US4895725A
(en)
*
|
1987-08-24 |
1990-01-23 |
Clinical Technologies Associates, Inc. |
Microencapsulation of fish oil
|
US5025004A
(en)
*
|
1988-06-13 |
1991-06-18 |
Eastman Kodak Company |
Water-dispersible polymeric compositions
|
US4960814A
(en)
*
|
1988-06-13 |
1990-10-02 |
Eastman Kodak Company |
Water-dispersible polymeric compositions
|
US5248516A
(en)
*
|
1989-12-19 |
1993-09-28 |
Fmc Corporation |
Film-forming composition: method of producing same and use for coating pharmaceuticals and foods and the like
|
US5043376A
(en)
*
|
1990-02-26 |
1991-08-27 |
Eastman Kodak Company |
Liquid-dispersible, polymeric colorant compositions and aqueous dispersions
|
US5104913A
(en)
*
|
1990-02-26 |
1992-04-14 |
Eastman Kodak Company |
Liquid-dispersible, polymeric colorant compositions and aqueous dispersions and process for the preparation thereof
|
US6331318B1
(en)
|
1994-09-30 |
2001-12-18 |
Emisphere Technologies Inc. |
Carbon-substituted diketopiperazine delivery systems
|
US6221367B1
(en)
|
1992-06-15 |
2001-04-24 |
Emisphere Technologies, Inc. |
Active agent transport systems
|
US6099856A
(en)
*
|
1992-06-15 |
2000-08-08 |
Emisphere Technologies, Inc. |
Active agent transport systems
|
US5447728A
(en)
*
|
1992-06-15 |
1995-09-05 |
Emisphere Technologies, Inc. |
Desferrioxamine oral delivery system
|
US5714167A
(en)
|
1992-06-15 |
1998-02-03 |
Emisphere Technologies, Inc. |
Active agent transport systems
|
US5443841A
(en)
*
|
1992-06-15 |
1995-08-22 |
Emisphere Technologies, Inc. |
Proteinoid microspheres and methods for preparation and use thereof
|
US5578323A
(en)
*
|
1992-06-15 |
1996-11-26 |
Emisphere Technologies, Inc. |
Proteinoid carriers and methods for preparation and use thereof
|
US5629020A
(en)
*
|
1994-04-22 |
1997-05-13 |
Emisphere Technologies, Inc. |
Modified amino acids for drug delivery
|
US5693338A
(en)
*
|
1994-09-29 |
1997-12-02 |
Emisphere Technologies, Inc. |
Diketopiperazine-based delivery systems
|
US5541155A
(en)
*
|
1994-04-22 |
1996-07-30 |
Emisphere Technologies, Inc. |
Acids and acid salts and their use in delivery systems
|
US5811127A
(en)
*
|
1992-06-15 |
1998-09-22 |
Emisphere Technologies, Inc. |
Desferrioxamine oral delivery system
|
US5792451A
(en)
*
|
1994-03-02 |
1998-08-11 |
Emisphere Technologies, Inc. |
Oral drug delivery compositions and methods
|
US5401516A
(en)
*
|
1992-12-21 |
1995-03-28 |
Emisphere Technologies, Inc. |
Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
|
US5709861A
(en)
*
|
1993-04-22 |
1998-01-20 |
Emisphere Technologies, Inc. |
Compositions for the delivery of antigens
|
US5643957A
(en)
*
|
1993-04-22 |
1997-07-01 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
US6461643B2
(en)
*
|
1993-04-22 |
2002-10-08 |
Emisphere Technologies, Inc. |
Oral drug delivery compositions and methods
|
US5958457A
(en)
*
|
1993-04-22 |
1999-09-28 |
Emisphere Technologies, Inc. |
Compositions for the delivery of antigens
|
EP1025840B1
(de)
*
|
1993-04-22 |
2005-06-29 |
Emisphere Technologies, Inc. |
Orale Dareichungsform
|
US5416157A
(en)
*
|
1993-09-09 |
1995-05-16 |
Eastman Chemical Company |
Process for improving mechanical shear stability of acrylic enteric polymers
|
US5380790A
(en)
*
|
1993-09-09 |
1995-01-10 |
Eastman Chemical Company |
Process for the preparation of acrylic polymers for pharmaceutical coatings
|
DE29522419U1
(de)
*
|
1994-07-08 |
2003-07-03 |
AstraZeneca AB, Södertälje |
Tablettierte Mehrfacheinheits-Dosisform
|
SE9500422D0
(sv)
*
|
1995-02-06 |
1995-02-06 |
Astra Ab |
New oral pharmaceutical dosage forms
|
CN1151836C
(zh)
*
|
1995-03-31 |
2004-06-02 |
艾米斯菲尔技术有限公司 |
用作传送活性剂的化合物和组合物
|
US5965121A
(en)
*
|
1995-03-31 |
1999-10-12 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
WO1997036480A1
(en)
*
|
1996-03-29 |
1997-10-09 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
US5866536A
(en)
*
|
1995-03-31 |
1999-02-02 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
US5650386A
(en)
*
|
1995-03-31 |
1997-07-22 |
Emisphere Technologies, Inc. |
Compositions for oral delivery of active agents
|
US5989539A
(en)
*
|
1995-03-31 |
1999-11-23 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
US6001347A
(en)
*
|
1995-03-31 |
1999-12-14 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
US6090958A
(en)
*
|
1995-03-31 |
2000-07-18 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
US5820881A
(en)
*
|
1995-04-28 |
1998-10-13 |
Emisphere Technologies, Inc. |
Microspheres of diamide-dicarboxylic acids
|
US5824345A
(en)
*
|
1995-06-07 |
1998-10-20 |
Emisphere Technologies, Inc. |
Fragrances and flavorants
|
US5750147A
(en)
*
|
1995-06-07 |
1998-05-12 |
Emisphere Technologies, Inc. |
Method of solubilizing and encapsulating itraconazole
|
US5667806A
(en)
*
|
1995-06-07 |
1997-09-16 |
Emisphere Technologies, Inc. |
Spray drying method and apparatus
|
US6051258A
(en)
*
|
1995-06-07 |
2000-04-18 |
Emisphere Technologies, Inc. |
Proteinoid emulsions and methods for preparation and use thereof
|
WO1997010197A1
(en)
*
|
1995-09-11 |
1997-03-20 |
Emisphere Technologies, Inc. |
METHOD FOR PREPARING φ-AMINOALKANOIC ACID DERIVATIVES FROM CYCLOALKANONES
|
US6270795B1
(en)
|
1995-11-09 |
2001-08-07 |
Microbiological Research Authority |
Method of making microencapsulated DNA for vaccination and gene therapy
|
SE9600072D0
(sv)
*
|
1996-01-08 |
1996-01-08 |
Astra Ab |
New oral formulation of two active ingredients II
|
SE512835C2
(sv)
*
|
1996-01-08 |
2000-05-22 |
Astrazeneca Ab |
Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare
|
SE9600070D0
(sv)
|
1996-01-08 |
1996-01-08 |
Astra Ab |
New oral pharmaceutical dosage forms
|
SE9600071D0
(sv)
|
1996-01-08 |
1996-01-08 |
Astra Ab |
New oral formulation of two active ingredients I
|
WO1997047288A1
(en)
|
1996-06-14 |
1997-12-18 |
Emisphere Technologies, Inc. |
Microencapsulated fragrances and method for preparation
|
US20020182258A1
(en)
*
|
1997-01-22 |
2002-12-05 |
Zycos Inc., A Delaware Corporation |
Microparticles for delivery of nucleic acid
|
US5939381A
(en)
*
|
1997-02-07 |
1999-08-17 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
US6313088B1
(en)
|
1997-02-07 |
2001-11-06 |
Emisphere Technologies, Inc. |
8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
|
US6060513A
(en)
*
|
1997-02-07 |
2000-05-09 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
US5990166A
(en)
*
|
1997-02-07 |
1999-11-23 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
US5804688A
(en)
*
|
1997-02-07 |
1998-09-08 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
US5876710A
(en)
*
|
1997-02-07 |
1999-03-02 |
Emisphere Technologies Inc. |
Compounds and compositions for delivering active agents
|
US6358504B1
(en)
*
|
1997-02-07 |
2002-03-19 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
US5879681A
(en)
*
|
1997-02-07 |
1999-03-09 |
Emisphere Technolgies Inc. |
Compounds and compositions for delivering active agents
|
US5863944A
(en)
*
|
1997-04-30 |
1999-01-26 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
US5962710A
(en)
*
|
1997-05-09 |
1999-10-05 |
Emisphere Technologies, Inc. |
Method of preparing salicyloylamino acids
|
US6165493A
(en)
*
|
1997-10-22 |
2000-12-26 |
New York Blood Center, Inc. |
"Methods and compositions for decreasing the frequency of HIV, herpesvirus and sexually transmitted bacterial infections"
|
US5985313A
(en)
*
|
1997-10-22 |
1999-11-16 |
New York Blood Center, Inc. |
Method for decreasing the frequency of transmission of viral infections using cellulose acetate phthalate or hydroxypropyl methylcellulose phthalate excipients
|
US6559158B1
(en)
|
1997-11-03 |
2003-05-06 |
Ur Labs, Inc. |
Use of methylnaltrexone and related compounds to treat chronic opioid use side affects
|
US20030158220A1
(en)
*
|
1997-11-03 |
2003-08-21 |
Foss Joseph F. |
Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
|
US6274591B1
(en)
*
|
1997-11-03 |
2001-08-14 |
Joseph F. Foss |
Use of methylnaltrexone and related compounds
|
US6733780B1
(en)
*
|
1999-10-19 |
2004-05-11 |
Genzyme Corporation |
Direct compression polymer tablet core
|
US20050037086A1
(en)
*
|
1999-11-19 |
2005-02-17 |
Zycos Inc., A Delaware Corporation |
Continuous-flow method for preparing microparticles
|
CA2410052A1
(en)
*
|
2000-06-02 |
2001-12-13 |
Zycos Inc. |
Delivery systems for bioactive agents
|
DE60234183D1
(de)
*
|
2001-06-05 |
2009-12-10 |
Univ Chicago |
Verwendung von methylnaltrexon zur behandlung von immunsuppression
|
US8071133B2
(en)
*
|
2001-08-20 |
2011-12-06 |
Stiefel Laboratories, Inc. |
Oral dosage forms of water insoluble drugs and methods of making the same
|
FR2833493B1
(fr)
*
|
2001-12-18 |
2005-09-23 |
Ioltechnologie Production |
Forme galenique solide et soluble pour l'administration occulaire de principes actifs et procede de fabrication d'un insert ophtalmique solide et soluble
|
US20040115266A1
(en)
*
|
2002-02-01 |
2004-06-17 |
Namburi Ranga Raju |
Oral itraconazole formulations and methods of making the same
|
WO2004030658A1
(en)
|
2002-10-01 |
2004-04-15 |
Banner Pharmacaps, Inc. |
Enteric composition for the manufacture of soft capsule wall
|
BRPI0409128A
(pt)
*
|
2003-04-08 |
2006-03-28 |
Progenics Pharm Inc |
uso de antagonistas de opióides periféricos, especialmente metilnaltrexona para tratar sìndrome de intestino irritável
|
DK2368554T3
(en)
|
2003-04-08 |
2015-01-26 |
Progenics Pharm Inc |
A pharmaceutical composition comprising methylnaltrexone
|
JP2006522819A
(ja)
*
|
2003-04-08 |
2006-10-05 |
プロジェニックス ファーマシューティカルズ,インコーポレーテッド |
緩下薬および末梢オピオイドアンタゴニストを組み合わせた便秘の組み合わせ療法
|
US20050070501A1
(en)
*
|
2003-09-29 |
2005-03-31 |
New York Blood Center, Inc. |
Water dispersible film
|
US7985418B2
(en)
|
2004-11-01 |
2011-07-26 |
Genzyme Corporation |
Aliphatic amine polymer salts for tableting
|
WO2006078842A1
(en)
*
|
2005-01-20 |
2006-07-27 |
Progenics Pharmaceuticals, Inc. |
Use of methylnaltrexone and related compounds to treat post-operative gastrointestinal dysfunction
|
US8524731B2
(en)
*
|
2005-03-07 |
2013-09-03 |
The University Of Chicago |
Use of opioid antagonists to attenuate endothelial cell proliferation and migration
|
US8518962B2
(en)
|
2005-03-07 |
2013-08-27 |
The University Of Chicago |
Use of opioid antagonists
|
US9662325B2
(en)
|
2005-03-07 |
2017-05-30 |
The University Of Chicago |
Use of opioid antagonists to attenuate endothelial cell proliferation and migration
|
US9662390B2
(en)
*
|
2005-03-07 |
2017-05-30 |
The University Of Chicago |
Use of opioid antagonists to attenuate endothelial cell proliferation and migration
|
AR057035A1
(es)
|
2005-05-25 |
2007-11-14 |
Progenics Pharm Inc |
SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
|
AR057325A1
(es)
*
|
2005-05-25 |
2007-11-28 |
Progenics Pharm Inc |
Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
|
US20080194611A1
(en)
*
|
2005-06-03 |
2008-08-14 |
Alverdy John C |
Modulation of Cell Barrier Dysfunction
|
CA2622693C
(en)
*
|
2005-09-15 |
2015-05-05 |
Genzyme Corporation |
Sachet formulation for amine polymers
|
US20070148248A1
(en)
|
2005-12-22 |
2007-06-28 |
Banner Pharmacaps, Inc. |
Gastric reflux resistant dosage forms
|
TW200817048A
(en)
*
|
2006-09-08 |
2008-04-16 |
Wyeth Corp |
Dry powder compound formulations and uses thereof
|
US20080129253A1
(en)
*
|
2006-11-03 |
2008-06-05 |
Advanced Desalination Inc. |
Battery energy reclamation apparatus and method thereby
|
CA2682125C
(en)
*
|
2007-03-29 |
2015-06-16 |
Progenics Pharmaceuticals, Inc. |
Peripheral opioid receptor antagonists and uses thereof
|
WO2008121352A2
(en)
*
|
2007-03-29 |
2008-10-09 |
Progenics Pharmaceuticals, Inc. |
Crystal forms of (r) -n-methylnaltrexone bromide and uses thereof
|
EP2139890B1
(de)
*
|
2007-03-29 |
2014-06-25 |
Wyeth LLC |
Peripherer opioid-rezeptor antagonisten und verwendungen davon
|
EP2215474A4
(de)
*
|
2007-07-16 |
2012-07-18 |
Avaxia Biologics Inc |
Antikörpertherapie zur modulation der funktion von darmrezeptoren
|
US8647626B2
(en)
*
|
2007-10-02 |
2014-02-11 |
Avaxia Biologics, Incorporated |
Compositions comprising TNF-specific antibodies for oral delivery
|
EP2244735A4
(de)
*
|
2007-10-02 |
2011-02-23 |
Avaxia Biologics Inc |
Antikörpertherapie zur verwendung im verdauungstrakt
|
EP2730578A1
(de)
|
2008-02-06 |
2014-05-14 |
Progenics Pharmaceuticals, Inc. |
Herstellung und Verwendung von (R),(R)-2,2'-bis-methylnaltrexon
|
JP5647098B2
(ja)
|
2008-03-21 |
2014-12-24 |
ザ ユニヴァーシティー オヴ シカゴ |
オピオイド拮抗薬とmTOR阻害薬を用いた治療
|
AU2009265034B2
(en)
|
2008-07-01 |
2015-09-03 |
University Of Chicago |
Particles containing an opioid receptor antagonist and methods of use
|
CA2676881C
(en)
*
|
2008-09-30 |
2017-04-25 |
Wyeth |
Peripheral opioid receptor antagonists and uses thereof
|
CA2777823A1
(en)
|
2009-10-15 |
2011-04-21 |
Avaxia Biologics, Inc. |
Antibody therapeutics with local activity in the digestive tract
|
CA2950311C
(en)
|
2014-06-23 |
2019-05-14 |
Banner Life Sciences Llc |
All natural enteric soft capsules comprising active ingredients
|
WO2016061531A1
(en)
|
2014-10-17 |
2016-04-21 |
Salix Pharmaceuticals, Inc. |
Use of methylnaltrexone to attenuate tumor progression
|
WO2020225395A1
(en)
|
2019-05-07 |
2020-11-12 |
Bausch Health Ireland Limited |
Liquid oral dosage formulations of methylnaltrexone
|
WO2021224138A1
(en)
|
2020-05-02 |
2021-11-11 |
Bausch Health Ireland Limited |
Methods of reducing mortality risk in subjects suffering from an underlying disease or condition by administration of methylnaltrexone
|