AU558709B2 - Multi chamber reactor - Google Patents

Multi chamber reactor

Info

Publication number
AU558709B2
AU558709B2 AU48561/85A AU4856185A AU558709B2 AU 558709 B2 AU558709 B2 AU 558709B2 AU 48561/85 A AU48561/85 A AU 48561/85A AU 4856185 A AU4856185 A AU 4856185A AU 558709 B2 AU558709 B2 AU 558709B2
Authority
AU
Australia
Prior art keywords
discs
bores
reaction
another
reaction chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU48561/85A
Other versions
AU4856185A (en
Inventor
Wilhelm Bannwarth
Patrick Iaiza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4286104&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU558709(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU4856185A publication Critical patent/AU4856185A/en
Application granted granted Critical
Publication of AU558709B2 publication Critical patent/AU558709B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00324—Reactor vessels in a multiple arrangement the reactor vessels or wells being arranged in plates moving in parallel to each other
    • B01J2219/00326—Movement by rotation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B01J2219/00488—Means for mixing reactants or products in the reaction vessels by rotation of the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Electrotherapy Devices (AREA)
  • Steering Control In Accordance With Driving Conditions (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Dram (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

1. Claims for the Contracting States : BE, GB, NL, AT An apparatus for perfoming chemical reaction sequences, characterized by a first number n of reaction discs (1) which are superposed in the form of a stack and are individually displaceable relative to one another, means for defining the displacement in a second number m of identical steps, m continuous bores (11, 14) disposed in the discs at the step distances from one another, one of the bores being widened out per disc to form a reaction chamber (14), means for retaining a support material in the reaction chamber on the flow of a reagent there-through. 1. Claims for the Contracting States : DE, FR, IT, CH, LI, SE An apparatus for performing chemical reaction sequences having a first number n of reaction discs (1) which are superposed in the form of a stack and are individually displaceable relative to one another, means for defining the displacement in a second number m of identical steps, m continuous bores (11, 14) disposed in the discs at the step distances from one another, one of the bores being widened out per disc to form a reaction chamber (14), means for retaining a support material in the reaction chamber on the flow of a reagent therethrough, characterized in that the undersides of the reaction discs have grooves extending concentrically to the bores and containing O-rings.
AU48561/85A 1984-10-18 1985-10-14 Multi chamber reactor Ceased AU558709B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH499484 1984-10-18
CH4994/84 1984-10-18

Publications (2)

Publication Number Publication Date
AU4856185A AU4856185A (en) 1986-04-24
AU558709B2 true AU558709B2 (en) 1987-02-05

Family

ID=4286104

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48561/85A Ceased AU558709B2 (en) 1984-10-18 1985-10-14 Multi chamber reactor

Country Status (11)

Country Link
EP (1) EP0181491B1 (en)
JP (2) JPS61118141A (en)
AT (1) ATE44244T1 (en)
AU (1) AU558709B2 (en)
CA (1) CA1304916C (en)
DE (1) DE3571207D1 (en)
DK (1) DK466285A (en)
ES (1) ES8705352A1 (en)
FI (1) FI81505C (en)
IL (1) IL76662A0 (en)
NO (1) NO166582C (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES533260A0 (en) * 1983-06-15 1985-02-01 Schering Ag PROCEDURE FOR THE PREPARATION OF 13A-ALQUILGONANOS
EP0164206B1 (en) * 1984-05-02 1988-11-02 Brendan James Hamill An apparatus for the chemical synthesis of oligonucleotides
DE3631662A1 (en) * 1986-09-17 1988-03-24 Biotechnolog Forschung Gmbh METHOD FOR SIMULTANEOUS SYNTHESIS OF SEVERAL PEPTIDES ON A SOLID PHASE
DE3813671A1 (en) * 1988-04-22 1989-11-02 Europ Lab Molekularbiolog DEVICE FOR CARRYING OUT CHEMICAL REACTIONS
GB8823182D0 (en) * 1988-10-03 1988-11-09 Ici Plc Reactor elements reactors containing them & processes performed therein
DE4206488C2 (en) * 1992-03-02 1993-12-23 Deutsches Krebsforsch Device for carrying out chemical reactions taking place simultaneously or sequentially
CH684554A5 (en) * 1992-09-22 1994-10-14 Sotax Ag Sample collector.
HUT73150A (en) * 1992-11-06 1996-06-28 Chiron Mimotopes Pty Ltd Modular polymer and support for the synthesis thereof
FR2714061B1 (en) * 1993-12-16 1996-03-08 Genset Sa Process for the preparation of polynucleotides on solid support and apparatus allowing its implementation.
US6469157B1 (en) 1993-12-16 2002-10-22 Proligo Llc Process for preparing polynucleotides on a solid support
WO1996003212A1 (en) * 1994-07-26 1996-02-08 Sydney Brenner Multidimensional conduit combinatorial library synthesis device
US6083682A (en) 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
NZ512726A (en) 1998-12-30 2003-03-28 Mwg Biotech Ag Device for carrying out chemical reactions
DE10042871A1 (en) * 2000-08-31 2002-05-16 Hte Ag The High Throughput Exp Three-dimensional material library and method for producing a three-dimensional material library
DE112004002936B4 (en) * 2004-08-18 2008-12-11 Agilent Technologies, Inc. (n.d.Ges.d. Staates Delaware), Santa Clara Microfluidic arrangement with a valve slide for a microfluidic coupling device

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876881A (en) * 1973-10-24 1975-04-08 Hoffmann La Roche Protein monitor
US4483964A (en) * 1983-06-20 1984-11-20 Chiron Corporation Reactor system and method for polynucleotide synthesis
EP0164206B1 (en) * 1984-05-02 1988-11-02 Brendan James Hamill An apparatus for the chemical synthesis of oligonucleotides

Also Published As

Publication number Publication date
NO166582C (en) 1991-08-14
CA1304916C (en) 1992-07-14
DE3571207D1 (en) 1989-08-03
NO854138L (en) 1986-04-21
FI854050L (en) 1986-04-19
JPS61118141A (en) 1986-06-05
NO166582B (en) 1991-05-06
DK466285D0 (en) 1985-10-11
AU4856185A (en) 1986-04-24
FI854050A0 (en) 1985-10-17
IL76662A0 (en) 1986-02-28
DK466285A (en) 1986-04-19
EP0181491B1 (en) 1989-06-28
ATE44244T1 (en) 1989-07-15
ES547950A0 (en) 1987-05-01
EP0181491A1 (en) 1986-05-21
FI81505B (en) 1990-07-31
FI81505C (en) 1990-11-12
ES8705352A1 (en) 1987-05-01
JPS6344948A (en) 1988-02-25

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