NO20042928L - Process for the synthesis of chirally pure beta-amino alcohols - Google Patents

Process for the synthesis of chirally pure beta-amino alcohols

Info

Publication number
NO20042928L
NO20042928L NO20042928A NO20042928A NO20042928L NO 20042928 L NO20042928 L NO 20042928L NO 20042928 A NO20042928 A NO 20042928A NO 20042928 A NO20042928 A NO 20042928A NO 20042928 L NO20042928 L NO 20042928L
Authority
NO
Norway
Prior art keywords
synthesis
amino alcohols
chirally pure
pure beta
beta
Prior art date
Application number
NO20042928A
Other languages
Norwegian (no)
Inventor
Derek Cecil Cole
Madelene Miyoko Antane
Anthony Frank Kreft
Joseph Raymond Stock
Dennis Martin Kubrak
Lynn Resnick
Zheng Wang
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20042928L publication Critical patent/NO20042928L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12—Formation of amino and carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/20—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/24—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and acyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20042928A 2001-12-11 2004-07-08 Process for the synthesis of chirally pure beta-amino alcohols NO20042928L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33926401P 2001-12-11 2001-12-11
PCT/US2002/038119 WO2003050063A2 (en) 2001-12-11 2002-11-26 PROCESS FOR THE SYNTHESIS OF CHIRALLY PURE β-AMINO-ALCOHOLS

Publications (1)

Publication Number Publication Date
NO20042928L true NO20042928L (en) 2004-07-08

Family

ID=23328219

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20042928A NO20042928L (en) 2001-12-11 2004-07-08 Process for the synthesis of chirally pure beta-amino alcohols

Country Status (19)

Country Link
US (1) US6800764B2 (en)
EP (1) EP1461303A4 (en)
JP (1) JP4250529B2 (en)
KR (1) KR100921641B1 (en)
CN (1) CN1602290B (en)
AR (1) AR037775A1 (en)
AU (1) AU2002359519B2 (en)
BR (1) BR0214863A (en)
CA (1) CA2469021A1 (en)
HU (1) HUP0402522A2 (en)
IL (1) IL162059A0 (en)
MX (1) MXPA04005570A (en)
NO (1) NO20042928L (en)
NZ (1) NZ533432A (en)
PL (1) PL370859A1 (en)
RU (1) RU2332397C2 (en)
TW (1) TWI262182B (en)
WO (1) WO2003050063A2 (en)
ZA (1) ZA200405450B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100869061B1 (en) 2000-12-13 2008-11-17 와이어쓰 Heterocyclic sulfonamide inhibitors of beta amyloid production
IL165265A0 (en) * 2002-06-11 2005-12-18 Wyeth Corp Substituted phenylsulfonamide inhibitors of beta amyloid production
CL2004000647A1 (en) 2003-03-31 2005-02-04 Wyeth Corp COMPOUNDS DERIVED FROM SULFONAMIDE HETEROCICLES CONTAINING FLUORO AND TRIFLUORO RENT; PHARMACEUTICAL COMPOSITION; PHARMACEUTICAL KIT; PREPARATION PROCEDURE; AND ITS USE AS BETA AMILOID INHIBITORS TO TREAT ALZHEIMER, ANGIOPATIA AM
US7687666B2 (en) * 2006-02-17 2010-03-30 Wyeth Methods for preparing sulfonamide substituted alcohols and intermediates thereof
PE20080109A1 (en) * 2006-02-17 2008-04-01 Wyeth Corp SELECTIVE N-SULPHONYLATION OF ALCOHOLS SUBSTITUTED WITH 2-AMINOTRIFLUORALKYL
BRPI0710470A2 (en) 2006-04-21 2011-08-16 Wyeth Corp methods for selectively preparing a chiral amino alcohol and a chiral sulfonamide
CN103396346A (en) * 2008-05-19 2013-11-20 杏林制药株式会社 Method for producing optically active aminoalcohol derivative
US8440844B2 (en) * 2011-06-21 2013-05-14 Council Of Scientific & Industrial Research Process for the preparation of β-amino alcohol
CN103319323A (en) * 2013-02-20 2013-09-25 上海晶纯实业有限公司 Odd-carbon saturated higher fatty acids, and preparation method for esters thereof
CN103360405B (en) * 2013-05-24 2015-09-09 武汉工程大学 A kind of spirocyclic compound 2,4,8,10-tetra-carbonyl-3,9-dioxa volution [5,5] undecanoic synthetic method
CN106397172A (en) * 2016-08-31 2017-02-15 海门华祥医药科技有限公司 Synthesis method of long-chain fatty acids

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US183361A (en) * 1876-10-17 Improvement in plow-fenders
US13892A (en) * 1855-12-04 Improvement in quartz-crushing machines
US2440356A (en) 1945-08-24 1948-04-27 Lilly Co Eli Process and culture media for the production of penicillin
US4105696A (en) * 1974-05-06 1978-08-08 Hoffmann-La Roche Inc. Asymmetric synthesis of organic compounds
DE3711911A1 (en) * 1987-04-08 1988-10-20 Bayer Ag OPTICALLY ACTIVE (ALPHA) -AMINOALDEHYDE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR STEREOSELECTIVE PRODUCTION OF OPTICALLY ACTIVE SS-AMINO ALCOHOLS
US5466798A (en) * 1992-03-06 1995-11-14 The Regents Of The University Of California Synthesis of lithium aminoborohydrides and reactions thereof
US5264577A (en) 1992-04-22 1993-11-23 Warner-Lambert Company Cyclic amino acids and derivatives thereof
US5783701A (en) * 1992-09-08 1998-07-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
US5470949A (en) * 1992-12-15 1995-11-28 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method for making amino acid glycosides and glycopeptides
US5455353A (en) * 1993-03-24 1995-10-03 Hoffmann-La Roche Inc. 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides
US5831132A (en) * 1994-10-28 1998-11-03 Sumika Fine Chemicals Company, Ltd. Process for producing optically active carbinols
ES2146036T3 (en) * 1995-11-16 2000-07-16 Searle & Co BETA-AMINO-HYDROXY-SULPHONATES PROTECTED IN N / REPLACED IN N.
WO1999059721A1 (en) * 1998-05-18 1999-11-25 The Penn State Research Foundation Catalytic asymmetric hydrogenation, hydroformylation, and hydrovinylation via transition metal catalysts with phosphines and phosphites
EP1146037B1 (en) * 1999-01-18 2006-06-21 Nippon Soda Co., Ltd. Process for the preparation of optically active amino alcohols
JP2003505474A (en) * 1999-07-26 2003-02-12 ニューヨーク・ユニバーシティ Electronically driven chiral switch
KR100869061B1 (en) * 2000-12-13 2008-11-17 와이어쓰 Heterocyclic sulfonamide inhibitors of beta amyloid production
US6657070B2 (en) * 2000-12-13 2003-12-02 Wyeth Production of chirally pure α-amino acids and N-sulfonyl α-amino acids

Also Published As

Publication number Publication date
CA2469021A1 (en) 2003-06-19
EP1461303A4 (en) 2006-07-05
US6800764B2 (en) 2004-10-05
EP1461303A2 (en) 2004-09-29
AR037775A1 (en) 2004-12-01
AU2002359519A1 (en) 2003-06-23
TWI262182B (en) 2006-09-21
RU2004121186A (en) 2006-01-10
HUP0402522A2 (en) 2005-03-29
AU2002359519B2 (en) 2009-07-16
TW200305560A (en) 2003-11-01
MXPA04005570A (en) 2004-12-06
JP4250529B2 (en) 2009-04-08
KR100921641B1 (en) 2009-10-14
CN1602290B (en) 2010-10-27
ZA200405450B (en) 2005-10-10
PL370859A1 (en) 2005-05-30
CN1602290A (en) 2005-03-30
IL162059A0 (en) 2005-11-20
WO2003050063A3 (en) 2003-10-09
KR20040074080A (en) 2004-08-21
WO2003050063A2 (en) 2003-06-19
JP2005511728A (en) 2005-04-28
BR0214863A (en) 2004-12-14
NZ533432A (en) 2006-01-27
RU2332397C2 (en) 2008-08-27
US20030144531A1 (en) 2003-07-31

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