NO20063757L - Substituted N-cyclohexylimidazolones with a MCH modulatory effect - Google Patents
Substituted N-cyclohexylimidazolones with a MCH modulatory effectInfo
- Publication number
- NO20063757L NO20063757L NO20063757A NO20063757A NO20063757L NO 20063757 L NO20063757 L NO 20063757L NO 20063757 A NO20063757 A NO 20063757A NO 20063757 A NO20063757 A NO 20063757A NO 20063757 L NO20063757 L NO 20063757L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- cyclohexylimidazolones
- compounds
- modulatory effect
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Det beskrives substituerte N-cykloheksylheterocykler så vel som de fysiologisk akseptable salter og fysiologisk funksjonelle derivater derav. Det beskrives videre fremgangsmåter for fremstilling derav samt anvendelsen av forbindelsene som medikamenter. Således beskrives det forbindelser med formel I der restene har de antydede betydninger og de fysiologisk akseptable salter derav samt deres fremstilling. Forbindelsene bevirker vekttap hos pattedyr og er for eksempel egnet for prevensjon eller terapi av for eksempel fedme eller diabetes.Substituted N-cyclohexyl heterocycles as well as the physiologically acceptable salts and physiologically functional derivatives thereof are described. Further, methods for the preparation thereof and the use of the compounds as medicaments are described. Thus, compounds of formula I are described in which the residues have the suggested meanings and the physiologically acceptable salts thereof and their preparation. The compounds cause weight loss in mammals and are, for example, suitable for birth control or therapy such as obesity or diabetes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004003811A DE102004003811A1 (en) | 2004-01-25 | 2004-01-25 | Substituted N-cyclohexylimidazolinones, processes for their preparation and their use as medicaments |
| PCT/EP2005/000700 WO2005070898A1 (en) | 2004-01-25 | 2005-01-25 | Substituted n-cyclohexyl imidazolinones having an mch-modulatory effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20063757L true NO20063757L (en) | 2006-10-11 |
Family
ID=34745115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20063757A NO20063757L (en) | 2004-01-25 | 2006-08-22 | Substituted N-cyclohexylimidazolones with a MCH modulatory effect |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1711473B1 (en) |
| JP (1) | JP2007518771A (en) |
| KR (1) | KR20060128955A (en) |
| CN (1) | CN1934090B (en) |
| AR (1) | AR047453A1 (en) |
| AT (1) | ATE383342T1 (en) |
| AU (1) | AU2005206308A1 (en) |
| BR (1) | BRPI0507104A (en) |
| CA (1) | CA2554233A1 (en) |
| CY (1) | CY1107429T1 (en) |
| DE (2) | DE102004003811A1 (en) |
| DK (1) | DK1711473T3 (en) |
| ES (1) | ES2297667T3 (en) |
| HR (1) | HRP20080077T3 (en) |
| IL (1) | IL176917A0 (en) |
| MA (1) | MA28345A1 (en) |
| MY (1) | MY139107A (en) |
| NO (1) | NO20063757L (en) |
| PE (1) | PE20051091A1 (en) |
| PL (1) | PL1711473T3 (en) |
| PT (1) | PT1711473E (en) |
| RS (1) | RS50543B (en) |
| RU (1) | RU2006130626A (en) |
| TW (1) | TW200604182A (en) |
| UY (1) | UY28726A1 (en) |
| WO (1) | WO2005070898A1 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2008129679A (en) | 2005-12-21 | 2010-01-27 | Янссен Фармацевтика Н.В. (Be) | NEW SUBSTITUTED PYRAZINONIC DERIVATIVES FOR USE IN SIT-1-MEDIATED DISEASES |
| RU2009108280A (en) | 2006-08-08 | 2010-09-20 | Санофи-Авентис (Fr) | Arylamino-arylalkyl-substituted imidazolidine-2,4-dione, methods for their preparation containing these compounds and their use |
| AU2007328979B2 (en) | 2006-12-05 | 2013-05-09 | Janssen Pharmaceutica N.V. | Novel substituted diaza spiro pyridinone derivatives for use in MCH-1 mediated diseases |
| KR100893394B1 (en) * | 2007-05-11 | 2009-04-17 | 한국화학연구원 | Imidazole derivatives having aryl piperidine substituents, method for the preparation thereof, and pharmaceutical compositions containing them |
| UY31968A (en) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | NEW HETEROCYCLIC DERIVATIVES, THEIR PROCESSES FOR THEIR PREPARATION, AND THEIR THERAPEUTIC USES |
| DE102008060967A1 (en) * | 2008-12-06 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Substituted phenylsulfonyltriazolones and their use |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| SG178880A1 (en) | 2009-08-26 | 2012-04-27 | Sanofi Sa | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
| EP2683699B1 (en) | 2011-03-08 | 2015-06-24 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8846666B2 (en) | 2011-03-08 | 2014-09-30 | Sanofi | Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| WO2012120052A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| WO2012120057A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Novel substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| WO2012120054A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8809325B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof |
| PL223830B1 (en) | 2012-04-03 | 2016-11-30 | Univ Jagielloński | Derivatives of aromatic imidazolidinones and their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2312637T3 (en) * | 2001-12-04 | 2009-03-01 | Schering Corporation | DERIVATIVES OF N-ARIL-N`-ARILCICLOALQUIL-UREA AS MCH ANTAGONISTS FOR THE TREATMENT OF OBESITY. |
| DE10233817A1 (en) * | 2002-07-25 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Substituted diaryl heterocycles, process for their preparation and their use as medicaments |
-
2004
- 2004-01-25 DE DE102004003811A patent/DE102004003811A1/en not_active Withdrawn
-
2005
- 2005-01-24 AR ARP050100240A patent/AR047453A1/en not_active Application Discontinuation
- 2005-01-25 JP JP2006550073A patent/JP2007518771A/en not_active Abandoned
- 2005-01-25 PE PE2005000095A patent/PE20051091A1/en not_active Application Discontinuation
- 2005-01-25 CN CN2005800091349A patent/CN1934090B/en not_active Expired - Fee Related
- 2005-01-25 AU AU2005206308A patent/AU2005206308A1/en not_active Abandoned
- 2005-01-25 BR BRPI0507104-6A patent/BRPI0507104A/en not_active IP Right Cessation
- 2005-01-25 RU RU2006130626/04A patent/RU2006130626A/en not_active Application Discontinuation
- 2005-01-25 ES ES05707002T patent/ES2297667T3/en active Active
- 2005-01-25 MY MYPI20050274A patent/MY139107A/en unknown
- 2005-01-25 PL PL05707002T patent/PL1711473T3/en unknown
- 2005-01-25 RS RSP-2008/0082A patent/RS50543B/en unknown
- 2005-01-25 CA CA002554233A patent/CA2554233A1/en not_active Abandoned
- 2005-01-25 KR KR1020067015035A patent/KR20060128955A/en not_active Application Discontinuation
- 2005-01-25 DK DK05707002T patent/DK1711473T3/en active
- 2005-01-25 WO PCT/EP2005/000700 patent/WO2005070898A1/en active Application Filing
- 2005-01-25 DE DE502005002497T patent/DE502005002497D1/en active Active
- 2005-01-25 UY UY28726A patent/UY28726A1/en unknown
- 2005-01-25 PT PT05707002T patent/PT1711473E/en unknown
- 2005-01-25 AT AT05707002T patent/ATE383342T1/en not_active IP Right Cessation
- 2005-01-25 TW TW094102156A patent/TW200604182A/en unknown
- 2005-01-25 EP EP05707002A patent/EP1711473B1/en active Active
-
2006
- 2006-07-17 IL IL176917A patent/IL176917A0/en not_active IP Right Cessation
- 2006-08-03 MA MA29233A patent/MA28345A1/en unknown
- 2006-08-22 NO NO20063757A patent/NO20063757L/en not_active Application Discontinuation
-
2008
- 2008-02-22 HR HR20080077T patent/HRP20080077T3/en unknown
- 2008-03-21 CY CY20081100322T patent/CY1107429T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UY28726A1 (en) | 2005-08-31 |
| ES2297667T3 (en) | 2008-05-01 |
| AR047453A1 (en) | 2006-01-18 |
| TW200604182A (en) | 2006-02-01 |
| AU2005206308A1 (en) | 2005-08-04 |
| DK1711473T3 (en) | 2008-05-26 |
| KR20060128955A (en) | 2006-12-14 |
| RS50543B (en) | 2010-05-07 |
| RU2006130626A (en) | 2008-02-27 |
| PL1711473T3 (en) | 2008-05-30 |
| IL176917A0 (en) | 2006-12-10 |
| DE502005002497D1 (en) | 2008-02-21 |
| WO2005070898A1 (en) | 2005-08-04 |
| CA2554233A1 (en) | 2005-08-04 |
| MA28345A1 (en) | 2006-12-01 |
| JP2007518771A (en) | 2007-07-12 |
| CN1934090A (en) | 2007-03-21 |
| BRPI0507104A (en) | 2007-06-19 |
| DE102004003811A1 (en) | 2005-08-11 |
| EP1711473A1 (en) | 2006-10-18 |
| ATE383342T1 (en) | 2008-01-15 |
| CN1934090B (en) | 2010-04-07 |
| HRP20080077T3 (en) | 2008-03-31 |
| MY139107A (en) | 2009-08-28 |
| EP1711473B1 (en) | 2008-01-09 |
| CY1107429T1 (en) | 2012-12-19 |
| PT1711473E (en) | 2008-03-07 |
| PE20051091A1 (en) | 2006-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |