NO934763L - Procedures for long-term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebrates - Google Patents
Procedures for long-term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebratesInfo
- Publication number
- NO934763L NO934763L NO934763A NO934763A NO934763L NO 934763 L NO934763 L NO 934763L NO 934763 A NO934763 A NO 934763A NO 934763 A NO934763 A NO 934763A NO 934763 L NO934763 L NO 934763L
- Authority
- NO
- Norway
- Prior art keywords
- prolactin
- peak
- long
- hyperinsulinemia
- term
- Prior art date
Links
Abstract
Fremgangsmåte for langtidsmodifisering og regulering av lipid- og glukosemetabolisme - generelt for å redusere fedme, insulinresistens og hyperinsulinemi, eller begge deler (idet dette er kjennetegnene til ikke-insulin- avhengig eller TYPE II-diabetes) - ved tilførsel til et virveldyr, dyr eller menneske, av en dopaminagonist og en prolaktinstimulator. Dopaminagonisten og prolaktin- stimulatoren tilføres i henholdsvis daglige doser ved en tid på dagen som er avhengig av den normale cirka- dianrytmen hos fete og slanke individer av tilsvarende art. Minskninger i kroppsfettlagre inntrer ved behand- linger av en fet art med en daglig tidsbestemt sekvens basert på cirkadianrytmene av topp prolaktin eller topp prolaktin og topp glykokortikosteroid, blodnivå etab- lert for slanke insulinsensitive individer av en til- svarende rase. Dopaminagonisten tilføres ved en tid tilsvarende eller like etter tiden til topp plasmapro- laktinkonsentrasjonen funnet hos slanke individer av samme art og prolaktinstimulatoren tilføres ved en tid like før plasmaprolaktinrytmen når sin topp hos slanke dyr. Insulinresistens og hyperinsulinemi eller hyper- glycemi eller begge deler, kan også bli bekjempet hos mennesker på en langtidsbasis ved behandling tilsvar- ende den ved behandlingen av fedme. Korttids daglige injeksjoner bestemmer på nytt hormonell utskillelse i de neurale sentre i hjernen for å gi langtidseffekter.Procedures for long-term modification and regulation of lipid and glucose metabolism - generally to reduce obesity, insulin resistance and hyperinsulinemia, or both (as these are the hallmarks of non-insulin dependent or TYPE II diabetes) - by administration to a vertebrate, animal or animal. human, by a dopamine agonist and a prolactin stimulator. The dopamine agonist and prolactin stimulator are administered in daily doses, respectively, at a time of day that is dependent on the normal circadian rhythm of obese and lean individuals of a similar nature. Decreases in body fat stores occur in treatments of an obese species with a daily timed sequence based on the circadian rhythms of peak prolactin or peak prolactin and peak glycocorticosteroid, blood level established for slender insulin-sensitive individuals of a similar race. The dopamine agonist is administered at a time similar to or just after the peak plasma prolactin concentration found in slim individuals of the same species and the prolactin stimulator is administered at a time just before the plasma prolactin rhythm reaches its peak in slim animals. Insulin resistance and hyperinsulinemia or hyperglycemia, or both, can also be combated in humans on a long-term basis by treatment similar to that of the treatment of obesity. Short-term daily injections re-determine hormonal secretion in the neural centers of the brain to produce long-term effects.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/719,745 US5344832A (en) | 1990-01-10 | 1991-06-24 | Method for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebrates |
| PCT/US1992/005074 WO1993000092A1 (en) | 1991-06-24 | 1992-06-24 | Improved process for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebrates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO934763D0 NO934763D0 (en) | 1993-12-22 |
| NO934763L true NO934763L (en) | 1994-02-24 |
Family
ID=26784837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO934763A NO934763L (en) | 1991-06-24 | 1993-12-22 | Procedures for long-term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebrates |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO934763L (en) |
-
1993
- 1993-12-22 NO NO934763A patent/NO934763L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO934763D0 (en) | 1993-12-22 |
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