIPS OF THEIR PREPARATION AND USE |
PCT/DK1992/000385 WO1993013103A1 (en) | 1991-12-20 | 1992-12-18 | Imidazoquinazoline compounds and their preparation and use |
Publications (2)
Publication Number | Publication Date |
---|---|
NO942301D0 NO942301D0 (en) | 1994-06-17 |
NO942301L true NO942301L (en) | 1994-08-19 |
Family
ID=8109668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO942301A NO942301L (en) | 1991-12-20 | 1994-06-17 | Imidazoquinazoline Compounds and Their Preparation and Use |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0619820A1 (en) |
JP (1) | JPH07502278A (en) |
AU (1) | AU673814B2 (en) |
CA (1) | CA2125854A1 (en) |
DK (1) | DK204291D0 (en) |
FI (1) | FI942963A (en) |
IL (1) | IL104099A (en) |
NO (1) | NO942301L (en) |
NZ (1) | NZ246558A (en) |
TW (1) | TW211568B (en) |
WO (1) | WO1993013103A1 (en) |
ZA (1) | ZA929770B (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK151890D0 (en) * | 1990-06-22 | 1990-06-22 | Ferrosan As | HETEROCYCLIC RELATIONSHIPS OF THEIR PREPARATION AND USE |
CN1052724C (en) * | 1996-07-01 | 2000-05-24 | 瑞安大药厂股份有限公司 | Optical active 2, 3-dihydro-imidazole and [1, 2-c] quinazoline derivative, preparation method and use thereof |
US8053762B2 (en) | 2005-12-13 | 2011-11-08 | Lg Chem, Ltd. | Imidazoquinazoline derivative, process for preparing the same, and organic electronic device using the same |
EP2125750B1 (en) | 2007-02-26 | 2014-05-21 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
AR069207A1 (en) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | CYCLIC UREAS AS INHIBITORS OF THE 11 BETA - HIDROXI-ESTEROIDE DESHIDROGENASA 1 |
US8440658B2 (en) | 2007-12-11 | 2013-05-14 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
CN102119160B (en) | 2008-07-25 | 2014-11-05 | 贝林格尔·英格海姆国际有限公司 | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
WO2010010157A2 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 |
WO2010089303A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1 |
MA33216B1 (en) | 2009-04-30 | 2012-04-02 | Boehringer Ingelheim Int | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 |
WO2011011123A1 (en) | 2009-06-11 | 2011-01-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
EP2448928B1 (en) | 2009-07-01 | 2014-08-13 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
JP5860042B2 (en) | 2010-06-16 | 2016-02-16 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | Substituted 5, 6 and 7 membered heterocycles, medicaments containing such compounds and their use |
EP2585444B1 (en) | 2010-06-25 | 2014-10-22 | Boehringer Ingelheim International GmbH | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
JP2013540801A (en) | 2010-11-02 | 2013-11-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Combination medicine for the treatment of metabolic disorders |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1297099C (en) * | 1985-10-17 | 1992-03-10 | Frank Watjen | Quinazoline compounds and their preparation and use |
DK155524C (en) * | 1987-03-18 | 1989-09-11 | Ferrosan As | CONDENSED IMIDAZOLD DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE |
DK443589D0 (en) * | 1989-09-08 | 1989-09-08 | Ferrosan As | HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE |
DK151890D0 (en) * | 1990-06-22 | 1990-06-22 | Ferrosan As | HETEROCYCLIC RELATIONSHIPS OF THEIR PREPARATION AND USE |
-
1991
- 1991-12-20 DK DK912042A patent/DK204291D0/en not_active Application Discontinuation
-
1992
- 1992-12-15 IL IL10409992A patent/IL104099A/en not_active IP Right Cessation
- 1992-12-17 ZA ZA929770A patent/ZA929770B/en unknown
- 1992-12-18 EP EP93902092A patent/EP0619820A1/en not_active Withdrawn
- 1992-12-18 TW TW081110173A patent/TW211568B/zh active
- 1992-12-18 NZ NZ246558A patent/NZ246558A/en unknown
- 1992-12-18 AU AU33448/93A patent/AU673814B2/en not_active Ceased
- 1992-12-18 WO PCT/DK1992/000385 patent/WO1993013103A1/en not_active Application Discontinuation
- 1992-12-18 CA CA002125854A patent/CA2125854A1/en not_active Abandoned
- 1992-12-18 JP JP5511363A patent/JPH07502278A/en active Pending
-
1994
- 1994-06-17 NO NO942301A patent/NO942301L/en unknown
- 1994-06-20 FI FI942963A patent/FI942963A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW211568B (en) | 1993-08-21 |
IL104099A (en) | 1996-07-23 |
JPH07502278A (en) | 1995-03-09 |
DK204291D0 (en) | 1991-12-20 |
IL104099A0 (en) | 1993-05-13 |
NO942301D0 (en) | 1994-06-17 |
NZ246558A (en) | 1995-07-26 |
AU673814B2 (en) | 1996-11-28 |
FI942963A0 (en) | 1994-06-20 |
EP0619820A1 (en) | 1994-10-19 |
ZA929770B (en) | 1994-06-17 |
AU3344893A (en) | 1993-07-28 |
WO1993013103A1 (en) | 1993-07-08 |
CA2125854A1 (en) | 1993-07-08 |
FI942963A (en) | 1994-06-20 |
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