NO20040811L - Diarylcycloalkyl derivatives, process for their preparation and their use as PPAR activators. - Google Patents

Diarylcycloalkyl derivatives, process for their preparation and their use as PPAR activators.

Info

Publication number
NO20040811L
NO20040811L NO20040811A NO20040811A NO20040811L NO 20040811 L NO20040811 L NO 20040811L NO 20040811 A NO20040811 A NO 20040811A NO 20040811 A NO20040811 A NO 20040811A NO 20040811 L NO20040811 L NO 20040811L
Authority
NO
Norway
Prior art keywords
derivatives
preparation
compounds
ppar activators
diarylcycloalkyl derivatives
Prior art date
Application number
NO20040811A
Other languages
Norwegian (no)
Other versions
NO327067B1 (en
Inventor
Heiner Glombik
Eugen Falk
Wendelin Frick
Hans-Ludwig Schafer
Lothar Schwink
Stefanie Keil
Wolfgang Wendler
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2002/009221 external-priority patent/WO2003020269A1/en
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20040811L publication Critical patent/NO20040811L/en
Publication of NO327067B1 publication Critical patent/NO327067B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det beskrives diaiylcykloalkylderivater samt fysiologisk godtakbare salter derav og fysiologisk funksjonelle derivater derav. Derivatene er forbindelser med formel 1 der restene har nærmere angitte betydninger og videre beskrives fremgangsmåter for fremstilling av forbindelsene.Forbindelsene har lipid- og/eller triglyceirdsenkende egenskaper og egner seg for eksempel for behandling av lipidstoffskifteforstyrrelser, type II diabetes og syndrom X.Diylcycloalkyl derivatives as well as physiologically acceptable salts thereof and physiologically functional derivatives thereof are described. The derivatives are compounds of formula 1 in which the residues have specified meanings and methods for the preparation of the compounds are further described. The compounds have lipid and / or triglyceride lowering properties and are suitable, for example, for the treatment of lipid metabolism disorders, type II diabetes and syndrome X.

NO20040811A 2002-05-24 2004-02-24 Diarylcycloalkyl derivatives, use thereof, drug containing one or more such compounds, and method of preparation of drug NO327067B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2002123273 DE10223273A1 (en) 2002-05-24 2002-05-24 New (((oxazolylalkyl)-cycloalkyl)-alkyl)-benzoic acid derivatives, are peroxisome proliferator activated receptor agonists or antagonists used e.g. for treating lipid metabolism disorders, type II diabetes, syndrome X and obesity
PCT/EP2002/009221 WO2003020269A1 (en) 2001-08-31 2002-08-17 Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as ppar activators

Publications (2)

Publication Number Publication Date
NO20040811L true NO20040811L (en) 2004-05-19
NO327067B1 NO327067B1 (en) 2009-04-14

Family

ID=29414152

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20040811A NO327067B1 (en) 2002-05-24 2004-02-24 Diarylcycloalkyl derivatives, use thereof, drug containing one or more such compounds, and method of preparation of drug

Country Status (2)

Country Link
DE (1) DE10223273A1 (en)
NO (1) NO327067B1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ555683A (en) 2004-12-14 2010-09-30 Astrazeneca Ab Oxadiazole derivatives as dgat inhibitors
JP2009520786A (en) 2005-12-22 2009-05-28 アストラゼネカ アクチボラグ Pyrimido- [4,5-B] -oxazine for use as a DGAT inhibitor
CA2651663A1 (en) 2006-05-30 2007-12-06 Astrazeneca Ab Chemical compounds
US8084478B2 (en) 2006-05-30 2011-12-27 Asstrazeneca Ab Substituted 5- phenylamino- 1, 3, 4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase
GB0611507D0 (en) * 2006-06-10 2006-07-19 Astrazeneca Ab Chemical compounds
PE20091682A1 (en) 2007-12-20 2009-12-04 Astrazeneca Ab CARBAMOYL COMPOUNDS AS INHIBITORS OF DGAT1 190
KR20120037939A (en) 2009-06-19 2012-04-20 아스트라제네카 아베 Pyrazine carboxamides as inhibitors of dgat1

Also Published As

Publication number Publication date
NO327067B1 (en) 2009-04-14
DE10223273A1 (en) 2003-12-04

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