CY1107639T1 - 2-Methoxymethyl-3- (3,4-dichlorophenyl) -8-azadicyclo [3.2.1] octane trivalent salts - Google Patents

2-Methoxymethyl-3- (3,4-dichlorophenyl) -8-azadicyclo [3.2.1] octane trivalent salts

Info

Publication number
CY1107639T1
CY1107639T1 CY20071100706T CY071100706T CY1107639T1 CY 1107639 T1 CY1107639 T1 CY 1107639T1 CY 20071100706 T CY20071100706 T CY 20071100706T CY 071100706 T CY071100706 T CY 071100706T CY 1107639 T1 CY1107639 T1 CY 1107639T1
Authority
CY
Cyprus
Prior art keywords
dichlorophenyl
methoxymethyl
octane
salts
azadicyclo
Prior art date
Application number
CY20071100706T
Other languages
Greek (el)
Inventor
Brian Frostrup
Frank Wätjen
Klaus Snej Jensen
Original Assignee
Neurosearch A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04766360A external-priority patent/EP1651223B1/en
Application filed by Neurosearch A/S filed Critical Neurosearch A/S
Publication of CY1107639T1 publication Critical patent/CY1107639T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Αυτή η εφεύρεση σχετίζεται με νέα τρυγικά άλατα του (lR,2R,3S,5S)-2-μεθοξυμεθυλο-3-(3,4διχλωροφαινυλο)-8-αζαδικυκλο[3.2. 1]οκτανίου όπως τα μονοένυδρα και τα άνυδρα L-τρυγικά (άλατα). Τα άλατα είναι χρήσιμα σαν αναστολείς της επανα-πρόσληψης των νευροδιαβιβαστών (από την ομάδα των) μονοαμινών. Σε άλλες απόψεις, η εφεύρεση σχετίζεται με τη χρήση αυτών των αλάτων σε μια μέθοδο για θεραπεία και με μια φαρμακευτική σύνθεση που περιέχει τα άλατα της εφεύρεσης.This invention relates to novel tartrates of (1R, 2R, 3S, 5S) -2-methoxymethyl-3- (3,4-dichlorophenyl) -8-azabicyclo [3.2. 1] octane such as monohydrates and anhydrous L-tartrates (salts). Salts are useful as inhibitors of the re-uptake of monoamine neurotransmitters. In other aspects, the invention relates to the use of these salts in a method for treatment and to a pharmaceutical composition comprising the salts of the invention.

CY20071100706T 2003-07-31 2007-05-24 2-Methoxymethyl-3- (3,4-dichlorophenyl) -8-azadicyclo [3.2.1] octane trivalent salts CY1107639T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200301117 2003-07-31
US49409003P 2003-08-12 2003-08-12
EP04766360A EP1651223B1 (en) 2003-07-31 2004-07-29 2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane tartrate salts

Publications (1)

Publication Number Publication Date
CY1107639T1 true CY1107639T1 (en) 2013-04-18

Family

ID=34117517

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100706T CY1107639T1 (en) 2003-07-31 2007-05-24 2-Methoxymethyl-3- (3,4-dichlorophenyl) -8-azadicyclo [3.2.1] octane trivalent salts

Country Status (9)

Country Link
KR (1) KR20060054386A (en)
CO (1) CO5640088A2 (en)
CY (1) CY1107639T1 (en)
HK (1) HK1089968A1 (en)
HR (1) HRP20070197T3 (en)
IL (1) IL172576A0 (en)
IS (1) IS2588B (en)
MX (1) MXPA06001050A (en)
NO (1) NO20060934L (en)

Also Published As

Publication number Publication date
IL172576A0 (en) 2006-04-10
NO20060934L (en) 2006-04-28
HK1089968A1 (en) 2006-12-15
KR20060054386A (en) 2006-05-22
CO5640088A2 (en) 2006-05-31
MXPA06001050A (en) 2006-04-24
HRP20070197T3 (en) 2007-06-30
IS2588B (en) 2010-02-15
IS8330A (en) 2006-02-27

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