NO312153B1 - Oral hygiene preparations for inhibiting halitosis - Google Patents
Oral hygiene preparations for inhibiting halitosis Download PDFInfo
- Publication number
- NO312153B1 NO312153B1 NO20005877A NO20005877A NO312153B1 NO 312153 B1 NO312153 B1 NO 312153B1 NO 20005877 A NO20005877 A NO 20005877A NO 20005877 A NO20005877 A NO 20005877A NO 312153 B1 NO312153 B1 NO 312153B1
- Authority
- NO
- Norway
- Prior art keywords
- copper
- oral hygiene
- tablet
- gluconate
- sodium
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 22
- 206010006326 Breath odour Diseases 0.000 title claims description 18
- 230000002401 inhibitory effect Effects 0.000 title claims description 8
- 208000032139 Halitosis Diseases 0.000 title claims description 5
- 239000002324 mouth wash Substances 0.000 claims description 15
- 229940051866 mouthwash Drugs 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 229910001868 water Inorganic materials 0.000 claims description 13
- 239000000843 powder Substances 0.000 claims description 11
- 229910052802 copper Inorganic materials 0.000 claims description 10
- 239000010949 copper Substances 0.000 claims description 10
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 10
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 9
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 6
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 6
- 235000019856 cupric gluconate Nutrition 0.000 claims description 6
- 239000011642 cupric gluconate Substances 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229910001431 copper ion Inorganic materials 0.000 claims description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 4
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 239000007884 disintegrant Substances 0.000 claims description 2
- 229940050410 gluconate Drugs 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003826 tablet Substances 0.000 description 16
- 210000000214 mouth Anatomy 0.000 description 6
- 230000000694 effects Effects 0.000 description 4
- 239000007937 lozenge Substances 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 229910021645 metal ion Inorganic materials 0.000 description 3
- 150000003464 sulfur compounds Chemical class 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- 240000001548 Camellia japonica Species 0.000 description 2
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 229940108925 copper gluconate Drugs 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 208000028169 periodontal disease Diseases 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical compound [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
- 239000005749 Copper compound Substances 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 244000010000 Hovenia dulcis Species 0.000 description 1
- 235000008584 Hovenia dulcis Nutrition 0.000 description 1
- 240000003553 Leptospermum scoparium Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 208000005888 Periodontal Pocket Diseases 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000004287 bisbiguanides Chemical class 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 235000018597 common camellia Nutrition 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- -1 copper cations Chemical class 0.000 description 1
- 150000001880 copper compounds Chemical class 0.000 description 1
- IGVXUBLWIFEMDL-UHFFFAOYSA-N copper(2+) Chemical compound [Cu+2].[Cu+2] IGVXUBLWIFEMDL-UHFFFAOYSA-N 0.000 description 1
- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 210000005081 epithelial layer Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000003891 ferrous sulphate Nutrition 0.000 description 1
- 239000011790 ferrous sulphate Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940079841 sodium copper chlorophyllin Drugs 0.000 description 1
- 235000013758 sodium copper chlorophyllin Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Description
Denne oppfinnelsen angår et munnhygiene-preparat for hemning av halitose, i form av en tablett eller et pulver som ved oppløsning i vann danner et munnvann. Det således oppnådde munnvann er effektivt mot dårlig ånde. This invention relates to an oral hygiene preparation for inhibiting halitosis, in the form of a tablet or a powder which, when dissolved in water, forms a mouthwash. The mouthwash thus obtained is effective against bad breath.
Det er velkjent at dårlig ånde skyldes flyktige svovelforbindelser (VSC) som dannes ved bakterie-katabolisme av proteiner i munnhulen, særlig i sprekker bakerst på tungen og i periodontale lommer. VSC er hovedsakelig hydrogensulfid og metylmerkaptan, som har en meget ubehagelig lukt, selv i lave konsentrasjoner. VSC er også kjent for å kunne trenge gjennom det orale epitellag og skade celler i det underliggende bindevev og ben, en prosess som antas å være en viktig faktor ved igangsettelse og utvikling av periodontale sykdommer. It is well known that bad breath is caused by volatile sulfur compounds (VSC) which are formed by bacterial catabolism of proteins in the oral cavity, particularly in fissures at the back of the tongue and in periodontal pockets. VSC is mainly hydrogen sulphide and methyl mercaptan, which have a very unpleasant smell, even in low concentrations. VSC are also known to be able to penetrate the oral epithelial layer and damage cells in the underlying connective tissue and bone, a process believed to be an important factor in the initiation and development of periodontal diseases.
Det er videre kjent at vannoppløselige salter av visse metaller, så som toverdige kationer av sink, kobber og tinn, kan hemme dårlig ånde. De ovennevnte metaller har en høy affinitet for svovel og fjerner VSC ved å danne uoppløselige sulfider med forløpere for de flyktige svovelforbindelser, en reaksjon som hemmer ytterligere dannelse av illeluktende gasser i munnhulen. It is also known that water-soluble salts of certain metals, such as divalent cations of zinc, copper and tin, can inhibit bad breath. The above metals have a high affinity for sulfur and remove VSC by forming insoluble sulfides with precursors of the volatile sulfur compounds, a reaction that inhibits further formation of malodorous gases in the oral cavity.
Det er også velkjent at vannoppløselige, kationiske, antibakterielle midler så som bis-biguanider og kvartære ammoniumforbindelser er i stand til å hemme dårlig ånde ved anvendelse som munnvann. It is also well known that water-soluble cationic antibacterial agents such as bis-biguanides and quaternary ammonium compounds are capable of inhibiting bad breath when used as mouthwashes.
Japansk patentsøknad JP 1996/356310 (publikasjon JP 98182384 A2) beskriver et preparat til bruk i munnhulen, som kan anvendes for å hindre dårlig ånde. Mulige bestanddeler i preparatet er triklosan, natriumbikarbonat, mentol og andre luktstoffer. Japanese patent application JP 1996/356310 (publication JP 98182384 A2) describes a preparation for use in the oral cavity, which can be used to prevent bad breath. Possible ingredients in the preparation are triclosan, sodium bicarbonate, menthol and other fragrances.
Japanske patentsøknad JP 1988/317621 (publikasjon JP 90164816 A2) angår en vandig drikk som inneholder jern(ll)sulfat og natriumbikarbonat. Det er angitt i søknaden at halitose hemmes ved å drikke denne drikk. Japanese patent application JP 1988/317621 (publication JP 90164816 A2) relates to an aqueous beverage containing ferrous sulfate and sodium bicarbonate. It is stated in the application that halitosis is inhibited by drinking this drink.
Japansk patentsøknad JP 1985/39538 (publikasjon JP 86197510 A2) angår et preparat som kan være i form av en tannpasta, et tannpulver, munnvann, massasjekrem for tannkjøttet eller en væske eller pasta for lokal påføring. Preparatet inneholder små mengder nitroimidazol. Preparatet inneholder dessuten ekstrakter fra blader av en kameliaplante så som te-tre eller kamelia eller natrium-kobber-klorofyllin. Preparatet anvendes for å hindre periodontale sykdommer og stomatose og kan også hindre at gramnegative, anaerobe mikroorganismer danner flyktige svovelforbindelser i munnhulen. Japanese patent application JP 1985/39538 (publication JP 86197510 A2) relates to a preparation which may be in the form of a toothpaste, a tooth powder, mouthwash, massage cream for the gums or a liquid or paste for local application. The preparation contains small amounts of nitroimidazole. The preparation also contains extracts from the leaves of a camellia plant such as tea tree or camellia or sodium-copper-chlorophyllin. The preparation is used to prevent periodontal diseases and stomatosis and can also prevent gram-negative, anaerobic microorganisms from forming volatile sulfur compounds in the oral cavity.
WO 99/56714 angår et baktericid for rensemidler, som omfatter en uorganisk bærer med antifungale metallioner, og et protese-rensemiddel inneholdende baktericidet. Baktericidet er særlig egnet for proteser, og det er angitt at det undertrykker dårlig ånde og protese-spesifikk stomatitt. WO 99/56714 relates to a bactericide for cleaning agents, comprising an inorganic carrier with antifungal metal ions, and a denture cleaner containing the bactericide. The bactericide is particularly suitable for dentures, and it is indicated that it suppresses bad breath and denture-specific stomatitis.
Artikkelen "Effects of new flavonoid gums eliminating bad breath", Shokuhin Kogyo (SKGYAQ, 05598990); 1995; Vol. 38 (4); s. 70-8, angår en tyggegummi som inneholder grønn te flavonoider, klorofyll-kobberkompleks og Hovenia dulcis. Den anvendes for å fjerne dårlig ånde. The article "Effects of new flavonoid gums eliminating bad breath", Shokuhin Kogyo (SKGYAQ, 05598990); 1995; Vol. 38 (4); pp. 70-8, relates to a chewing gum containing green tea flavonoids, chlorophyll-copper complex and Hovenia dulcis. It is used to remove bad breath.
WO-0023040 angår et tørt preparat for bekjempelse av dårlig ånde, som omfatter: A. minst ett bæremateriale valgt fra sakkaridmaterialer (søtningsstoffer); WO-0023040 relates to a dry preparation for combating bad breath, comprising: A. at least one carrier material selected from saccharide materials (sweeteners);
B. minst ett hjelpestoff valgt blant oljeaktige stoffer; og B. at least one excipient selected from oily substances; and
C. minst ett aktivt stoff hvor det blant en rekke totalt forskjellige stoffer også nevnes metallioner. C. at least one active substance where, among a number of completely different substances, metal ions are also mentioned.
Det er også nevnt at metallionene kan være fra kobberglukonat, og dessuten er det nevnt at forskjellige søtningsstoffer kan være tilstede. It is also mentioned that the metal ions may be from copper gluconate, and furthermore it is mentioned that various sweeteners may be present.
Det er nu funnet at et munnvann dannet fra en tablett eller et pulver, som raskt kan oppløses i vann og som inneholder toverdige kationer av kobber, oppviser en markert hemmende virking mot dårlig ånde. It has now been found that a mouthwash formed from a tablet or a powder, which can be quickly dissolved in water and which contains divalent cations of copper, exhibits a marked inhibitory effect against bad breath.
Foreliggende oppfinnelse tilveiebringer et munnhygiene-preparat for hemning av halitose, i form av en tablett eller et pulver som ved oppløsning i vann danner et munnvann. Preparatet inneholder kobber(ll)glukonat som gir kobberioner i vann, og natrium- eller kalsiumbikarbonat som virker som et oppspaltningsmiddel. The present invention provides an oral hygiene preparation for inhibiting halitosis, in the form of a tablet or a powder which, when dissolved in water, forms a mouthwash. The preparation contains copper(ll) gluconate, which gives copper ions in water, and sodium or calcium bicarbonate, which acts as a splitting agent.
Kobber(ll)glukonat inneholder ca. 15% kobber. En passende mengde kobber i en tablett eller i en pulverdose er en mengde som gir en kobberkonsentrasjon på 0,003 til 0,3 vekt-% i 10 ml vann, og fortrinnsvis en konsentrasjon på ca. 0,015%. For å få en egnet konsentrasjon av kobber i munnvannet, bør en tablett eller en pulverdose inneholde en vannoppløselig kobberforbindelse i en mengde på ca. 0,3 til 30 mg, fortrinnsvis 0,5 til 5 mg, beregnet som frie kobber(ll)kobberioner. Dette svarer til 2 til 200 mg, fortrinnsvis 3,5 til 35 mg kobberglukonat. Copper (II) gluconate contains approx. 15% copper. A suitable amount of copper in a tablet or in a powder dose is an amount which gives a copper concentration of 0.003 to 0.3% by weight in 10 ml of water, and preferably a concentration of approx. 0.015%. To get a suitable concentration of copper in the mouthwash, a tablet or a powder dose should contain a water-soluble copper compound in an amount of approx. 0.3 to 30 mg, preferably 0.5 to 5 mg, calculated as free copper(II) copper ions. This corresponds to 2 to 200 mg, preferably 3.5 to 35 mg of copper gluconate.
Preparatet i henhold til oppfinnelsen inneholder natrium- eller kalsiumbikarbonat som virker som et oppspaltningsmiddel som letter den hurtige oppløsning av preparatet, innbefattet kobber(ll)glukonatet. Natrium- eller kalsiumbikarbonat kan anvendes i mengder på 20 til 2000 mg, særlig 50 til 500 mg i en tablett som er tenkt oppløst i 10 ml vann. I et pulver vil mengden av natriumbikarbonat vanligvis være mindre enn i en tablett. The preparation according to the invention contains sodium or calcium bicarbonate which acts as a disintegrant which facilitates the rapid dissolution of the preparation, including the copper (II) gluconate. Sodium or calcium bicarbonate can be used in amounts of 20 to 2000 mg, in particular 50 to 500 mg in a tablet which is intended to be dissolved in 10 ml of water. In a powder, the amount of sodium bicarbonate will usually be less than in a tablet.
Et særlig foretrukket prepratet ifølge oppfinnelsen er en tablett som inneholder 50 til 500 mg natriumbikarbonat og 5 til 50 mg kobber(ll)glukonat. A particularly preferred preparation according to the invention is a tablet containing 50 to 500 mg of sodium bicarbonate and 5 to 50 mg of copper (II) gluconate.
Preparatet ifølge oppfinnelsen kan også inneholde andre komponenter så som søtningsmidler, smaksstoffer, hjelpestoffer og fyllstoffer. Eksempler på slike andre komponenter er acesulfam K, aspartam, sakkarin, xylitol og sorbitol. Tabletter i form av sugetabletter inneholdende kobber er allerede på markedet som diett-suppleringsmidler eller for hemning av dårlig ånde. Slike tabletter er laget for å bli oppløst i munnen ved suging og er derfor ofte bare lite oppløselige i vann. Slike tabletter er klart forskjellige fra tablettene ifølge foreliggende oppfinnelse. Et middel med en hemmende virkning på dårlig ånde er langt mer effektivt i den vandige form av et munnvann enn i den tørre form man har med en sugetablett. Grunnen til dette er at VSC er meget oppløselig i vann. Den vandige del av et munnvann er således effektivt som sådan, og dette er i tillegg til virkningen av de oppløste midler som er tilstede i munnvannet som nevnt ovenfor. Dette understøttes av den velkjente iakttakelse at dårlig ånde ofte er forbundet med tørr munn. The preparation according to the invention may also contain other components such as sweeteners, flavourings, excipients and fillers. Examples of such other components are acesulfame K, aspartame, saccharin, xylitol and sorbitol. Tablets in the form of lozenges containing copper are already on the market as dietary supplements or for inhibiting bad breath. Such tablets are designed to be dissolved in the mouth by sucking and are therefore often only slightly soluble in water. Such tablets are clearly different from the tablets according to the present invention. An agent with an inhibitory effect on bad breath is far more effective in the aqueous form of a mouthwash than in the dry form you have with a lozenge. The reason for this is that VSC is very soluble in water. The aqueous part of a mouthwash is thus effective as such, and this is in addition to the effect of the dissolved agents present in the mouthwash as mentioned above. This is supported by the well-known observation that bad breath is often associated with dry mouth.
Foreliggende oppfinnelse kombinerer således tilgjengeligheten og det praktiske ved anvendelse av tabletter, pulvere eller andre faste preparater, med den særlig gode virkning som oppnås ved hjelp av munnvann. The present invention thus combines the availability and practicality of using tablets, powders or other solid preparations, with the particularly good effect achieved by means of mouthwash.
En ytterligere fordel med et munnvann sammenlignet med en sugetablett, er at anvendelse av munnvann bare medfører en lokal virkning av kobberkationene i munnen, ettersom munnvannet spyttes ut etter bruk, mens bestanddelene av en sugetablett blir svelget. A further advantage of a mouthwash compared to a lozenge is that the use of mouthwash only results in a local effect of the copper cations in the mouth, as the mouthwash is spit out after use, while the components of a lozenge are swallowed.
Eksempel 1 Example 1
Et pulver som er laget for å bli oppløst i 20 ml vann: A powder made to be dissolved in 20 ml of water:
Eksempel 2 Example 2
Tablett laget for å bli oppløst i 10 ml vann: Tablet made to be dissolved in 10 ml of water:
Eksempel 3 Example 3
Tablett laget for å bli oppløst i 10 ml vann: Tablet made to be dissolved in 10 ml of water:
Eksempel 4 Example 4
Tablett laget for å bli oppløst 110 ml vann: Tablet made to be dissolved in 110 ml of water:
Claims (6)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20005877A NO312153B1 (en) | 2000-11-21 | 2000-11-21 | Oral hygiene preparations for inhibiting halitosis |
| PCT/NO2001/000458 WO2002041862A1 (en) | 2000-11-21 | 2001-11-19 | An oral hygiene preparation for inhibiting halitosis |
| AU2002224224A AU2002224224A1 (en) | 2000-11-21 | 2001-11-19 | An oral hygiene preparation for inhibiting halitosis |
| US09/988,718 US20020114767A1 (en) | 2000-11-21 | 2001-11-20 | Oral hygiene preparation for inhibiting halitosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20005877A NO312153B1 (en) | 2000-11-21 | 2000-11-21 | Oral hygiene preparations for inhibiting halitosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20005877D0 NO20005877D0 (en) | 2000-11-21 |
| NO20005877A NO20005877A (en) | 2002-04-02 |
| NO312153B1 true NO312153B1 (en) | 2002-04-02 |
Family
ID=19911823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20005877A NO312153B1 (en) | 2000-11-21 | 2000-11-21 | Oral hygiene preparations for inhibiting halitosis |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2002224224A1 (en) |
| NO (1) | NO312153B1 (en) |
| WO (1) | WO2002041862A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11007143B2 (en) * | 2013-03-15 | 2021-05-18 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the oral-respiratory-otic areas of the body |
| US11000545B2 (en) | 2013-03-15 | 2021-05-11 | Cda Research Group, Inc. | Copper ion compositions and methods of treatment for conditions caused by coronavirus and influenza |
| US11318089B2 (en) | 2013-03-15 | 2022-05-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of making topical copper ion treatments for use in various anatomical areas of the body |
| US10398733B2 (en) | 2013-03-15 | 2019-09-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body |
| US11083750B2 (en) | 2013-03-15 | 2021-08-10 | Cda Research Group, Inc. | Methods of treatment using topical copper ion formulations |
| US11193184B2 (en) | 2019-02-22 | 2021-12-07 | Cda Research Group, Inc. | System for use in producing a metal ion suspension and process of using same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1203308A (en) * | 1967-10-02 | 1970-08-26 | Miles Lab | Improvements in or relating to tableting lubricants and tableting processes |
| US4112066A (en) * | 1976-06-21 | 1978-09-05 | Life Savers, Inc. | Breath freshener composition and method |
| US4971785A (en) * | 1988-03-14 | 1990-11-20 | Spectrum Consumer Products Co., Inc. | Non-alcoholic delivery system for orally ingestible active ingredients |
| US5037634A (en) * | 1990-08-16 | 1991-08-06 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Oral compositions containing stabilized copper |
| US6030605A (en) * | 1997-04-03 | 2000-02-29 | Nabisco, Inc. | Breath freshening compositions and methods using them |
| AU6428099A (en) * | 1998-10-16 | 2000-05-08 | Fuisz Technologies Ltd. | Dry deodorizing composition for oral administration |
-
2000
- 2000-11-21 NO NO20005877A patent/NO312153B1/en not_active IP Right Cessation
-
2001
- 2001-11-19 AU AU2002224224A patent/AU2002224224A1/en not_active Abandoned
- 2001-11-19 WO PCT/NO2001/000458 patent/WO2002041862A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20005877A (en) | 2002-04-02 |
| NO20005877D0 (en) | 2000-11-21 |
| AU2002224224A1 (en) | 2002-06-03 |
| WO2002041862A1 (en) | 2002-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2019201243B2 (en) | Oral care compositions and methods of using the compositions | |
| US3962417A (en) | Dentifrice | |
| RU2241436C2 (en) | Aromatic mixture for masking unpleasant taste of zinc compounds | |
| US8679463B2 (en) | Oral hygiene products and method | |
| TW201625201A (en) | Dentifrice comprising zinc - amino acid complex and phosphates | |
| WO2006117029A1 (en) | Use of polylysine in combination with either green tea or olive extracts or both for use against halitosis | |
| EP2413922A1 (en) | Antibacterial composition comprising 4 -isopropyl-3-methylpheno and zinc ions | |
| CN116172889A (en) | Oral care compositions and methods of use | |
| TW201223554A (en) | Dentifrice composition with reduced astringency | |
| JPH0798737B2 (en) | Tartar prevention and oral deodorant solid composition | |
| RU2493812C2 (en) | Dental seal | |
| NO315731B1 (en) | Anti-stone dental preparation, and its use for the manufacture of a dentifrice | |
| HUT70072A (en) | Oral compositions | |
| CA3202906A1 (en) | Oral care compositions and methods | |
| JPS62503033A (en) | Solid oral composition for caries prevention | |
| JP2002003353A (en) | Methionase and/or protease inhibitor and composition for oral cavity | |
| US20020114767A1 (en) | Oral hygiene preparation for inhibiting halitosis | |
| CN116600770A (en) | Oral care compositions with amine fluoride | |
| NO312153B1 (en) | Oral hygiene preparations for inhibiting halitosis | |
| JP2013528618A (en) | Bad breath control method and product | |
| JP2003160459A (en) | Methionase activity inhibitor and composition for oral cavity | |
| CN116546959A (en) | Oral care compositions and preservative systems | |
| EP4199886A1 (en) | Oral care compositions and methods | |
| MXPA01010307A (en) | Dentrifice compositions having reduced abrasivity. | |
| JP2005002107A (en) | Composition for cleaning inside of oral cavity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CB | Opposition filed (par. 26,5 patents act) |
Opponent name: EJVIND JERSIE PEDERSEN, ULVSHALEVEJ 10, DK-4780 ST Effective date: 20021230 |
|
| MK1K | Patent expired |