NO930247L - 1,4-DISUBSTITUTED PIPERAZINES - Google Patents
1,4-DISUBSTITUTED PIPERAZINESInfo
- Publication number
- NO930247L NO930247L NO93930247A NO930247A NO930247L NO 930247 L NO930247 L NO 930247L NO 93930247 A NO93930247 A NO 93930247A NO 930247 A NO930247 A NO 930247A NO 930247 L NO930247 L NO 930247L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- alkyl
- cyano
- alkenyl
- alkoxy
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Disubstituert piperazin-forbindelse med formel (I) hvor R1 er halogen, metoksy, C-^g-alkyl eller trifluormetyl, og R2 er metyl eller substituert C-^g-alkyl, C3_8-alkenyl eller C3_ 8-cykloalkyl, hvor substituenter kan være hydroksy-, keto- eller oksimino-grupper i hvilken som helst stilling som fører til et stabilt tertiært amin; eller R2 er en rettkjedet eller forgrenet C-^g-alkyl eller C3_8-alkenyl, som i hvilken som helst stilling kan være substituert som ovenfor, men som er terminal-substituert med en av fsigende grupper: cyano, even- tuelt C1_4-alkoksy-substituert C1_4-alkoksy, dimetoksy, even- tuelt substituert fenoksy, fosfonsyre, tienyl, furyl, oksa- zolin, isoksazol, oksadiazol, hvor den eventuelle substitusjon er representert av Cj.g-alkyl eller fenyl, under forutsetning av at når cyano er den eneste substituent i R2, må R2 innehol- de minst fire karbon atomer, og farmasøytisk tilfredstillende syreaddisjonssalter derav. Forbindelsene er egnet ved be- handling av mentale forstyrrelser hvor det inngår en dopamin- ergisk mangel.Disubstituted piperazine compound of formula (I) wherein R 1 is halogen, methoxy, C 1-6 alkyl or trifluoromethyl, and R 2 is methyl or substituted C 1-6 alkyl, C 3-8 alkenyl or C 3-8 cycloalkyl, wherein substituents can be be hydroxy, keto or oxymino groups in any position leading to a stable tertiary amine; or R 2 is a straight-chain or branched C 1-6 alkyl or C 3-8 alkenyl, which at any position may be substituted as above, but which is terminally substituted by one of the following groups: cyano, optionally C 1-4 alkoxy -substituted C 1-4 alkoxy, dimethoxy, optionally substituted phenoxy, phosphonic acid, thienyl, furyl, oxazoline, isoxazole, oxadiazole, where any substitution is represented by C 1-6 alkyl or phenyl, provided that when cyano is the only substituent in R 2, R 2 must contain at least four carbon atoms, and pharmaceutically satisfactory acid addition salts thereof. The compounds are suitable for the treatment of mental disorders involving a dopaminergic deficiency.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK178590A DK178590D0 (en) | 1990-07-26 | 1990-07-26 | 1,4-DISUBSTITUTED PIPERAZINES |
| PCT/DK1991/000205 WO1992001679A1 (en) | 1990-07-26 | 1991-07-15 | 1,4-disubstituted piperazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO930247D0 NO930247D0 (en) | 1993-01-25 |
| NO930247L true NO930247L (en) | 1993-03-25 |
Family
ID=26066112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO93930247A NO930247L (en) | 1990-07-26 | 1993-01-25 | 1,4-DISUBSTITUTED PIPERAZINES |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO930247L (en) |
-
1993
- 1993-01-25 NO NO93930247A patent/NO930247L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO930247D0 (en) | 1993-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8105299A1 (en) | 4-Aroylimidazol-2-ones | |
| DE3888756D1 (en) | Carbamoylpyrrolidone derivatives, their use and preparation. | |
| SE7501114L (en) | PROCEDURE FOR THE PREPARATION OF D.L-TYROSIN DERIVATIVES WITH PHARMACEUTICAL ACTIVITY ON SMOOTH MUSCLES. | |
| NZ239115A (en) | Substituted piperazine derivatives and pharmaceutical compositions | |
| ES521125A0 (en) | PROCEDURE FOR PREPARING SPIRAL (PIPERIDINE-OXOBENZOXAZINES) SUBSTITUTED IN POSITION 1 ANTI-HYPERTENSIVE. | |
| IE40511L (en) | Pyridyl piperidine derivatives | |
| BR1101136A (en) | Derived from pristinamycin iib, (diethylamino-2 methyl-1 ethyl) sulfinyl-26 pristinamycin iib, (diethylamino-2 propyl) sulfonyl-26 pristinamycin iib, (diisopropylamino-2 ethyl) sulfonyl-26 pristinamycin iib, process of preparing a new derivative of pristinamycin iib and pharmaceutical composition | |
| DE69311118D1 (en) | PHOSPHONO-ARYLETHANOLAMINE COMPOUNDS WITH ANTI-HYPERGLYCEMIC AND / OR ANTIOBESIC EFFECT | |
| ES419871A1 (en) | Aroyl-substituted phenylacetic acid derivatives | |
| GB1424450A (en) | Isoindoline intermediates | |
| ES308210A1 (en) | 1, 3, 4, 9b-tetrahydro-2h-indeno(1, 2-c)pyridine derivatives | |
| FR2663634B1 (en) | NOVEL ACYL BENZOXAZOLINONES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| NO930247L (en) | 1,4-DISUBSTITUTED PIPERAZINES | |
| CA1246583A (en) | 4-(isoxazolyl)-thiazole-2- oxamic acids and derivatives thereof | |
| EP0347902A3 (en) | Pyrrolecarboxylic acid derivatives | |
| ATE123487T1 (en) | DERIVATIVES OF CAFEIC ACID AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| IE41219L (en) | Aralkyl esters of aminoalkanoic acids | |
| SE7900601L (en) | 1-NAFTHYL-ETHIC ACID DERIVATIVE AND PROCEDURES FOR THEIR PREPARATION | |
| SE8302452D0 (en) | METHOD FOR TREATMENT OF SENILE DEMENTIA | |
| ES8505653A1 (en) | Treatment of migraine with N-alkyl-piperidinyl benzoate derivatives. | |
| JPS5573677A (en) | Thienylbenzoic acid derivative and its production | |
| IL97611A (en) | Heterocyclic compounds, their preparation and pharmaceutical compositions containing them | |
| ES272324A1 (en) | Nu-(carbamylmethyl)-4-phenyl-4-carbethoxy piperidines | |
| ES454285A1 (en) | 4-amino-trans-decahydroquinoline derivatives | |
| TH919A (en) | Preparation of the derivative 1- alkyl-2-amino-tetralin |