NO20073389L - Tetrahydropyridln-4-yllndoler med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseter - Google Patents
Tetrahydropyridln-4-yllndoler med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseterInfo
- Publication number
- NO20073389L NO20073389L NO20073389A NO20073389A NO20073389L NO 20073389 L NO20073389 L NO 20073389L NO 20073389 A NO20073389 A NO 20073389A NO 20073389 A NO20073389 A NO 20073389A NO 20073389 L NO20073389 L NO 20073389L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- hydrogen
- tetrahydropyridin
- dopamine
- receptors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Den foreliggende oppfinnelsen vedrører en gruppe nye tetrahydropyridin-4-yl-indoler med en todelt virkemåte: serotonin-reopptaksinhibisjon og affinitet for dopamin-D2 reseptorer, fremgangsmåter for fremstilling av disse forbindelsene og nye mellomprodukter som er nyttige ved syntesen av de nevnte tetrahydropyridin-4-yl-indolene. Oppfinnelsen vedrører også anvendelse av en forbindelse som her er beskrevet for fremstilling av et medikament som gir en fordelaktig effekt. Oppfinnelsen vedrører nye tetrahydropyridin-4-yl-indoler med formel (I). Og tautomerer, isomerer, prodrugs, N-oksider, farmakologisk akseptable salter, hydrater og solvater derav, der: - R1 er hydrogen, halogen, alkyl(C1-3) eller alkoksy(C1-3), CN eller CF3, - R2 er hydrogen eller alkyl(C1-3), R3 er hydrogen eller alkyl (C1-3), -Z er hydrogen eller alkyl (C1-3), alkoksy (C1-3) eller alkyltio(C1-3), - A er hydrogen eller alkyl (C1-3), eller -A og Z danner sammen en mettet eller (delvis) umettet 5- eller 6-leddet ring som kan være substituert med halogen, alkyl (C1-3) eller fenyl, der Z i ringen står for karbon, svovel eller nitrogen.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63343904P | 2004-12-07 | 2004-12-07 | |
EP04106351 | 2004-12-07 | ||
PCT/EP2005/056501 WO2006061373A2 (en) | 2004-12-07 | 2005-12-06 | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-d2 receptors and serotonin reuptake sites |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20073389L true NO20073389L (no) | 2007-07-05 |
Family
ID=36578275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20073389A NO20073389L (no) | 2004-12-07 | 2007-07-02 | Tetrahydropyridln-4-yllndoler med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseter |
Country Status (2)
Country | Link |
---|---|
IL (1) | IL183202A0 (no) |
NO (1) | NO20073389L (no) |
-
2007
- 2007-05-15 IL IL183202A patent/IL183202A0/en unknown
- 2007-07-02 NO NO20073389A patent/NO20073389L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL183202A0 (en) | 2007-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW200639158A (en) | New compounds with therapeutic effect | |
ATE431345T1 (de) | Als modulatoren von dopamin-d3-rezeptoren geeignete azabicyclo-(3,1,0)-hexan-derivate | |
NO20065112L (no) | Kinolinon-karboksamidforbindelser som 5-HT4 receptoragonister | |
TW200732313A (en) | Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators | |
MX2009005252A (es) | Aminopirrolidinas como antagonistas del receptor de quimiocina. | |
PH12014501033A1 (en) | Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin | |
MY142807A (en) | Benzimidazole derivative and use thereof. | |
CO6321269A2 (es) | Derivados de benzoxazinona que actuan como agonistas de receptores adrenergicos beta 2 para el tratamiento de transtornos respiratorios | |
NO20082243L (no) | Fremgangsmater og forbindelser for fremstiliing av CC-1065 analoger | |
IL183063A0 (en) | Phenylpiperazine derivatives with a combination of partial dopamine d2 receptor agonism and serotonin reuptake inhibition | |
MY170822A (en) | Ethynyl derivatives as mglur5 allosteric modulators | |
TW200732338A (en) | Aromatic compound | |
MY163164A (en) | Ethynyl derivatives as positive allosteric modulators of the mglur5 | |
MX2009011922A (es) | Tetrahidrobenzazepinas ariloxi- y heteroariloxi-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina. | |
NZ597810A (en) | Indole derivative or pharmacologically acceptable salt thereof, as ep1 receptor antagonists for the treatment of lower urinary tract dysfunction | |
MY161403A (en) | 5- (phenyl/pyridinyl-ethinyl) -2-pyridine/ 2-pyrimidine-carborxamides as mglur5 modulators | |
EA201270421A1 (ru) | 1,2-дигидро-2-оксохинолиновые соединения в качестве лигандов рецептора 5-нт | |
UA102397C2 (ru) | Производные индола как активаторы nurr-1 и их применение для лечения болезни паркинсона | |
PE20091890A1 (es) | COMPUESTOS DE 3-FENILPIRAZOLO [5,1-b] TIAZOL | |
TW200619201A (en) | Process for the preparation of pyrazoles | |
PE20081342A1 (es) | Derivados eter como moduladores duales de los receptores de 5-ht2a y d3 | |
TW200631952A (en) | Benzdioxan piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | |
NO20073389L (no) | Tetrahydropyridln-4-yllndoler med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseter | |
DK1523486T3 (da) | Tetracykliske arylsulfonylindoler med serotoninreceptor-affinitet | |
TW200640928A (en) | 5,6-Dialkyl-7-aminoazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |