NO20062563L - Nye 5,6-Dihydropyrin-2-on forbindelser anvendelige som inhibitorer av trombin - Google Patents
Nye 5,6-Dihydropyrin-2-on forbindelser anvendelige som inhibitorer av trombinInfo
- Publication number
- NO20062563L NO20062563L NO20062563A NO20062563A NO20062563L NO 20062563 L NO20062563 L NO 20062563L NO 20062563 A NO20062563 A NO 20062563A NO 20062563 A NO20062563 A NO 20062563A NO 20062563 L NO20062563 L NO 20062563L
- Authority
- NO
- Norway
- Prior art keywords
- thrombin
- inhibitors
- dihydropyrin
- new
- compounds useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/98—Nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Det tilveiebringes en forbindelse med formel I hvor R1, R2a, R2b, R3a, R3b, R4, R5, R6, A, G og L har betydninger som angitt i beskrivelsen, idet forbindelsene er anvendelige som, eller er anvendelige som promedikamenter til, konkurrerende hemmere av trypsin-lignende proteaser, så som trombin, og således spesielt ved behandling av lidelser hvor hemning av trombin er fordelaktig (f.eks. lidelser så som trombo-embolismer, hvor hemning av trombin er nødvendig eller ønsket, og/eller lidelser hvor antikoagulerende terapi er indikert).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0303452A SE0303452D0 (sv) | 2003-12-18 | 2003-12-18 | New compounds |
| SE0401344A SE0401344D0 (sv) | 2004-05-25 | 2004-05-25 | New compounds |
| PCT/SE2004/001878 WO2005058826A1 (en) | 2003-12-18 | 2004-12-15 | New 5,6-dihydropyrin-2-one compounds useful as inhibitors of thrombin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20062563L true NO20062563L (no) | 2006-06-29 |
Family
ID=34703498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20062563A NO20062563L (no) | 2003-12-18 | 2006-06-02 | Nye 5,6-Dihydropyrin-2-on forbindelser anvendelige som inhibitorer av trombin |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070099962A1 (no) |
| EP (1) | EP1697323A1 (no) |
| JP (1) | JP2007514742A (no) |
| AR (1) | AR047408A1 (no) |
| AU (1) | AU2004299433A1 (no) |
| BR (1) | BRPI0417635A (no) |
| CA (1) | CA2547064A1 (no) |
| IL (1) | IL175791A0 (no) |
| MX (1) | MXPA06006927A (no) |
| NO (1) | NO20062563L (no) |
| RU (1) | RU2335492C2 (no) |
| SA (1) | SA04250414B1 (no) |
| TW (1) | TW200530216A (no) |
| UY (1) | UY28675A1 (no) |
| WO (1) | WO2005058826A1 (no) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5932733A (en) * | 1994-06-17 | 1999-08-03 | Corvas International, Inc. | 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors |
| US5668289A (en) * | 1996-06-24 | 1997-09-16 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
| US5792779A (en) * | 1997-02-19 | 1998-08-11 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
| US5866573A (en) * | 1997-04-21 | 1999-02-02 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
| WO2002057225A2 (en) * | 2000-12-18 | 2002-07-25 | Merck & Co., Inc. | Thrombin inhibitors |
| SI21097A (sl) * | 2001-12-04 | 2003-06-30 | Univerza V Ljubljani | Inhibitorji trombina |
| AR047521A1 (es) * | 2004-02-06 | 2006-01-25 | Astrazeneca Ab | Compuestos piridin-2-ona utiles como inhibidores de trombina |
-
2004
- 2004-12-15 SA SA04250414A patent/SA04250414B1/ar unknown
- 2004-12-15 US US10/596,506 patent/US20070099962A1/en not_active Abandoned
- 2004-12-15 MX MXPA06006927A patent/MXPA06006927A/es unknown
- 2004-12-15 AU AU2004299433A patent/AU2004299433A1/en not_active Abandoned
- 2004-12-15 WO PCT/SE2004/001878 patent/WO2005058826A1/en active Application Filing
- 2004-12-15 EP EP04820555A patent/EP1697323A1/en not_active Withdrawn
- 2004-12-15 JP JP2006545286A patent/JP2007514742A/ja not_active Withdrawn
- 2004-12-15 CA CA002547064A patent/CA2547064A1/en not_active Abandoned
- 2004-12-15 TW TW093139012A patent/TW200530216A/zh unknown
- 2004-12-15 BR BRPI0417635-9A patent/BRPI0417635A/pt not_active IP Right Cessation
- 2004-12-15 RU RU2006123361/04A patent/RU2335492C2/ru not_active IP Right Cessation
- 2004-12-17 UY UY28675A patent/UY28675A1/es not_active Application Discontinuation
- 2004-12-17 AR ARP040104748A patent/AR047408A1/es not_active Application Discontinuation
-
2006
- 2006-05-21 IL IL175791A patent/IL175791A0/en unknown
- 2006-06-02 NO NO20062563A patent/NO20062563L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2335492C2 (ru) | 2008-10-10 |
| MXPA06006927A (es) | 2006-08-23 |
| WO2005058826A8 (en) | 2005-10-27 |
| US20070099962A1 (en) | 2007-05-03 |
| JP2007514742A (ja) | 2007-06-07 |
| EP1697323A1 (en) | 2006-09-06 |
| UY28675A1 (es) | 2005-07-29 |
| IL175791A0 (en) | 2006-10-05 |
| SA04250414B1 (ar) | 2007-07-31 |
| RU2006123361A (ru) | 2008-01-27 |
| TW200530216A (en) | 2005-09-16 |
| CA2547064A1 (en) | 2005-06-30 |
| AR047408A1 (es) | 2006-01-18 |
| AU2004299433A1 (en) | 2005-06-30 |
| BRPI0417635A (pt) | 2007-03-27 |
| WO2005058826A1 (en) | 2005-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |