NO161974B - PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITIES 1,8-Naphthyridine and 1,5,8-AZA-Naphthyridine Derivatives. - Google Patents
PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITIES 1,8-Naphthyridine and 1,5,8-AZA-Naphthyridine Derivatives. Download PDFInfo
- Publication number
- NO161974B NO161974B NO832534A NO832534A NO161974B NO 161974 B NO161974 B NO 161974B NO 832534 A NO832534 A NO 832534A NO 832534 A NO832534 A NO 832534A NO 161974 B NO161974 B NO 161974B
- Authority
- NO
- Norway
- Prior art keywords
- naphthyridine
- oxide
- electromagnesium
- aza
- procedure
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 8
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical compound N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000007789 gas Substances 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- 238000007669 thermal treatment Methods 0.000 claims description 8
- 230000001603 reducing effect Effects 0.000 claims description 7
- 230000007935 neutral effect Effects 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 4
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000011282 treatment Methods 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 229910021529 ammonia Inorganic materials 0.000 claims description 2
- 229910052786 argon Inorganic materials 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 239000001569 carbon dioxide Substances 0.000 claims description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 4
- 230000001590 oxidative effect Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- -1 argon Chemical class 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000010891 electric arc Methods 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- 150000002835 noble gases Chemical class 0.000 description 1
- 239000000615 nonconductor Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Fremgangsmåte til fremstilling av elektromagnesiumoksyd med forbedret elektrisk isoleringsevne. Process for the production of electromagnesium oxide with improved electrical insulating properties.
Magnesiumoksyd som er smeltet i den Magnesium oxide that is melted in it
elektriske lysbue, og som i det følgende kalles elektromagnesiumoksyd, kan etter smeltens stivning males og etter oppar-beidelse til kornblandinger med fastlagt kornstørrelsefordeling f. eks. anvendes til fremstilling av elektriske varmeplater eller rørvarmelegemer. I denne form tjener de til fylling av mellomrommene mellom var-mekveilens viklinger og rommet mellom varmekveilen og det ytre for det meste jordede metallrør. electric arc, and which is called electromagnesium oxide in the following, can be ground after solidification of the melt and after processing into grain mixtures with a defined grain size distribution, e.g. used for the production of electric heating plates or tube heaters. In this form, they serve to fill the spaces between the windings of the heating coil and the space between the heating coil and the outer, mostly earthed metal pipe.
Til et slikt elektromagnesiumoksyd må det fremfor alt stilles det krav at det også er en god elektrisk isolator ved høye temperaturer. Above all, such an electromagnesium oxide must be required to be a good electrical insulator at high temperatures.
Det er kjent å underkaste elektromagnesiumoksyd for å forbedre dets isoleringsevne en termisk behandling i en oksy-der ende atmosfære. It is known to subject electromagnesium oxide to a thermal treatment in an oxidizing atmosphere in order to improve its insulating properties.
Det er nu overraskende funnet at man ytterligere kan forbedre elektromagne-siumoksydets isoleringsevne når man un-derkaster det en termisk behandling i en strøm av reduserende eller nøytrale gasser eller i vakuum. It has now surprisingly been found that the insulating ability of the electromagnesium oxide can be further improved when it is subjected to a thermal treatment in a stream of reducing or neutral gases or in a vacuum.
Som reduserende gasser skal det her As reducing gases it should here
forståes slike som består av gasser eller gassblandinger med reduserende egenskaper, som f. eks. hydrogen, hydrogen og nitrogen, ammoniakk, svovelhydrogen og nitrogen o. 1., med unntak av hydrokarbonfor-bindelser eller deres gassblandinger som ved reaksjonstemperaturene utskiller kull- are understood to consist of gases or gas mixtures with reducing properties, such as e.g. hydrogen, hydrogen and nitrogen, ammonia, hydrogen sulphide and nitrogen etc. 1., with the exception of hydrocarbon compounds or their gas mixtures which at the reaction temperatures release carbon
stoff, som f. eks. karbonmonooksyd, hyd-rokarboner, som f. eks. metan o. 1. eller f. eks. lysgass. material, such as carbon monoxide, hydrocarbons, such as methane etc. 1. or e.g. light gas.
Som nøytrale gasser skal det forståes slike gasser eller gassblandinger som ved fremgangsmåtetemperaturer hverken har oksyderende eller reduserende egenskaper, som f. eks. oksygenfritt nitrogen, oksygen-frie edelgasser, som f. eks. argon, eller karbondioksyd. Neutral gases are to be understood as such gases or gas mixtures which, at process temperatures, have neither oxidizing nor reducing properties, such as e.g. oxygen-free nitrogen, oxygen-free noble gases, such as argon, or carbon dioxide.
Den termiske behandling gjennomfører man ved en temperatur fra omtrent 900° til 1500°C, fortrinnsvis ved temperaturer på 1000 til 1200oC, i løpet av 1 til 8, fortrinnsvis 2 til 6 timer. Behandlingen kan foregå f. eks. i rør- eller muffelovner som har innretninger til opprettholdelse av den ønskede gassatmosfære. The thermal treatment is carried out at a temperature of approximately 900° to 1500°C, preferably at temperatures of 1000 to 1200°C, during 1 to 8, preferably 2 to 6 hours. The treatment can take place e.g. in tube or muffle furnaces that have devices for maintaining the desired gas atmosphere.
Med fremgangsmåten ifølge oppfin-nelsen kan det fremstilles et elektromagnesiumoksyd med vesentlig bedre isoleringsevne enn det som er oppnåelig ved de kjente oksyderende termiske behandlinger, slik det fremgår av de følgende eksempler. With the method according to the invention, an electromagnesium oxide can be produced with significantly better insulating properties than that which is obtainable by the known oxidizing thermal treatments, as is evident from the following examples.
Undersøkelser på elektrisk isoleringsevne i de følgende eksempler foregikk ved forarbeiding av elektromagnesiumoksydet i et rett rørvarmelegeme av 8,2 mm ytre diameter, 50 cm lengde og 3 mm kveildia-meter. Dette drives med en ytelse på nøy-aktig 6 Watt pr. cm<2> varmeflate. Ved an-legg av en vekselspenning på 500 Volt og 50 Hz mellom kveil og ytre rør strømmer en strøm gjennom elektromagnesiumoksydet, hvis størrelse, den såkalte avlednings-strøm, er måltall for den elektriske isoleringsevne. Investigations on electrical insulating ability in the following examples took place by processing the electromagnesium oxide in a straight tube heater of 8.2 mm outer diameter, 50 cm length and 3 mm coil diameter. This is operated with a performance of exactly 6 Watts per cm<2> heating surface. When an alternating voltage of 500 Volts and 50 Hz is applied between the coil and the outer tube, a current flows through the electromagnesium oxide, the size of which, the so-called diversion current, is a measure of the electrical insulating ability.
Eksempel 1. Example 1.
(Sammenligningseksempel.) (Comparison example.)
200 g av et elektromagnesiumoksyd hvis avledningsstrøm før den termiske behandling utgjorde 2,70 mA ble underkastet en 4 timers glødebehandling ved 1000°C i en strøm av følgende oksyderende gasser: 200 g of an electromagnesium oxide whose discharge current before the thermal treatment was 2.70 mA was subjected to a 4-hour annealing treatment at 1000°C in a stream of the following oxidizing gases:
Eksempel 2. Example 2.
200 g av det i eksempel 1 anvendte elektromagnesiumoksyd ble behandlet i en strøm av en reduserende eller nøytral gass under ellers identiske betingelser: 200 g of the electromagnesium oxide used in example 1 was treated in a stream of a reducing or neutral gas under otherwise identical conditions:
Avledningsstrømmen etter den termiske behandling i vakuum (ca. 0,5 Torr) utgjorde 0,46 mA. The discharge current after the thermal treatment in vacuum (approx. 0.5 Torr) amounted to 0.46 mA.
Eksempel 3. Example 3.
(Sammenligningseksempel.) (Comparison example.)
Under identiske betingelser som angitt i eksempel 1 ble 200 g av et elektromagnesiumoksyd, hvis avledningsstrøm i termisk ubehandlet tilstand utgjorde 0,64 mA, behandlet termisk. Under identical conditions as stated in Example 1, 200 g of an electromagnesium oxide, whose discharge current in the thermally untreated state was 0.64 mA, was thermally treated.
Eksempel 4. Example 4.
200 g av det i eksempel 3 anvendte elektromagnesiumoksyd ble behandlet termisk i en strøm av følgende reduserende eller nøytrale gasser under ellers like betingelser som angitt i eksempel 3. 200 g of the electromagnesium oxide used in example 3 was thermally treated in a stream of the following reducing or neutral gases under otherwise identical conditions as stated in example 3.
Claims (4)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43868182A | 1982-11-03 | 1982-11-03 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO832534L NO832534L (en) | 1984-05-04 |
| NO161974B true NO161974B (en) | 1989-07-10 |
| NO161974C NO161974C (en) | 1989-10-18 |
Family
ID=23741589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO832534A NO161974C (en) | 1982-11-03 | 1983-07-12 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC EFFECTIVE 1,8-Naphthyridine AND 1,5,8-AZA-Naphthyridine Derivatives. |
Country Status (6)
| Country | Link |
|---|---|
| KR (1) | KR890004662B1 (en) |
| FI (1) | FI78088C (en) |
| GR (1) | GR79325B (en) |
| HU (1) | HU189715B (en) |
| NO (1) | NO161974C (en) |
| OA (1) | OA07522A (en) |
-
1983
- 1983-07-12 NO NO832534A patent/NO161974C/en unknown
- 1983-07-13 HU HU832500A patent/HU189715B/en not_active IP Right Cessation
- 1983-07-14 GR GR71944A patent/GR79325B/el unknown
- 1983-07-28 KR KR1019830003511A patent/KR890004662B1/en not_active IP Right Cessation
- 1983-08-12 OA OA58089A patent/OA07522A/en unknown
- 1983-09-02 FI FI833137A patent/FI78088C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GR79325B (en) | 1984-10-22 |
| FI833137A (en) | 1984-05-04 |
| FI833137A0 (en) | 1983-09-02 |
| FI78088B (en) | 1989-02-28 |
| FI78088C (en) | 1989-06-12 |
| KR840006998A (en) | 1984-12-04 |
| KR890004662B1 (en) | 1989-11-24 |
| NO161974C (en) | 1989-10-18 |
| NO832534L (en) | 1984-05-04 |
| OA07522A (en) | 1985-03-31 |
| HU189715B (en) | 1986-07-28 |
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