NO942301L - Imidazoquinazoline Compounds and Their Preparation and Use - Google Patents

Imidazoquinazoline Compounds and Their Preparation and Use

Info

Publication number
NO942301L
NO942301L NO942301A NO942301A NO942301L NO 942301 L NO942301 L NO 942301L NO 942301 A NO942301 A NO 942301A NO 942301 A NO942301 A NO 942301A NO 942301 L NO942301 L NO 942301L
Authority
NO
Norway
Prior art keywords
alkyl
alkoxyalkyl
alkoxy
substituted
compounds
Prior art date
Application number
NO942301A
Other languages
Norwegian (no)
Other versions
NO942301D0 (en
Inventor
Holger Claus Hansen
Marit Kristiansen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO942301D0 publication Critical patent/NO942301D0/en
Publication of NO942301L publication Critical patent/NO942301L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Imidazokinazolinforbindelser med. formel (I). hvor Q er (a), (b), (c) eller (d),-COeller -CN; hvorer H, alkyl,. usubstituert eller substituert sykloalkyl, alkoksy, alkoksyalkyl eller CF;. er alkyl;oger uavhengig av. hverandre H, alkyl som eventuelt er. substituert, sykloalkyl, hydroksyalkyl,. alkoksy, alkoksyalkyl, alkoksykarbonyl-alkyl, formylalkyl eller et acetal. derav, eller Rog Rdanner sammen med. N-atomet en syklisk aminogruppe med 4-6 medlemmer, hvor ett eller flere av karbonatomene i ringsystemet kan være byttet ut med N, 0 eller S, sulfinyl, sulfonyl eller karbonyl eller et acetal derav, idet hvert av disse ring-systemene eventuelt er substituert;. ,, Roger uavhengig av hverandre H, OH, halogen, CF, N0, NH, CN, alkyl, alkenyl, alkynyl, alkoksy, alkoksyalkyl eller alkoksykarbonyl. Forbindelsene kan anvendes i psyko-farmasøytiske preparater som anti-konvulsjonsmidler, anxiolytika, hypnotika, antipsykotika eller anti-emetika, for forbedring av den kognitive funksjon av hjernen hos pattedyr, eller som benzodiazepin-antagonister.Imidazoquinazoline compounds with. formula (I). wherein Q is (a), (b), (c) or (d), -CO or -CN; where H, alkyl,. unsubstituted or substituted cycloalkyl, alkoxy, alkoxyalkyl or CF;. is alkyl; and independent of. each other H, alkyl which is optionally. substituted, cycloalkyl, hydroxyalkyl,. alkoxy, alkoxyalkyl, alkoxycarbonylalkyl, formylalkyl or an acetal. hence, or Rog Rdanner together with. The N atom a cyclic amino group with 4-6 members, where one or more of the carbon atoms in the ring system can be replaced by N, 0 or S, sulfinyl, sulfonyl or carbonyl or an acetal thereof, each of these ring systems possibly being substituted;. ,, Roger independently of each other H, OH, halogen, CF, N0, NH, CN, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl or alkoxycarbonyl. The compounds can be used in psycho-pharmaceutical preparations such as anticonvulsants, anxiolytics, hypnotics, antipsychotics or antiemetics, for improving the cognitive function of the brain in mammals, or as benzodiazepine antagonists.

NO942301A 1991-12-20 1994-06-17 Imidazoquinazoline Compounds and Their Preparation and Use NO942301L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK912042A DK204291D0 (en) 1991-12-20 1991-12-20 HETEROCYCLIC RELATIONSHIPS OF THEIR PREPARATION AND USE
PCT/DK1992/000385 WO1993013103A1 (en) 1991-12-20 1992-12-18 Imidazoquinazoline compounds and their preparation and use

Publications (2)

Publication Number Publication Date
NO942301D0 NO942301D0 (en) 1994-06-17
NO942301L true NO942301L (en) 1994-08-19

Family

ID=8109668

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942301A NO942301L (en) 1991-12-20 1994-06-17 Imidazoquinazoline Compounds and Their Preparation and Use

Country Status (12)

Country Link
EP (1) EP0619820A1 (en)
JP (1) JPH07502278A (en)
AU (1) AU673814B2 (en)
CA (1) CA2125854A1 (en)
DK (1) DK204291D0 (en)
FI (1) FI942963A (en)
IL (1) IL104099A (en)
NO (1) NO942301L (en)
NZ (1) NZ246558A (en)
TW (1) TW211568B (en)
WO (1) WO1993013103A1 (en)
ZA (1) ZA929770B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK151890D0 (en) * 1990-06-22 1990-06-22 Ferrosan As HETEROCYCLIC RELATIONSHIPS OF THEIR PREPARATION AND USE
CN1052724C (en) * 1996-07-01 2000-05-24 瑞安大药厂股份有限公司 Optical active 2, 3-dihydro-imidazole and [1, 2-c] quinazoline derivative, preparation method and use thereof
US8053762B2 (en) 2005-12-13 2011-11-08 Lg Chem, Ltd. Imidazoquinazoline derivative, process for preparing the same, and organic electronic device using the same
EP2125750B1 (en) 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1
AR069207A1 (en) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc CYCLIC UREAS AS INHIBITORS OF THE 11 BETA - HIDROXI-ESTEROIDE DESHIDROGENASA 1
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
CN102119160B (en) 2008-07-25 2014-11-05 贝林格尔·英格海姆国际有限公司 Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
WO2010010157A2 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
WO2010089303A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1
MA33216B1 (en) 2009-04-30 2012-04-02 Boehringer Ingelheim Int CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5860042B2 (en) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Substituted 5, 6 and 7 membered heterocycles, medicaments containing such compounds and their use
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
JP2013540801A (en) 2010-11-02 2013-11-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Combination medicine for the treatment of metabolic disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1297099C (en) * 1985-10-17 1992-03-10 Frank Watjen Quinazoline compounds and their preparation and use
DK155524C (en) * 1987-03-18 1989-09-11 Ferrosan As CONDENSED IMIDAZOLD DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE
DK443589D0 (en) * 1989-09-08 1989-09-08 Ferrosan As HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE
DK151890D0 (en) * 1990-06-22 1990-06-22 Ferrosan As HETEROCYCLIC RELATIONSHIPS OF THEIR PREPARATION AND USE

Also Published As

Publication number Publication date
TW211568B (en) 1993-08-21
IL104099A (en) 1996-07-23
JPH07502278A (en) 1995-03-09
DK204291D0 (en) 1991-12-20
IL104099A0 (en) 1993-05-13
NO942301D0 (en) 1994-06-17
NZ246558A (en) 1995-07-26
AU673814B2 (en) 1996-11-28
FI942963A0 (en) 1994-06-20
EP0619820A1 (en) 1994-10-19
ZA929770B (en) 1994-06-17
AU3344893A (en) 1993-07-28
WO1993013103A1 (en) 1993-07-08
CA2125854A1 (en) 1993-07-08
FI942963A (en) 1994-06-20

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