NO20060934L - 2-methoxymethyl-3- (3,4-dichlorophenyl) -8-azabicyclo [3.2.1] octane tartrase salts - Google Patents

2-methoxymethyl-3- (3,4-dichlorophenyl) -8-azabicyclo [3.2.1] octane tartrase salts

Info

Publication number
NO20060934L
NO20060934L NO20060934A NO20060934A NO20060934L NO 20060934 L NO20060934 L NO 20060934L NO 20060934 A NO20060934 A NO 20060934A NO 20060934 A NO20060934 A NO 20060934A NO 20060934 L NO20060934 L NO 20060934L
Authority
NO
Norway
Prior art keywords
salts
azabicyclo
dichlorophenyl
methoxymethyl
octane
Prior art date
Application number
NO20060934A
Other languages
Norwegian (no)
Inventor
Klaus Snej Jensen
Brian Frostrup
Frank Watjen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2004/051651 external-priority patent/WO2005011694A1/en
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NO20060934L publication Critical patent/NO20060934L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Denne oppfinnelsen vedrører nye (1R, 2R, 3S, 5S)-2-metoksymetyl-3-(3,4-diklor-fenyl)-8-azabisyklo[3 2 l]oktantartratsalter, slik som L-tartratmonohydrater og -anhydrater. Saltene er anvendbare som monoaminnevro-transmittergjenopptaksinhibitorer. Ved andre aspekter vedrører oppfinnelsen anvendelsen av disse saltene i en fremgangsmåte for terapi, og farmasøytiske preparater som omfatter saltene ifølge oppfinnelsenThis invention relates to novel (1R, 2R, 3S, 5S) -2-methoxymethyl-3- (3,4-dichlorophenyl) -8-azabicyclo [3.2] octane tartrate salts, such as L-tartrate monohydrates and anhydrates. The salts are useful as monoamine neurotransmitter reuptake inhibitors. In other aspects, the invention relates to the use of these salts in a method of therapy, and to pharmaceutical compositions comprising the salts of the invention.

NO20060934A 2003-07-31 2006-02-27 2-methoxymethyl-3- (3,4-dichlorophenyl) -8-azabicyclo [3.2.1] octane tartrase salts NO20060934L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200301117 2003-07-31
US49409003P 2003-08-12 2003-08-12
PCT/EP2004/051651 WO2005011694A1 (en) 2003-07-31 2004-07-29 2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane tartrate salts

Publications (1)

Publication Number Publication Date
NO20060934L true NO20060934L (en) 2006-04-28

Family

ID=34117517

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060934A NO20060934L (en) 2003-07-31 2006-02-27 2-methoxymethyl-3- (3,4-dichlorophenyl) -8-azabicyclo [3.2.1] octane tartrase salts

Country Status (9)

Country Link
KR (1) KR20060054386A (en)
CO (1) CO5640088A2 (en)
CY (1) CY1107639T1 (en)
HK (1) HK1089968A1 (en)
HR (1) HRP20070197T3 (en)
IL (1) IL172576A0 (en)
IS (1) IS2588B (en)
MX (1) MXPA06001050A (en)
NO (1) NO20060934L (en)

Also Published As

Publication number Publication date
HK1089968A1 (en) 2006-12-15
CO5640088A2 (en) 2006-05-31
IS2588B (en) 2010-02-15
IS8330A (en) 2006-02-27
HRP20070197T3 (en) 2007-06-30
IL172576A0 (en) 2006-04-10
MXPA06001050A (en) 2006-04-24
CY1107639T1 (en) 2013-04-18
KR20060054386A (en) 2006-05-22

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application