NO166582C - DEVICE FOR PARALLEL IMPLEMENTATION OF MULTIPLE REACTION SEQUENCES. - Google Patents

DEVICE FOR PARALLEL IMPLEMENTATION OF MULTIPLE REACTION SEQUENCES.

Info

Publication number
NO166582C
NO166582C NO854138A NO854138A NO166582C NO 166582 C NO166582 C NO 166582C NO 854138 A NO854138 A NO 854138A NO 854138 A NO854138 A NO 854138A NO 166582 C NO166582 C NO 166582C
Authority
NO
Norway
Prior art keywords
discs
bores
reaction
another
reaction chamber
Prior art date
Application number
NO854138A
Other languages
Norwegian (no)
Other versions
NO854138L (en
NO166582B (en
Inventor
Wilhelm Bannwarth
Patrick Iaiza
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4286104&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO166582(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO854138L publication Critical patent/NO854138L/en
Publication of NO166582B publication Critical patent/NO166582B/en
Publication of NO166582C publication Critical patent/NO166582C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00324—Reactor vessels in a multiple arrangement the reactor vessels or wells being arranged in plates moving in parallel to each other
    • B01J2219/00326—Movement by rotation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B01J2219/00488—Means for mixing reactants or products in the reaction vessels by rotation of the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Electrotherapy Devices (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Detergent Compositions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Dram (AREA)
  • Steering Control In Accordance With Driving Conditions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Abstract

1. Claims for the Contracting States : BE, GB, NL, AT An apparatus for perfoming chemical reaction sequences, characterized by a first number n of reaction discs (1) which are superposed in the form of a stack and are individually displaceable relative to one another, means for defining the displacement in a second number m of identical steps, m continuous bores (11, 14) disposed in the discs at the step distances from one another, one of the bores being widened out per disc to form a reaction chamber (14), means for retaining a support material in the reaction chamber on the flow of a reagent there-through. 1. Claims for the Contracting States : DE, FR, IT, CH, LI, SE An apparatus for performing chemical reaction sequences having a first number n of reaction discs (1) which are superposed in the form of a stack and are individually displaceable relative to one another, means for defining the displacement in a second number m of identical steps, m continuous bores (11, 14) disposed in the discs at the step distances from one another, one of the bores being widened out per disc to form a reaction chamber (14), means for retaining a support material in the reaction chamber on the flow of a reagent therethrough, characterized in that the undersides of the reaction discs have grooves extending concentrically to the bores and containing O-rings.
NO854138A 1984-10-18 1985-10-17 DEVICE FOR PARALLEL IMPLEMENTATION OF MULTIPLE REACTION SEQUENCES. NO166582C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH499484 1984-10-18

Publications (3)

Publication Number Publication Date
NO854138L NO854138L (en) 1986-04-21
NO166582B NO166582B (en) 1991-05-06
NO166582C true NO166582C (en) 1991-08-14

Family

ID=4286104

Family Applications (1)

Application Number Title Priority Date Filing Date
NO854138A NO166582C (en) 1984-10-18 1985-10-17 DEVICE FOR PARALLEL IMPLEMENTATION OF MULTIPLE REACTION SEQUENCES.

Country Status (11)

Country Link
EP (1) EP0181491B1 (en)
JP (2) JPS61118141A (en)
AT (1) ATE44244T1 (en)
AU (1) AU558709B2 (en)
CA (1) CA1304916C (en)
DE (1) DE3571207D1 (en)
DK (1) DK466285A (en)
ES (1) ES8705352A1 (en)
FI (1) FI81505C (en)
IL (1) IL76662A0 (en)
NO (1) NO166582C (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8502612A1 (en) * 1983-06-15 1985-02-01 Schering Ag 13-Alpha-alkyl gonanes, their preparation and pharmaceutical compositions containing them.
EP0164206B1 (en) * 1984-05-02 1988-11-02 Brendan James Hamill An apparatus for the chemical synthesis of oligonucleotides
DE3631662A1 (en) * 1986-09-17 1988-03-24 Biotechnolog Forschung Gmbh METHOD FOR SIMULTANEOUS SYNTHESIS OF SEVERAL PEPTIDES ON A SOLID PHASE
DE3813671A1 (en) * 1988-04-22 1989-11-02 Europ Lab Molekularbiolog DEVICE FOR CARRYING OUT CHEMICAL REACTIONS
GB8823182D0 (en) * 1988-10-03 1988-11-09 Ici Plc Reactor elements reactors containing them & processes performed therein
DE4206488C2 (en) * 1992-03-02 1993-12-23 Deutsches Krebsforsch Device for carrying out chemical reactions taking place simultaneously or sequentially
CH684554A5 (en) * 1992-09-22 1994-10-14 Sotax Ag Sample collector.
JPH08505604A (en) * 1992-11-06 1996-06-18 カイロン ミモトープス プロプライエトリー リミテッド Support for synthesizing modular polymers
US6469157B1 (en) 1993-12-16 2002-10-22 Proligo Llc Process for preparing polynucleotides on a solid support
FR2714061B1 (en) * 1993-12-16 1996-03-08 Genset Sa Process for the preparation of polynucleotides on solid support and apparatus allowing its implementation.
AU2990595A (en) * 1994-07-26 1996-02-22 Sydney Brenner Multidimensional conduit combinatorial library synthesis device
US6083682A (en) 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
DE59906395D1 (en) 1998-12-30 2003-08-28 Mwg Biotech Ag DEVICE FOR CARRYING OUT CHEMICAL REACTIONS
DE10042871A1 (en) * 2000-08-31 2002-05-16 Hte Ag The High Throughput Exp Three-dimensional material library and method for producing a three-dimensional material library
WO2006018043A2 (en) * 2004-08-18 2006-02-23 Agilent Technologies, Inc. Valve slider for a microfluidic coupling device

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876881A (en) * 1973-10-24 1975-04-08 Hoffmann La Roche Protein monitor
US4483964A (en) * 1983-06-20 1984-11-20 Chiron Corporation Reactor system and method for polynucleotide synthesis
EP0164206B1 (en) * 1984-05-02 1988-11-02 Brendan James Hamill An apparatus for the chemical synthesis of oligonucleotides

Also Published As

Publication number Publication date
CA1304916C (en) 1992-07-14
NO854138L (en) 1986-04-21
ES547950A0 (en) 1987-05-01
FI81505B (en) 1990-07-31
ATE44244T1 (en) 1989-07-15
DE3571207D1 (en) 1989-08-03
EP0181491A1 (en) 1986-05-21
AU4856185A (en) 1986-04-24
FI854050A0 (en) 1985-10-17
DK466285A (en) 1986-04-19
JPS6344948A (en) 1988-02-25
EP0181491B1 (en) 1989-06-28
AU558709B2 (en) 1987-02-05
IL76662A0 (en) 1986-02-28
FI854050L (en) 1986-04-19
JPS61118141A (en) 1986-06-05
NO166582B (en) 1991-05-06
DK466285D0 (en) 1985-10-11
ES8705352A1 (en) 1987-05-01
FI81505C (en) 1990-11-12

Similar Documents

Publication Publication Date Title
NO166582C (en) DEVICE FOR PARALLEL IMPLEMENTATION OF MULTIPLE REACTION SEQUENCES.
DK93888A (en) PROCEDURE FOR PROVIDING CHEMICAL REACTIONS
CA2174140A1 (en) Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
BR9007425A (en) PROCESSES TO PREPARE SEQUENCES, TO SYNTHESIZE AND TO SELECT SEVERAL SEQUENCES, AND TO IDENTIFY AT LEAST ONE SEQUENCE AND APPLIANCES TO PREPARE SEVERAL POLYMERS AND A SUBSTRATE, TO SELECT POLYMERS, TO SELECT A BIOCHEMICAL ACTIVITY, TO SELECT A DIVERSE ACTIVITY MARKED REGIONS AND SUBSTRATE FOR SELECTION OF BIOLOGICAL ACTIVITY
WO1996017969A3 (en) Method and equipment for growing thin films
CA2013473A1 (en) Spacer element for handling fluids
FI971473A0 (en) Marking system for molecules
DK0472565T4 (en) Hiking Rent Reactor Facility
AU635143B2 (en) Analysis element and process for its manufacture
FR2381731A1 (en) PROCESS FOR INHIBITING THE POLYMERIZATION OF EASILY POLYMERIZABLE VINYLAROMATIC COMPOUNDS
ES8801854A1 (en) Colouration process.
ATE243072T1 (en) METHOD FOR CARRYING OUT MATERIAL CONVERSIONS USING CATALYSTS SUSPENDED IN LIQUIDS
DE3469275D1 (en) Process and reactor for carrying out an endothermic reaction
ATE39494T1 (en) DEWAXING CATALYSTS AND PROCESSES USING SILICOALUMINOPHOSPHATE MOLECULAR SIEVES.
BR9003843A (en) PROCESS FOR THE PREPARATION OF POLYMERS
EP0669388A3 (en)
DK0443923T3 (en) Novel aminophosphine phosphinites, processes for their preparation and their use in enantio-selective reactions
SU874304A1 (en) Device for fixing of parts
IT1196451B (en) COATED POLYOLEFINIC FILMS AND PROCEDURE FOR THEIR PREPARATION
IT8025190A0 (en) EXHALER WITH POLYMER SUBSTRATE, WITH HIGH CONCENTRATION OF VOLATILE SUBSTANCES, WITH CONTROLLED RELEASE, AND PROCEDURE FOR MANUFACTURING IT.
SU952314A1 (en) Apparatus for carrying-out chemical processes
DK566281A (en) PROCEDURE FOR CATALYTIC DEOXYGENATION OF PROTECTIVE COATING PREPARATIONS