NO932148L - fusion polypeptides - Google Patents

fusion polypeptides

Info

Publication number
NO932148L
NO932148L NO93932148A NO932148A NO932148L NO 932148 L NO932148 L NO 932148L NO 93932148 A NO93932148 A NO 93932148A NO 932148 A NO932148 A NO 932148A NO 932148 L NO932148 L NO 932148L
Authority
NO
Norway
Prior art keywords
dpp
fusion polypeptides
fusion protein
extension
proteins
Prior art date
Application number
NO93932148A
Other languages
Norwegian (no)
Other versions
NO932148D0 (en
Inventor
Teresa M Kubiak
Satish K Sharma
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of NO932148D0 publication Critical patent/NO932148D0/en
Publication of NO932148L publication Critical patent/NO932148L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF] (urogastrone)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Abstract

Et ikke-naturlig forekommende fusjonsprotein omfattende en forlengelsespeptiddel kovalent kjedet ved dens C-ende til N-enden av en biologisk aktiv del, er beskrevet. Forlengelses- peptiddelen kan fjernes ved DPP IV- spaltning. Anvendelse av fusjonspro- teiner med DPP IV-spaltbare forlengel- sespeptiddeler i medisinske preparater er beskrevet. En metode for rensing av ønskede proteiner fra en blanding inneholdende et fusjonsprotein, er be- skrevet.A non-naturally occurring fusion protein comprising an extension peptide covalently linked at its C-end to the N-end of a biologically active moiety is described. The extension peptide moiety can be removed by DPP IV cleavage. The use of fusion proteins with DPP IV cleavable extension peptides in medical preparations is described. A method for purifying desired proteins from a mixture containing a fusion protein is described.

NO93932148A 1990-12-13 1993-06-11 fusion polypeptides NO932148L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62672790A 1990-12-13 1990-12-13
PCT/US1991/009152 WO1992010576A1 (en) 1990-12-13 1991-12-12 Fusion polypeptides

Publications (2)

Publication Number Publication Date
NO932148D0 NO932148D0 (en) 1993-06-11
NO932148L true NO932148L (en) 1993-08-09

Family

ID=24511577

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93932148A NO932148L (en) 1990-12-13 1993-06-11 fusion polypeptides

Country Status (13)

Country Link
EP (1) EP0561971A1 (en)
JP (1) JPH06503473A (en)
AU (1) AU662508B2 (en)
CA (1) CA2094512A1 (en)
CZ (1) CZ109393A3 (en)
FI (1) FI932680A (en)
HU (1) HUT69963A (en)
IE (1) IE914347A1 (en)
NO (1) NO932148L (en)
RU (1) RU2114119C1 (en)
SK (1) SK60893A3 (en)
TW (1) TW213923B (en)
WO (1) WO1992010576A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050272652A1 (en) 1999-03-29 2005-12-08 Gault Victor A Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
JP2000350590A (en) * 1999-04-12 2000-12-19 Pfizer Prod Inc Growth hormone and growth hormone releasing hormone composition
US6759393B1 (en) 1999-04-12 2004-07-06 Pfizer Inc. Growth hormone and growth hormone releasing hormone compositions
US7229793B1 (en) 1999-11-19 2007-06-12 Shire Human Genetic Therapies, Inc. Constructs and cells for production of small peptides
EP1205551A1 (en) * 2000-11-09 2002-05-15 Pfizer Products Inc. Growth hormone and growth hormone releasing hormone compositions
EP1694356B1 (en) 2003-12-09 2011-02-16 Novo Nordisk A/S Regulation of food preference using glp-1 agonists
WO2005120492A1 (en) 2004-06-11 2005-12-22 Novo Nordisk A/S Counteracting drug-induced obesity using glp-1 agonists
US8263545B2 (en) 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
CA2597649A1 (en) 2005-02-11 2006-08-17 Amylin Pharmaceuticals, Inc. Gip analog and hybrid polypeptides with selectable properties
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
EP2863222A1 (en) † 2006-03-06 2015-04-22 Amunix Operating Inc. Unstructured recombinant polymers and uses thereof
US8497240B2 (en) 2006-08-17 2013-07-30 Amylin Pharmaceuticals, Llc DPP-IV resistant GIP hybrid polypeptides with selectable properties
NZ628987A (en) 2009-02-03 2015-11-27 Amunix Operating Inc Extended recombinant polypeptides and compositions comprising same
WO2011028228A1 (en) 2009-08-24 2011-03-10 Amunix Operating Inc. Coagulation factor vii compositions and methods of making and using same
CN107936092B (en) * 2010-01-29 2022-08-09 阿切尔丹尼尔斯密德兰公司 Peptide domains binding small molecules of industrial interest
NZ628014A (en) 2012-02-15 2016-09-30 Biogen Ma Inc Recombinant factor viii proteins
CN104487452A (en) 2012-02-15 2015-04-01 阿穆尼克斯运营公司 Factor viii compositions and methods of making and using same
EP3033097B1 (en) 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
EA201890423A1 (en) 2015-08-03 2018-07-31 Биовератив Терапьютикс Инк. SLIGHT PROTEINS OF THE FACTOR IX, METHODS OF THEIR RECEPTION AND APPLICATION
KR102398777B1 (en) * 2017-06-29 2022-05-17 유레카 에스에이알엘 Prodrug peptides with improved pharmaceutical properties

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703004A (en) * 1984-01-24 1987-10-27 Immunex Corporation Synthesis of protein with an identification peptide
US4569794A (en) * 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
CA1340522C (en) * 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
WO1990015821A1 (en) * 1989-06-16 1990-12-27 The Upjohn Company Stabilized, potent grf analogs
JP3346563B2 (en) * 1990-04-09 2002-11-18 ファルマシア・アンド・アップジョン・カンパニー Improved method for purifying recombinant proteins and compounds useful in the method

Also Published As

Publication number Publication date
CA2094512A1 (en) 1992-06-14
EP0561971A1 (en) 1993-09-29
IE914347A1 (en) 1992-06-17
AU662508B2 (en) 1995-09-07
TW213923B (en) 1993-10-01
SK60893A3 (en) 1993-10-06
AU9116591A (en) 1992-07-08
WO1992010576A1 (en) 1992-06-25
CZ109393A3 (en) 1994-01-19
FI932680A0 (en) 1993-06-11
HU9301705D0 (en) 1993-10-28
NO932148D0 (en) 1993-06-11
FI932680A (en) 1993-06-11
JPH06503473A (en) 1994-04-21
RU2114119C1 (en) 1998-06-27
HUT69963A (en) 1995-09-28

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