NO153107B - CLEANING CLEANING FOR CLEANING CONTACT LENSES - Google Patents
CLEANING CLEANING FOR CLEANING CONTACT LENSES Download PDFInfo
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- NO153107B NO153107B NO791335A NO791335A NO153107B NO 153107 B NO153107 B NO 153107B NO 791335 A NO791335 A NO 791335A NO 791335 A NO791335 A NO 791335A NO 153107 B NO153107 B NO 153107B
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- cleaning
- contact lenses
- cleaning liquid
- lens
- lenses
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- 238000004140 cleaning Methods 0.000 title claims description 38
- 239000007788 liquid Substances 0.000 claims description 20
- 102000004190 Enzymes Human genes 0.000 claims description 12
- 108090000790 Enzymes Proteins 0.000 claims description 12
- 229920000642 polymer Polymers 0.000 claims description 10
- 108091005804 Peptidases Proteins 0.000 claims description 9
- 102000035195 Peptidases Human genes 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 230000002366 lipolytic effect Effects 0.000 claims description 8
- 239000004367 Lipase Substances 0.000 claims description 4
- 102000004882 Lipase Human genes 0.000 claims description 4
- 108090001060 Lipase Proteins 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 4
- 235000019421 lipase Nutrition 0.000 claims description 4
- 239000008363 phosphate buffer Substances 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 description 13
- 229940088598 enzyme Drugs 0.000 description 11
- 239000012530 fluid Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 108010088751 Albumins Proteins 0.000 description 6
- 102000009027 Albumins Human genes 0.000 description 6
- 108010019160 Pancreatin Proteins 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 229940055695 pancreatin Drugs 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229940067606 lecithin Drugs 0.000 description 3
- 235000010445 lecithin Nutrition 0.000 description 3
- 239000000787 lecithin Substances 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000009835 boiling Methods 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 238000004383 yellowing Methods 0.000 description 2
- 102100026735 Coagulation factor VIII Human genes 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 241000519995 Stachys sylvatica Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000002194 fatty esters Chemical class 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 229940066779 peptones Drugs 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Detergent Compositions (AREA)
- Eyeglasses (AREA)
Description
Denne oppfinnelse angår en rensevæske for rengjøring This invention relates to a cleaning liquid for cleaning
av myke kontaklinser. of soft contact lenses.
Avsetninger som dannes under bruk av myke kontaklinser, resulterer vanligvis i en ugjennomsiktig film, gultoning, hvite flekker og trådlignende mønstere på linsene. Undersøkel-ser som er blitt utført, har vist at disse avsetninger kan be-stå av albumin, Ig-y-globulin, lysozymer og lipoproteiner. Deposits that form during soft contact lens wear usually result in an opaque film, yellowing, white spots and thread-like patterns on the lenses. Investigations that have been carried out have shown that these deposits can consist of albumin, Ig-γ-globulin, lysozymes and lipoproteins.
Avsetningene består ofte for en stor del av lipider og denaturert albumin, som avsettes på linsene fra tårevæsken som følge av at saltoppløsningen som linsene er impregnert med, erstattes med tårevæsken. Uttørringen av en linse, for eksempel som følge av at den anvendes i tørre omgivelser og som følge av at det strømmer luft forbi den, osv. fører til at en viss mengde albumin denatureres og avsettes på linsen. Selv når kontaklinser steriliseres ved koking, denatureres albumin, hvilket gir opphav til apolare, indre grupper av lipider. Det kan også være andre grunner, såsom for eksempel kontinuerlig bruk, til at albumin og lipider avsettes på kontaktlinser i temmelig store mengder. The deposits often consist to a large extent of lipids and denatured albumin, which are deposited on the lenses from the tear fluid as a result of the salt solution with which the lenses are impregnated being replaced by the tear fluid. The drying out of a lens, for example as a result of it being used in a dry environment and as a result of air flowing past it, etc. leads to a certain amount of albumin being denatured and deposited on the lens. Even when contact lenses are sterilized by boiling, albumin is denatured, giving rise to apolar inner groups of lipids. There may also be other reasons, such as continuous use, for albumin and lipids to be deposited on contact lenses in rather large quantities.
Polymerene som for tiden anvendes for fremstilling av myke kontaktlinser, nemlig PMMA, HEMA og PvP, har alle et felles kjennetegn, nemlig det at de er lipid- og protein-re-tensive. Det er riktignok blitt foreslått nye materialer såsom silicon, men også dette materiale er lipid-retensivt. The polymers currently used for the production of soft contact lenses, namely PMMA, HEMA and PvP, all have a common characteristic, namely that they are lipid and protein-retentive. It is true that new materials such as silicon have been proposed, but this material is also lipid-retentive.
For tiden synes det ikke mulig å finne et materiale Currently, it does not seem possible to find a material
for fremstilling av myke kontaklinser, som ikke er beheftet med denne ulempe. for the production of soft contact lenses, which are not affected by this disadvantage.
Problemet med fettavsetninger fra tårevæsker har gitt seg til kjenne i mange undersøkelser. Den stadige akkumulering av fettavsetninger på og i linsematerialet kan opptre etter kort tid, idet det synes som om mengden av lipider i tårevæsken varierer fra den ene person til den annen. The problem of fat deposits from tear fluids has made itself known in many investigations. The constant accumulation of fat deposits on and in the lens material can occur after a short time, as it seems that the amount of lipids in the tear fluid varies from one person to another.
Lipidavsetningene opptrer enten som en gultoning av linsen eller som et hvitaktig slør. The lipid deposits appear either as a yellowing of the lens or as a whitish veil.
I kjemisk henseende er avsetningene sammensatt av fos-folipider, formodentlig i form av lecitin, som sammen med proteinet danner et lecitoprotein (når lecitin utsettes for-varme og lys, har det tendens til å autooxydere eller spaltes In chemical terms, the deposits are composed of phospholipids, presumably in the form of lecithin, which together with the protein form a lecitoprotein (when lecithin is exposed to heat and light, it tends to autoxidize or split
til gulaktige stoffer) eller av cholesterol og fettestere, to yellowish substances) or of cholesterol and fatty esters,
som er hvitfarvede. which are white in colour.
Plaketter, eller hva man kunne kalle lesjoner, opptrer også på linsene etter en tid. I typiske tilfeller består plaketten av en sentral kjerne av lipidet som ligger fritt på polymeren og rager inn i linsematerialet, og som gir en følelse av sandkorn på øyet. Plaques, or what you might call lesions, also appear on the lenses after a while. In typical cases, the plaque consists of a central core of the lipid that lies freely on the polymer and protrudes into the lens material, giving the eye a feeling of grains of sand.
Uheldigvis har man kun teorier for å forklare hvordan fettstoffer i tårevæsken omdannes til generende plaketter. Disse plaketter har imidlertid sitt utgangspunkt i et over-skudd av lipider, spesielt cholesterol og lecitin. Unfortunately, there are only theories to explain how fatty substances in the tear fluid are converted into troublesome plaques. However, these plaques are based on an excess of lipids, especially cholesterol and lecithin.
På grunnlag av disse observasjoner er det derfor ganske klart at en rensevæske for rengjøring av myke kontaktlinser, som kan tilfredsstille både dagens og morgendagens krav, må være i stand til å fjerne lipid- og proteinavsetninger som dannes på det myke kontaktlinsemateriale under bruk. Based on these observations, it is therefore quite clear that a cleaning fluid for cleaning soft contact lenses, which can satisfy both today's and tomorrow's requirements, must be able to remove lipid and protein deposits that form on the soft contact lens material during use.
Det er allerede kjent en fremgangsmåte for rengjøring av kontaktlinser,ved hvilken et proteolytisk enzym i tablett-form oppløses i vann og linsene som skal rengjøres, holdes i denne oppløsning i minst 2 timer. Denne fremgangsmåte har vært ansett som omstendelig av brukerne av kontaktlinser, slik at rengjøringen ikke alltid har vært utført så regelmessig som ønskelig, og dette har resultert i at linsene til slutt har fått et slikt belegg at de er blitt ubrukelige. En annen ting er at den kjente fremgangsmåte, ved hvilken det kun anvendes proteolytiske enzymer, ikke fører til fullstendig fjerning av avsetningene, fordi avsetninger av lipid opprin-nelse forblir hovedsakelig upåvirket av de kjente oppløsninger. A method for cleaning contact lenses is already known, in which a proteolytic enzyme in tablet form is dissolved in water and the lenses to be cleaned are kept in this solution for at least 2 hours. This method has been considered cumbersome by the users of contact lenses, so that the cleaning has not always been carried out as regularly as desired, and this has resulted in the lenses eventually getting such a coating that they have become unusable. Another thing is that the known method, in which only proteolytic enzymes are used, does not lead to complete removal of the deposits, because deposits of lipid origin remain mainly unaffected by the known solutions.
I US patentskrift nr. 4 096 870 redegjøres det for an-vendelse av en vandig suspensjon av pancreatin for å fjerne proteinholdig materiale fra kontaklinser. Pancreatin er en blanding av enzymer omfattende både proteolytiske enzymer og lipolytiske enzymer. Pancreatinets mangel på spesifisitet er imidlertid en ulempe, idet pancreatinet ikke er så virk-ningsfullt overfor proteiner og lipider avsatt på linsene som man skulle kunne ønske. Dessuten er pancreatinet lite opp-løselig i vandige medier, og det er derfor ikke i stand til å danne stabile preparater. Preparatene ifølge nevnte US patentskrift har derfor form av tabletter beregnet for dis-pergering i vann for dannelse av en oppslemning. En slik oppslemning er også beheftet med den ulempe at den proteolytiske fraksjon i den vandige oppslemning av pancreatin vil ødelegge den lipolytiske enzymfraksjon. US Patent No. 4,096,870 describes the use of an aqueous suspension of pancreatin to remove proteinaceous material from contact lenses. Pancreatin is a mixture of enzymes comprising both proteolytic enzymes and lipolytic enzymes. However, pancreatin's lack of specificity is a disadvantage, as pancreatin is not as effective against proteins and lipids deposited on the lenses as one might wish. Furthermore, the pancreatin is poorly soluble in aqueous media, and is therefore unable to form stable preparations. The preparations according to the aforementioned US patent are therefore in the form of tablets intended for dispersion in water to form a slurry. Such a slurry is also burdened with the disadvantage that the proteolytic fraction in the aqueous slurry of pancreatin will destroy the lipolytic enzyme fraction.
Det har nu vist seg at man ved å benytte visse selek-tive, separat tilsatte enzymer, nemlig henholdsvis et proteolytisk enzym og et lipolytisk enzym, i en nærmere bestemt vandig væske kan fjerne avsetningene på myke kontaktlinser mer effektivt, samtidig som det unngåes at det proteolytiske enzym ødelegger detlipolytiske enzym. It has now been shown that by using certain selective, separately added enzymes, namely a proteolytic enzyme and a lipolytic enzyme respectively, in a specific aqueous liquid, the deposits on soft contact lenses can be removed more effectively, while avoiding that the proteolytic enzyme destroys the lipolytic enzyme.
I henhold til oppfinnelsen tilveiebringes det således en rensevæske for rengjøring av myke kontaklinser, inneholdende lipolytisk enzym og proteolytisk enzym, hvilken rensevæske utmerker seg ved at den består av: According to the invention, a cleaning liquid is thus provided for cleaning soft contact lenses, containing lipolytic enzyme and proteolytic enzyme, which cleaning liquid is distinguished by the fact that it consists of:
fortynnet til 1 liter med destillert vann, inneholdende lipase fra cand. cylindracae i en mengde svarende til ca. 50 000 enheter, i 1000 ml 0,1M fosfatbuffer i et vandig polymerkompleks. diluted to 1 liter with distilled water, containing lipase from cand. cylindracae in an amount corresponding to approx. 50,000 units, in 1000 ml of 0.1M phosphate buffer in an aqueous polymer complex.
Rensevæsken er fortrinnsvis hypertonisk, hvilket vil si at dens osmotiske trykk overskrider det osmotiske trykk i en fysiologisk oppløsning, slik at der ved behandling med oppløsningen finner sted en viss avvanning av linsen, hvilket synes å ha gunstig virkning på rensevirkningen. Under etter-behandling med en isotonisk oppløsning, for eksempel en salt-oppløsning, vil linsen reversibelt oppta vann igjen og vende tilbake til sin opprinnelige tilstand. The cleaning liquid is preferably hypertonic, which means that its osmotic pressure exceeds the osmotic pressure in a physiological solution, so that during treatment with the solution a certain amount of dewatering of the lens takes place, which seems to have a beneficial effect on the cleaning effect. During post-treatment with an isotonic solution, for example a saline solution, the lens will reversibly reabsorb water and return to its original state.
En pakning for rengjøring av myke kontaktlinser kan omfatte et volum av rensevæsken ifølge oppfinnelsen, en innretning for å danne små dråper av oppløsningen for avsetning på overflaten av de myke kontaklinser og et volum av en steril isotonisk fysiologisk saltoppløsning, i hvilken linsen kan skylles o_g deretter kokes. A package for cleaning soft contact lenses may comprise a volume of the cleaning liquid according to the invention, a device for forming small droplets of the solution for deposition on the surface of the soft contact lenses and a volume of a sterile isotonic physiological saline solution, in which the lens can be rinsed and then is boiled.
For rengjøring av myke kontaklinser kan man gå frem som følger: Det anbringes minst én dråpe av rensevæsken ifølge oppfinnelsen på kontaktlinsen som skal rengjøres, hvorved både albumin og lipider som måtte være 'tilstede, reduseres til vannoppløselige peptoner, fettsyrer og estere. De dannede produkter fjernes så ved skylling med og kokning i fysiologisk saltoppløsning. For cleaning soft contact lenses, you can proceed as follows: At least one drop of the cleaning liquid according to the invention is placed on the contact lens to be cleaned, whereby both albumin and lipids that may be present are reduced to water-soluble peptones, fatty acids and esters. The products formed are then removed by rinsing with and boiling in physiological salt solution.
Vanligvis bør rengjøringsoperasjonen utføres daglig. Dersom linsene benyttes både om natten og om dagen, kan det imidlertid være tilstrekkelig å foreta rengjøringen hver andre eller sågar hver tredje dag. Generally, the cleaning operation should be performed daily. If the lenses are used both at night and during the day, however, it may be sufficient to carry out the cleaning every second or even every third day.
Ved hjelp av oppfinnelsen tilveiebringes det således By means of the invention it is thus provided
en enklere rengjøringsmetode enn den teknikk som er kjent i faget, og som krever oppløsning av tabletter i vann. Likeledes er rengjøringstiden kortere enn ved den kjente teknikk. Det viktigste er imidlertid at oppfinnelsen muliggjør en mer fullstendig rengjøring av kontaktlinsen som følge av den høyere enzymatiske aktivitet. I motsetning til tidligere kjente rensepreparater er preparatet ifølge oppfinnelsen også berégnet på å skulle anvendes daglig, på den ene side. for å rengjøre linsene, og på den annen side som en fore-byggende forholdsregel for å forhindre oppbygging av større avsetninger av protein og lipider, som etter en viss tid blir vanskeligere å fjerne og forringer linsens egenskaper. a simpler cleaning method than the technique known in the art, which requires dissolving tablets in water. Likewise, the cleaning time is shorter than with the known technique. The most important thing, however, is that the invention enables a more complete cleaning of the contact lens as a result of the higher enzymatic activity. In contrast to previously known cleaning preparations, the preparation according to the invention is also intended to be used daily, on the one hand. to clean the lenses, and on the other hand as a preventive measure to prevent the build-up of larger deposits of protein and lipids, which after a certain time become more difficult to remove and impair the properties of the lens.
Fortrinnsvis er enzymaktiviteten i rensevæsken av størrelsesordenen 100 tyrosinenheter pr. ug protein. Preferably, the enzyme activity in the cleaning liquid is of the order of 100 tyrosine units per and protein.
Væsken tillates å virke på linsene i et tidsrom av størrelsesordenen 15 minutter. The liquid is allowed to act on the lenses for a period of around 15 minutes.
Fortrinnsvis har den fysiologiske saltoppløsning en partikkelstørrelse under 0,2 ug. Videre er den fortrinnsvis isotonisk, har en pH-verdi på 7,0, har en bufferkapasitet på 6 - 8 og er steril. Preferably, the physiological saline solution has a particle size below 0.2 µg. Furthermore, it is preferably isotonic, has a pH value of 7.0, has a buffer capacity of 6 - 8 and is sterile.
En foretrukken rensevæske ifølge oppfinnelsen består av: A preferred cleaning liquid according to the invention consists of:
fortynnet til 1 liter med destillert vann, inneholdende lipase fra cand. cylindracae, i en mengde svarende til ca. 50 000 enheter, i 1000 ml 0,1 M fosfatbuffer i et vandig polymerkompleks. Liposen kan hensiktsmessig være fremstilt ved lyofilisering. diluted to 1 liter with distilled water, containing lipase from cand. cylindracae, in an amount corresponding to approx. 50,000 units, in 1000 ml of 0.1 M phosphate buffer in an aqueous polymer complex. The lipose can conveniently be prepared by lyophilization.
For å unngå interaksjon mellom det proteolytiske enzym og det lipolytiske enzym i rensevæsken innlemmes det i rensevæsken et såkalt "vandig polymerkompleks". Dette binder det lipolytiske enzym, slik at det ikke blir ødelagt av det proteolytiske enzym. Arten av dette polymerkompleks er ikke av avgjørende betydning, og et hvilket som helst kommersielt produkt kan anvendes,såsom for eksempel polyethylenglycol, polyvinylalkohol, polyvinylpyrrolidon og lig-nende. Som et eksempel kan nevnes polymerkomplekset "Kollodon" 25 eller 30. In order to avoid interaction between the proteolytic enzyme and the lipolytic enzyme in the cleaning liquid, a so-called "aqueous polymer complex" is incorporated into the cleaning liquid. This binds the lipolytic enzyme, so that it is not destroyed by the proteolytic enzyme. The nature of this polymer complex is not of decisive importance, and any commercial product can be used, such as, for example, polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone and the like. As an example, the polymer complex "Kollodon" 25 or 30 can be mentioned.
Den nye rensevæske kan lagres i normale omgivelser uten tap av enzymaktivitet, hvorved det blir unødvendig å opp-løse en tablett eller et kvantum pulver i vann for å danne rensevæsken for linsen. På denne måte er det tilstrekkelig å anvende bare den mengde rensevæske som kreves for å dekke overflaten av linsen, og med dette for øyet anbringes rensevæsken i en innretning for utporsjonering av små dråper. The new cleaning liquid can be stored in normal surroundings without loss of enzyme activity, whereby it becomes unnecessary to dissolve a tablet or a quantity of powder in water to form the cleaning liquid for the lens. In this way, it is sufficient to use only the amount of cleaning liquid required to cover the surface of the lens, and with this in mind, the cleaning liquid is placed in a device for dispensing small drops.
Eksempel Example
En rensevæske (kjent under navnet "PROLEN") for myke kontaktlinser tilberedes som følger: A cleaning fluid (known under the name "PROLEN") for soft contact lenses is prepared as follows:
Blandingen fortynnes til 1 liter med destillert vann. Det tilsettes så lipase fra cand. cylindracae i en mengde av 50 000 enheter i 1000 ml 0,1 M fosfatbuffer i et vandig polymerkompleks. The mixture is diluted to 1 liter with distilled water. Lipase from Cand. cylindracae is then added in an amount of 50,000 units in 1,000 ml of 0.1 M phosphate buffer in an aqueous polymer complex.
Bruksmåter: Noen få dråper (0,3 ml) av rensevæsken anbringes How to use: A few drops (0.3 ml) of the cleaning liquid are applied
på en linse og tillates å virke på linsen i 15 minutter. Linsen skylles deretter i en fysiologisk, isotonisk saltoppløs-ning, hvoretter den kokes i saltoppløsningen i 20 minutter. Sluttelig skylles linsen ennu en gang isaltoppløsningen, on a lens and allowed to act on the lens for 15 minutes. The lens is then rinsed in a physiological, isotonic saline solution, after which it is boiled in the saline solution for 20 minutes. Finally, the lens is once again rinsed with the saline solution,
før den gjeninnsettes. before reinserting it.
Claims (3)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7804614A SE411152B (en) | 1978-04-21 | 1978-04-21 | WAY TO CLEAN SOFT CONTACT LENSES |
| GB7838873A GB2019721B (en) | 1978-04-21 | 1978-10-02 | Method and materials for cleaning soft contact lenses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO791335L NO791335L (en) | 1979-10-23 |
| NO153107B true NO153107B (en) | 1985-10-07 |
| NO153107C NO153107C (en) | 1986-01-15 |
Family
ID=26269028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO791335A NO153107C (en) | 1978-04-21 | 1979-04-20 | CLEANING CLEANING FOR CLEANING CONTACT LENSES. |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP0005131B1 (en) |
| JP (1) | JPS55500262A (en) |
| CH (1) | CH643663A5 (en) |
| DE (1) | DE2965421D1 (en) |
| FI (1) | FI791296A (en) |
| NO (1) | NO153107C (en) |
| WO (1) | WO1979000963A1 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4521254A (en) * | 1981-02-09 | 1985-06-04 | Anderson Ronald L | Cleaning contact lenses with solution of bromelain and carboxypeptidase |
| ATE28757T1 (en) * | 1982-04-23 | 1987-08-15 | Thilo & Co Gmbh Dr | ENZYMATIC CLEANING AGENT FOR CONTACT LENSES WITH PH CONTROLLED EFFECT. |
| IE55711B1 (en) | 1983-10-24 | 1990-12-19 | Bausch & Lomb | Improved method for enzymatic cleaning and disinfecting contact lenses |
| US4614549A (en) * | 1983-10-24 | 1986-09-30 | Bausch & Lomb Incorporated | Method for enzymatic cleaning and disinfecting contact lenses |
| US4690773A (en) * | 1983-10-24 | 1987-09-01 | Bausch & Lomb Incorporated | Microbial enzymatic contact lens cleaner and methods of use |
| CA1231069A (en) * | 1983-10-24 | 1988-01-05 | Bausch & Lomb Incorporated | Microbial enzymatic contact lens cleaner and methods of use |
| JPS62913A (en) * | 1985-06-26 | 1987-01-06 | Lion Corp | Cleaner for contact lens |
| GB8629538D0 (en) † | 1986-12-10 | 1987-01-21 | Unilever Plc | Enzymatic dishwashing & rinsing composition |
| GB8816443D0 (en) * | 1988-07-11 | 1988-08-17 | Albright & Wilson | Liquid enzymatic detergents |
| JPH01180515A (en) * | 1988-01-13 | 1989-07-18 | Tome Sangyo Kk | Cleaning liquid and cleaning method for contact lens |
| HU209538B (en) * | 1990-05-09 | 1994-07-28 | Vepex Contractor Ltd | Set and cleaning composition for treating contactlenses |
| KR920007641A (en) * | 1990-10-25 | 1992-05-27 | 스기우라 켄이찌 | Contact Lens Solution |
| GR1001126B (en) * | 1991-10-09 | 1993-04-28 | Tsakas Spyros Lavipharm Ae | Cleaning-sterilization of contact lenses via a new enzymatic and technical methodology |
| WO1995018204A1 (en) * | 1993-12-29 | 1995-07-06 | Bausch & Lomb Incorporated | Carbohydrate composition and method for cleaning and disinfecting contact lenses |
| CN110199013A (en) * | 2017-01-20 | 2019-09-03 | A·斯图姆 | Contact lenses detergent |
| KR102694601B1 (en) * | 2021-12-01 | 2024-08-13 | 주식회사 휴메디솔 | MPC and protease-based contact lens cleaning solution and manufacturing method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3855142A (en) * | 1971-07-15 | 1974-12-17 | Lever Brothers Ltd | Enzymatic denture cleanser |
| US3910296A (en) * | 1973-04-20 | 1975-10-07 | Allergan Pharma | Method of removing proteinaceous deposits from contact lenses |
| JPS5064303A (en) * | 1973-10-11 | 1975-05-31 | ||
| US4096870A (en) * | 1977-06-09 | 1978-06-27 | Burton, Parsons And Company, Inc. | Method for cleaning soft hydrophilic gel contact lenses |
-
1979
- 1979-04-20 FI FI791296A patent/FI791296A/en not_active Application Discontinuation
- 1979-04-20 WO PCT/SE1979/000097 patent/WO1979000963A1/en unknown
- 1979-04-20 NO NO791335A patent/NO153107C/en unknown
- 1979-04-20 JP JP50072079A patent/JPS55500262A/ja active Pending
- 1979-04-20 CH CH1153779A patent/CH643663A5/en not_active IP Right Cessation
- 1979-04-23 EP EP79850032A patent/EP0005131B1/en not_active Expired
- 1979-04-23 DE DE7979850032T patent/DE2965421D1/en not_active Expired
- 1979-11-19 EP EP79900454A patent/EP0015968A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPS55500262A (en) | 1980-05-01 |
| EP0015968A1 (en) | 1980-10-01 |
| NO791335L (en) | 1979-10-23 |
| EP0005131B1 (en) | 1983-05-18 |
| EP0005131A3 (en) | 1979-11-28 |
| CH643663A5 (en) | 1984-06-15 |
| DE2965421D1 (en) | 1983-07-07 |
| FI791296A (en) | 1979-10-22 |
| NO153107C (en) | 1986-01-15 |
| EP0005131A2 (en) | 1979-10-31 |
| WO1979000963A1 (en) | 1979-11-15 |
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