NO20050127L - 9-alpha-substituted ostratrienes as selectively active oestrogens - Google Patents

9-alpha-substituted ostratrienes as selectively active oestrogens

Info

Publication number
NO20050127L
NO20050127L NO20050127A NO20050127A NO20050127L NO 20050127 L NO20050127 L NO 20050127L NO 20050127 A NO20050127 A NO 20050127A NO 20050127 A NO20050127 A NO 20050127A NO 20050127 L NO20050127 L NO 20050127L
Authority
NO
Norway
Prior art keywords
ostratrienes
oestrogens
alpha
substituted
selectively active
Prior art date
Application number
NO20050127A
Other languages
Norwegian (no)
Other versions
NO20050127D0 (en
NO329563B1 (en
Inventor
Karl-Heinrich Fritzemeier
Peter Muhn
Gerd Mueller
Dirk Kosemund
Alexander Hillisch
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20050127D0 publication Critical patent/NO20050127D0/en
Publication of NO20050127L publication Critical patent/NO20050127L/en
Publication of NO329563B1 publication Critical patent/NO329563B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0055—Estrane derivatives not substituted in position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
NO20050127A 2002-06-11 2005-01-10 9-alpha-substituted ostratrienes as selectively active oestrogens, pharmaceutical compositions containing the compounds, and their use in the preparation of pharmaceutical agents NO329563B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10226326A DE10226326A1 (en) 2002-06-11 2002-06-11 9-alpha-substituted estratrienes as selective estrogens
PCT/EP2003/006172 WO2003104253A2 (en) 2002-06-11 2003-06-11 9-alpha-substituted estratrienes as selectively active estrogen

Publications (3)

Publication Number Publication Date
NO20050127D0 NO20050127D0 (en) 2005-01-10
NO20050127L true NO20050127L (en) 2005-03-11
NO329563B1 NO329563B1 (en) 2010-11-15

Family

ID=29723144

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050127A NO329563B1 (en) 2002-06-11 2005-01-10 9-alpha-substituted ostratrienes as selectively active oestrogens, pharmaceutical compositions containing the compounds, and their use in the preparation of pharmaceutical agents

Country Status (29)

Country Link
EP (1) EP1517914B1 (en)
JP (1) JP4615998B2 (en)
KR (1) KR101006612B1 (en)
CN (1) CN1293090C (en)
AR (1) AR040188A1 (en)
AT (1) ATE303397T1 (en)
AU (1) AU2003242683B9 (en)
BR (1) BR0312140A (en)
CA (1) CA2486495C (en)
CR (1) CR10289A (en)
CU (1) CU23414B7 (en)
DE (2) DE10226326A1 (en)
DK (1) DK1517914T3 (en)
EA (1) EA008442B1 (en)
EC (1) ECSP055530A (en)
ES (1) ES2248770T3 (en)
HK (1) HK1081203A1 (en)
HR (1) HRP20050009B1 (en)
IL (1) IL165321A (en)
MX (1) MXPA04012491A (en)
NO (1) NO329563B1 (en)
PE (1) PE20040613A1 (en)
PL (1) PL209910B1 (en)
RS (1) RS50878B (en)
TW (1) TWI286140B (en)
UA (1) UA78062C2 (en)
UY (1) UY27844A1 (en)
WO (1) WO2003104253A2 (en)
ZA (1) ZA200500217B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10027887A1 (en) 2000-05-31 2001-12-13 Jenapharm Gmbh Compounds with a sulfonamide group and pharmaceutical compositions containing these compounds
PL1689410T3 (en) * 2003-11-26 2008-10-31 Bayer Schering Pharma Ag Prevention and treatment of hypertensive heart diseases by the selective estrogens 8beta-vinyl-estra-1,3,5(10)-trien-3,17beta-diol and 17beta-fluor-9alpha-vinyl-estra-1,3,5(10)-trien-3,16alpha-diol
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
DE102005057224A1 (en) * 2005-11-29 2007-05-31 Bayer Schering Pharma Ag New 9-alpha substituted estratriene derivatives esterified with a sulfamoylphenyl-substituted acid residue, are prodrugs useful as carboanhydrase inhibitors for treating estrogen deficiency disorders
JP2011511816A (en) * 2008-02-13 2011-04-14 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト Drug delivery system with stabilizing effect
EP2143432A1 (en) 2008-07-11 2010-01-13 Bayer Schering Pharma AG 9-alpha estratriene derivatives as ER-beta selective ligands for the prevention and treatment of intestinal cancer
JP2012509286A (en) * 2008-11-21 2012-04-19 バイエル ファーマ アクチエンゲゼルシャフト Drug delivery system
JP2017529388A (en) 2014-08-26 2017-10-05 ベタニエン ホスピタル Methods, agents and compositions for the treatment of inflammatory conditions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2336432A1 (en) * 1973-07-13 1975-01-30 Schering Ag 3.17.18-TRIHYDROXY-1.3.5 (10) -OESTRATRIENE
US6154158A (en) * 1998-06-30 2000-11-28 Qualcomm Incorporated Digital-to-analog converter D.C. offset correction comparing converter input and output signals
DE19906159A1 (en) * 1999-02-09 2000-08-10 Schering Ag 16-hydroxyestratrienes as selectively active estrogens
ES2286042T3 (en) * 1999-11-02 2007-12-01 Bayer Schering Pharma Aktiengesellschaft 18-NOR-STEROIDS AS EFFECTIVE STROGENS SELECTIVELY.
US7378404B2 (en) * 2000-04-12 2008-05-27 Schering Aktiengesellschaft 8β-hydrocarbyl-substituted estratrienes for use as selective estrogens

Also Published As

Publication number Publication date
KR101006612B1 (en) 2011-01-10
CR10289A (en) 2008-11-26
TWI286140B (en) 2007-09-01
ATE303397T1 (en) 2005-09-15
RS107004A (en) 2006-10-27
DE10226326A1 (en) 2004-01-15
HRP20050009B1 (en) 2013-07-31
HRP20050009A2 (en) 2005-04-30
ECSP055530A (en) 2005-03-10
TW200407331A (en) 2004-05-16
CU23414B7 (en) 2009-09-08
AU2003242683A1 (en) 2003-12-22
PL209910B1 (en) 2011-11-30
JP4615998B2 (en) 2011-01-19
HK1081203A1 (en) 2006-05-12
EP1517914A2 (en) 2005-03-30
IL165321A (en) 2009-08-03
ZA200500217B (en) 2006-03-29
NO20050127D0 (en) 2005-01-10
JP2005533053A (en) 2005-11-04
WO2003104253A3 (en) 2004-09-16
RS50878B (en) 2010-08-31
UY27844A1 (en) 2003-12-31
CN1293090C (en) 2007-01-03
CN1659181A (en) 2005-08-24
EP1517914B1 (en) 2005-08-31
AR040188A1 (en) 2005-03-16
AU2003242683B2 (en) 2009-07-02
KR20050009745A (en) 2005-01-25
MXPA04012491A (en) 2005-06-08
CA2486495A1 (en) 2003-12-18
DE50301116D1 (en) 2005-10-06
AU2003242683B9 (en) 2009-08-27
ES2248770T3 (en) 2006-03-16
WO2003104253A2 (en) 2003-12-18
CA2486495C (en) 2011-04-19
PE20040613A1 (en) 2004-12-01
EA008442B1 (en) 2007-06-29
UA78062C2 (en) 2007-02-15
BR0312140A (en) 2005-04-05
EA200401544A1 (en) 2005-06-30
PL373090A1 (en) 2005-08-08
NO329563B1 (en) 2010-11-15
DK1517914T3 (en) 2006-01-16

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: BAYER INTELLECTUAL PROPERTY GMBH, DE

MM1K Lapsed by not paying the annual fees