NO20053363L - Malrettede enkle epitoper. - Google Patents

Malrettede enkle epitoper.

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Publication number
NO20053363L
NO20053363L NO20053363A NO20053363A NO20053363L NO 20053363 L NO20053363 L NO 20053363L NO 20053363 A NO20053363 A NO 20053363A NO 20053363 A NO20053363 A NO 20053363A NO 20053363 L NO20053363 L NO 20053363L
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NO
Norway
Prior art keywords
receptor
methods
binding protein
relates
immunogens
Prior art date
Application number
NO20053363A
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English (en)
Other versions
NO20053363D0 (no
Inventor
Soren Mouritsen
Original Assignee
Pharmexa As
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Publication date
Application filed by Pharmexa As filed Critical Pharmexa As
Publication of NO20053363L publication Critical patent/NO20053363L/no
Publication of NO20053363D0 publication Critical patent/NO20053363D0/no

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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
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    • C07—ORGANIC CHEMISTRY
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    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Oppfinnelsen angår nye immunogene midler som kan indusere spesifikk B-celleimmunitet rettet mot en enkelt epitop tilstede i et selv-antigen. Det immunogene middelet er et kimært bindingsprotein som bindes spesifikt til en første reseptor, hvor nevnte første reseptor er en som binder en andre reseptor som er tilstede i et antigen til et pattedyr, hvor nevnte kimære bindingsprotein omfatter: (a) En B-celleepitop i form av et bindingssete som spesifikt binder den første reseptoren og som konkurrerer med den andre reseptoren for binding til den første reseptoren, (b) en plattformproteinstruktur som er autolog i nevnte pattedyr og (c) i det minste én toleransebrytende aminosyresekvens som er heterolog i nevnte pattedyr og som binder til et MHC klasse IImolekyl i nevnte pattedyr. I foretrukne utførelsesformer er det kimære bindingsproteinet i form av et antiidiotypisk antistoff med en introdusert toleransebrytende aminosyresekvens. Oppfinnelsen angår videre fremgangsmåter for å fremstille immunogenene og fremgangsmåter for å anvende immunogenene i terapi. Oppfinnelsen angår også proteiner, nukleinsyrefragmenter, rekombinant modifiserte vertsceller og virus som er anvendelige i utøvelsen av 25 fremgangsmåtene ifølge oppfinnelsen.
NO20053363A 2002-12-11 2005-07-11 Malrettede enkle epitoper. NO20053363D0 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43253202P 2002-12-11 2002-12-11
DKPA200201893 2002-12-11
US44670703P 2003-02-12 2003-02-12
DKPA200300198 2003-02-12
PCT/DK2003/000859 WO2004052930A2 (en) 2002-12-11 2003-12-11 Targeting single epitopes

Publications (2)

Publication Number Publication Date
NO20053363L true NO20053363L (no) 2005-07-11
NO20053363D0 NO20053363D0 (no) 2005-07-11

Family

ID=32512419

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053363A NO20053363D0 (no) 2002-12-11 2005-07-11 Malrettede enkle epitoper.

Country Status (6)

Country Link
EP (1) EP1572740A2 (no)
AU (1) AU2003285280A1 (no)
CA (1) CA2505870A1 (no)
MX (1) MXPA05006113A (no)
NO (1) NO20053363D0 (no)
WO (1) WO2004052930A2 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004312411B8 (en) 2003-12-31 2011-11-24 Schering-Plough Pty. Limited Neutralizing epitope-based growth enhancing vaccine
EP1831372A2 (en) 2004-12-30 2007-09-12 Schering-Plough Ltd. Neutralizing epitope-based growth enhancing vaccine
EP2344184A4 (en) * 2008-10-07 2012-08-29 Biovest Int Inc METHOD FOR INTRODUCING A CONTINUOUS IMMUNE RESPONSE TO A B-CELL IDIOTYPE BY AUTOLOGIC ANTIIDIOTYPIC VACCINES
WO2013040142A2 (en) * 2011-09-16 2013-03-21 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
CN102184348B (zh) * 2011-01-12 2013-10-02 湖北大学 基于自然生殖过程的昆虫遗传群体的模拟方法
WO2014036488A1 (en) 2012-08-31 2014-03-06 Biovest International, Inc. Methods for producing high-fidelity autologous idiotype vaccines
KR102184377B1 (ko) * 2018-02-19 2020-11-30 고려대학교 산학협력단 열충격단백질의 에피토프를 포함하는 백신 및 이의 용도
TW202144387A (zh) * 2020-02-11 2021-12-01 美商聯合生物醫學公司 針對胰島澱粉樣多肽（iapp）的胜肽免疫原及其預防和治療與聚集iapp相關疾病的製劑

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK96493D0 (da) * 1993-08-26 1993-08-26 Mouritsen Og Elsner Aps Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden
WO1995007707A1 (en) * 1993-09-14 1995-03-23 Cytel Corporation Alteration of immune response using pan dr-binding peptides
EP0659438A1 (en) * 1993-12-23 1995-06-28 Boehringer Mannheim Gmbh Conjugates consisting of peptidic T cell antigens and cell binding groups, and their use for therapy
PT876398E (pt) * 1996-01-24 2002-12-31 Epimmune Inc Inducao de respostas imunitarias contra determinantes desejados
WO1999058658A2 (en) * 1998-05-13 1999-11-18 Epimmune, Inc. Expression vectors for stimulating an immune response and methods of using the same
US20030228324A1 (en) * 1999-05-06 2003-12-11 Malcolm Andrew J. Peptide compositions and methods of producing and using same
AU2273701A (en) * 1999-12-13 2001-06-18 Epimmune, Inc. Hla class i a2 tumor associated antigen peptides and vaccine compositions
US20030185845A1 (en) * 2001-11-16 2003-10-02 Steen Klysner Novel immunogenic mimetics of multimer proteins
HUP0402155A2 (hu) * 2001-11-16 2005-01-28 Pharmexa A/S Multimer fehérjék új immunogén mimetikumai széleskörű T-sejt-epitóp-inszertekkel

Also Published As

Publication number Publication date
WO2004052930A2 (en) 2004-06-24
CA2505870A1 (en) 2004-06-24
MXPA05006113A (es) 2005-09-30
NO20053363D0 (no) 2005-07-11
WO2004052930A3 (en) 2004-07-29
EP1572740A2 (en) 2005-09-14
AU2003285280A1 (en) 2004-06-30

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