NO905625L - PROCEDURE FOR THE PREPARATION OF CARBAPENEM DERIVATIVES AND THEIR INITIAL MATERIALS. - Google Patents

PROCEDURE FOR THE PREPARATION OF CARBAPENEM DERIVATIVES AND THEIR INITIAL MATERIALS.

Info

Publication number
NO905625L
NO905625L NO90905625A NO905625A NO905625L NO 905625 L NO905625 L NO 905625L NO 90905625 A NO90905625 A NO 90905625A NO 905625 A NO905625 A NO 905625A NO 905625 L NO905625 L NO 905625L
Authority
NO
Norway
Prior art keywords
procedure
preparation
initial materials
carbapenem derivatives
pyrazolo
Prior art date
Application number
NO90905625A
Other languages
Norwegian (no)
Other versions
NO905625D0 (en
NO176102B (en
NO176102C (en
Inventor
Satoshi Tamai
Takao Abe
Yunosuke Nagase
Original Assignee
Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lederle Japan Ltd filed Critical Lederle Japan Ltd
Publication of NO905625D0 publication Critical patent/NO905625D0/en
Publication of NO905625L publication Critical patent/NO905625L/en
Priority to NO941274A priority Critical patent/NO177592C/en
Publication of NO176102B publication Critical patent/NO176102B/en
Publication of NO176102C publication Critical patent/NO176102C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel and improved simple process for preparing carbapenem compound, (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo [1,2-a][1,2,4]triazolium-6-yl)]thio-6-[(R)-1-hydroxyethyl]-1-methyl-ca rbapenem-3-carboxylate represented by the following formula: <CHEM> This compound may be prepared by using a mercapto reagent, 6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazolium derivative of the following formula: <CHEM> wherein X<(-)> is an anion charge. g a
NO905625A 1990-10-12 1990-12-28 Process for the preparation of carbapenem derivatives and their starting materials NO176102C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO941274A NO177592C (en) 1990-10-12 1994-04-08 New intermediates for the preparation of carbapenem derivatives

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27242690 1990-10-12
JP27242790 1990-10-12
JP27242890 1990-10-12

Publications (4)

Publication Number Publication Date
NO905625D0 NO905625D0 (en) 1990-12-28
NO905625L true NO905625L (en) 1992-04-13
NO176102B NO176102B (en) 1994-10-24
NO176102C NO176102C (en) 1995-02-01

Family

ID=27335996

Family Applications (1)

Application Number Title Priority Date Filing Date
NO905625A NO176102C (en) 1990-10-12 1990-12-28 Process for the preparation of carbapenem derivatives and their starting materials

Country Status (13)

Country Link
EP (1) EP0480100B1 (en)
KR (1) KR970011387B1 (en)
AT (1) ATE144260T1 (en)
AU (1) AU627970B2 (en)
CA (1) CA2033479C (en)
DE (1) DE69028920T2 (en)
DK (1) DK0480100T3 (en)
ES (1) ES2093010T3 (en)
FI (1) FI906464A (en)
GR (1) GR3021807T3 (en)
IL (1) IL96843A (en)
NO (1) NO176102C (en)
TW (1) TW239142B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0776574A (en) * 1993-09-06 1995-03-20 Wako Pure Chem Ind Ltd Production of disulfide compound
CN101768174B (en) * 2009-01-07 2012-08-08 四川科伦药业股份有限公司 Method for preparing biapenem
CN103497207B (en) * 2011-01-29 2015-09-30 正大天晴药业集团股份有限公司 Biapenem B-type crystallinity
CN102731534B (en) * 2011-04-13 2016-02-03 石药集团中奇制药技术（石家庄）有限公司 A kind of preparation method of biapenem
CN102268025A (en) * 2011-07-15 2011-12-07 海南美兰史克制药有限公司 Biapenem compound and preparation method thereof
CN103965220A (en) * 2013-02-01 2014-08-06 上海医药工业研究院 Preparation method for high purity biapenem
CN103570750A (en) * 2013-11-15 2014-02-12 安徽悦康凯悦制药有限公司 Preparation process of biapenem
CN105481883A (en) * 2015-10-26 2016-04-13 山东鲁抗生物制造有限公司 Synthetic method for high-purity biapenem

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE851586L (en) * 1984-07-02 1986-01-02 Interchem Internat S A I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent
JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
US5102877A (en) * 1989-04-28 1992-04-07 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
JPH02292269A (en) * 1989-05-06 1990-12-03 Lederle Japan Ltd Active amide compound

Also Published As

Publication number Publication date
IL96843A0 (en) 1991-09-16
NO905625D0 (en) 1990-12-28
IL96843A (en) 1995-07-31
AU6862891A (en) 1992-06-11
ATE144260T1 (en) 1996-11-15
DE69028920T2 (en) 1997-02-13
KR970011387B1 (en) 1997-07-10
EP0480100A3 (en) 1992-10-21
NO176102B (en) 1994-10-24
FI906464A (en) 1992-04-13
FI906464A0 (en) 1990-12-31
GR3021807T3 (en) 1997-02-28
EP0480100B1 (en) 1996-10-16
ES2093010T3 (en) 1996-12-16
DK0480100T3 (en) 1996-11-18
EP0480100A2 (en) 1992-04-15
TW239142B (en) 1995-01-21
CA2033479C (en) 2001-01-23
KR920008039A (en) 1992-05-27
DE69028920D1 (en) 1996-11-21
CA2033479A1 (en) 1992-04-13
NO176102C (en) 1995-02-01
AU627970B2 (en) 1992-09-03

Similar Documents

Publication Publication Date Title
EP0905255A3 (en) Process for the preparation of pharmaceutically active thiazolidine or oxazolidine compounds by a yeast reductase
IE820240L (en) Carbapenem derivatives
NO905625D0 (en) PROCEDURE FOR THE PREPARATION OF CARBAPENEM DERIVATIVES AND THEIR INITIAL MATERIALS.
AU3227189A (en) Acyl derivatives
HK1012366A1 (en) Process for the preparation of cyano-methoxyiminomethyl derivatives
EP0366301A3 (en) Preparation of 1,4-diazabicyclo [3.2.2]nonane
FI103576B1 (en) A process for the preparation of a crystalline carbapenem derivative useful as a medicament
IE820239L (en) Carbapenem derivatives
CA2101252A1 (en) Process for preparing trans-piperidine-2,5- dicarboxylates
AU8457591A (en) Process for the preparation of carbapenem compounds
AU2025788A (en) (1r,5s,6s)-2-substituted thio-6-{(r)-1-hydroxyethyl}-1-methyl-carbapenem-3- carboxylic acid derivatives
EP0590681A3 (en) A process for the preparation of aminothiadiazolylacetyl halide derivatives
AU6530796A (en) Process for producing carbamoylmethylurea derivatives
ES8402302A1 (en) A carbapenem compound, preparation and use.
JPS6426580A (en) Production of carbapenem derivative
ZA9114B (en) Process for preparing(1r,5s,6s)-2-((6,7-dihydro-5h-pyrazolo(1,2-a)(1,2,4)triazolium-6-yl))thio-6-((r)-1-hydroxyethyl)-1-methyl-carbapenem-3-carboxylate and starting materials thereof

Legal Events

Date Code Title Description
MK1K Patent expired