NO20012543L - Substituted benzo [de] isoquinoline-1,3-dione - Google Patents

Substituted benzo [de] isoquinoline-1,3-dione

Info

Publication number
NO20012543L
NO20012543L NO20012543A NO20012543A NO20012543L NO 20012543 L NO20012543 L NO 20012543L NO 20012543 A NO20012543 A NO 20012543A NO 20012543 A NO20012543 A NO 20012543A NO 20012543 L NO20012543 L NO 20012543L
Authority
NO
Norway
Prior art keywords
isoquinoline
dione
substituted benzo
benzo
substituted
Prior art date
Application number
NO20012543A
Other languages
Norwegian (no)
Other versions
NO20012543D0 (en
Inventor
Werner Mederski
Ralf Devant
Gerhard Barnickel
Sabine Bernotat-Danielowski
Guido Melzer
Peter Raddatz
Zhengdong Wu
Daljit Dhanoa
Richard M Soll
James Rinker
Todd L Graybill
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20012543D0 publication Critical patent/NO20012543D0/en
Publication of NO20012543L publication Critical patent/NO20012543L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nye forbindelser med fe hvor R, r\ r- og i har betydnin i patentkrav 1, og deres saltei solvater, som glykoprotein Ihll gonister.New compounds with cattle wherein R, R and R have the meaning of Claim 1 and their salts in solvates, such as glycoprotein II gonists.

NO20012543A 1998-11-25 2001-05-23 Substituted benzo [de] isoquinoline-1,3-dione NO20012543L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19940998A 1998-11-25 1998-11-25
US40099299A 1999-09-21 1999-09-21
PCT/EP1999/008560 WO2000031039A1 (en) 1998-11-25 1999-11-09 Substituted benzo[de]isoquinoline-1,3-diones

Publications (2)

Publication Number Publication Date
NO20012543D0 NO20012543D0 (en) 2001-05-23
NO20012543L true NO20012543L (en) 2001-05-23

Family

ID=26894739

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20012543A NO20012543L (en) 1998-11-25 2001-05-23 Substituted benzo [de] isoquinoline-1,3-dione

Country Status (15)

Country Link
EP (1) EP1133475A1 (en)
JP (1) JP2002530379A (en)
CN (1) CN1328549A (en)
AR (1) AR029152A1 (en)
AU (1) AU1504900A (en)
BR (1) BR9915611A (en)
CA (1) CA2351348A1 (en)
CZ (1) CZ20011792A3 (en)
HU (1) HUP0104469A3 (en)
ID (1) ID29425A (en)
MX (1) MXPA01005228A (en)
NO (1) NO20012543L (en)
PL (1) PL347766A1 (en)
SK (1) SK7012001A3 (en)
WO (1) WO2000031039A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0104236D0 (en) 2001-02-21 2001-04-11 Clariant Int Ltd New dye compounds
GB0104240D0 (en) 2001-02-21 2001-04-11 Clariant Int Ltd Copolymer composition having pigment like properties
GB0419850D0 (en) * 2004-09-07 2004-10-13 Angeletti P Ist Richerche Bio Therapeutic agents
US8097725B2 (en) 2004-12-03 2012-01-17 Roche Diagnostics Operations, Inc. Luminescent indicator dye and optical sensor
WO2012115945A1 (en) * 2011-02-21 2012-08-30 The Board Of Regents Of The University Of Texas System Viral inhibitors
CN103848787A (en) * 2012-12-06 2014-06-11 中国科学院大连化学物理研究所 Fluorescence probe and application thereof in reversible detection of hypochlorous acid
WO2014149198A1 (en) * 2013-03-15 2014-09-25 Alumend, Llc Compositions and methods of using the compositions for plaque softening
CN107417616A (en) * 2013-05-01 2017-12-01 中央研究院 Treat the method and composition of beta Thalassemia and drepanocytosis
JP7301259B2 (en) * 2017-05-19 2023-07-03 株式会社同仁化学研究所 Fluorescent compound and autophagy detection reagent using the same
CN111253368B (en) * 2018-11-30 2020-12-25 沈阳药科大学 Stable nitroxide radical modified naphthalimide compound and application thereof
CN111777557B (en) * 2020-07-28 2022-11-22 中国科学院上海有机化学研究所 Novel anti-tumor lead compound with aromatic biphenyl alkene as framework and application thereof
CN113087702B (en) * 2021-03-29 2022-07-12 苏州大学 Multifunctional perchloroethylene derivative and preparation method and application thereof
WO2023166531A1 (en) * 2022-03-04 2023-09-07 Jawaharlal Nehru Centre For Advanced Scientific Research Amyloid and associated pathology modulators and methods thereof
WO2024042539A1 (en) * 2022-08-22 2024-02-29 Jawaharlal Nehru Centre For Advanced Scientific Research Modulators of tau liquid-liquid phase separation and methods thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
DE2360705A1 (en) * 1973-12-06 1975-06-26 Hoechst Ag HYDRO-INSOLUBLE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS COLORS
US4200752A (en) * 1978-02-16 1980-04-29 Bertelson Robert C 4-Disubstituted amino, N-substituted naphthalimide dyestuffs
JPS54160977A (en) * 1978-06-09 1979-12-20 Kawasaki Steel Corp Functioning speed changing method by means of operating lever
GB2183667B (en) * 1985-10-29 1989-11-22 Univ Brunel Preparation of amino-1;8-naphthalimides.
DE3614414A1 (en) * 1986-04-29 1987-11-05 Knoll Ag NEW BENZO (DE) ISOCHINOLIN-1,3-DIONE, THEIR PRODUCTION AND USE
US5308773A (en) * 1992-11-16 1994-05-03 Microbiomed Corp. Non-azo 1,8-naphthalimide dyes for the detection and quantitation of a paramagnetic metal cation in a non-aqueous medium
DE19505941A1 (en) * 1995-02-21 1996-08-22 Bayer Ag 1,8-naphthalimide derivatives, process for their preparation and their use as intermediates
NZ335291A (en) * 1996-10-21 2001-02-23 Allelix Biopharma Neurotrophin antagonist compositions

Also Published As

Publication number Publication date
NO20012543D0 (en) 2001-05-23
MXPA01005228A (en) 2002-06-21
JP2002530379A (en) 2002-09-17
EP1133475A1 (en) 2001-09-19
AU1504900A (en) 2000-06-13
CN1328549A (en) 2001-12-26
HUP0104469A2 (en) 2002-04-29
HUP0104469A3 (en) 2003-06-30
ID29425A (en) 2001-08-30
CZ20011792A3 (en) 2001-09-12
AR029152A1 (en) 2003-06-18
PL347766A1 (en) 2002-04-22
SK7012001A3 (en) 2001-11-06
WO2000031039A1 (en) 2000-06-02
CA2351348A1 (en) 2000-06-02
BR9915611A (en) 2001-08-14

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application