NO20062569L - New crystalline anhydrides with anticholinergic effect - Google Patents

New crystalline anhydrides with anticholinergic effect

Info

Publication number
NO20062569L
NO20062569L NO20062569A NO20062569A NO20062569L NO 20062569 L NO20062569 L NO 20062569L NO 20062569 A NO20062569 A NO 20062569A NO 20062569 A NO20062569 A NO 20062569A NO 20062569 L NO20062569 L NO 20062569L
Authority
NO
Norway
Prior art keywords
new crystalline
anticholinergic effect
anhydrides
crystalline anhydrides
treatment
Prior art date
Application number
NO20062569A
Other languages
Norwegian (no)
Inventor
Waldemar Pfrengle
Peter Sieger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530662&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20062569(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of NO20062569L publication Critical patent/NO20062569L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Abstract

Oppfinnelsen angår et nytt, krystallinsk anhydrat av tiotropiumbromid, en metode for fremstilling av nevnte anhydrat, og anvendelsen av dette for fremstilling av et legemiddel for behandling av luftveislidelser, spesielt for behandling av kronisk obstruktiv lungesykdom (KOLS) og astma.The invention relates to a new crystalline anhydrate of tiotropium bromide, a method for the preparation of said anhydrate, and its use for the manufacture of a medicament for the treatment of respiratory disorders, in particular for the treatment of chronic obstructive pulmonary disease (COPD) and asthma.

NO20062569A 2003-11-03 2006-06-02 New crystalline anhydrides with anticholinergic effect NO20062569L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025077 2003-11-03
PCT/EP2004/012269 WO2005042527A1 (en) 2003-11-03 2004-10-29 Novel crystalline anhydride with anticholinergic effect

Publications (1)

Publication Number Publication Date
NO20062569L true NO20062569L (en) 2006-07-12

Family

ID=34530662

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062569A NO20062569L (en) 2003-11-03 2006-06-02 New crystalline anhydrides with anticholinergic effect

Country Status (34)

Country Link
EP (1) EP1682542B1 (en)
JP (1) JP4553902B2 (en)
KR (2) KR101285571B1 (en)
CN (1) CN100509809C (en)
AR (1) AR046319A1 (en)
AT (1) ATE453641T1 (en)
AU (1) AU2004285684B2 (en)
BR (1) BRPI0415636A (en)
CA (1) CA2544352C (en)
CO (1) CO5690641A2 (en)
CY (1) CY1110339T1 (en)
DE (1) DE502004010602D1 (en)
DK (1) DK1682542T3 (en)
EA (1) EA008587B1 (en)
EC (1) ECSP066543A (en)
ES (1) ES2338563T3 (en)
HK (1) HK1099752A1 (en)
HR (1) HRP20100029T1 (en)
IL (1) IL175126A (en)
ME (1) ME00349B (en)
MX (1) MX272045B (en)
MY (1) MY146628A (en)
NO (1) NO20062569L (en)
NZ (1) NZ547581A (en)
PE (1) PE20050996A1 (en)
PL (1) PL1682542T3 (en)
PT (1) PT1682542E (en)
RS (2) RS20060291A (en)
SI (1) SI1682542T1 (en)
TW (1) TWI336330B (en)
UA (1) UA82909C2 (en)
UY (1) UY28596A1 (en)
WO (1) WO2005042527A1 (en)
ZA (1) ZA200602344B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2606552A1 (en) * 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Crystalline forms of tiotropium bromide
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
RU2453547C2 (en) * 2005-12-19 2012-06-20 Сикор Инк. Novel forms of tiotropium bromide and synthesis methods thereof
EP2123650B1 (en) 2005-12-19 2012-04-04 Sicor, Inc. Novel form of tiotropium bromide and process for preparation thereof
CA2634984C (en) * 2006-01-04 2014-05-06 Boehringer Ingelheim International Gmbh Use of tiotropium salts in the treatment of moderate persistent asthma
CN100999521B (en) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 Crystal anti-choline medicine thiatropic bromoammonium
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
CN101032484B (en) * 2007-04-02 2010-05-26 南京卡文迪许生物工程技术有限公司 Capsule type tiotropium bromide inhalation powder
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
US20110250149A1 (en) * 2008-11-04 2011-10-13 Cipla Limited Tiotropium Bromide Having a Low Degree of Crystallinity
NZ592861A (en) * 2008-11-04 2013-01-25 Cipla Ltd Pharmaceutical aerosol composition
US8697719B2 (en) * 2009-08-07 2014-04-15 Generics [Uk] Limited Anhydrate of tiotropium bromide
TR201111589A2 (en) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropium bromide anhydrous crystal form.
CZ304368B6 (en) 2011-11-28 2014-04-02 Zentiva, K.S. Tiotropium bromide mixed solvate and process for preparing thereof
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
CN104797579A (en) 2012-11-05 2015-07-22 赞蒂瓦有限合伙公司 Stabilization of tiotropium solvates
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
EP4108230A1 (en) 2021-06-24 2022-12-28 Laboratoires SMB New dry powder composition of tiotropium for inhalation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (en) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them
TR200402579T4 (en) * 2000-10-12 2004-12-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline monohydrate, its method of manufacture and its use in the manufacture of a drug substance
DE10111843A1 (en) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Compounds for the treatment of inflammatory diseases
SI1401445T1 (en) * 2001-06-22 2007-02-28 Boehringer Ingelheim Pharma Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Also Published As

Publication number Publication date
CY1110339T1 (en) 2015-01-14
JP4553902B2 (en) 2010-09-29
BRPI0415636A (en) 2006-12-12
EA008587B1 (en) 2007-06-29
IL175126A (en) 2010-11-30
PT1682542E (en) 2010-01-27
DK1682542T3 (en) 2010-05-10
ATE453641T1 (en) 2010-01-15
MX272045B (en) 2009-11-23
TW200526652A (en) 2005-08-16
PL1682542T3 (en) 2010-06-30
RS20060291A (en) 2008-06-05
HK1099752A1 (en) 2007-08-24
SI1682542T1 (en) 2010-04-30
MXPA06004940A (en) 2006-07-20
CN100509809C (en) 2009-07-08
IL175126A0 (en) 2006-09-05
EP1682542A1 (en) 2006-07-26
CA2544352A1 (en) 2005-05-12
EP1682542B1 (en) 2009-12-30
MEP51708A (en) 2011-02-10
JP2007509894A (en) 2007-04-19
UY28596A1 (en) 2005-06-30
ECSP066543A (en) 2006-10-17
ES2338563T3 (en) 2010-05-10
AU2004285684A1 (en) 2005-05-12
UA82909C2 (en) 2008-05-26
WO2005042527A1 (en) 2005-05-12
ME00349B (en) 2011-05-10
RS51599B (en) 2011-08-31
AU2004285684B2 (en) 2011-07-14
AR046319A1 (en) 2005-11-30
HRP20100029T1 (en) 2010-02-28
CO5690641A2 (en) 2006-10-31
KR101313904B1 (en) 2013-09-30
KR101285571B1 (en) 2013-07-15
MY146628A (en) 2012-09-14
ZA200602344B (en) 2007-07-25
KR20060121131A (en) 2006-11-28
CN1875019A (en) 2006-12-06
CA2544352C (en) 2013-07-16
NZ547581A (en) 2009-03-31
TWI336330B (en) 2011-01-21
KR20120036381A (en) 2012-04-17
PE20050996A1 (en) 2005-12-20
DE502004010602D1 (en) 2010-02-11
EA200600853A1 (en) 2006-10-27

Similar Documents

Publication Publication Date Title
NO20062569L (en) New crystalline anhydrides with anticholinergic effect
NO20061441L (en) New tiotropium salts, methods of their preparation, and pharmaceutical formulations containing them
TW200708513A (en) Novel crystalline forms of tiotropium bromide
WO2006117300A3 (en) Crystalline forms of tiotropium bromide
NO20063882L (en) New combination of anticholinergics and beta mimetics for the treatment of respiratory diseases
NO20025221L (en) New preparation
SE0200356D0 (en) Novel use
NO20083090L (en) New combinations of anticholinergics, beta2-adrenoceptor agonists, antilukotrins (leukotrine receptor antagonists), glucocorticosteroids and / or PDE 4 inhibitors for the treatment of inflammatory diseases
MEP30108A (en) Formoterol superfine formulation
NO20075287L (en) Combination of anticholinergics and leukotnene receptor antagonists for the treatment of respiratory disorders
RS20050484A (en) Powdered medicament for inhalation comprising a tiotropium salt and salmeterol xinafoate
EA200970158A1 (en) QUINUCLIDINE DERIVATIVES AS ANTAGONISTS M3
WO2009019598A3 (en) Inhalation therapy for respiratory disorders
MY143364A (en) Method for producing tiotropium salts
NO20081483L (en) Combination of compounds that can be used in the treatment of respiratory diseases, especially chronic obstructive pulmonary disease (COPD) and asthma
RS20050400A (en) Pulverulent formulation for inhalation containing tiotropium

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application