NO922521L - PIPERIDINYLETANODE DERIVATIVES WITH THERAPEUTIC EFFECT - Google Patents

PIPERIDINYLETANODE DERIVATIVES WITH THERAPEUTIC EFFECT

Info

Publication number
NO922521L
NO922521L NO92922521A NO922521A NO922521L NO 922521 L NO922521 L NO 922521L NO 92922521 A NO92922521 A NO 92922521A NO 922521 A NO922521 A NO 922521A NO 922521 L NO922521 L NO 922521L
Authority
NO
Norway
Prior art keywords
group
piperidinyletanode
derivatives
therapeutic effect
hydrogen
Prior art date
Application number
NO92922521A
Other languages
Norwegian (no)
Other versions
NO922521D0 (en
Inventor
Jonathan Frost
Patrick Lardenois
Maria-Carmen Renones
Corinne Rousselle
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9107936A external-priority patent/FR2678270B1/en
Priority claimed from FR9107934A external-priority patent/FR2678265B1/en
Priority claimed from FR9204507A external-priority patent/FR2689891B3/en
Application filed by Synthelabo filed Critical Synthelabo
Publication of NO922521D0 publication Critical patent/NO922521D0/en
Publication of NO922521L publication Critical patent/NO922521L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Forbindelser i form av optisk rene isomerer eller blanding av to enantiomerer med generell formel (I). hvori er et hydrogen- eller halogenatom eller en metyl-gruppe, Rer en eller to substituenter valgt blant hydrogen-og halogenatomene og gruppen (C_)alkyl, hydroksy, (C_)alkoksy, trifluormetyl, acetylamino og metylsulfonylamino, og X er enten en CHgruppe og Y er en CH2. (C)eller CO gruppe, eller X er en CO gruppe og Y er en CHgruppe.En fremgangsmåte for deres fremstilling er beskrevet.Forbindelsene har terapeutisk anvendelse.Compounds in the form of optically pure isomers or mixtures of two enantiomers of general formula (I). wherein is a hydrogen or halogen atom or a methyl group, R 1 is one or two substituents selected from the hydrogen and halogen atoms and the group (C 1) alkyl, hydroxy, (C 1) alkoxy, trifluoromethyl, acetylamino and methylsulfonylamino, and X is either a CH group and Y is a CH 2. (C) or CO group, or X is a CO group and Y is a CH group. A process for their preparation is described. The compounds have therapeutic use.

NO92922521A 1991-06-27 1992-06-26 PIPERIDINYLETANODE DERIVATIVES WITH THERAPEUTIC EFFECT NO922521L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9107936A FR2678270B1 (en) 1991-06-27 1991-06-27 DERIVATIVES OF 2- (PIPERIDIN-1-YL) ETHANOL, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
FR9107934A FR2678265B1 (en) 1991-06-27 1991-06-27 DERIVATIVES OF 4- (2-PHENYLETHYL) PIPERIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.
FR9204507A FR2689891B3 (en) 1992-04-13 1992-04-13 DERIVATIVES OF 2- (PIPERIDIN-1-YL) ETHANOL, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION.

Publications (2)

Publication Number Publication Date
NO922521D0 NO922521D0 (en) 1992-06-26
NO922521L true NO922521L (en) 1992-12-28

Family

ID=27252473

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92922521A NO922521L (en) 1991-06-27 1992-06-26 PIPERIDINYLETANODE DERIVATIVES WITH THERAPEUTIC EFFECT

Country Status (14)

Country Link
EP (1) EP0524846A1 (en)
JP (1) JPH05186460A (en)
KR (1) KR930000505A (en)
CN (1) CN1069491A (en)
AU (1) AU644296B2 (en)
CA (1) CA2072520A1 (en)
CZ (1) CZ199992A3 (en)
FI (1) FI922979A (en)
HU (1) HUT61743A (en)
IE (1) IE922090A1 (en)
IL (1) IL102334A0 (en)
MX (1) MX9203452A (en)
NO (1) NO922521L (en)
NZ (1) NZ243337A (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994001403A1 (en) * 1992-07-08 1994-01-20 Shell Internationale Research Maatschappij B.V. Piperidine derivatives
CZ280669B6 (en) * 1992-10-30 1996-03-13 Pfizer Inc. Derivatives of 3,4-dihydro-2(1h)-quinolone and pharmaceutical composition based thereon
FR2727864B1 (en) * 1994-12-12 1997-04-04 Synthelabo USE OF LIGANDS FROM THE PERIPHERAL BINDING SITES FOR BENZODIAZEPINES FOR THE PREPARATION OF DRUGS USEFUL IN THE TREATMENT OF PERIPHERAL NEUROPATHIES
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
WO1999058117A1 (en) * 1998-05-13 1999-11-18 Sanofi-Synthelabo Use of compounds for reducing apoptosis
FR2778564B1 (en) * 1998-05-13 2001-07-13 Sanofi Sa USE OF COMPOUNDS REDUCING APOPTOSIS
ATE333281T1 (en) 1998-12-18 2006-08-15 Scios Inc AGONISTS AND ANTAGONISTS OF BENZODIAZEPINE RECEPTORS OF THE PERIPHERAL TYPE
JPWO2005097782A1 (en) * 2004-04-07 2007-08-16 協和醗酵工業株式会社 Piperidine derivatives
CN103896835A (en) * 2014-04-20 2014-07-02 武汉珈瑜科技有限公司 Quinolinone derivatives and application thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1030415A (en) * 1987-02-20 1989-01-18 山之内制药株式会社 Saturated heterocycle carboxamide derivatives and its preparation method
FR2640266B2 (en) * 1988-07-12 1992-07-10 Synthelabo INDOLONES-2, QUINOLEINONES-2, BENZO (B) AZEPINONES-2 AND BENZIMIDAZOLONES-2 DERIVATIVES OF (HYDROXY-1 PIPERIDINYL-2 ALKYL), THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
JP2969359B2 (en) * 1989-01-13 1999-11-02 武田薬品工業株式会社 Cyclic amine compounds
FR2644786B1 (en) * 1989-03-21 1993-12-31 Adir Cie NOVEL 4-FLUORO-4 BENZOIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JPH03130263A (en) * 1989-07-19 1991-06-04 Eisai Co Ltd Optically active naphthylethanol derivative
FR2668149B1 (en) * 1990-10-18 1994-09-23 Synthelabo 1- (3,4-DIHYDRO-2-OXO-1H-QUINOLEIN-6-YL) -2- [4- (2-PHENYL-ETHYL) PIPERIDIN-1-YL] ETHANOL, ITS PREPARATION AND THERAPEUTIC APPLICATION .

Also Published As

Publication number Publication date
NO922521D0 (en) 1992-06-26
HUT61743A (en) 1993-03-01
FI922979A0 (en) 1992-06-26
IL102334A0 (en) 1993-01-14
CN1069491A (en) 1993-03-03
KR930000505A (en) 1993-01-15
EP0524846A1 (en) 1993-01-27
AU644296B2 (en) 1993-12-02
CA2072520A1 (en) 1992-12-28
NZ243337A (en) 1994-03-25
FI922979A (en) 1992-12-28
CZ199992A3 (en) 1993-01-13
HU9202138D0 (en) 1992-10-28
IE922090A1 (en) 1992-12-30
AU1858992A (en) 1993-01-07
MX9203452A (en) 1994-01-31
JPH05186460A (en) 1993-07-27

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