NO20042143L - Process for the preparation of high-dissolving preparations with high content of ribavirin - Google Patents

Process for the preparation of high-dissolving preparations with high content of ribavirin

Info

Publication number
NO20042143L
NO20042143L NO20042143A NO20042143A NO20042143L NO 20042143 L NO20042143 L NO 20042143L NO 20042143 A NO20042143 A NO 20042143A NO 20042143 A NO20042143 A NO 20042143A NO 20042143 L NO20042143 L NO 20042143L
Authority
NO
Norway
Prior art keywords
ribavirin
preparation
dissolving preparations
high content
content
Prior art date
Application number
NO20042143A
Other languages
Norwegian (no)
Inventor
Amol Singh Matharu
Mahendra R Patel
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of NO20042143L publication Critical patent/NO20042143L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
NO20042143A 2001-11-02 2004-05-25 Process for the preparation of high-dissolving preparations with high content of ribavirin NO20042143L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33685301P 2001-11-02 2001-11-02
PCT/US2002/034899 WO2003039517A1 (en) 2001-11-02 2002-10-31 Process for preparing quick dissolving, high loading ribavirin compositions

Publications (1)

Publication Number Publication Date
NO20042143L true NO20042143L (en) 2004-05-25

Family

ID=23317956

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20042143A NO20042143L (en) 2001-11-02 2004-05-25 Process for the preparation of high-dissolving preparations with high content of ribavirin

Country Status (16)

Country Link
US (1) US20030104050A1 (en)
EP (1) EP1443911A1 (en)
JP (1) JP2005511587A (en)
KR (1) KR20050042035A (en)
CN (1) CN1585631A (en)
AU (1) AU2002350082B9 (en)
BR (1) BR0213861A (en)
CA (1) CA2465159A1 (en)
HR (1) HRP20040384A2 (en)
HU (1) HUP0402364A2 (en)
IL (1) IL161697A0 (en)
MX (1) MXPA04004181A (en)
NO (1) NO20042143L (en)
PL (1) PL368550A1 (en)
RU (1) RU2004116821A (en)
WO (1) WO2003039517A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720000B2 (en) * 2001-03-19 2004-04-13 Three Rivers Pharmaceutical, Llc Process for producing wet ribavirin pellets
US7538094B2 (en) * 2002-09-19 2009-05-26 Three Rivers Pharmacueticals, Llc Composition containing ribavirin and use thereof
CZ298224B6 (en) * 2003-04-29 2007-07-25 Pliva Istrazivanje I Razvoj D.O.O. Pharmaceutical composition containing ribavirin as active substance and process for its preparation
MY144631A (en) * 2004-05-24 2011-10-14 Nycomed Pharma As Particulate comprising a calcium-containing compound and a sugar alcohol
US20080124400A1 (en) * 2004-06-24 2008-05-29 Angiotech International Ag Microparticles With High Loadings Of A Bioactive Agent
US7723310B2 (en) * 2004-10-18 2010-05-25 Three Rivers Pharmaceuticals, Llc Large dose ribavirin formulations
US20060110479A1 (en) * 2004-11-24 2006-05-25 Mitra Shankar K Natural composition for curing hepatitis-B, methods for making the same and pharmaceutical formulations thereof
US8263137B2 (en) 2005-08-04 2012-09-11 Vertical Pharmaceuticals, Inc. Nutritional supplement for women
US7901710B2 (en) 2005-08-04 2011-03-08 Vertical Pharmaceuticals, Inc. Nutritional supplement for use under physiologically stressful conditions
US8202546B2 (en) 2005-08-04 2012-06-19 Vertical Pharmaceuticals, Inc. Nutritional supplement for use under physiologically stressful conditions
EP2101739A2 (en) * 2006-12-21 2009-09-23 Mallinckrodt Inc. Composition of and method for preparing orally disintegrating tablets containing a high dose of pharmaceutically active ingredients
US8202996B2 (en) * 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
WO2010062996A2 (en) * 2008-11-28 2010-06-03 Adamas Pharmaceuticals, Inc. Ribavirin composition
EP2295037A1 (en) 2009-09-11 2011-03-16 Ratiopharm GmbH Pharmaceutical formulation containing Ribavirin
US20130190263A1 (en) * 2010-06-08 2013-07-25 Laboratorio De Diagnostico Gam, S.A. Oral veterinarian composition for salmonids comprising 1-beta-d-ribofuranosyl-1h-1,2,4-triazole-3-carboxamide and use thereof in the treatment of infectious anemia in salmonids
US20190076467A1 (en) * 2015-06-09 2019-03-14 Commonwealth Scientific And Industrial Research Organisation Antiviral conjugates of polyanionic polymer and antiviral drug
CN106806345B (en) * 2015-11-27 2020-10-13 北京科信必成医药科技发展有限公司 Ribavirin taste masking granules and preparation method thereof
CN108464972A (en) * 2018-07-02 2018-08-31 福州大学 A kind of anti-pulmonary hypertension oral tablet and preparation method thereof containing Snopori
EP4225274A1 (en) 2020-10-05 2023-08-16 XWPharma Ltd. Modified release compositions of a gamma-hydroxybutyric acid derivative
CN113304114B (en) * 2021-06-08 2022-06-10 药大制药有限公司 Ribavirin granules and preparation method thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3277520A (en) * 1963-06-18 1966-10-11 Fuji Denki Kogyo Kabushiki Kai Method and apparatus for making spherical granules
US3798209A (en) * 1971-06-01 1974-03-19 Icn Pharmaceuticals 1,2,4-triazole nucleosides
US4211771A (en) * 1971-06-01 1980-07-08 Robins Ronald K Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
US3927216A (en) * 1971-06-01 1975-12-16 Icn Pharmaceuticals 1,2,4-Triazol E-3-carboxamides for inhibiting virus infections
US3976545A (en) * 1973-03-12 1976-08-24 Icn Pharmaceuticals, Inc. 1,2,4-Triazol E-3-carboxamides as antiviral agents
US3948885A (en) * 1973-03-19 1976-04-06 Icn Pharmaceuticals, Inc. 5-Hydroxyl-1,2,3-triazole-4-carboxamide nucleoside
US4138547A (en) * 1977-12-22 1979-02-06 Icn Pharmaceuticals, Inc. Process for preparing 1,2,4-triazole nucleosides
US4439453A (en) * 1980-12-22 1984-03-27 Monsanto Company Directly compressible acetaminophen granulation
GB9009861D0 (en) * 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
US5405837A (en) * 1993-05-18 1995-04-11 Indiana University Foundation Method for the treatment of neoplastic disease utilizing tiazofurin and ribavirin
PT858343E (en) * 1995-11-02 2004-07-30 Schering Corp THERAPY FOR CONTINUOUS INFUSE OF A LOW DOSE OF CYTOKINE
US5908621A (en) * 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
US5767097A (en) * 1996-01-23 1998-06-16 Icn Pharmaceuticals, Inc. Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes
US6150337A (en) * 1996-01-23 2000-11-21 Icn Pharmaceuticals, Inc. Specific modulation of Th1/Th2 cytokine expression by Ribavirin in activated T-lymphocytes
ATE238328T1 (en) * 1996-10-16 2003-05-15 Ribapharm Inc MONOCYCLIC L-NUCLEOSIDES, ANALOGAS AND THEIR APPLICATIONS
US6472373B1 (en) * 1997-09-21 2002-10-29 Schering Corporation Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
US6172046B1 (en) * 1997-09-21 2001-01-09 Schering Corporation Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection
US5916594A (en) * 1997-12-22 1999-06-29 Schering Corporation Process of making solid ribavirin dosage forms
CN1155388C (en) * 1997-12-22 2004-06-30 先灵公司 Orally administrable solid ribavirin dosafe forms and process for making them
US5914128A (en) * 1997-12-22 1999-06-22 Schering Corporation Orally administrable solid dosage form
US20030104048A1 (en) * 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US6720000B2 (en) * 2001-03-19 2004-04-13 Three Rivers Pharmaceutical, Llc Process for producing wet ribavirin pellets

Also Published As

Publication number Publication date
US20030104050A1 (en) 2003-06-05
AU2002350082B9 (en) 2006-08-31
JP2005511587A (en) 2005-04-28
AU2002350082B2 (en) 2006-07-20
KR20050042035A (en) 2005-05-04
PL368550A1 (en) 2005-04-04
MXPA04004181A (en) 2005-01-25
HRP20040384A2 (en) 2005-08-31
BR0213861A (en) 2004-12-21
CA2465159A1 (en) 2003-05-15
EP1443911A1 (en) 2004-08-11
WO2003039517A1 (en) 2003-05-15
RU2004116821A (en) 2005-04-20
CN1585631A (en) 2005-02-23
HUP0402364A2 (en) 2005-02-28
IL161697A0 (en) 2004-09-27

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application