NO20032821L - Sea-trosy og beslektede fremgangsmåter - Google Patents

Sea-trosy og beslektede fremgangsmåter

Info

Publication number
NO20032821L
NO20032821L NO20032821A NO20032821A NO20032821L NO 20032821 L NO20032821 L NO 20032821L NO 20032821 A NO20032821 A NO 20032821A NO 20032821 A NO20032821 A NO 20032821A NO 20032821 L NO20032821 L NO 20032821L
Authority
NO
Norway
Prior art keywords
macromolecule
proton
sample
trosy
sea
Prior art date
Application number
NO20032821A
Other languages
English (en)
Other versions
NO20032821D0 (no
Inventor
Maurizio Pellecchia
Original Assignee
Triad Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Triad Therapeutics Inc filed Critical Triad Therapeutics Inc
Publication of NO20032821D0 publication Critical patent/NO20032821D0/no
Publication of NO20032821L publication Critical patent/NO20032821L/no

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4608—RF excitation sequences for enhanced detection, e.g. NOE, polarisation transfer, selection of a coherence transfer pathway
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of Length, Angles, Or The Like Using Electric Or Magnetic Means (AREA)

Abstract

Fremgangsmåte for å utføre fortrinnsvis observering av en eksponert posisjon (I c) i et makromolekyl. En prøve blir anskaffet som har et makromolekyl (1 a) med et første proton (1) og et andre molekyl (2a) med et andre proton (2). Det påtrykkes et magnetisk felt (4) på prøven og så blir prøven bestrålt med en pulssekvens (5) som fortrinnsvis demagnetiserer protoner i makromolekylet (1, 3) relativ til det andre protonet (2), å utveksles (6) med et eksponert proton (1) i makromolekylet, og å detektere magnetiseringen fra det relativt magnetiserte andre protonet (2), som nå er bundet til den eksponerte posisjonen (lc) i makromolekylet. Foreliggende oppfinnelse gir også en fremgangsmåte for å observere posisjon i makromolekylet som binder en ligand.
NO20032821A 2000-12-21 2003-06-19 Sea-trosy og beslektede fremgangsmåter NO20032821L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25862100P 2000-12-21 2000-12-21
US26347501P 2001-01-22 2001-01-22
PCT/US2001/050811 WO2002050538A2 (en) 2000-12-21 2001-12-19 Sea-trosy and related methods

Publications (2)

Publication Number Publication Date
NO20032821D0 NO20032821D0 (no) 2003-06-19
NO20032821L true NO20032821L (no) 2003-08-01

Family

ID=26946760

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032821A NO20032821L (no) 2000-12-21 2003-06-19 Sea-trosy og beslektede fremgangsmåter

Country Status (8)

Country Link
US (2) US6979531B2 (no)
EP (1) EP1350121A2 (no)
JP (1) JP2004516476A (no)
KR (1) KR20030074674A (no)
AU (1) AU2002256556A1 (no)
CA (1) CA2432924A1 (no)
NO (1) NO20032821L (no)
WO (1) WO2002050538A2 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020133296A1 (en) * 2000-12-22 2002-09-19 Sem Daniel S. Classification of polypeptides by ligand geometry and related methods
US20030008326A1 (en) * 2001-05-30 2003-01-09 Sem Daniel S Nuclear magnetic resonance-docking of compounds
US7964534B2 (en) 2003-03-13 2011-06-21 Triad Liquidating Company, Llc Nuclear magnetic resonance assembly of chemical entities using advanced antenna probes
KR100877172B1 (ko) * 2004-08-02 2009-01-07 인터디지탈 테크날러지 코포레이션 다중 입력 다중 출력(ｍｉｍｏ) 직교 주파수 분할다중화(ｏｆｄｍ) 시스템의 품질 제어 방법
SE0950363A1 (sv) * 2009-05-22 2010-06-29 Cr Dev Ab Metod och system för magnetisk resonanstomografi, samt användning därav.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5050609B1 (en) * 1987-10-04 1999-11-02 Us Health Magnetization transfer contrast and proton relaxation and use thereof in magnetic resonance imaging
US5321357A (en) * 1992-08-07 1994-06-14 Yale University Three-dimensional detection, dosimetry and imaging of an energy field by formation of a polymer in a gel
US5698401A (en) * 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
DE19648391C1 (de) 1996-11-22 1998-04-23 Univ Leiden Verfahren zum Verbessern der Auflösung in zweidimensionalen heteronuklearen Korrelationsspektren der Festkörper-NMR
US6043024A (en) * 1997-04-18 2000-03-28 Abbott Laboratories Use of one-dimensional nuclear magnetic resonance to identify ligands to target biomolecules
EP0916963B1 (en) 1997-10-18 1999-07-28 Bruker AG Transverse relaxation-optimized NMR spectroscopy (TROSY)
US6333149B1 (en) * 1999-06-04 2001-12-25 Triad Biotechnology, Inc. NMR-solve method for rapid identification of bi-ligand drug candidates

Also Published As

Publication number Publication date
EP1350121A2 (en) 2003-10-08
AU2002256556A1 (en) 2002-07-01
US20020127731A1 (en) 2002-09-12
US6979531B2 (en) 2005-12-27
JP2004516476A (ja) 2004-06-03
US20060166279A1 (en) 2006-07-27
KR20030074674A (ko) 2003-09-19
WO2002050538A3 (en) 2002-08-29
CA2432924A1 (en) 2002-06-27
WO2002050538A8 (en) 2003-11-13
WO2002050538A2 (en) 2002-06-27
NO20032821D0 (no) 2003-06-19

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