NO328798B1 - Fremgangsmate for a bestemme en mimotopsekvens - Google Patents
Fremgangsmate for a bestemme en mimotopsekvens Download PDFInfo
- Publication number
- NO328798B1 NO328798B1 NO20012345A NO20012345A NO328798B1 NO 328798 B1 NO328798 B1 NO 328798B1 NO 20012345 A NO20012345 A NO 20012345A NO 20012345 A NO20012345 A NO 20012345A NO 328798 B1 NO328798 B1 NO 328798B1
- Authority
- NO
- Norway
- Prior art keywords
- receptor
- sequence
- library
- test
- activity
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 56
- 238000012360 testing method Methods 0.000 claims abstract description 90
- 230000000694 effects Effects 0.000 claims abstract description 57
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims abstract description 3
- 230000027455 binding Effects 0.000 claims description 25
- 150000001413 amino acids Chemical class 0.000 claims description 17
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 244000005700 microbiome Species 0.000 claims description 3
- 150000002772 monosaccharides Chemical class 0.000 claims description 3
- 239000002773 nucleotide Substances 0.000 claims description 3
- 125000003729 nucleotide group Chemical group 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims 4
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 55
- 108020003175 receptors Proteins 0.000 description 38
- 238000004458 analytical method Methods 0.000 description 23
- 102000004196 processed proteins & peptides Human genes 0.000 description 22
- 238000006467 substitution reaction Methods 0.000 description 20
- 235000001014 amino acid Nutrition 0.000 description 15
- 238000003556 assay Methods 0.000 description 11
- 235000018102 proteins Nutrition 0.000 description 9
- 235000018417 cysteine Nutrition 0.000 description 8
- 108091035707 Consensus sequence Proteins 0.000 description 7
- 238000002965 ELISA Methods 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000012216 screening Methods 0.000 description 5
- 108010067902 Peptide Library Proteins 0.000 description 4
- 150000001945 cysteines Chemical class 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 238000002823 phage display Methods 0.000 description 4
- 108010016626 Dipeptides Chemical group 0.000 description 3
- 150000008575 L-amino acids Chemical class 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000005457 optimization Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 150000008574 D-amino acids Chemical group 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 238000012300 Sequence Analysis Methods 0.000 description 2
- 230000009830 antibody antigen interaction Effects 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- -1 cells Proteins 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 150000002333 glycines Chemical class 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 101710132601 Capsid protein Proteins 0.000 description 1
- 101710094648 Coat protein Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- 101710125418 Major capsid protein Proteins 0.000 description 1
- 101710141454 Nucleoprotein Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 101710083689 Probable capsid protein Proteins 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 108091008039 hormone receptors Proteins 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- AYOOGWWGECJQPI-NSHDSACASA-N n-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(3-propan-2-yloxy-1h-pyrazol-5-yl)imidazo[4,5-b]pyridin-5-amine Chemical compound N1C(OC(C)C)=CC(N2C3=NC(N[C@@H](C)C=4N=CC(F)=CN=4)=CC=C3N=C2)=N1 AYOOGWWGECJQPI-NSHDSACASA-N 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Error Detection And Correction (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Image Analysis (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98203830 | 1998-11-13 | ||
| PCT/NL1999/000700 WO2000029851A1 (en) | 1998-11-13 | 1999-11-15 | A method for determining a mimotope sequence |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20012345D0 NO20012345D0 (no) | 2001-05-11 |
| NO20012345L NO20012345L (no) | 2001-07-05 |
| NO328798B1 true NO328798B1 (no) | 2010-05-18 |
Family
ID=8234328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20012345A NO328798B1 (no) | 1998-11-13 | 2001-05-11 | Fremgangsmate for a bestemme en mimotopsekvens |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1129354B1 (de) |
| JP (1) | JP4510292B2 (de) |
| AT (1) | ATE403871T1 (de) |
| AU (1) | AU758980B2 (de) |
| CA (1) | CA2350141C (de) |
| CY (1) | CY1108475T1 (de) |
| DE (1) | DE69939270D1 (de) |
| DK (1) | DK1129354T3 (de) |
| ES (1) | ES2312218T3 (de) |
| HU (1) | HUP0104306A2 (de) |
| IL (1) | IL143045A0 (de) |
| NO (1) | NO328798B1 (de) |
| NZ (1) | NZ511629A (de) |
| PT (1) | PT1129354E (de) |
| WO (1) | WO2000029851A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002073209A2 (de) * | 2001-03-10 | 2002-09-19 | Affina Immuntechnik Gmbh | Verfahren zur identifikation von immunreaktiven epitopen auf proteinen |
| GB2579392A (en) * | 2018-11-30 | 2020-06-24 | Airbus Operations Ltd | Non-destructive testing |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1255586A (en) * | 1984-07-24 | 1989-06-13 | Hendrik M. Geysen | Method of determining mimotopes |
| US6197529B1 (en) * | 1990-11-21 | 2001-03-06 | Torrey Pines Institute For Molecular Studies | Linear substituted oligoalkyleneimine libraries |
| CA2090860C (en) * | 1990-11-21 | 2003-09-16 | Richard A. Houghten | Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures |
| US5565325A (en) * | 1992-10-30 | 1996-10-15 | Bristol-Myers Squibb Company | Iterative methods for screening peptide libraries |
| US5480971A (en) * | 1993-06-17 | 1996-01-02 | Houghten Pharmaceuticals, Inc. | Peralkylated oligopeptide mixtures |
| US5645996A (en) * | 1994-08-24 | 1997-07-08 | Torrey Pines Institute For Molecular Studies | Melittin-related polypeptides, mixture sets and libraries thereof |
| US5582997A (en) * | 1994-08-24 | 1996-12-10 | Torrey Pines Institute For Molecular Studies | Lysine/leucine polypeptides, mixture sets and libraries thereof |
-
1999
- 1999-11-15 ES ES99956348T patent/ES2312218T3/es not_active Expired - Lifetime
- 1999-11-15 EP EP99956348A patent/EP1129354B1/de not_active Expired - Lifetime
- 1999-11-15 WO PCT/NL1999/000700 patent/WO2000029851A1/en active IP Right Grant
- 1999-11-15 CA CA002350141A patent/CA2350141C/en not_active Expired - Fee Related
- 1999-11-15 AT AT99956348T patent/ATE403871T1/de active
- 1999-11-15 NZ NZ511629A patent/NZ511629A/en not_active IP Right Cessation
- 1999-11-15 AU AU12973/00A patent/AU758980B2/en not_active Ceased
- 1999-11-15 PT PT99956348T patent/PT1129354E/pt unknown
- 1999-11-15 HU HU0104306A patent/HUP0104306A2/hu unknown
- 1999-11-15 DK DK99956348T patent/DK1129354T3/da active
- 1999-11-15 JP JP2000582803A patent/JP4510292B2/ja not_active Expired - Fee Related
- 1999-11-15 IL IL14304599A patent/IL143045A0/xx not_active IP Right Cessation
- 1999-11-15 DE DE69939270T patent/DE69939270D1/de not_active Expired - Lifetime
-
2001
- 2001-05-11 NO NO20012345A patent/NO328798B1/no not_active IP Right Cessation
-
2008
- 2008-11-03 CY CY20081101243T patent/CY1108475T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1129354T3 (da) | 2008-11-10 |
| WO2000029851A1 (en) | 2000-05-25 |
| EP1129354B1 (de) | 2008-08-06 |
| EP1129354A1 (de) | 2001-09-05 |
| NZ511629A (en) | 2004-04-30 |
| NO20012345D0 (no) | 2001-05-11 |
| JP4510292B2 (ja) | 2010-07-21 |
| IL143045A0 (en) | 2002-04-21 |
| HUP0104306A2 (hu) | 2002-03-28 |
| CA2350141C (en) | 2009-01-06 |
| AU758980B2 (en) | 2003-04-03 |
| ATE403871T1 (de) | 2008-08-15 |
| NO20012345L (no) | 2001-07-05 |
| AU1297300A (en) | 2000-06-05 |
| ES2312218T3 (es) | 2009-02-16 |
| JP2002531809A (ja) | 2002-09-24 |
| PT1129354E (pt) | 2008-11-11 |
| DE69939270D1 (de) | 2008-09-18 |
| CY1108475T1 (el) | 2014-04-09 |
| CA2350141A1 (en) | 2000-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |