NO323542B1 - Salter av bicykliske, N-acylerte imidazo-3-aminer og imidazo-5-aminer, fremgangsmate for fremstilling derav, deres anvendelse for fremstilling avlegemidler, samt legemidler inneholdende forbindelsene. - Google Patents
Salter av bicykliske, N-acylerte imidazo-3-aminer og imidazo-5-aminer, fremgangsmate for fremstilling derav, deres anvendelse for fremstilling avlegemidler, samt legemidler inneholdende forbindelsene. Download PDFInfo
- Publication number
- NO323542B1 NO323542B1 NO20024838A NO20024838A NO323542B1 NO 323542 B1 NO323542 B1 NO 323542B1 NO 20024838 A NO20024838 A NO 20024838A NO 20024838 A NO20024838 A NO 20024838A NO 323542 B1 NO323542 B1 NO 323542B1
- Authority
- NO
- Norway
- Prior art keywords
- imidazo
- acetyl
- ium chloride
- pyridin
- acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 120
- 150000003839 salts Chemical class 0.000 title claims description 59
- 125000002619 bicyclic group Chemical class 0.000 title claims description 51
- 238000002360 preparation method Methods 0.000 title claims description 44
- 150000001875 compounds Chemical class 0.000 title claims description 18
- 239000003814 drug Substances 0.000 title claims description 9
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- 239000003599 detergent Substances 0.000 title 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 323
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- 238000006243 chemical reaction Methods 0.000 claims description 48
- 239000002253 acid Substances 0.000 claims description 47
- 239000007795 chemical reaction product Substances 0.000 claims description 36
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- 150000002431 hydrogen Chemical class 0.000 claims description 32
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 25
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- 238000011282 treatment Methods 0.000 claims description 21
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 19
- 239000002904 solvent Substances 0.000 claims description 15
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 7
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 7
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- 125000003118 aryl group Chemical group 0.000 claims description 7
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- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 6
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- WJHBIPJMKROIHO-UHFFFAOYSA-M methyl 2-[(1-acetyl-2-cyclohexylimidazo[1,2-a]pyrimidin-4-ium-3-yl)amino]acetate;chloride Chemical compound [Cl-].CC(=O)[N+]1=C2N=CC=CN2C(NCC(=O)OC)=C1C1CCCCC1 WJHBIPJMKROIHO-UHFFFAOYSA-M 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
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- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 description 1
- 229960004127 naloxone Drugs 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- REEZZSHJLXOIHL-UHFFFAOYSA-N octanoyl chloride Chemical compound CCCCCCCC(Cl)=O REEZZSHJLXOIHL-UHFFFAOYSA-N 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 210000002975 pon Anatomy 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000001525 receptor binding assay Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000002731 stomach secretion inhibitor Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10019714A DE10019714A1 (de) | 2000-04-20 | 2000-04-20 | Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen |
| PCT/EP2001/003772 WO2001081344A1 (de) | 2000-04-20 | 2001-04-03 | Salze von bicyclischen, n-acylierten imidazo-3-aminen und imidazo-5-aminen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20024838D0 NO20024838D0 (no) | 2002-10-07 |
| NO20024838L NO20024838L (no) | 2002-10-07 |
| NO323542B1 true NO323542B1 (no) | 2007-06-11 |
Family
ID=7639529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20024838A NO323542B1 (no) | 2000-04-20 | 2002-10-07 | Salter av bicykliske, N-acylerte imidazo-3-aminer og imidazo-5-aminer, fremgangsmate for fremstilling derav, deres anvendelse for fremstilling avlegemidler, samt legemidler inneholdende forbindelsene. |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7087607B2 (da) |
| EP (1) | EP1274709B1 (da) |
| JP (1) | JP2003531208A (da) |
| KR (1) | KR100756594B1 (da) |
| CN (1) | CN1232520C (da) |
| AR (1) | AR030559A1 (da) |
| AT (1) | ATE277045T1 (da) |
| AU (2) | AU2001258305B2 (da) |
| BR (1) | BR0110357A (da) |
| CA (1) | CA2402808A1 (da) |
| CZ (1) | CZ20023476A3 (da) |
| DE (2) | DE10019714A1 (da) |
| DK (1) | DK1274709T3 (da) |
| ES (1) | ES2227186T3 (da) |
| HK (1) | HK1052703B (da) |
| HU (1) | HUP0300532A3 (da) |
| IL (2) | IL152352A0 (da) |
| MX (1) | MXPA02009602A (da) |
| NO (1) | NO323542B1 (da) |
| NZ (1) | NZ521069A (da) |
| PE (1) | PE20011213A1 (da) |
| PL (1) | PL365676A1 (da) |
| PT (1) | PT1274709E (da) |
| RU (1) | RU2268888C2 (da) |
| SI (1) | SI1274709T1 (da) |
| SK (1) | SK15022002A3 (da) |
| TR (1) | TR200402755T4 (da) |
| UY (1) | UY26675A1 (da) |
| WO (1) | WO2001081344A1 (da) |
| ZA (1) | ZA200209408B (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10019714A1 (de) | 2000-04-20 | 2002-01-10 | Gruenenthal Gmbh | Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen |
| DE10050663A1 (de) † | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
| BRPI0610863A2 (pt) | 2005-05-20 | 2010-08-03 | Array Biopharma Inc | compostos inibidores de raf e métodos para sua utilização |
| TW200800213A (en) | 2005-09-02 | 2008-01-01 | Abbott Lab | Novel imidazo based heterocycles |
| PL1973545T3 (pl) | 2005-12-23 | 2013-05-31 | Ariad Pharma Inc | Bicykliczne Związki Heteroarylowe |
| CA2646437C (en) * | 2006-03-17 | 2016-05-17 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
| EA200870592A1 (ru) * | 2006-05-31 | 2009-08-28 | Галапагос Н.В. | Триазолопиразиновые соединения, пригодные для лечения дегенеративных и воспалительных заболеваний |
| MX2009003650A (es) * | 2006-10-06 | 2009-04-22 | Abbott Lab | Nuevos imidazotiazoles e imidazoxazoles. |
| US8703492B2 (en) | 2007-04-06 | 2014-04-22 | Qiagen Gaithersburg, Inc. | Open platform hybrid manual-automated sample processing system |
| US7985375B2 (en) * | 2007-04-06 | 2011-07-26 | Qiagen Gaithersburg, Inc. | Sample preparation system and method for processing clinical specimens |
| EP2201018B1 (en) | 2007-09-19 | 2016-03-16 | Ambit Biosciences Corporation | Solid forms comprising n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-ý7-(2-morpholin-4-yl-ethoxy)imidazoý2,1-b¨ý1,3¨benzothiazol-2-yl¨phenyl}urea, compositions thereof, and uses therewith |
| WO2011063139A1 (en) | 2009-11-18 | 2011-05-26 | Qiagen | Laboratory central control unit method and system |
| KR200453430Y1 (ko) * | 2011-01-10 | 2011-05-03 | 백현숙 | 싱크대용 선반 |
| MX2014012741A (es) | 2012-04-26 | 2015-04-13 | Bristol Myers Squibb Co | Derivados de imidazotiadiazol e imidazopirazina como inhibidores del receptor 4 activado de proteasa (par4) para tratamiento de agregacion plaquetaria. |
| DK3243826T3 (da) | 2012-04-26 | 2020-02-03 | Bristol Myers Squibb Co | Imidazothiadiazol-og imidazopyrazinderivater som proteaseaktiverede receptor 4- (par4) hæmmere til behandling af blodpladeaggregation |
| EA201491967A1 (ru) | 2012-04-26 | 2015-03-31 | Бристол-Майерс Сквибб Компани | Производные имидазотиадиазола в качестве ингибиторов активируемых протеазой рецепторов 4 (par4) для лечения агрегации тромбоцитов |
| US9617279B1 (en) | 2014-06-24 | 2017-04-11 | Bristol-Myers Squibb Company | Imidazooxadiazole compounds |
| US9598419B1 (en) | 2014-06-24 | 2017-03-21 | Universite De Montreal | Imidazotriazine and imidazodiazine compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2857776A (en) | 1955-01-13 | 1958-10-28 | American Metal Prod | Lead screw selectively operable and releasable under load |
| US3489755A (en) | 1966-08-03 | 1970-01-13 | Pfizer & Co C | Imidazo (1,2-b) pyridazines |
| US3792166A (en) * | 1970-11-16 | 1974-02-12 | American Cyanamid Co | Method of using substituted imidazo (2,1-b)thiazoles as anthelmintic agents |
| US3894022A (en) * | 1973-06-25 | 1975-07-08 | Sandoz Ag | Tetracyclic quinazolinones and quinazolinium salts |
| JPS5398997A (en) | 1977-02-09 | 1978-08-29 | Sumitomo Chem Co Ltd | Fused pyridine derivertives and process for their preparation |
| GB2039882A (en) * | 1979-01-05 | 1980-08-20 | Ciba Geigy Ag | Bicyclic thiadiaza compounds and their use as medicaments |
| EP0068378B1 (en) * | 1981-06-26 | 1986-03-05 | Schering Corporation | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| FR2568880B1 (fr) * | 1984-08-07 | 1986-12-12 | Synthelabo | Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique |
| FR2627491B1 (fr) | 1988-02-18 | 1992-01-24 | Roussel Uclaf | Nouveaux derives du benzocyclohexane et du benzocycloheptane ainsi que leurs sels, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
| JPH0753730B2 (ja) * | 1988-07-26 | 1995-06-07 | 三共株式会社 | イミダゾピラゾール誘導体 |
| US5536853A (en) * | 1994-04-11 | 1996-07-16 | Chiron Corporation | Opiate receptor ligands |
| DE10019714A1 (de) | 2000-04-20 | 2002-01-10 | Gruenenthal Gmbh | Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen |
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2000
- 2000-04-20 DE DE10019714A patent/DE10019714A1/de not_active Withdrawn
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2001
- 2001-04-03 TR TR2004/02755T patent/TR200402755T4/xx unknown
- 2001-04-03 PT PT01931560T patent/PT1274709E/pt unknown
- 2001-04-03 PL PL01365676A patent/PL365676A1/xx not_active Application Discontinuation
- 2001-04-03 EP EP01931560A patent/EP1274709B1/de not_active Expired - Lifetime
- 2001-04-03 AT AT01931560T patent/ATE277045T1/de active
- 2001-04-03 MX MXPA02009602A patent/MXPA02009602A/es active IP Right Grant
- 2001-04-03 CZ CZ20023476A patent/CZ20023476A3/cs unknown
- 2001-04-03 IL IL15235201A patent/IL152352A0/xx unknown
- 2001-04-03 JP JP2001578434A patent/JP2003531208A/ja not_active Withdrawn
- 2001-04-03 BR BR0110357-1A patent/BR0110357A/pt not_active Application Discontinuation
- 2001-04-03 SK SK1502-2002A patent/SK15022002A3/sk unknown
- 2001-04-03 RU RU2002130245/04A patent/RU2268888C2/ru active
- 2001-04-03 ES ES01931560T patent/ES2227186T3/es not_active Expired - Lifetime
- 2001-04-03 DK DK01931560T patent/DK1274709T3/da active
- 2001-04-03 AU AU2001258305A patent/AU2001258305B2/en not_active Ceased
- 2001-04-03 SI SI200130236T patent/SI1274709T1/xx unknown
- 2001-04-03 KR KR1020027014037A patent/KR100756594B1/ko not_active IP Right Cessation
- 2001-04-03 DE DE50103764T patent/DE50103764D1/de not_active Expired - Lifetime
- 2001-04-03 HU HU0300532A patent/HUP0300532A3/hu unknown
- 2001-04-03 CN CNB018079423A patent/CN1232520C/zh not_active Expired - Fee Related
- 2001-04-03 CA CA002402808A patent/CA2402808A1/en not_active Abandoned
- 2001-04-03 WO PCT/EP2001/003772 patent/WO2001081344A1/de active IP Right Grant
- 2001-04-03 NZ NZ521069A patent/NZ521069A/en unknown
- 2001-04-03 AU AU5830501A patent/AU5830501A/xx active Pending
- 2001-04-17 AR ARP010101796A patent/AR030559A1/es unknown
- 2001-04-19 PE PE2001000355A patent/PE20011213A1/es not_active Application Discontinuation
- 2001-04-20 UY UY26675A patent/UY26675A1/es not_active Application Discontinuation
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2002
- 2002-10-07 NO NO20024838A patent/NO323542B1/no not_active IP Right Cessation
- 2002-10-17 IL IL152352A patent/IL152352A/en active IP Right Grant
- 2002-10-18 US US10/273,344 patent/US7087607B2/en not_active Expired - Fee Related
- 2002-11-19 ZA ZA200209408A patent/ZA200209408B/en unknown
-
2003
- 2003-07-10 HK HK03105003.1A patent/HK1052703B/zh not_active IP Right Cessation
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2006
- 2006-06-06 US US11/447,141 patent/US7153873B2/en not_active Expired - Fee Related
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