NO20042781L - Pharmaceutical compositions based on azetidine derivatives - Google Patents
Pharmaceutical compositions based on azetidine derivativesInfo
- Publication number
- NO20042781L NO20042781L NO20042781A NO20042781A NO20042781L NO 20042781 L NO20042781 L NO 20042781L NO 20042781 A NO20042781 A NO 20042781A NO 20042781 A NO20042781 A NO 20042781A NO 20042781 L NO20042781 L NO 20042781L
- Authority
- NO
- Norway
- Prior art keywords
- azetidine
- general formula
- optionally
- azetidine derivative
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Oppfinnelsen vedrører en stabil farmasøytisk sammensetning som omfatter minst et azetidinderivat med generell formel (la) eller (Ib) der: Ar er en aromatisk eller heteroaromatisk gruppe som eventuelt er substituert med en eller flere av (Cl -C4)alkyl, halogen, N0, CN, (Cl -C4)alkoksy eller OH, som eventuelt er kombinert med en annen aktiv bestanddel som er i stand til å potensiere effektene av azetidinderivatet med generell formel (la) eller (lb), i et system som ikke omfatter mer enn to vesentlige eksipienter som er valgt blant en ikke-ionisk surfaktant med hydrofil karakter som er i stand til å oppløse azetidinderivatet med generell formel (la) eller (Ib) og eventuelt der den aktive bestanddelen som potensierer effektene av azetidinderivatet, og som er i stand til å forårsake dannelsen av et kolloidalt system eventuelt med tilsetning av en annen lipofil eksipient, stabiliserer formuleringen. De farmasøytiske sammensetningene som omfatter azetidinderivater med formel (Ia) eller (Ib) er særlig nyttige på grunn av den høye affiniteten hos de nevnte derivatene for cannabinoidreseptorer.The invention relates to a stable pharmaceutical composition comprising at least one azetidine derivative of general formula (Ia) or (Ib) wherein: Ar is an aromatic or heteroaromatic group optionally substituted by one or more of (C 1 -C 4) alkyl, halogen, NO CN, (C1 -C4) alkoxy or OH, optionally combined with another active ingredient capable of potentiating the effects of the azetidine derivative of general formula (Ia) or (lb), in a system comprising not more than two essential excipients selected from a hydrophilic nonionic surfactant capable of dissolving the azetidine derivative of general formula (Ia) or (Ib) and optionally wherein the active ingredient potentiating the effects of the azetidine derivative, and capable of to cause the formation of a colloidal system, optionally with the addition of another lipophilic excipient, stabilizes the formulation. The pharmaceutical compositions comprising azetidine derivatives of formula (Ia) or (Ib) are particularly useful due to the high affinity of the said derivatives for cannabinoid receptors.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0116638A FR2833842B1 (en) | 2001-12-21 | 2001-12-21 | PHARMACEUTICAL COMPOSITIONS BASED ON AZETIDINE DERIVATIVES |
| PCT/FR2002/004514 WO2003053431A2 (en) | 2001-12-21 | 2002-12-20 | Pharmaceutical compositions based on azetidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20042781L true NO20042781L (en) | 2004-09-20 |
Family
ID=8870824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20042781A NO20042781L (en) | 2001-12-21 | 2004-07-01 | Pharmaceutical compositions based on azetidine derivatives |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP1458413B1 (en) |
| JP (1) | JP5021887B2 (en) |
| KR (1) | KR20040068308A (en) |
| CN (1) | CN100388918C (en) |
| AP (1) | AP1754A (en) |
| AR (1) | AR037687A1 (en) |
| AU (1) | AU2002364866B2 (en) |
| BR (1) | BR0215048A (en) |
| CA (1) | CA2470443A1 (en) |
| CO (1) | CO5590911A2 (en) |
| DE (1) | DE60233071D1 (en) |
| DK (1) | DK1458413T3 (en) |
| EA (1) | EA006510B1 (en) |
| EC (1) | ECSP045162A (en) |
| FR (1) | FR2833842B1 (en) |
| HK (1) | HK1070840A1 (en) |
| HR (1) | HRP20040575A2 (en) |
| HU (1) | HUP0402586A3 (en) |
| IL (1) | IL162563A0 (en) |
| MA (1) | MA27086A1 (en) |
| ME (1) | MEP16608A (en) |
| MX (1) | MXPA04005558A (en) |
| MY (1) | MY138172A (en) |
| NO (1) | NO20042781L (en) |
| NZ (1) | NZ533225A (en) |
| OA (1) | OA12750A (en) |
| PL (1) | PL203248B1 (en) |
| RS (1) | RS55504A (en) |
| TW (1) | TWI256304B (en) |
| UA (1) | UA77736C2 (en) |
| WO (1) | WO2003053431A2 (en) |
| ZA (1) | ZA200404338B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1498122A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Semi-solid systems containing azetidine derivatives |
| EP1498123A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Emulsifying systems containing azetidine derivatives |
| KR20060124756A (en) | 2004-02-17 | 2006-12-05 | 라보라토리오스 델 드라. 에스테브.에스.에이. | Substituted azetidine compounds, their preparation and use as medicaments |
| FR2879932B1 (en) * | 2004-12-27 | 2007-03-23 | Aventis Pharma Sa | FORMULATIONS INJECTABLE OR ORALLY ADMINISTRATIVE OF AZETIDINE DERIVATIVES |
| EP2308840A1 (en) | 2005-06-30 | 2011-04-13 | Prosidion Limited | GPCR agonists |
| GB0700122D0 (en) | 2007-01-04 | 2007-02-14 | Prosidion Ltd | GPCR agonists |
| CL2008000018A1 (en) | 2007-01-04 | 2008-08-01 | Prosidion Ltd | COMPOUNDS DERIVED FROM NITROGEN AND OXYGEN HETEROCICLES, GPCR AGONISTS; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND FOR THE TREATMENT OF OBESITY, DIABETES, METABOLIC SYNDROME, HYPERLIPIDEMIA, TOLERANCE |
| EP2114933B1 (en) | 2007-01-04 | 2011-09-07 | Prosidion Ltd | Piperidine gpcr agonists |
| EP2114936A1 (en) | 2007-01-04 | 2009-11-11 | Prosidion Limited | Piperidine gpcr agonists |
| CL2008000017A1 (en) | 2007-01-04 | 2008-08-01 | Prosidion Ltd | COMPOUNDS DERIVED FROM NITROGEN AND OXYGEN HETEROCICLES, GPCR AGONISTS; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND FOR THE TREATMENT OF OBESITY, DIABETES, METABOLIC SYNDROME, HYPERLIPIDEMIA, TOLERANCE |
| GB0720389D0 (en) | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
| GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
| FR2923719B1 (en) * | 2007-11-15 | 2009-11-20 | Sanofi Aventis | PHARMACEUTICAL COMPOSITIONS BASED ON AZETIDINE DERIVATIVES |
| FR2928149B1 (en) | 2008-02-29 | 2011-01-14 | Sanofi Aventis | AZETIDINE-DERIVED COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
| FR2946650B1 (en) * | 2009-06-16 | 2011-08-19 | Sanofi Aventis | ESTERS DERIVED FROM AZETIDINES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS. |
| UA153183U (en) | 2022-10-27 | 2023-05-31 | Андрій Валерійович Максимов | GLASS FOR DRINK PREPARATION |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR73668B (en) * | 1978-11-21 | 1984-03-28 | Hoffmann La Roche | |
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| HRP980026A2 (en) * | 1998-01-20 | 1999-10-31 | Pliva Pharm & Chem Works | 1-izothiazolydinone derivatives of azetidine-2-ones, processes for the preparation and use thereof |
| CN1273526A (en) * | 1998-07-14 | 2000-11-15 | Em工业股份有限公司 | Microdisperse drug delivery systems |
| FR2783246B1 (en) * | 1998-09-11 | 2000-11-17 | Aventis Pharma Sa | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THE MEDICINES CONTAINING THEM |
| FR2805810B1 (en) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | PHARMACEUTICAL COMPOSITIONS CONTAINING 3- AMINO-AZETIDINE DERIVATIVES, THE NEW DERIVATIVES AND THEIR PREPARATION |
| FR2805818B1 (en) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR2805817B1 (en) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | PHARMACEUTICAL COMPOSITIONS CONTAINING AZETIDINE DERIVATIVES, NOVEL AZETIDINE DERIVATIVES AND THEIR PREPARATION |
| FR2814678B1 (en) * | 2000-10-04 | 2002-12-20 | Aventis Pharma Sa | COMBINATION OF AN ANTAGONIST OF THE CB1 RECEPTOR AND SIBUTRAMINE, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE FOR THE TREATMENT OF OBESITY |
-
2001
- 2001-12-21 FR FR0116638A patent/FR2833842B1/en not_active Expired - Fee Related
-
2002
- 2002-12-02 AR ARP020104646A patent/AR037687A1/en unknown
- 2002-12-03 TW TW091135077A patent/TWI256304B/en active
- 2002-12-20 KR KR10-2004-7009708A patent/KR20040068308A/en not_active Application Discontinuation
- 2002-12-20 JP JP2003554188A patent/JP5021887B2/en not_active Expired - Fee Related
- 2002-12-20 WO PCT/FR2002/004514 patent/WO2003053431A2/en active IP Right Grant
- 2002-12-20 BR BR0215048-4A patent/BR0215048A/en not_active IP Right Cessation
- 2002-12-20 CN CNB028248406A patent/CN100388918C/en not_active Expired - Fee Related
- 2002-12-20 DK DK02801165T patent/DK1458413T3/en active
- 2002-12-20 AU AU2002364866A patent/AU2002364866B2/en not_active Ceased
- 2002-12-20 EA EA200400843A patent/EA006510B1/en not_active IP Right Cessation
- 2002-12-20 UA UA20040706001A patent/UA77736C2/en unknown
- 2002-12-20 EP EP02801165A patent/EP1458413B1/en not_active Expired - Lifetime
- 2002-12-20 IL IL16256302A patent/IL162563A0/en unknown
- 2002-12-20 DE DE60233071T patent/DE60233071D1/en not_active Expired - Lifetime
- 2002-12-20 NZ NZ533225A patent/NZ533225A/en not_active IP Right Cessation
- 2002-12-20 HU HU0402586A patent/HUP0402586A3/en unknown
- 2002-12-20 CA CA002470443A patent/CA2470443A1/en not_active Abandoned
- 2002-12-20 MY MYPI20024828A patent/MY138172A/en unknown
- 2002-12-20 PL PL372708A patent/PL203248B1/en not_active IP Right Cessation
- 2002-12-20 AP APAP/P/2004/003066A patent/AP1754A/en active
- 2002-12-20 RS YUP-555/04A patent/RS55504A/en unknown
- 2002-12-20 MX MXPA04005558A patent/MXPA04005558A/en active IP Right Grant
- 2002-12-20 ME MEP-166/08A patent/MEP16608A/en unknown
- 2002-12-20 OA OA1200400178A patent/OA12750A/en unknown
-
2004
- 2004-05-21 MA MA27694A patent/MA27086A1/en unknown
- 2004-06-02 ZA ZA200404338A patent/ZA200404338B/en unknown
- 2004-06-17 CO CO04056913A patent/CO5590911A2/en not_active Application Discontinuation
- 2004-06-18 EC EC2004005162A patent/ECSP045162A/en unknown
- 2004-06-18 HR HR20040575A patent/HRP20040575A2/en not_active Application Discontinuation
- 2004-07-01 NO NO20042781A patent/NO20042781L/en not_active Application Discontinuation
-
2005
- 2005-05-04 HK HK05103765A patent/HK1070840A1/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |