NO924690L - PROCEDURE FOR THE PREPARATION OF MONO-N-SUBSTITUTED TETRAAZACROCYCLUSES - Google Patents
PROCEDURE FOR THE PREPARATION OF MONO-N-SUBSTITUTED TETRAAZACROCYCLUSESInfo
- Publication number
- NO924690L NO924690L NO92924690A NO924690A NO924690L NO 924690 L NO924690 L NO 924690L NO 92924690 A NO92924690 A NO 92924690A NO 924690 A NO924690 A NO 924690A NO 924690 L NO924690 L NO 924690L
- Authority
- NO
- Norway
- Prior art keywords
- mono
- preparation
- substituted
- tetraazacrocycluses
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A novel process for the preparation of mono-N-substituted tetraazamacrocycles is described.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4140779A DE4140779A1 (en) | 1991-12-06 | 1991-12-06 | METHOD FOR PRODUCING MONO-N SUBSTITUTED TETRAAZAMACROCYCLES |
Publications (3)
Publication Number | Publication Date |
---|---|
NO924690D0 NO924690D0 (en) | 1992-12-04 |
NO924690L true NO924690L (en) | 1993-06-07 |
NO303496B1 NO303496B1 (en) | 1998-07-20 |
Family
ID=6446767
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO924690A NO303496B1 (en) | 1991-12-06 | 1992-12-04 | Process for the preparation of mono-N-substituted tetraazacyclododecane and tetradecane derivatives |
NO973579A NO303387B1 (en) | 1991-12-06 | 1997-08-04 | Process for the preparation of mono-N-substituted tetraazacyclododecane and tetradecane derivatives |
NO973580A NO303386B1 (en) | 1991-12-06 | 1997-08-04 | Process for the preparation of mono-N-substituted tetraazacyclododecane and tetradecane derivatives |
NO973578A NO303384B1 (en) | 1991-12-06 | 1997-08-04 | Process for the preparation of mono-N-substituted tetraazacycloodecane and tetradecane derivatives |
NO973581A NO303385B1 (en) | 1991-12-06 | 1997-08-04 | Process for the preparation of mono-N-substituted tetracyclododecane and tetradecane derivatives |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO973579A NO303387B1 (en) | 1991-12-06 | 1997-08-04 | Process for the preparation of mono-N-substituted tetraazacyclododecane and tetradecane derivatives |
NO973580A NO303386B1 (en) | 1991-12-06 | 1997-08-04 | Process for the preparation of mono-N-substituted tetraazacyclododecane and tetradecane derivatives |
NO973578A NO303384B1 (en) | 1991-12-06 | 1997-08-04 | Process for the preparation of mono-N-substituted tetraazacycloodecane and tetradecane derivatives |
NO973581A NO303385B1 (en) | 1991-12-06 | 1997-08-04 | Process for the preparation of mono-N-substituted tetracyclododecane and tetradecane derivatives |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0545511B1 (en) |
JP (1) | JP3471836B2 (en) |
AT (1) | ATE218131T1 (en) |
CA (1) | CA2084582C (en) |
CZ (1) | CZ290232B6 (en) |
DE (2) | DE4140779A1 (en) |
DK (1) | DK0545511T3 (en) |
ES (1) | ES2176183T3 (en) |
HU (2) | HU224923B1 (en) |
IL (1) | IL103996A (en) |
NO (5) | NO303496B1 (en) |
PT (1) | PT545511E (en) |
SK (1) | SK282386B6 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4237943C2 (en) * | 1992-11-06 | 1997-10-23 | Schering Ag | Process for the preparation of metal complexes of N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane Derivatives |
DE4317588C2 (en) * | 1993-05-24 | 1998-04-16 | Schering Ag | Macrocyclic metal complexes containing fluorine, process for their preparation and their use |
DE4318369C1 (en) * | 1993-05-28 | 1995-02-09 | Schering Ag | Use of macrocyclic metal complexes as temperature probes |
DE4340809C2 (en) * | 1993-11-24 | 2000-08-03 | Schering Ag | 1.4,7,10-tetraazacyclododecane derivatives, pharmaceutical compositions containing them and process for their preparation |
FR2725449B1 (en) * | 1994-10-05 | 1996-12-27 | Air Liquide | POLYAZACYCLOALCANE DERIVATIVES, THEIR METAL COMPLEXES AND PHARMACEUTICAL PRODUCTS INCORPORATING THESE COMPLEXES |
DE19724186C2 (en) * | 1997-06-02 | 2002-07-18 | Schering Ag | Process for the mono- and 1,7-bis-N-ß-hydroxyalkylation of cycles and the corresponding N-ß-hydroxyalkyl-1,4,7,10-tetraazacyclododecane-Li salt complexes |
IT1297035B1 (en) * | 1997-12-30 | 1999-08-03 | Bracco Spa | 1,4,7,10-TETRAAZACICLODODECAN-1,4-DIACETIC ACID DERIVATIVES |
DE19914101C1 (en) * | 1999-03-22 | 2000-10-12 | Schering Ag | Perfluoroalkylamides, their preparation and their use in diagnostics |
DE10002939C1 (en) * | 2000-01-13 | 2001-09-20 | Schering Ag | New aromatic-substituted tetraazacyclododecane-triacetic acid paramagnetic metal complex compounds, are useful as contrast agents for magnetic resonance imaging of necrotic or infarction tissue |
WO2012027727A2 (en) * | 2010-08-26 | 2012-03-01 | Kunyuan Cui | Lipomacrocycles and uses thereof |
EA201600272A1 (en) | 2011-04-21 | 2016-12-30 | Байер Интеллектчуал Проперти Гмбх | GETTING HADOBUTROL OF HIGH PURITY |
KR101653064B1 (en) * | 2014-12-26 | 2016-09-09 | 에스티팜 주식회사 | A Method for Gadobutrol |
KR102033964B1 (en) * | 2018-01-19 | 2019-10-18 | 주식회사 엔지켐생명과학 | Gadoteridol intermediate and method for preparing gadoteridol using the same |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3772785D1 (en) * | 1986-01-23 | 1991-10-17 | Squibb & Sons Inc | 1-SUBSTITUTED-4,7,10-TRISCARBOXYMETHYL-1,4,7,10-TETRAAZACYCLODODECAN AND ANALOG. |
DE3625417C2 (en) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecane derivatives |
US4994560A (en) * | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
FR2644453A1 (en) * | 1989-03-20 | 1990-09-21 | Centre Nat Rech Scient | PROCESS FOR THE PREPARATION OF MONOFUNCTIONALIZED CYCLIC TETRAMINES |
AU625529B2 (en) * | 1989-12-22 | 1992-07-16 | E.R. Squibb & Sons, Inc. | 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes |
AU6709390A (en) * | 1989-12-22 | 1991-06-27 | E.R. Squibb & Sons, Inc. | 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-tris-carboxymethyl -1,4,7,10-tetraazacyclododecane |
DE4009119A1 (en) * | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-TETRAAZACYCLODODECANE-BUTYLTRIOLS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM |
DE4035760A1 (en) * | 1990-11-08 | 1992-05-14 | Schering Ag | MONO-N-SUBSTITUTED 1,4,7,10-TETRAAZACYCLODODECAN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM |
-
1991
- 1991-12-06 DE DE4140779A patent/DE4140779A1/en not_active Withdrawn
-
1992
- 1992-12-03 EP EP92250351A patent/EP0545511B1/en not_active Expired - Lifetime
- 1992-12-03 DK DK92250351T patent/DK0545511T3/en active
- 1992-12-03 DE DE59209957T patent/DE59209957D1/en not_active Expired - Lifetime
- 1992-12-03 AT AT92250351T patent/ATE218131T1/en active
- 1992-12-03 ES ES92250351T patent/ES2176183T3/en not_active Expired - Lifetime
- 1992-12-03 PT PT92250351T patent/PT545511E/en unknown
- 1992-12-04 HU HU9203860A patent/HU224923B1/en unknown
- 1992-12-04 CZ CS19923573A patent/CZ290232B6/en not_active IP Right Cessation
- 1992-12-04 NO NO924690A patent/NO303496B1/en not_active IP Right Cessation
- 1992-12-04 SK SK3573-92A patent/SK282386B6/en not_active IP Right Cessation
- 1992-12-04 HU HU9203860A patent/HU9203860D0/en unknown
- 1992-12-04 CA CA002084582A patent/CA2084582C/en not_active Expired - Lifetime
- 1992-12-06 IL IL103996A patent/IL103996A/en not_active IP Right Cessation
- 1992-12-07 JP JP32657092A patent/JP3471836B2/en not_active Expired - Lifetime
-
1997
- 1997-08-04 NO NO973579A patent/NO303387B1/en not_active IP Right Cessation
- 1997-08-04 NO NO973580A patent/NO303386B1/en not_active IP Right Cessation
- 1997-08-04 NO NO973578A patent/NO303384B1/en not_active IP Right Cessation
- 1997-08-04 NO NO973581A patent/NO303385B1/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |