NO923517L - Heterocyclic Compounds - Google Patents

Heterocyclic Compounds

Info

Publication number
NO923517L
NO923517L NO92923517A NO923517A NO923517L NO 923517 L NO923517 L NO 923517L NO 92923517 A NO92923517 A NO 92923517A NO 923517 A NO923517 A NO 923517A NO 923517 L NO923517 L NO 923517L
Authority
NO
Norway
Prior art keywords
optionally substituted
group
hydrogen
alkyl group
cycloalkyl
Prior art date
Application number
NO92923517A
Other languages
Norwegian (no)
Other versions
NO923517D0 (en
Inventor
John Frederick Batchelor
Clive Leonard Yeates
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909005518A external-priority patent/GB9005518D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of NO923517D0 publication Critical patent/NO923517D0/en
Publication of NO923517L publication Critical patent/NO923517L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/40—Oxygen atoms attached in positions 3 and 4, e.g. maltol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Forbindelse med formel (1): (D der R1 representerer et hydrogen eller halogenatom, eller en cyanogruppe; P2 representerer en valgfri substituert karbocykllsk gruppe som har 6 til 10 rlngatomer og som Inneholder minst en aromatisk ring; en valgfri substituert heterocykllsk gruppe som har 5 til 10 ringatomer, som Inkluderer l til 4 heteroatomer valgt blant O, N og S, og som Inneholder minst en aromatisk ring; eller en valgfri substituert C_ ,-cykloalkyl, C__,- cykloalkyl-C._6-alkyl eller C1_10-alkylgruppe; R3 og R* som kan være Ilke eller forskjellige, representerer hver et hydrogen eller halogenatom, eller en C ,-alkylgruppe valgfritt substituert med l til 3 halogenatomer; og E5 representerer et hydrogenatom, en hydroksylgruppe eller en C1_6~alkylgruppe, valgfritt substituert med hydroksy, karboksy. amlno eller mono- eller di-(C1-4)-alkylamino, og salter og andre fysiologisk funksjonelle derivater derav. Forbindelsene er nyttige l behandling av parasltlske Infeksjoner, f.eks. malaria, coccldlose og Pneumocystls carlnll lungebetennelse.Compound of Formula (1): (D wherein R 1 represents a hydrogen or halogen atom, or a cyano group; P 2 represents an optionally substituted carbocyclic group having 6 to 10 ring atoms and containing at least one aromatic ring; an optional substituted heterocyclic group having 5 to 10 ring atoms which include 1 to 4 heteroatoms selected from O, N and S and containing at least one aromatic ring; or an optionally substituted C1-6 cycloalkyl, C1-, cycloalkyl-C1-6 alkyl or C1-10 alkyl group; R 3 and R * which may be different or different, each represent a hydrogen or halogen atom, or a C 1 -alkyl group optionally substituted with 1 to 3 halogen atoms, and E 5 represents a hydrogen atom, a hydroxyl group or a C 1-6 alkyl group, optionally substituted by hydroxy , carboxy, amino or mono- or di- (C1-4) -alkylamino, and salts and other physiologically functional derivatives thereof. coccldlose and Pneumocysts carlnll pneumonia.

NO92923517A 1990-03-12 1992-09-10 Heterocyclic Compounds NO923517L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909005518A GB9005518D0 (en) 1990-03-12 1990-03-12 Heterocyclic compounds
PCT/GB1991/000380 WO1991013873A1 (en) 1990-03-12 1991-03-11 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
NO923517D0 NO923517D0 (en) 1992-09-10
NO923517L true NO923517L (en) 1992-10-19

Family

ID=26296775

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92923517A NO923517L (en) 1990-03-12 1992-09-10 Heterocyclic Compounds

Country Status (3)

Country Link
AU (1) AU644425B2 (en)
MC (1) MC2252A1 (en)
NO (1) NO923517L (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN142614B (en) * 1974-08-28 1977-08-06 Lilly Co Eli
US4235617A (en) * 1979-03-05 1980-11-25 Ford Motor Company Fabrication of rotary heat exchangers made of magnesium aluminum silicate glass-ceramic
FR2612189B1 (en) * 1987-03-13 1989-06-23 Roussel Uclaf NOVEL PYRIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
MC2252A1 (en) 1993-03-25
NO923517D0 (en) 1992-09-10
AU7454891A (en) 1991-10-10
AU644425B2 (en) 1993-12-09

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