NO941346L - Preparation of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose - Google Patents

Preparation of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose

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Publication number
NO941346L
NO941346L NO941346A NO941346A NO941346L NO 941346 L NO941346 L NO 941346L NO 941346 A NO941346 A NO 941346A NO 941346 A NO941346 A NO 941346A NO 941346 L NO941346 L NO 941346L
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NO
Norway
Prior art keywords
gdp
fucose
synthesis
carbohydrates
preparation
Prior art date
Application number
NO941346A
Other languages
Norwegian (no)
Other versions
NO941346D0 (en
Inventor
Chi-Huey Wong
Yoshitaka Ichikawa
Gwo-Jenn Shen
Kun-Chin Liu
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/961,076 external-priority patent/US6319695B1/en
Priority claimed from PCT/US1992/008789 external-priority patent/WO1993008205A1/en
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of NO941346D0 publication Critical patent/NO941346D0/en
Publication of NO941346L publication Critical patent/NO941346L/en

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Abstract

Forbedrede fremgangsmåter for enzymatisk fremstilling av karbo- hydrater, spesielt fukosylerte karbo- hydrater. Forbedrede synteser av glyko- syl-1- eller -2rfosfater ved anvendelse av både kjemiske og enzymatiske frem- gangsmåter er også beskrevet. De fos- forylerte glykosider anvendes deretter for å fremstille sukkernukleotider som .i sin tur anvendes som donorsukkere for glykosylering av akseptorkarbohydrater. Anvendelse av en spesielt foretrukket fremgangsmåte for fukosylering er også beskrevet.Improved processes for the enzymatic production of carbohydrates, especially fucosylated carbohydrates. Improved syntheses of glycosyl-1 or -2r phosphates using both chemical and enzymatic procedures are also described. The phosphorylated glycosides are then used to prepare sugar nucleotides which in turn are used as donor sugars for glycosylation of acceptor carbohydrates. Use of a particularly preferred method for fucosylation is also described.

NO941346A 1991-10-15 1994-04-14 Preparation of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose NO941346L (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77766291A 1991-10-15 1991-10-15
US90126092A 1992-06-19 1992-06-19
US91061292A 1992-07-08 1992-07-08
US07/961,076 US6319695B1 (en) 1991-10-15 1992-10-14 Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
PCT/US1992/008789 WO1993008205A1 (en) 1991-10-15 1992-10-15 Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of gdp-fucose

Publications (2)

Publication Number Publication Date
NO941346D0 NO941346D0 (en) 1994-04-14
NO941346L true NO941346L (en) 1994-06-14

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Application Number Title Priority Date Filing Date
NO941346A NO941346L (en) 1991-10-15 1994-04-14 Preparation of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose

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NO (1) NO941346L (en)

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Publication number Publication date
NO941346D0 (en) 1994-04-14

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