NO940881L - Enantiomers of 1 - [(4-chlorophenyl) phenylmethyl] -4 - [(4-methylphenyl) sulfonyl] piperazine - Google Patents

Enantiomers of 1 - [(4-chlorophenyl) phenylmethyl] -4 - [(4-methylphenyl) sulfonyl] piperazine

Info

Publication number
NO940881L
NO940881L NO940881A NO940881A NO940881L NO 940881 L NO940881 L NO 940881L NO 940881 A NO940881 A NO 940881A NO 940881 A NO940881 A NO 940881A NO 940881 L NO940881 L NO 940881L
Authority
NO
Norway
Prior art keywords
chlorophenyl
ethyl
methylphenyl
enantiomers
phenylmethyl
Prior art date
Application number
NO940881A
Other languages
Norwegian (no)
Other versions
NO940881D0 (en
NO305908B1 (en
Inventor
Eric Cossement
Guy Bodson
Jean Gobert
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of NO940881D0 publication Critical patent/NO940881D0/en
Publication of NO940881L publication Critical patent/NO940881L/en
Publication of NO305908B1 publication Critical patent/NO305908B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Abstract

The use of levorotatory or dextrorotatory enantiomers of 1-(4-chlorophenyl)phenylmethylpiperazine derivatives (V) or their salts in medicines for the treatment of allergies, is new. The use of levorotatory or dextrorotatory enantiomers of 1-(4-chlorophenyl)phenylmethylpiperazine derivatives of formula (V) or their salts, in medicines for the treatment of allergies, is new: R = H, (3-methylphenyl)methyl, (4-tert-butylphenyl)methyl, 2-(2-hydroxyethoxy)ethyl, 2-(2-(hydroxyethoxy)ethoxy)ethyl, 2-(carbamoylethoxy)ethyl, 2-(methoxycarbonylmethoxy)ethyl or 2-(carboxymethoxy)ethyl.
NO940881A 1993-03-15 1994-03-11 Enantiomers of 1 - [(4-chlorophenyl) phenylmethyl] -4 - [(4-methylphenyl) sulfonyl] piperazine and process for their preparation NO305908B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939305282A GB9305282D0 (en) 1993-03-15 1993-03-15 Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine

Publications (3)

Publication Number Publication Date
NO940881D0 NO940881D0 (en) 1994-03-11
NO940881L true NO940881L (en) 1994-09-16
NO305908B1 NO305908B1 (en) 1999-08-16

Family

ID=10732080

Family Applications (2)

Application Number Title Priority Date Filing Date
NO940881A NO305908B1 (en) 1993-03-15 1994-03-11 Enantiomers of 1 - [(4-chlorophenyl) phenylmethyl] -4 - [(4-methylphenyl) sulfonyl] piperazine and process for their preparation
NO990351A NO306616B1 (en) 1993-03-15 1999-01-26 Process for Preparation of the Left-Turn and Right-Turn Enantiomers of a 1 - [(4-Chlorophenyl) Phenylmethyl] -piperazine

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO990351A NO306616B1 (en) 1993-03-15 1999-01-26 Process for Preparation of the Left-Turn and Right-Turn Enantiomers of a 1 - [(4-Chlorophenyl) Phenylmethyl] -piperazine

Country Status (24)

Country Link
US (17) US5478941A (en)
EP (3) EP1413307A1 (en)
JP (3) JP3267434B2 (en)
KR (1) KR100322415B1 (en)
AT (2) ATE267185T1 (en)
AU (1) AU678426B2 (en)
CA (2) CA2118859C (en)
DE (2) DE69424893T2 (en)
DK (1) DK0617028T3 (en)
ES (2) ES2147569T3 (en)
FI (3) FI105477B (en)
GB (1) GB9305282D0 (en)
GR (1) GR3034340T3 (en)
HK (1) HK1024232A1 (en)
HU (1) HU219230B (en)
NO (2) NO305908B1 (en)
NZ (1) NZ260062A (en)
PL (1) PL178546B1 (en)
PT (1) PT617028E (en)
RU (1) RU2118320C1 (en)
SG (1) SG43683A1 (en)
SI (2) SI0617028T1 (en)
TW (1) TW237452B (en)
ZA (1) ZA941724B (en)

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Also Published As

Publication number Publication date
US20060229320A1 (en) 2006-10-12
DK0617028T3 (en) 2000-09-04
NO306616B1 (en) 1999-11-29
US20070142400A1 (en) 2007-06-21
NO990351D0 (en) 1999-01-26
CA2443216C (en) 2007-05-08
ATE267185T1 (en) 2004-06-15
US5478941A (en) 1995-12-26
AU5777194A (en) 1994-09-22
SI0955295T1 (en) 2004-10-31
CA2443216A1 (en) 1994-09-16
JP3267434B2 (en) 2002-03-18
US5703082A (en) 1997-12-30
JPH072816A (en) 1995-01-06
EP0955295B1 (en) 2004-05-19
NO940881D0 (en) 1994-03-11
NZ260062A (en) 1995-09-26
FI19991729A (en) 1999-08-16
DE69424893D1 (en) 2000-07-20
HUT70959A (en) 1995-11-28
HK1024232A1 (en) 2000-10-05
JP2006342190A (en) 2006-12-21
ZA941724B (en) 1994-10-13
DE69433802D1 (en) 2004-06-24
FI105477B (en) 2000-08-31
CA2118859A1 (en) 1994-09-16
US20060229319A1 (en) 2006-10-12
SI0617028T1 (en) 2000-10-31
FI105915B (en) 2000-10-31
US20030105113A1 (en) 2003-06-05
PT617028E (en) 2000-11-30
US5792770A (en) 1998-08-11
HU9400727D0 (en) 1994-06-28
CA2118859C (en) 2004-07-13
FI19991730A (en) 1999-08-16
US20040122021A1 (en) 2004-06-24
US20060252934A1 (en) 2006-11-09
US20050176732A1 (en) 2005-08-11
US20040072845A1 (en) 2004-04-15
GB9305282D0 (en) 1993-05-05
ATE193889T1 (en) 2000-06-15
ES2147569T3 (en) 2000-09-16
KR100322415B1 (en) 2002-06-20
HU219230B (en) 2001-03-28
EP0617028B1 (en) 2000-06-14
US20030105112A1 (en) 2003-06-05
DE69433802T2 (en) 2005-05-12
EP0955295A1 (en) 1999-11-10
FI105914B (en) 2000-10-31
RU2118320C1 (en) 1998-08-27
ES2221262T3 (en) 2004-12-16
US20050182070A1 (en) 2005-08-18
EP1413307A1 (en) 2004-04-28
EP0617028A1 (en) 1994-09-28
NO990351L (en) 1999-01-26
JP2002201187A (en) 2002-07-16
GR3034340T3 (en) 2000-12-29
DE69424893T2 (en) 2000-10-12
US20030204089A1 (en) 2003-10-30
US20050182069A1 (en) 2005-08-18
PL178546B1 (en) 2000-05-31
US6436942B1 (en) 2002-08-20
FI941134A (en) 1994-09-16
AU678426B2 (en) 1997-05-29
TW237452B (en) 1995-01-01
JP3880842B2 (en) 2007-02-14
SG43683A1 (en) 1997-11-14
US20040122023A1 (en) 2004-06-24
NO305908B1 (en) 1999-08-16
FI941134A0 (en) 1994-03-10

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