NO20025201L - 19-nor-17 <alfa> -pregna-1,3,5 (10) -triene-17 <beta> -ols with a 21.16 <alfa> -lactone ring - Google Patents

19-nor-17 <alfa> -pregna-1,3,5 (10) -triene-17 <beta> -ols with a 21.16 <alfa> -lactone ring

Info

Publication number
NO20025201L
NO20025201L NO20025201A NO20025201A NO20025201L NO 20025201 L NO20025201 L NO 20025201L NO 20025201 A NO20025201 A NO 20025201A NO 20025201 A NO20025201 A NO 20025201A NO 20025201 L NO20025201 L NO 20025201L
Authority
NO
Norway
Prior art keywords
pregna
ols
alfa
lactone ring
trien
Prior art date
Application number
NO20025201A
Other languages
Norwegian (no)
Other versions
NO20025201D0 (en
Inventor
Gerd Mueller
Uwe Kollenkirchen
Dirk Kosemund
Karl-Heinrich Fritzemeier
Original Assignee
Jenapharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm Gmbh filed Critical Jenapharm Gmbh
Publication of NO20025201D0 publication Critical patent/NO20025201D0/en
Publication of NO20025201L publication Critical patent/NO20025201L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Abstract

Oppfinnelsen vedrører nye 19-nor-17a-pregna-1,3,5(10)-trien-17p-oler med en 21,16a-laktonring med formel (II). en fremgangsmåte for fremstilling derav og farmasøytiske preparater som inneholder forbindelsene, i tillegg til 17a-cyanmetylerte østra-1,3,5(10)- triener som utgjør mellomprodukter ved fremstillingen av 19-nor- 17oc-pregna- 1,3,5(10)-trien-17(3-oler. 19-nor-17a- pregna-l,3,5(10)-trien-17p-olene utgjør nye selektive østrogener som i motsetning til klassiske østrogener, slik som østradiol, utviser preferanse for østrogen-alfa-reseptoren, én av de to kjente østrogenreseptorene.The invention relates to new 19-nor-17a-pregna-1,3,5(10)-trien-17p-ols with a 21,16a-lactone ring of formula (II). a method for the production thereof and pharmaceutical preparations containing the compounds, in addition to 17a-cyanomethylated estra-1,3,5(10)-trienes which constitute intermediate products in the production of 19-nor-17oc-pregna-1,3,5( 10)-trien-17(3-ols. 19-nor-17a-pregna-1,3,5(10)-trien-17p-ols constitute new selective estrogens which, in contrast to classical estrogens, such as estradiol, show preference for the estrogen-alpha receptor, one of the two known estrogen receptors.

NO20025201A 2000-09-27 2002-10-30 19-nor-17 <alfa> -pregna-1,3,5 (10) -triene-17 <beta> -ols with a 21.16 <alfa> -lactone ring NO20025201L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10048634A DE10048634A1 (en) 2000-09-27 2000-09-27 19-Nor-17alpha-pregna-1,3,5 (10) -trien-17beta-ole with a 21, 16alpha lactone ring
PCT/EP2001/011061 WO2002026763A1 (en) 2000-09-27 2001-09-25 19-NOR-17α-PREGNA-1,3,5 (10)-TRIEN-17β-OLS OF A 21,16α-LACTONE RING

Publications (2)

Publication Number Publication Date
NO20025201D0 NO20025201D0 (en) 2002-10-30
NO20025201L true NO20025201L (en) 2002-10-30

Family

ID=7658321

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20025201A NO20025201L (en) 2000-09-27 2002-10-30 19-nor-17 <alfa> -pregna-1,3,5 (10) -triene-17 <beta> -ols with a 21.16 <alfa> -lactone ring

Country Status (7)

Country Link
EP (1) EP1322662A1 (en)
AU (1) AU2001293843A1 (en)
DE (1) DE10048634A1 (en)
HU (1) HUP0300504A3 (en)
IL (1) IL151782A0 (en)
NO (1) NO20025201L (en)
WO (1) WO2002026763A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10214180A1 (en) * 2002-03-27 2003-10-16 Schering Ag 11beta-lankgettig-substituted 19-nor-17alpha-pregna-1,3,5 (10) -triene-17beta-ols with a 21,16alpha lactone ring

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920634A (en) * 1974-08-30 1975-11-18 Lilly Co Eli 2,3-Dihydroestra-1,3,5(10)-trieno (16{60 ,17{60 -{62 ) furan-17{62 ols
DE19906159A1 (en) * 1999-02-09 2000-08-10 Schering Ag 16-hydroxyestratrienes as selectively active estrogens
DE19917930A1 (en) * 1999-04-15 2000-10-19 Schering Ag Treating estrogen deficiency associated disorders, e.g. menopausal problems, osteoporosis, neoplasia or neurodegenerative disease, using new or known ent-steroids having bone-selective estrogenic activity
DE19954105A1 (en) * 1999-11-02 2001-05-17 Schering Ag Treatment of estrogen deficiency-associated conditions, e.g. menopausal syndrome, osteoporosis, infertility or prostatic hypertrophy, using new or known gonatrienes having tissue-selective estrogenic activity

Also Published As

Publication number Publication date
NO20025201D0 (en) 2002-10-30
DE10048634A1 (en) 2002-04-18
AU2001293843A1 (en) 2002-04-08
IL151782A0 (en) 2003-04-10
EP1322662A1 (en) 2003-07-02
HUP0300504A2 (en) 2003-06-28
WO2002026763A1 (en) 2002-04-04
HUP0300504A3 (en) 2003-12-29

Similar Documents

Publication Publication Date Title
DK1090029T3 (en) 14,15-Cyclopropane steroids from the 19-norandrostan series, process for their preparation, and pharmaceutical preparations containing these compounds
NO20032805D0 (en) Preparations of estrogen cyclodextrin complexes
HK1031869A1 (en) 1-Ä(1-Substituted-4-piperidinyl)methylÜ-4-piperdine derivatives, process for producing the same, medicinal compositions containing the same and intermediates of these compounds.
AP1830A (en) Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same.
MXPA03004549A (en) 3-arylindole derivatives and their use as cb2 receptor agonists.
DK0712311T3 (en) Antiglucocorticoid steroids for the treatment of anxiety disorders
DK1487859T3 (en) Preparation Methods for Making Eplerenone
MY125975A (en) Crystalline form vii of cabergoline
NO20025201L (en) 19-nor-17 &lt;alfa&gt; -pregna-1,3,5 (10) -triene-17 &lt;beta&gt; -ols with a 21.16 &lt;alfa&gt; -lactone ring
DK1322660T3 (en) 17α-fluoroalkyl steroids, processes for their preparation and pharmaceutical compositions containing these compounds
NO20020260L (en) 11 &lt;beta&gt; -aryl-17,17-spirothiolane-substituted steroids
DK0946585T3 (en) Steroid compounds substituted at position 11, process for their preparation, their use as drugs and pharmaceutical compositions containing them
DK1150968T3 (en) Process for the preparation of phytosterines
DK1090028T3 (en) Unsaturated 14,15-cyclopropano-androstanes, processes for their preparation and pharmaceutical compositions containing these compounds
AU2002339199A8 (en) Solvates of 3.beta., 28-diacetoxy-18-oxo-19, 20, 21, 29, 30-pentanorlupan-22-oic acid, processes for their preparation and pharmaceutical compositions thereof
BR0203869A (en) 19-nor-17alfa-pregna-1,3,5 (10) -trien-17betaols with one ring 21,16 alpha-lactone
IL150082A0 (en) Unsaturated 14, 15-cyclopropane-andostranes, a method for their production and pharmaceutical compositions containing these compounds
HRP990129B1 (en) New compounds of 3-deoxy-desmycosin class and process for the preparation thereof
NO20022713D0 (en) 14,15-cyclopropane steroids from the 19-norandrostancer series, process for the preparation of the compounds, and pharmaceutical preparations containing the compounds
DK1157028T3 (en) New 11.beta-substituted steroid derivatives, processes for their preparation and intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions containing them
MX9709667A (en) Process to obtain 3-(1-hydroxyphenyl-1-alcoxyiminmethyl) dioxazines.
AU2002302817A1 (en) Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives

Legal Events

Date Code Title Description
RE Reestablishment of rights (par. 72 patents act)
FC2A Withdrawal, rejection or dismissal of laid open patent application