NO324820B1 - Metoder for oppdrett og innprenting av fisk ved bruk av en odorant - Google Patents
Metoder for oppdrett og innprenting av fisk ved bruk av en odorant Download PDFInfo
- Publication number
- NO324820B1 NO324820B1 NO20041919A NO20041919A NO324820B1 NO 324820 B1 NO324820 B1 NO 324820B1 NO 20041919 A NO20041919 A NO 20041919A NO 20041919 A NO20041919 A NO 20041919A NO 324820 B1 NO324820 B1 NO 324820B1
- Authority
- NO
- Norway
- Prior art keywords
- fish
- pvcr
- odorant
- water
- olfactory
- Prior art date
Links
- 241000251468 Actinopterygii Species 0.000 title claims description 573
- 238000000034 method Methods 0.000 title claims description 198
- 239000003205 fragrance Substances 0.000 title claims description 194
- 238000009395 breeding Methods 0.000 title description 5
- 230000001488 breeding effect Effects 0.000 title description 5
- 235000019688 fish Nutrition 0.000 claims description 586
- 239000013535 sea water Substances 0.000 claims description 136
- 239000013505 freshwater Substances 0.000 claims description 135
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 128
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 96
- 239000005667 attractant Substances 0.000 claims description 78
- 239000011575 calcium Substances 0.000 claims description 72
- 230000031902 chemoattractant activity Effects 0.000 claims description 64
- 239000011780 sodium chloride Substances 0.000 claims description 64
- 150000001413 amino acids Chemical class 0.000 claims description 61
- 230000014509 gene expression Effects 0.000 claims description 53
- 230000035945 sensitivity Effects 0.000 claims description 46
- 241000972773 Aulopiformes Species 0.000 claims description 39
- 235000019515 salmon Nutrition 0.000 claims description 38
- 229910052791 calcium Inorganic materials 0.000 claims description 32
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 30
- 239000011777 magnesium Substances 0.000 claims description 29
- 230000001965 increasing effect Effects 0.000 claims description 27
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 20
- 210000002966 serum Anatomy 0.000 claims description 19
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 18
- 229910052749 magnesium Inorganic materials 0.000 claims description 18
- 230000001418 larval effect Effects 0.000 claims description 15
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 230000035764 nutrition Effects 0.000 claims description 9
- 235000016709 nutrition Nutrition 0.000 claims description 9
- 241000277293 Salvelinus alpinus Species 0.000 claims description 7
- 241000269913 Pseudopleuronectes americanus Species 0.000 claims description 4
- 241000935974 Paralichthys dentatus Species 0.000 claims description 3
- 230000008786 sensory perception of smell Effects 0.000 claims description 3
- 241000723298 Dicentrarchus labrax Species 0.000 claims description 2
- 241000276438 Gadus morhua Species 0.000 claims description 2
- 241000276495 Melanogrammus aeglefinus Species 0.000 claims description 2
- 241000276489 Merlangius merlangus Species 0.000 claims description 2
- 241000269980 Pleuronectidae Species 0.000 claims description 2
- 241000269821 Scombridae Species 0.000 claims description 2
- 241000269959 Xiphias gladius Species 0.000 claims description 2
- 235000020640 mackerel Nutrition 0.000 claims description 2
- 235000021335 sword fish Nutrition 0.000 claims description 2
- 241001327682 Oncorhynchus mykiss irideus Species 0.000 claims 1
- 241000276498 Pollachius virens Species 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 description 59
- 229940024606 amino acid Drugs 0.000 description 58
- 235000001014 amino acid Nutrition 0.000 description 58
- 102000004169 proteins and genes Human genes 0.000 description 56
- 235000018102 proteins Nutrition 0.000 description 55
- 230000004044 response Effects 0.000 description 55
- 230000008569 process Effects 0.000 description 48
- 238000012546 transfer Methods 0.000 description 45
- 239000005871 repellent Substances 0.000 description 40
- 230000002940 repellent Effects 0.000 description 40
- 239000000556 agonist Substances 0.000 description 39
- 210000004027 cell Anatomy 0.000 description 37
- 239000000203 mixture Substances 0.000 description 33
- 210000000196 olfactory nerve Anatomy 0.000 description 32
- 210000001519 tissue Anatomy 0.000 description 32
- 210000001706 olfactory mucosa Anatomy 0.000 description 30
- 241000277263 Salmo Species 0.000 description 27
- 230000012010 growth Effects 0.000 description 27
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 26
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 26
- 241000894007 species Species 0.000 description 26
- 150000001875 compounds Chemical class 0.000 description 23
- 239000000243 solution Substances 0.000 description 21
- 108020004414 DNA Proteins 0.000 description 20
- 235000005911 diet Nutrition 0.000 description 20
- 230000037213 diet Effects 0.000 description 20
- 102000005962 receptors Human genes 0.000 description 19
- 108020003175 receptors Proteins 0.000 description 19
- 102000012547 Olfactory receptors Human genes 0.000 description 18
- 108050002069 Olfactory receptors Proteins 0.000 description 18
- 244000309466 calf Species 0.000 description 18
- 235000013305 food Nutrition 0.000 description 18
- 238000009396 hybridization Methods 0.000 description 18
- 210000001541 thymus gland Anatomy 0.000 description 18
- 238000002474 experimental method Methods 0.000 description 17
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 16
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 15
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 15
- 229960003767 alanine Drugs 0.000 description 15
- 239000012153 distilled water Substances 0.000 description 15
- 229960004799 tryptophan Drugs 0.000 description 15
- 210000001035 gastrointestinal tract Anatomy 0.000 description 13
- 150000002500 ions Chemical class 0.000 description 13
- 210000003734 kidney Anatomy 0.000 description 13
- 230000002829 reductive effect Effects 0.000 description 13
- 241000277331 Salmonidae Species 0.000 description 12
- 150000001768 cations Chemical class 0.000 description 12
- 150000007523 nucleic acids Chemical class 0.000 description 12
- 210000000956 olfactory bulb Anatomy 0.000 description 12
- 238000003757 reverse transcription PCR Methods 0.000 description 12
- 230000001953 sensory effect Effects 0.000 description 12
- 230000006870 function Effects 0.000 description 11
- 210000002816 gill Anatomy 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 230000000366 juvenile effect Effects 0.000 description 10
- 230000008859 change Effects 0.000 description 9
- 235000012631 food intake Nutrition 0.000 description 9
- 238000003365 immunocytochemistry Methods 0.000 description 9
- 210000000936 intestine Anatomy 0.000 description 9
- 210000005036 nerve Anatomy 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 229910052688 Gadolinium Inorganic materials 0.000 description 8
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 8
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 8
- 108020004999 messenger RNA Proteins 0.000 description 8
- 239000013615 primer Substances 0.000 description 8
- 239000011734 sodium Substances 0.000 description 8
- 210000001325 yolk sac Anatomy 0.000 description 8
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 7
- 241000277277 Oncorhynchus nerka Species 0.000 description 7
- 241001280377 Oncorhynchus tshawytscha Species 0.000 description 7
- 241000269908 Platichthys flesus Species 0.000 description 7
- 230000037396 body weight Effects 0.000 description 7
- 229940098773 bovine serum albumin Drugs 0.000 description 7
- 210000004556 brain Anatomy 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 238000011161 development Methods 0.000 description 7
- 230000018109 developmental process Effects 0.000 description 7
- 210000000056 organ Anatomy 0.000 description 7
- 210000003932 urinary bladder Anatomy 0.000 description 7
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 6
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
- 241000277338 Oncorhynchus kisutch Species 0.000 description 6
- 241000277275 Oncorhynchus mykiss Species 0.000 description 6
- 210000004534 cecum Anatomy 0.000 description 6
- 230000001976 improved effect Effects 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 238000002372 labelling Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 6
- 102000039446 nucleic acids Human genes 0.000 description 6
- 235000015097 nutrients Nutrition 0.000 description 6
- 230000008447 perception Effects 0.000 description 6
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 5
- 238000002965 ELISA Methods 0.000 description 5
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 5
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 5
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 5
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 5
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 5
- 241000277326 Oncorhynchus gorbuscha Species 0.000 description 5
- 241000277329 Oncorhynchus keta Species 0.000 description 5
- 238000009360 aquaculture Methods 0.000 description 5
- 244000144974 aquaculture Species 0.000 description 5
- 230000006399 behavior Effects 0.000 description 5
- 230000027455 binding Effects 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 229960000310 isoleucine Drugs 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 210000004415 olfactory epithelial cell Anatomy 0.000 description 5
- 230000008723 osmotic stress Effects 0.000 description 5
- 230000036961 partial effect Effects 0.000 description 5
- 239000008188 pellet Substances 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 230000001846 repelling effect Effects 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 229930182844 L-isoleucine Natural products 0.000 description 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 4
- 230000009102 absorption Effects 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- -1 but not limited to Chemical class 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- 239000004568 cement Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 210000002919 epithelial cell Anatomy 0.000 description 4
- 210000000981 epithelium Anatomy 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 4
- 230000002262 irrigation Effects 0.000 description 4
- 238000003973 irrigation Methods 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
- 241000283707 Capra Species 0.000 description 3
- 241000251730 Chondrichthyes Species 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 229920001917 Ficoll Polymers 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 108700019146 Transgenes Proteins 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 210000000628 antibody-producing cell Anatomy 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 229960000633 dextran sulfate Drugs 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 229960002885 histidine Drugs 0.000 description 3
- 230000004807 localization Effects 0.000 description 3
- 229910001629 magnesium chloride Inorganic materials 0.000 description 3
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 3
- 235000019341 magnesium sulphate Nutrition 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000005012 migration Effects 0.000 description 3
- 238000013508 migration Methods 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 3
- 235000011007 phosphoric acid Nutrition 0.000 description 3
- 229920000768 polyamine Polymers 0.000 description 3
- 108010011110 polyarginine Proteins 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- QDGAVODICPCDMU-UHFFFAOYSA-N 2-amino-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid Chemical compound OC(=O)C(N)CC1=CC=CC(N(CCCl)CCCl)=C1 QDGAVODICPCDMU-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 108010050543 Calcium-Sensing Receptors Proteins 0.000 description 2
- 102000013830 Calcium-Sensing Receptors Human genes 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 241000238366 Cephalopoda Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 description 2
- 239000003155 DNA primer Substances 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241001481760 Erethizon dorsatum Species 0.000 description 2
- 102000030782 GTP binding Human genes 0.000 description 2
- 108091000058 GTP-Binding Proteins 0.000 description 2
- 239000007995 HEPES buffer Substances 0.000 description 2
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 2
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
- 125000003412 L-alanyl group Chemical group [H]N([H])[C@@](C([H])([H])[H])(C(=O)[*])[H] 0.000 description 2
- 150000008575 L-amino acids Chemical class 0.000 description 2
- 229930064664 L-arginine Natural products 0.000 description 2
- 235000014852 L-arginine Nutrition 0.000 description 2
- 239000004201 L-cysteine Substances 0.000 description 2
- 235000013878 L-cysteine Nutrition 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
- 229930182816 L-glutamine Natural products 0.000 description 2
- 239000004395 L-leucine Substances 0.000 description 2
- 235000019454 L-leucine Nutrition 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- 229930195722 L-methionine Natural products 0.000 description 2
- 229930182821 L-proline Natural products 0.000 description 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 2
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 description 2
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229930193140 Neomycin Natural products 0.000 description 2
- 238000000636 Northern blotting Methods 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 108010002724 Pheromone Receptors Proteins 0.000 description 2
- 241000269978 Pleuronectiformes Species 0.000 description 2
- 108010039918 Polylysine Proteins 0.000 description 2
- 239000005700 Putrescine Substances 0.000 description 2
- 101100236310 Rattus norvegicus Gaa gene Proteins 0.000 description 2
- 241000277289 Salmo salar Species 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 241000251778 Squalus acanthias Species 0.000 description 2
- 239000004473 Threonine Substances 0.000 description 2
- 102100038344 Vomeronasal type-1 receptor 2 Human genes 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 238000000246 agarose gel electrophoresis Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 229960001230 asparagine Drugs 0.000 description 2
- 229960005261 aspartic acid Drugs 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000003542 behavioural effect Effects 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- VHRGRCVQAFMJIZ-UHFFFAOYSA-N cadaverine Chemical compound NCCCCCN VHRGRCVQAFMJIZ-UHFFFAOYSA-N 0.000 description 2
- 230000002092 calcimimetic effect Effects 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 235000011148 calcium chloride Nutrition 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229960002433 cysteine Drugs 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 238000009313 farming Methods 0.000 description 2
- YFHXZQPUBCBNIP-UHFFFAOYSA-N fura-2 Chemical compound CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC=2C(=CC=3OC(=CC=3C=2)C=2OC(=CN=2)C(O)=O)N(CC(O)=O)CC(O)=O)=C1 YFHXZQPUBCBNIP-UHFFFAOYSA-N 0.000 description 2
- 229960002989 glutamic acid Drugs 0.000 description 2
- 229960002743 glutamine Drugs 0.000 description 2
- 230000012447 hatching Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000008991 intestinal motility Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 229960003136 leucine Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 229910001425 magnesium ion Inorganic materials 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 229960004452 methionine Drugs 0.000 description 2
- 238000010369 molecular cloning Methods 0.000 description 2
- 230000004899 motility Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 229960004927 neomycin Drugs 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 102000013415 peroxidase activity proteins Human genes 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 239000002427 pheromone receptor Substances 0.000 description 2
- 229920000656 polylysine Polymers 0.000 description 2
- 229960002429 proline Drugs 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 230000000384 rearing effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000007634 remodeling Methods 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 229960001153 serine Drugs 0.000 description 2
- 235000015170 shellfish Nutrition 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 description 2
- 229940063675 spermine Drugs 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 229960002898 threonine Drugs 0.000 description 2
- 230000009261 transgenic effect Effects 0.000 description 2
- 210000005239 tubule Anatomy 0.000 description 2
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 2
- 229910052721 tungsten Inorganic materials 0.000 description 2
- 239000010937 tungsten Substances 0.000 description 2
- 229960004295 valine Drugs 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- XZCDLPDABRHPCN-PVSSEACSSA-N (2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-amino-3-(1h-indol-3-yl)propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1.C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 XZCDLPDABRHPCN-PVSSEACSSA-N 0.000 description 1
- HWTAKVLMACWHLD-UHFFFAOYSA-N 2-(9h-carbazol-1-yl)ethanamine Chemical compound C12=CC=CC=C2NC2=C1C=CC=C2CCN HWTAKVLMACWHLD-UHFFFAOYSA-N 0.000 description 1
- YJXUXANREVNZLH-PFEQFJNWSA-N 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine;hydrochloride Chemical compound Cl.COC1=CC=CC([C@@H](C)NCCCC=2C(=CC=CC=2)Cl)=C1 YJXUXANREVNZLH-PFEQFJNWSA-N 0.000 description 1
- 241001519451 Abramis brama Species 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000273930 Brevoortia tyrannus Species 0.000 description 1
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 241000258955 Echinodermata Species 0.000 description 1
- 241000251729 Elasmobranchii Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000239366 Euphausiacea Species 0.000 description 1
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
- 108091006027 G proteins Proteins 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 101000938351 Homo sapiens Ephrin type-A receptor 3 Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- GRSZFWQUAKGDAV-KQYNXXCUSA-N IMP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-KQYNXXCUSA-N 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- TYYLDKGBCJGJGW-UHFFFAOYSA-N L-tryptophan-L-tyrosine Natural products C=1NC2=CC=CC=C2C=1CC(N)C(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 TYYLDKGBCJGJGW-UHFFFAOYSA-N 0.000 description 1
- 241000251238 Lamna nasus Species 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 239000005089 Luciferase Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 239000007832 Na2SO4 Substances 0.000 description 1
- 241001447767 Oeneis nevadensis Species 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 101710176384 Peptide 1 Proteins 0.000 description 1
- 102100026918 Phospholipase A2 Human genes 0.000 description 1
- 108010058864 Phospholipases A2 Proteins 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 238000010240 RT-PCR analysis Methods 0.000 description 1
- 101000947107 Rattus norvegicus Extracellular calcium-sensing receptor Proteins 0.000 description 1
- 241000157468 Reinhardtius hippoglossoides Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 241000269809 Sparus aurata Species 0.000 description 1
- 241000692569 Stylephorus chordatus Species 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 102000030621 adenylate cyclase Human genes 0.000 description 1
- 108060000200 adenylate cyclase Proteins 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 210000003503 anal sac Anatomy 0.000 description 1
- 229910052925 anhydrite Inorganic materials 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000009697 arginine Nutrition 0.000 description 1
- 238000000376 autoradiography Methods 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 230000007321 biological mechanism Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000011095 buffer preparation Methods 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 235000011116 calcium hydroxide Nutrition 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000033077 cellular process Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000003399 chemotactic effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 230000002964 excitative effect Effects 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 235000020680 filtered tap water Nutrition 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 229940013317 fish oils Drugs 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000004459 forage Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 210000003736 gastrointestinal content Anatomy 0.000 description 1
- 239000003629 gastrointestinal hormone Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 229940049906 glutamate Drugs 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000003284 homeostatic effect Effects 0.000 description 1
- 102000057382 human EPHA3 Human genes 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 235000013902 inosinic acid Nutrition 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000003871 intestinal function Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 230000037427 ion transport Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- OTCKOJUMXQWKQG-UHFFFAOYSA-L magnesium bromide Chemical compound [Mg+2].[Br-].[Br-] OTCKOJUMXQWKQG-UHFFFAOYSA-L 0.000 description 1
- 229910001623 magnesium bromide Inorganic materials 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000014380 magnesium carbonate Nutrition 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000897 modulatory effect Effects 0.000 description 1
- 238000001823 molecular biology technique Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- WOPAHKKTEVUGOE-OAHLLOKOSA-N n-[(1r)-1-(3-methoxyphenyl)ethyl]-3-phenylpropan-1-amine Chemical compound COC1=CC=CC([C@@H](C)NCCCC=2C=CC=CC=2)=C1 WOPAHKKTEVUGOE-OAHLLOKOSA-N 0.000 description 1
- 239000008239 natural water Substances 0.000 description 1
- 230000007830 nerve conduction Effects 0.000 description 1
- 210000004412 neuroendocrine cell Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229960005190 phenylalanine Drugs 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 230000008288 physiological mechanism Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 description 1
- 229920002704 polyhistidine Polymers 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 108010055896 polyornithine Proteins 0.000 description 1
- 229920002714 polyornithine Polymers 0.000 description 1
- 230000020073 positive regulation of transport Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000004853 protein function Effects 0.000 description 1
- 230000026447 protein localization Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 210000003370 receptor cell Anatomy 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000009394 selective breeding Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 229940063673 spermidine Drugs 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- UYPYRKYUKCHHIB-UHFFFAOYSA-N trimethylamine N-oxide Chemical compound C[N+](C)(C)[O-] UYPYRKYUKCHHIB-UHFFFAOYSA-N 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 230000007279 water homeostasis Effects 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K79/00—Methods or means of catching fish in bulk not provided for in groups A01K69/00 - A01K77/00, e.g. fish pumps; Detection of fish; Whale fishery
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K79/00—Methods or means of catching fish in bulk not provided for in groups A01K69/00 - A01K77/00, e.g. fish pumps; Detection of fish; Whale fishery
- A01K79/02—Methods or means of catching fish in bulk not provided for in groups A01K69/00 - A01K77/00, e.g. fish pumps; Detection of fish; Whale fishery by electrocution
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Animal Husbandry (AREA)
- Marine Sciences & Fisheries (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Biophysics (AREA)
- Birds (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Insects & Arthropods (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Farming Of Fish And Shellfish (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Meat, Egg Or Seafood Products (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Confectionery (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32846401P | 2001-10-11 | 2001-10-11 | |
| PCT/US2002/032217 WO2003030639A2 (en) | 2001-10-11 | 2002-10-08 | Methods for growing and imprinting fish using an odorant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20041919D0 NO20041919D0 (no) | 2004-05-10 |
| NO20041919L NO20041919L (no) | 2004-07-07 |
| NO324820B1 true NO324820B1 (no) | 2007-12-10 |
Family
ID=23281091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20041919A NO324820B1 (no) | 2001-10-11 | 2004-05-10 | Metoder for oppdrett og innprenting av fisk ved bruk av en odorant |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6748900B2 (da) |
| EP (1) | EP1434482B9 (da) |
| JP (1) | JP4614118B2 (da) |
| AT (1) | ATE322159T1 (da) |
| AU (1) | AU2002337833A1 (da) |
| CA (1) | CA2463556A1 (da) |
| DE (1) | DE60210487D1 (da) |
| DK (1) | DK1434482T3 (da) |
| NO (1) | NO324820B1 (da) |
| WO (1) | WO2003030639A2 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2250069A1 (en) | 1996-03-27 | 1997-10-02 | Brigham And Women's Hospital | Polycation-sensing receptor in aquatic species and methods of use thereof |
| US6463883B1 (en) | 2000-10-12 | 2002-10-15 | Marical, Llc | Methods for raising pre-adult anadromous fish |
| US6951739B2 (en) | 2000-10-12 | 2005-10-04 | Marical, Inc. | Polyvalent cation-sensing receptor in atlantic salmon |
| WO2002030182A2 (en) * | 2000-10-12 | 2002-04-18 | Marical, Inc. | Methods for raising pre-adult anadromous fish |
| US6979558B2 (en) | 2000-10-12 | 2005-12-27 | Marical, Inc. | Polyvalent cation-sensing receptor in Atlantic salmon |
| US6979559B2 (en) | 2000-10-12 | 2005-12-27 | Marical, Inc. | Polyvalent cation-sensing receptor in atlantic salmon |
| US7101988B2 (en) | 2000-10-12 | 2006-09-05 | Marical, Inc. | Polyvalent cation-sensing receptor in Atlantic salmon |
| RU2008136456A (ru) * | 2006-03-07 | 2010-04-20 | Оушен Рисорс Эксчэйндж Ллс (Сша/Сша) (Us) | Передаваемые квоты на ловлю |
| WO2009102558A2 (en) * | 2008-02-11 | 2009-08-20 | Monsanto Technology Llc | Aquaculture feed, products, and methods comprising beneficial fatty acids |
| WO2015191136A1 (en) * | 2014-06-11 | 2015-12-17 | CRUSHtacean, Inc. | Synthetic bait for attracting marine organisms |
| US10136648B1 (en) * | 2016-07-13 | 2018-11-27 | Peter Fein | Fish attraction composition |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3406662A (en) * | 1965-08-20 | 1968-10-22 | Nor Laks O C Vik & K O Vik | Method for breeding fish, such as salmon or sea trout |
| GB1361616A (en) * | 1971-01-28 | 1974-07-30 | Unilever Ltd | Rearing of fish |
| US4172124A (en) * | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
| JPS5764601A (en) * | 1980-10-07 | 1982-04-19 | Mikasa Kagaku Kogyo Kk | Animal atrracting and repellent aerosol composition |
| JPS61145196A (ja) * | 1984-12-19 | 1986-07-02 | Suntory Ltd | ステロイド配糖体 |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US6001884A (en) * | 1991-08-23 | 1999-12-14 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US5763569A (en) * | 1991-08-23 | 1998-06-09 | The Brigham And Women's Hospital, Inc | Calcium receptor-active molecules |
| US5858684A (en) * | 1991-08-23 | 1999-01-12 | The Brigham And Women's Hospital, Inc. | Method of screening calcium receptor-active molecules |
| AU663386B2 (en) * | 1992-06-30 | 1995-10-05 | Senju Pharmaceutical Co., Ltd. | Artificial sea-water |
| US5962314A (en) * | 1993-02-23 | 1999-10-05 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US5823141A (en) * | 1994-07-22 | 1998-10-20 | International Flavors & Fragrances Inc. | Process and for exciting, attracting, stimulating, and/or inciting members of the class crustacea |
| US5837490A (en) * | 1996-06-17 | 1998-11-17 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| CA2250069A1 (en) * | 1996-03-27 | 1997-10-02 | Brigham And Women's Hospital | Polycation-sensing receptor in aquatic species and methods of use thereof |
| US5722346A (en) * | 1996-04-17 | 1998-03-03 | The Board Of Governors For Higher Education | Smolting feed |
| US5827551A (en) * | 1996-04-23 | 1998-10-27 | Berkley Inc. | Fish attractant |
| ES2280460T3 (es) * | 1996-05-01 | 2007-09-16 | Nps Pharmaceuticals, Inc. | Compuestos activos frente a receptores de iones inorganicos. |
| US5651651A (en) * | 1996-08-16 | 1997-07-29 | Spencer; Paul E. | Tamper resistant fastening assembly and method of use |
| US6269586B1 (en) * | 1999-05-21 | 2001-08-07 | Pure Fishing, Inc. | Baits with electrolyte mixtures |
| US6016770A (en) * | 1999-06-16 | 2000-01-25 | Fisher; Jerold W. | Acclimating salt-water fish to brackish or fresh water |
| AU764158B2 (en) * | 1999-07-20 | 2003-08-14 | Regents Of The University Of California, The | Odorant receptors |
| US6481379B1 (en) * | 2000-10-12 | 2002-11-19 | Marical, Llc | Methods for raising pre-adult anadromous fish |
| US6463882B1 (en) * | 2000-10-12 | 2002-10-15 | Marical, Llc | Growing marine fish in freshwater |
| US6463883B1 (en) * | 2000-10-12 | 2002-10-15 | Marical, Llc | Methods for raising pre-adult anadromous fish |
| WO2002030182A2 (en) * | 2000-10-12 | 2002-04-18 | Marical, Inc. | Methods for raising pre-adult anadromous fish |
| US6475792B1 (en) * | 2000-10-12 | 2002-11-05 | Marical, Llc | Methods for raising pre-adult anadromous fish |
-
2002
- 2002-10-08 EP EP02773731A patent/EP1434482B9/en not_active Expired - Lifetime
- 2002-10-08 WO PCT/US2002/032217 patent/WO2003030639A2/en active IP Right Grant
- 2002-10-08 CA CA002463556A patent/CA2463556A1/en not_active Abandoned
- 2002-10-08 AT AT02773731T patent/ATE322159T1/de not_active IP Right Cessation
- 2002-10-08 DE DE60210487T patent/DE60210487D1/de not_active Expired - Lifetime
- 2002-10-08 DK DK02773731T patent/DK1434482T3/da active
- 2002-10-08 US US10/268,051 patent/US6748900B2/en not_active Expired - Lifetime
- 2002-10-10 AU AU2002337833A patent/AU2002337833A1/en not_active Abandoned
- 2002-10-10 JP JP2003533685A patent/JP4614118B2/ja not_active Expired - Fee Related
-
2004
- 2004-05-10 NO NO20041919A patent/NO324820B1/no not_active IP Right Cessation
- 2004-05-21 US US10/851,047 patent/US7055461B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO20041919L (no) | 2004-07-07 |
| WO2003030639A2 (en) | 2003-04-17 |
| WO2003030639A3 (en) | 2004-03-11 |
| US7055461B2 (en) | 2006-06-06 |
| NO20041919D0 (no) | 2004-05-10 |
| EP1434482A2 (en) | 2004-07-07 |
| US20030124090A1 (en) | 2003-07-03 |
| AU2002337833A1 (en) | 2003-04-22 |
| CA2463556A1 (en) | 2003-04-17 |
| JP4614118B2 (ja) | 2011-01-19 |
| EP1434482B9 (en) | 2007-11-28 |
| ATE322159T1 (de) | 2006-04-15 |
| US20040244714A1 (en) | 2004-12-09 |
| DE60210487D1 (de) | 2006-05-18 |
| EP1434482B1 (en) | 2006-04-05 |
| JP2005505278A (ja) | 2005-02-24 |
| DK1434482T3 (da) | 2006-08-14 |
| US6748900B2 (en) | 2004-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4098080B2 (ja) | 成魚前溯上性魚を飼育するための方法 | |
| US20050181426A1 (en) | Polyvalent cation-sensing receptor in atlantic salmon | |
| US20050181427A1 (en) | Polyvalent cation-sensing receptor in atlantic salmon | |
| Targońska et al. | Influence of temperature during four following spawning seasons on the spawning effectiveness of common bream, Abramis brama (L.) under natural and controlled conditions | |
| US7121227B2 (en) | Methods for raising pre-adult anadromous fish | |
| US7055461B2 (en) | Methods for growing and imprinting fish using an odorant | |
| JP2000507822A (ja) | 水生生物種における多価カチオンセンシングレセプターおよびその使用方法 | |
| US20070031864A1 (en) | Polyvalent cation-sensing receptor in atlantic salmon | |
| Williot et al. | Induced maturation and spawning in an incidentally caught adult pair of critically endangered European sturgeon, Acipenser sturio L. | |
| US20050181425A1 (en) | Polyvalent cation-sensing receptor in atlantic salmon | |
| Kucharczyk et al. | Artificial reproduction of the indoor-cultured brackish form of maraena whitefish (Coregonus maraena) under recirculated aquaculture system (RAS) conditions | |
| Paulsen et al. | Growth rate and nutritional status of wild and released reared juvenile turbot in southern Kattegat, Denmark | |
| Ueda | Physiological mechanisms of imprinting and homing migration of Pacific salmon | |
| Żarski et al. | Reproduction of Nase,(L.), Under Controlled Conditions | |
| Das et al. | First Record of Induced Breeding of Indian Potasi, Neotropius atherinoides (Bloch 1794) in Bangladesh. | |
| WO2003087331A2 (en) | Polyvalent cation-sensing receptor in atlantic salmon | |
| Ueda | Physiology of imprinting and homing migration of Pacific salon | |
| US20180153924A1 (en) | Compositions and methods for aquaculture | |
| CA2481827C (en) | Polyvalent cation-sensing receptor in atlantic salmon | |
| Fares | Effect of temperature treatment on some reproductive and physiological performance in female nile tilapia (Oreochromis niloticus) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |