NO20032227L - En laktoniseringsfremgangsmåte - Google Patents

En laktoniseringsfremgangsmåte

Info

Publication number
NO20032227L
NO20032227L NO20032227A NO20032227A NO20032227L NO 20032227 L NO20032227 L NO 20032227L NO 20032227 A NO20032227 A NO 20032227A NO 20032227 A NO20032227 A NO 20032227A NO 20032227 L NO20032227 L NO 20032227L
Authority
NO
Norway
Prior art keywords
lactonization method
lactonization
Prior art date
Application number
NO20032227A
Other languages
English (en)
Other versions
NO20032227D0 (no
Inventor
Frantisek Picha
Theodorus Hendricus Ant Peters
Maria Jacobus Lemmens
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of NO20032227D0 publication Critical patent/NO20032227D0/no
Publication of NO20032227L publication Critical patent/NO20032227L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20032227A 2001-03-09 2003-05-16 En laktoniseringsfremgangsmåte NO20032227L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1017548A NL1017548C2 (nl) 2001-03-09 2001-03-09 Een lactonisatie proces.
PCT/NL2002/000161 WO2002072566A1 (en) 2001-03-09 2002-03-11 A lactonization process

Publications (2)

Publication Number Publication Date
NO20032227D0 NO20032227D0 (no) 2003-05-16
NO20032227L true NO20032227L (no) 2003-09-08

Family

ID=19773028

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032227A NO20032227L (no) 2001-03-09 2003-05-16 En laktoniseringsfremgangsmåte

Country Status (7)

Country Link
US (1) US6562984B2 (no)
EP (1) EP1368332A1 (no)
CN (1) CN1476440A (no)
NL (1) NL1017548C2 (no)
NO (1) NO20032227L (no)
NZ (1) NZ525972A (no)
WO (1) WO2002072566A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
DE602004017784D1 (de) * 2004-03-30 2008-12-24 Lupin Ltd Verbessertes verfahren zur herstellung von 4-hydroxypyran-2-onderivaten
EP1786765B1 (en) * 2004-09-08 2009-09-02 Jubilant Organosys Limited An improved process for lactonization in the preparation of statins
BRPI0519874A2 (pt) 2005-02-04 2010-03-23 Lupin Ltd processo aprimorado para a preparaÇço de um composto
CN101704808A (zh) * 2009-11-20 2010-05-12 西南合成制药股份有限公司 制备他汀类化合物的内酯化方法
CN104098537A (zh) * 2009-11-20 2014-10-15 北大医药股份有限公司 制备他汀类化合物的内酯化方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444784A (en) 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4582915A (en) 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
US4855481A (en) 1984-11-19 1989-08-08 Merck Frosst Canada, Inc. Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein
US4820850A (en) 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US4916239A (en) 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof
US5223415A (en) 1990-10-15 1993-06-29 Merck & Co., Inc. Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
US5393893A (en) 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
CA2185961A1 (en) 1996-09-19 1998-03-20 K.S. Keshava Murthy Process for producing simvastatin
DE69813538T2 (de) 1997-01-28 2004-04-01 Plus Chemicals B.V. Verfahren zur herstellung von halbsynthetischen statinen vianeue zwischenprodukte
IN186879B (no) 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
IN186880B (no) 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
SI20070A (sl) 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nove soli inhibitorjev HMG-CoA reduktaze
WO2001000606A1 (en) * 1999-06-29 2001-01-04 Kaneka Corporation Process for selective lactonization
IN191580B (no) * 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

Also Published As

Publication number Publication date
NL1017548C2 (nl) 2002-09-10
US20020147351A1 (en) 2002-10-10
CN1476440A (zh) 2004-02-18
NZ525972A (en) 2005-09-30
WO2002072566A1 (en) 2002-09-19
EP1368332A1 (en) 2003-12-10
NO20032227D0 (no) 2003-05-16
US6562984B2 (en) 2003-05-13

Similar Documents

Publication Publication Date Title
DE60205413D1 (de) Herstellungsverfahren
EE05587B1 (et) Meetod kollageenk„sna valmistamiseks
DE60203451D1 (de) Einschubschrank
DE60226131D1 (de) Strickverfahren
DE60103427D1 (de) Übereinstimmungssteuerverfahren
PL365417A1 (en) Patterning method
IS2523B (is) Turn vindorkuvers
ITMI20020092A0 (it) Un impianto
NO20032227D0 (no) En laktoniseringsfremgangsmåte
DE60226093D1 (de) Urmedium-Reinigungsmethode
DK1379128T3 (da) Planteinvigorator
DE50107729D1 (de) Regelverfahren
FI20011252A (fi) Rakennusmenetelmä
SE0104471D0 (sv) New method
FI20011169A0 (fi) Menetelmä petun modifioimiseksi
DOP2001000312A (es) Metodo
SE0102004L (sv) Indiviva-metoden
SE0100900D0 (sv) Method
SE0101479D0 (sv) Method
SE0100899D0 (sv) Method
NO20013389D0 (no) Kontrollmetode
SE0103416D0 (sv) New method
SE0103357D0 (sv) New method
SE0103573D0 (sv) New method
SE0104227D0 (sv) New method

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application