NO20073389L - Tetrahydropyridln-4-yllndoler med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseter - Google Patents

Tetrahydropyridln-4-yllndoler med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseter

Info

Publication number
NO20073389L
NO20073389L NO20073389A NO20073389A NO20073389L NO 20073389 L NO20073389 L NO 20073389L NO 20073389 A NO20073389 A NO 20073389A NO 20073389 A NO20073389 A NO 20073389A NO 20073389 L NO20073389 L NO 20073389L
Authority
NO
Norway
Prior art keywords
alkyl
hydrogen
tetrahydropyridin
dopamine
receptors
Prior art date
Application number
NO20073389A
Other languages
English (en)
Inventor
Cornelis G Kruse
Roelof Van Hes
Pieter Smid
Martinus Th M Tulp
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2005/056501 external-priority patent/WO2006061373A2/en
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of NO20073389L publication Critical patent/NO20073389L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Den foreliggende oppfinnelsen vedrører en gruppe nye tetrahydropyridin-4-yl-indoler med en todelt virkemåte: serotonin-reopptaksinhibisjon og affinitet for dopamin-D2 reseptorer, fremgangsmåter for fremstilling av disse forbindelsene og nye mellomprodukter som er nyttige ved syntesen av de nevnte tetrahydropyridin-4-yl-indolene. Oppfinnelsen vedrører også anvendelse av en forbindelse som her er beskrevet for fremstilling av et medikament som gir en fordelaktig effekt. Oppfinnelsen vedrører nye tetrahydropyridin-4-yl-indoler med formel (I). Og tautomerer, isomerer, prodrugs, N-oksider, farmakologisk akseptable salter, hydrater og solvater derav, der: - R1 er hydrogen, halogen, alkyl(C1-3) eller alkoksy(C1-3), CN eller CF3, - R2 er hydrogen eller alkyl(C1-3), R3 er hydrogen eller alkyl (C1-3), -Z er hydrogen eller alkyl (C1-3), alkoksy (C1-3) eller alkyltio(C1-3), - A er hydrogen eller alkyl (C1-3), eller -A og Z danner sammen en mettet eller (delvis) umettet 5- eller 6-leddet ring som kan være substituert med halogen, alkyl (C1-3) eller fenyl, der Z i ringen står for karbon, svovel eller nitrogen.
NO20073389A 2004-12-07 2007-07-02 Tetrahydropyridln-4-yllndoler med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseter NO20073389L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63343904P 2004-12-07 2004-12-07
EP04106351 2004-12-07
PCT/EP2005/056501 WO2006061373A2 (en) 2004-12-07 2005-12-06 Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-d2 receptors and serotonin reuptake sites

Publications (1)

Publication Number Publication Date
NO20073389L true NO20073389L (no) 2007-07-05

Family

ID=36578275

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073389A NO20073389L (no) 2004-12-07 2007-07-02 Tetrahydropyridln-4-yllndoler med en kombinasjon av affinitet for dopamin-D2-reseptorer og serotoningjenopptaksseter

Country Status (2)

Country Link
IL (1) IL183202A0 (no)
NO (1) NO20073389L (no)

Also Published As

Publication number Publication date
IL183202A0 (en) 2007-08-19

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application