NO872461L - PROCEDURE FOR THE PREPARATION OF NEW ANTIHYPERTENSIVE AGENTS. - Google Patents

PROCEDURE FOR THE PREPARATION OF NEW ANTIHYPERTENSIVE AGENTS.

Info

Publication number
NO872461L
NO872461L NO872461A NO872461A NO872461L NO 872461 L NO872461 L NO 872461L NO 872461 A NO872461 A NO 872461A NO 872461 A NO872461 A NO 872461A NO 872461 L NO872461 L NO 872461L
Authority
NO
Norway
Prior art keywords
alkyl
preparation
substituted
independently hydrogen
aryl
Prior art date
Application number
NO872461A
Other languages
Norwegian (no)
Other versions
NO872461D0 (en
NO168584B (en
NO168584C (en
Inventor
Gary A Flynn
Douglas W Beight
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO872461D0 publication Critical patent/NO872461D0/en
Publication of NO872461L publication Critical patent/NO872461L/en
Publication of NO168584B publication Critical patent/NO168584B/en
Publication of NO168584C publication Critical patent/NO168584C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

The invention relates to 6-oxopyrido(2,1-α) and (1,4)thiazino(3,4-a)(2)benzazepine-4-carboxylic acid derivatives and their preparation and also to intermediates which can be used in the preparation. The said derivatives have a pharmacological effect by inhibiting angiotensin converting enzyme and they can be used for treating hypertension. The novel compounds have the formula <IMAGE> in which R and R1 are independently hydrogen; alkyl; substituted alkyl; aryl; substituted aryl; heteroaryl; or substituted heteroaryloxy; R2 is hydrogen, straight-chain or branched alkyl, alkenyl or alkinyl; cycloalkyl, arylalkyl; or substituted alkyl; R3 is H, alkyl, phenyl or benzyl; R4 is a natural amino acid residue, and R3 and R4 have been linked, by way of the carbon atoms to which they are bonded, in order to form a 6-8-membered condensed ring which optionally contains a sulfur or oxygen atom, and R5 and R6 are independently hydrogen, hydroxyl; halogen; alkyl; or alkyloxy.
NO872461A 1986-06-13 1987-06-12 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1,2,3,4,6,7,8,12B-OCTAHYDRO-6-OXOPYRIDO (2,1-A) - (2) BENZAZEPINE-4-CARBOXYLIC ACID DERIVATIVES NO168584C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87375486A 1986-06-13 1986-06-13

Publications (4)

Publication Number Publication Date
NO872461D0 NO872461D0 (en) 1987-06-12
NO872461L true NO872461L (en) 1987-12-14
NO168584B NO168584B (en) 1991-12-02
NO168584C NO168584C (en) 1992-03-11

Family

ID=25362243

Family Applications (1)

Application Number Title Priority Date Filing Date
NO872461A NO168584C (en) 1986-06-13 1987-06-12 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1,2,3,4,6,7,8,12B-OCTAHYDRO-6-OXOPYRIDO (2,1-A) - (2) BENZAZEPINE-4-CARBOXYLIC ACID DERIVATIVES

Country Status (9)

Country Link
CN (1) CN1020612C (en)
AT (1) ATE81511T1 (en)
DE (1) DE3782190T2 (en)
FI (1) FI84481C (en)
HU (2) HU201326B (en)
IL (1) IL82850A (en)
NO (1) NO168584C (en)
NZ (1) NZ220649A (en)
PT (1) PT85070B (en)

Also Published As

Publication number Publication date
PT85070A (en) 1987-07-01
PT85070B (en) 1990-03-08
HU197328B (en) 1989-03-28
DE3782190D1 (en) 1992-11-19
NO872461D0 (en) 1987-06-12
ATE81511T1 (en) 1992-10-15
FI872613A0 (en) 1987-06-11
NO168584B (en) 1991-12-02
CN1020612C (en) 1993-05-12
FI872613A (en) 1987-12-14
FI84481B (en) 1991-08-30
HUT44518A (en) 1988-03-28
IL82850A (en) 1991-03-10
CN87104166A (en) 1988-01-20
HU201326B (en) 1990-10-28
IL82850A0 (en) 1987-12-20
FI84481C (en) 1991-12-10
DE3782190T2 (en) 1993-02-25
NZ220649A (en) 1990-09-26
NO168584C (en) 1992-03-11

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Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN DECEMBER 2000