NO934653L - Use of thrombin inhibitors for inhibition of ocular fibrin formation - Google Patents
Use of thrombin inhibitors for inhibition of ocular fibrin formationInfo
- Publication number
- NO934653L NO934653L NO934653A NO934653A NO934653L NO 934653 L NO934653 L NO 934653L NO 934653 A NO934653 A NO 934653A NO 934653 A NO934653 A NO 934653A NO 934653 L NO934653 L NO 934653L
- Authority
- NO
- Norway
- Prior art keywords
- inhibition
- thrombin inhibitors
- fibrin formation
- ocular
- ocular fibrin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Det er beskrevet anvendelsen av stoffer som er i stand til å inhibere aktiviteten av oppløselig og fibrin- og cellebundet trombin, spesielt hirudin, dets derivater, peptider avledet derfra og trombininhibitorer av lav raolekylvekt i en fremgangsmåte for fremstilling av et farmasøyt ikum for inhlberingen av okkular fibrindan- nelse og ¿avsetning.There is disclosed the use of substances capable of inhibiting the activity of soluble and fibrin- and cell-bound thrombin, particularly hirudin, its derivatives, peptides derived therefrom, and low molecular weight thrombin inhibitors in a process for the preparation of a pharmaceutical medium for the inhibition of ocular fibrin formation and ¿deposition.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4242655A DE4242655A1 (en) | 1992-12-17 | 1992-12-17 | Use of thrombin inhibitors to inhibit ocular fibrin formation |
Publications (1)
Publication Number | Publication Date |
---|---|
NO934653L true NO934653L (en) | 1994-06-20 |
Family
ID=6475561
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO934653D NO934653D0 (en) | 1992-12-17 | 1993-12-16 | Use of thrombin inhibitors for inhibition of ocular fibrin formation |
NO934653A NO934653L (en) | 1992-12-17 | 1993-12-16 | Use of thrombin inhibitors for inhibition of ocular fibrin formation |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO934653D NO934653D0 (en) | 1992-12-17 | 1993-12-16 | Use of thrombin inhibitors for inhibition of ocular fibrin formation |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0603112A1 (en) |
JP (1) | JPH06228006A (en) |
KR (1) | KR940013532A (en) |
AU (1) | AU675090B2 (en) |
CA (1) | CA2111644A1 (en) |
DE (1) | DE4242655A1 (en) |
NO (2) | NO934653D0 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5510369A (en) * | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
US5629324A (en) * | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
US5798377A (en) * | 1996-10-21 | 1998-08-25 | Merck & Co., Inc. | Thrombin inhibitors |
WO2001070273A1 (en) * | 2000-03-20 | 2001-09-27 | Knoll Gmbh | The use of anticoagulant agents in the extracorporeal treatment of blood |
AU2002230836A1 (en) | 2000-12-18 | 2002-07-01 | Merck & Co., Inc. | Benzylamine derivatives and their use as thrombin inhibitors |
US6528503B2 (en) | 2000-12-18 | 2003-03-04 | Merck & Co., Inc. | Thrombin inhibitors |
US7144899B2 (en) | 2001-02-09 | 2006-12-05 | Merck & Co., Inc. | Thrombin inhibitors |
US7084134B2 (en) | 2002-05-02 | 2006-08-01 | Merk & Co., Inc. | Thrombin inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8203887D0 (en) * | 1982-06-23 | 1982-06-23 | Kabivitrum Ab | NEW TROMBIN INHIBITIVE ASSOCIATIONS |
DE3445532A1 (en) * | 1984-12-13 | 1986-06-19 | Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn | HIRUDIN-PA, DESULFATOHIRUDINE-PA, METHOD FOR PRODUCTION AND PHARMACEUTICAL AGENTS THAT CONTAIN THESE ACTIVE SUBSTANCES |
GB8504025D0 (en) * | 1985-02-16 | 1985-03-20 | Biopharm Ltd | Hyaluronidase |
PT84170B (en) * | 1986-01-24 | 1989-03-30 | Sanofi Sa | N-ALPHA-ARIL-SULFONYLAMINOACYL D-AMIDINEFENYL-ALANINAMID D NON-SUBSTITUTED DERIVATIVES PROCESS FOR THE PREPARATION OF N ALPHA-SUBSTITUTED DERIVATIVES |
NL8902454A (en) * | 1989-10-03 | 1991-05-01 | Stichting Centraal Lab | MUTANTS OF THE HUMANE PLASMINOGENIC ACTIVATOR INHIBITOR 1 (PAI-1), THEIR PREPARATION AND USE, AND RECOMBINANT POLYNUCLEOTIDES INCLUDING GENETIC INFORMATION CODING FOR THESE MUTANTS. |
TW201303B (en) * | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
DE4111394A1 (en) * | 1991-04-09 | 1992-10-15 | Behringwerke Ag | AMIDINOPHENYLALANINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THE USE THEREOF AND MEANS THEREOF |
-
1992
- 1992-12-17 DE DE4242655A patent/DE4242655A1/en not_active Withdrawn
-
1993
- 1993-12-04 EP EP93710021A patent/EP0603112A1/en not_active Withdrawn
- 1993-12-15 AU AU52436/93A patent/AU675090B2/en not_active Ceased
- 1993-12-16 CA CA002111644A patent/CA2111644A1/en not_active Abandoned
- 1993-12-16 JP JP5316198A patent/JPH06228006A/en active Pending
- 1993-12-16 KR KR1019930027965A patent/KR940013532A/en not_active Application Discontinuation
- 1993-12-16 NO NO934653D patent/NO934653D0/en unknown
- 1993-12-16 NO NO934653A patent/NO934653L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO934653D0 (en) | 1993-12-16 |
EP0603112A1 (en) | 1994-06-22 |
KR940013532A (en) | 1994-07-15 |
DE4242655A1 (en) | 1994-06-23 |
JPH06228006A (en) | 1994-08-16 |
AU5243693A (en) | 1994-06-30 |
AU675090B2 (en) | 1997-01-23 |
CA2111644A1 (en) | 1994-06-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |