NO930247L - 1,4-DISUBSTITUTED PIPERAZINES - Google Patents
1,4-DISUBSTITUTED PIPERAZINESInfo
- Publication number
- NO930247L NO930247L NO93930247A NO930247A NO930247L NO 930247 L NO930247 L NO 930247L NO 93930247 A NO93930247 A NO 93930247A NO 930247 A NO930247 A NO 930247A NO 930247 L NO930247 L NO 930247L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- alkyl
- cyano
- alkenyl
- alkoxy
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Disubstituert piperazin-forbindelse med formel (I) hvor R1 er halogen, metoksy, C-^g-alkyl eller trifluormetyl, og R2 er metyl eller substituert C-^g-alkyl, C3_8-alkenyl eller C3_ 8-cykloalkyl, hvor substituenter kan være hydroksy-, keto- eller oksimino-grupper i hvilken som helst stilling som fører til et stabilt tertiært amin; eller R2 er en rettkjedet eller forgrenet C-^g-alkyl eller C3_8-alkenyl, som i hvilken som helst stilling kan være substituert som ovenfor, men som er terminal-substituert med en av fsigende grupper: cyano, even- tuelt C1_4-alkoksy-substituert C1_4-alkoksy, dimetoksy, even- tuelt substituert fenoksy, fosfonsyre, tienyl, furyl, oksa- zolin, isoksazol, oksadiazol, hvor den eventuelle substitusjon er representert av Cj.g-alkyl eller fenyl, under forutsetning av at når cyano er den eneste substituent i R2, må R2 innehol- de minst fire karbon atomer, og farmasøytisk tilfredstillende syreaddisjonssalter derav. Forbindelsene er egnet ved be- handling av mentale forstyrrelser hvor det inngår en dopamin- ergisk mangel.Disubstituted piperazine compound of formula (I) wherein R 1 is halogen, methoxy, C 1-6 alkyl or trifluoromethyl, and R 2 is methyl or substituted C 1-6 alkyl, C 3-8 alkenyl or C 3-8 cycloalkyl, wherein substituents can be be hydroxy, keto or oxymino groups in any position leading to a stable tertiary amine; or R 2 is a straight-chain or branched C 1-6 alkyl or C 3-8 alkenyl, which at any position may be substituted as above, but which is terminally substituted by one of the following groups: cyano, optionally C 1-4 alkoxy -substituted C 1-4 alkoxy, dimethoxy, optionally substituted phenoxy, phosphonic acid, thienyl, furyl, oxazoline, isoxazole, oxadiazole, where any substitution is represented by C 1-6 alkyl or phenyl, provided that when cyano is the only substituent in R 2, R 2 must contain at least four carbon atoms, and pharmaceutically satisfactory acid addition salts thereof. The compounds are suitable for the treatment of mental disorders involving a dopaminergic deficiency.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK178590A DK178590D0 (en) | 1990-07-26 | 1990-07-26 | 1,4-DISUBSTITUTED PIPERAZINES |
| PCT/DK1991/000205 WO1992001679A1 (en) | 1990-07-26 | 1991-07-15 | 1,4-disubstituted piperazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO930247D0 NO930247D0 (en) | 1993-01-25 |
| NO930247L true NO930247L (en) | 1993-03-25 |
Family
ID=26066112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO93930247A NO930247L (en) | 1990-07-26 | 1993-01-25 | 1,4-DISUBSTITUTED PIPERAZINES |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO930247L (en) |
-
1993
- 1993-01-25 NO NO93930247A patent/NO930247L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO930247D0 (en) | 1993-01-25 |
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