NO159079C - Analogifremgangsmaate for fremstilling av farmakologisk aktive alkan- og alken-derivater. - Google Patents
Analogifremgangsmaate for fremstilling av farmakologisk aktive alkan- og alken-derivater.Info
- Publication number
- NO159079C NO159079C NO823537A NO823537A NO159079C NO 159079 C NO159079 C NO 159079C NO 823537 A NO823537 A NO 823537A NO 823537 A NO823537 A NO 823537A NO 159079 C NO159079 C NO 159079C
- Authority
- NO
- Norway
- Prior art keywords
- sub
- compounds
- hydrogen
- carbon atoms
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000000144 pharmacologic effect Effects 0.000 title abstract 2
- 150000001335 aliphatic alkanes Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- -1 2,3-epoxypropoxy, 2,3-dihydroxypropoxy Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005336 allyloxy group Chemical group 0.000 abstract 1
- 230000001833 anti-estrogenic effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000328 estrogen antagonist Substances 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
- C07C37/002—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
- C07C37/003—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by hydrogenation of an unsaturated part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
- C07C37/20—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms using aldehydes or ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
- C07C39/11—Alkylated hydroxy benzenes containing also acyclically bound hydroxy groups, e.g. saligenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
- C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/21—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Inorganic Insulating Materials (AREA)
- Separation Of Gases By Adsorption (AREA)
- Treating Waste Gases (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08132240A GB2108486B (en) | 1981-10-26 | 1981-10-26 | Alkane and alkene derivatives and their preparation and use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO823537L NO823537L (no) | 1983-04-27 |
| NO159079B NO159079B (no) | 1988-08-22 |
| NO159079C true NO159079C (no) | 1988-11-30 |
Family
ID=10525401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO823537A NO159079C (no) | 1981-10-26 | 1982-10-25 | Analogifremgangsmaate for fremstilling av farmakologisk aktive alkan- og alken-derivater. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4556677A (de) |
| EP (1) | EP0078158B1 (de) |
| JP (1) | JPS5879934A (de) |
| AT (1) | ATE22065T1 (de) |
| AU (1) | AU555477B2 (de) |
| CA (1) | CA1310974C (de) |
| DD (1) | DD211548A1 (de) |
| DE (1) | DE3273219D1 (de) |
| DK (1) | DK472082A (de) |
| FI (1) | FI77842C (de) |
| GB (1) | GB2108486B (de) |
| HU (1) | HU193268B (de) |
| IE (1) | IE54586B1 (de) |
| IL (1) | IL67049A (de) |
| NO (1) | NO159079C (de) |
| NZ (1) | NZ202269A (de) |
| SU (1) | SU1329615A3 (de) |
| ZA (1) | ZA827742B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2108486B (en) * | 1981-10-26 | 1986-01-29 | Farmos Group Ltd | Alkane and alkene derivatives and their preparation and use |
| US4775660A (en) * | 1984-08-02 | 1988-10-04 | Fernand Labrie | Treatment of breast cancer by combination therapy |
| US4666885A (en) * | 1985-02-08 | 1987-05-19 | Fernand Labrie | Combination therapy for treatment of female breast cancer |
| US4760053A (en) * | 1984-08-02 | 1988-07-26 | Fernand Labrie | Combination therapy for selected sex steroid dependent cancers |
| US4895715A (en) * | 1988-04-14 | 1990-01-23 | Schering Corporation | Method of treating gynecomastia |
| PH30747A (en) * | 1989-03-10 | 1997-10-17 | Endorech Inc | Combination therapy for the treatment of estrogen sensitive disease. |
| NL1018247C2 (nl) | 2001-06-08 | 2002-12-10 | Sara Lee De Nv | Inrichting voor het bereiden van een voor consumptie geschikte drank zoals koffie. |
| JP2004010479A (ja) * | 2002-06-03 | 2004-01-15 | Japan Science & Technology Corp | ブロック共重合体とアンスラサイクリン系抗癌剤を含む新規固型製剤及びその製造法 |
| CN102317464B (zh) | 2008-12-12 | 2014-10-29 | 塞莱西翁有限公司 | 从α-酮酸生物合成双官能烷烃 |
| FR3071837B1 (fr) | 2017-09-29 | 2019-11-01 | Institut National De La Recherche Agronomique | Derive de lignine chimiquement stable et procede pour sa preparation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1306604A (fr) * | 1959-03-03 | 1962-10-19 | Ferrosan Ab | Procédé pour préparer des bisphényléthylènes substitués |
| GB1289966A (de) * | 1968-12-24 | 1972-09-20 | ||
| US3661976A (en) * | 1969-05-16 | 1972-05-09 | Parke Davis & Co | 4,4'-(2-cycloalkyl-alkylidene) diphenols and ethers and esters thereof |
| BE793686A (fr) * | 1972-01-07 | 1973-07-04 | Beecham Group Ltd | Composes di-aryliques biologiquement actifs |
| GB2108486B (en) * | 1981-10-26 | 1986-01-29 | Farmos Group Ltd | Alkane and alkene derivatives and their preparation and use |
-
1981
- 1981-10-26 GB GB08132240A patent/GB2108486B/en not_active Expired
-
1982
- 1982-10-12 FI FI823465A patent/FI77842C/fi not_active IP Right Cessation
- 1982-10-18 SU SU823503159A patent/SU1329615A3/ru active
- 1982-10-21 DE DE8282305612T patent/DE3273219D1/de not_active Expired
- 1982-10-21 EP EP82305612A patent/EP0078158B1/de not_active Expired
- 1982-10-21 AT AT82305612T patent/ATE22065T1/de not_active IP Right Cessation
- 1982-10-22 IL IL67049A patent/IL67049A/xx not_active IP Right Cessation
- 1982-10-22 AU AU89702/82A patent/AU555477B2/en not_active Ceased
- 1982-10-22 ZA ZA827742A patent/ZA827742B/xx unknown
- 1982-10-22 IE IE2551/82A patent/IE54586B1/en not_active IP Right Cessation
- 1982-10-22 NZ NZ202269A patent/NZ202269A/en unknown
- 1982-10-23 JP JP57186650A patent/JPS5879934A/ja active Granted
- 1982-10-25 DK DK472082A patent/DK472082A/da not_active Application Discontinuation
- 1982-10-25 CA CA000414128A patent/CA1310974C/en not_active Expired - Fee Related
- 1982-10-25 DD DD82244246A patent/DD211548A1/de not_active IP Right Cessation
- 1982-10-25 NO NO823537A patent/NO159079C/no unknown
- 1982-10-25 HU HU823395A patent/HU193268B/hu not_active IP Right Cessation
- 1982-10-26 US US06/436,805 patent/US4556677A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| SU1329615A3 (ru) | 1987-08-07 |
| GB2108486B (en) | 1986-01-29 |
| EP0078158A2 (de) | 1983-05-04 |
| GB2108486A (en) | 1983-05-18 |
| EP0078158B1 (de) | 1986-09-10 |
| FI823465A0 (fi) | 1982-10-12 |
| FI77842C (fi) | 1989-05-10 |
| NO823537L (no) | 1983-04-27 |
| ATE22065T1 (de) | 1986-09-15 |
| JPH0239492B2 (de) | 1990-09-05 |
| EP0078158A3 (en) | 1984-01-18 |
| AU8970282A (en) | 1983-05-12 |
| CA1310974C (en) | 1992-12-01 |
| FI77842B (fi) | 1989-01-31 |
| IL67049A (en) | 1987-07-31 |
| NZ202269A (en) | 1985-05-31 |
| NO159079B (no) | 1988-08-22 |
| HU193268B (en) | 1987-09-28 |
| JPS5879934A (ja) | 1983-05-13 |
| IE54586B1 (en) | 1989-12-06 |
| DK472082A (da) | 1983-04-27 |
| FI823465L (fi) | 1983-04-27 |
| US4556677A (en) | 1985-12-03 |
| DE3273219D1 (en) | 1986-10-16 |
| AU555477B2 (en) | 1986-09-25 |
| DD211548A1 (de) | 1984-07-18 |
| ZA827742B (en) | 1983-08-31 |
| IE822551L (en) | 1983-04-26 |
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