SE411152B - WAY TO CLEAN SOFT CONTACT LENSES - Google Patents

WAY TO CLEAN SOFT CONTACT LENSES

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Publication number
SE411152B
SE411152B SE7804614A SE7804614A SE411152B SE 411152 B SE411152 B SE 411152B SE 7804614 A SE7804614 A SE 7804614A SE 7804614 A SE7804614 A SE 7804614A SE 411152 B SE411152 B SE 411152B
Authority
SE
Sweden
Prior art keywords
solution
contact lenses
lens
boiling
lenses
Prior art date
Application number
SE7804614A
Other languages
Swedish (sv)
Other versions
SE7804614L (en
Inventor
Sok
Original Assignee
Bedding Peter Michael John
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bedding Peter Michael John filed Critical Bedding Peter Michael John
Priority to SE7804614A priority Critical patent/SE411152B/en
Priority to GB7838873A priority patent/GB2019721B/en
Priority to GB7836972A priority patent/GB2029225B/en
Priority to NO791335A priority patent/NO153107C/en
Priority to JP50072079A priority patent/JPS55500262A/ja
Priority to PCT/SE1979/000097 priority patent/WO1979000963A1/en
Priority to FI791296A priority patent/FI791296A/en
Priority to CH1153779A priority patent/CH643663A5/en
Priority to EP79850032A priority patent/EP0005131B1/en
Priority to DE7979850032T priority patent/DE2965421D1/en
Publication of SE7804614L publication Critical patent/SE7804614L/en
Priority to EP79900454A priority patent/EP0015968A1/en
Publication of SE411152B publication Critical patent/SE411152B/en
Priority to SE7804614A priority patent/SE407470B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Detergent Compositions (AREA)
  • Eyeglasses (AREA)
  • Microelectronics & Electronic Packaging (AREA)

Abstract

A cleaning solution for soft contact lenses is described. The solution differs from previously known solutions in that it includes a lipolytic enzyme in addition to Papain or Bromolain so that not only are Albumin deposits removed from the surface of the lens but also any Lipids present are also split into fatty acids and esters for removal by subsequent rinsing and boiling in physiological saline solution. A supplementary cleaning solution comprises a Lipase and phosphate buffer which is typically applied to the lens after the primary cleaning solution and before the rinsing and boiling stage. By utilising a stable enzyme containing solution, only relatively small volumes of the liquid are required to clean a lens and the solution is applied using a droplet technique.

Description

2 780461 4-1, genom kokning denatueras äggvita, vilken medför uppkomst av apolara inre grupper av lipider. Även andra orsaker, såsom t.ex. kontinuer- lig användning, medför större avlagring av äggvita och lipider vid kontaktlinser. 2 780461 4-1, by boiling, egg whites are denatured, resulting in the formation of apolar inner groups of lipids. Also other causes, such as e.g. continuous use, results in greater deposition of egg whites and lipids in contact lenses.

Ett sätt att rengöra mjuka kontaktliner är förut känt, inne- fattande stegen att i vatten upplösa en protelytisk enzym i tab- lettform och att därefter placera de linser som skall rengöras i lösningen under en tidsrymd av minst två timmar. Genom att detta förfarande ofta anses alltför komplicerat av kontaktlinsbäraren, så utföres ej rengöring regelbundet, vilket resulterar i att linserna slutligen erhåller en så kraftig beläggning, att linserna är oanvändbara. ' 'Avsikten med föreliggande uppfinning är att påvisa_ett sätt för rengöring, vilket dels medger ett förenklat handhavande för en kontaktlinbärare, dels även medger en förbättrad rengörande effekt.One way of cleaning soft contact lines is known in the art, including the steps of dissolving a protelytic enzyme in tablet form in water and then placing the lenses to be cleaned in the solution for a period of at least two hours. Because this method is often considered too complicated by the contact lens wearer, cleaning is not performed regularly, which results in the lenses finally obtaining such a strong coating that the lenses are unusable. The object of the present invention is to demonstrate a method for cleaning, which partly allows a simplified handling for a contact line carrier, and partly also allows an improved cleaning effect.

Vidare åstadkommes en förebyggande effekt mot större uppbyggnad av protein och lipider.Furthermore, a preventive effect is achieved against greater build-up of protein and lipids.

Sättet enligt föreliggande uppfinning kännetecknas i huvudsak av de kännetecken som anges i efterföljande patentkrav.The method according to the present invention is mainly characterized by the features stated in the appended claims.

I syfte att underlätta förståelsen för sättet enligt förelig- gande uppfinning, så skall en rengöringsoperation av kontaminerade kontaktlinser, utövad enligt föreliggande uppfinning, nedan närmare beskrivas.In order to facilitate the understanding of the method according to the present invention, a cleaning operation of contaminated contact lenses, practiced according to the present invention, will be described in more detail below.

De linser som skall rengöras, vanligen med en avlagring av- protein, lipoproteiner och lipider, tillföres såsom ett första steg ett medel med hög enzymatisk effekt, samt innefattande såväl protelytiska som lipolytiska enzymer. Nämnda medel, vilket droppas på linserna, innehåller en stabiliserad proteas och en lipas med hög aktivitet. Efter det att medlet droppats på linserna, lämnas det att verka under 15 minuter.The lenses to be cleaned, usually with a deposit of protein, lipoproteins and lipids, are supplied as a first step with an agent with a high enzymatic effect, and comprising both protelytic and lipolytic enzymes. Said agent, which is dropped on the lenses, contains a stabilized protease and a high activity lipase. After the agent is dropped on the lenses, it is left to work for 15 minutes.

I syfte att erhålla en fullständig rengöring, med borttagning av förekommande lipider från kontaktlinserna, anbringas därefter med fördel såsom-ett andra steg en stabiliserande enzym i vätske- form, vilken även droppas på kontaktlinserna, varigenom lipidav- lagringen slutgiltigt avlägsnas.In order to obtain a complete cleaning, with the removal of any lipids from the contact lenses, a stabilizing enzyme in liquid form is then advantageously applied as a second step, which is also dropped on the contact lenses, whereby the lipid deposit is finally removed.

Såsom avslutande steg i rengöringsoperationen, sköljes kon- taktlinserna, varefter de kokas i fysiologisk koksaltlösning.As a final step in the cleaning operation, the contact lenses are rinsed, after which they are boiled in physiological saline solution.

Nämnda koksaltlösning bör även uppfylla vissa krav, såsom i princip partikelfrå, varmed förstås en partikelstorlek understigande 0,2 micron, isotonisk, pHvärde 7,0 med bufferkapacitet 6-8, samt steril. u 3 I 7ao461n-1 Med avseende på pflvärdet, så är detta angivet så, att Smärtkänslor vid anbringande av linsen undvikas, vilket eljest ej kan undvikas med felaktigt pH-värde. Felaktigt pH-värde medgör även att pro- teinet i tårvätska denatueras spontant, vilket givetvis ej är önskvärt. I syfte att bibehålla uppställda krav på renhet och sterilitet, så bör lösningen vara engångsförpackad, lämpligen steriliserad genom gammastrâlning.Said saline solution should also meet certain requirements, such as in principle particle-free, by which is meant a particle size of less than 0.2 microns, isotonic, pH value 7.0 with buffer capacity 6-8, and sterile. u 3 I 7ao461n-1 With respect to p fl value, this is stated so that Feelings of pain when applying the lens are avoided, which otherwise can not be avoided with incorrect pH value. Incorrect pH value also means that the protein in tear fluid is denatured spontaneously, which is of course not desirable. In order to maintain the requirements for purity and sterility, the solution should be disposable, preferably sterilized by gamma radiation.

I syfte att klarlägga den rengörande effekten, har undersök* ningar utförts; för protein enligt Lowry, modifierad av Wedler, samt för lipider enligt Boyer et al. Tårvätskeanalys, enligt flera olika källor, anger att vätskan består av Lysozym, Ig G-Globulin, 1-lipoprotein, små mängder av kolhydrater och fosfolipider.In order to clarify the cleansing effect, investigations have been carried out; for Lowry protein, modified by Wedler, and for lipids by Boyer et al. Tear fluid analysis, according to several different sources, indicates that the fluid consists of Lysozyme, Ig G-Globulin, 1-lipoprotein, small amounts of carbohydrates and phospholipids.

En sådan lösning bereddes med följande innehåll: G-Chymotryp- sin, serum albumin, lysozym, bovin mucin, globulin II, B-Globulin III, globulin samt B-lipoprotein, i 0,91 NaCl lösning. Linserna placerades i denna lösning, samt fick kvarligga under natten.Such a solution was prepared with the following contents: G-Chymotrypsin, serum albumin, lysozyme, bovine mucin, globulin II, B-Globulin III, globulin and B-lipoprotein, in 0.91 NaCl solution. The lenses were placed in this solution, and allowed to remain overnight.

Undersökningsmaterialet uppdelades därefter i fyra grupper: l. Efter förvaring i vätskan, sköljdes linserna, samt kokades därefter i steril koksaltlösning. 2. Efter förvaring i vätskan, sköljdes linserna i en "o1eaner“, varefter de förvarades i konserverande koksaltlösning. 3. Efter förvaring i vätskan, behandlades linserna med en enzym- lösning, varpå de sköljdes och kokades. 4. Kontrollinser förvarades i steril koksaltlösning i stället för den enligt ovan beredda vätskan. Därefter behandlades linserna enligt ovan.The test material was then divided into four groups: 1. After storage in the liquid, the lenses were rinsed, and then boiled in sterile saline. After storage in the liquid, the lenses were rinsed in an "oleaner", after which they were stored in preservative saline solution 3. After storage in the liquid, the lenses were treated with an enzyme solution, after which they were rinsed and boiled. instead of the liquid prepared as above, after which the lenses were treated as above.

Efter ovan angiven behandling erhölls följande resultat med avseende på protein och lipider för de fyra grupperna: 1. Protein 3-8 ug per lins.After the above treatment, the following results were obtained with respect to protein and lipids for the four groups: 1. Protein 3-8 μg per lens.

.Total lipider 100-250 ug per lins. 2. Protein 1-N ug per lins..Total lipids 100-250 ug per lens. 2. Protein 1-N ug per lens.

Total lipider 60-120 ug per lins. 3. Protein 0-0,5 ng per lins.Total lipids 60-120 ug per lens. 3. Protein 0-0.5 ng per lens.

Total lipider 0-30 ug per lins. 4. Protein 0-0,2 ng per lins Total lipider 0 ug per lins.Total lipids 0-30 ug per lens. 4. Protein 0-0.2 ng per lens Total lipids 0 ug per lens.

Sättet enligt föreliggande uppfinning medger enkel, snabb och effektiv rengöring av mjuka kontaktlinser. Nämnda rengöringsopera- .tion bör utföras dagligen, med vid högvätskehaltiga linser, vilka bäres dygnet runt, så kan intervallen mellan varje rengöring 780lr61h-1 H utsträckas till varannan eller var tredje dag.The method of the present invention allows simple, fast and efficient cleaning of soft contact lenses. Said cleaning operation should be performed daily, but with high-liquid lenses, which are worn around the clock, the intervals between each cleaning 780lr61h-1H can be extended to every other or every third day.

Med hänvisning till tidigare beskrivna rengöringsoperation, så utgöres det först anbringade vätskeformiga mediet av: Brome- lain, Mannitol, Sorbitol, Etylenediaminotetraacetylsyra samt natrium metabisulfat.With reference to the previously described cleaning operation, the first applied liquid medium consists of: Bromelain, Mannitol, Sorbitol, Ethylenediaminotetraacetyl acid and sodium metabisulfate.

Det därefter anbringade vätskeformiga mediet utgöres av lipas och fosfat buffer. ' Vid en jämförelse med tidigare känd teknik, vilken innefattar en ytterligare operation, nämligen upplösning av det tablettformiga preparatet i vatten, samt även en längre rengöringstid, så är up- penbarligen sättet enligt föreliggande uppfinning ägnat att medge dels ett förenklat handhavande, dels en förkortat rengöringstid.The liquid medium then applied consists of lipase and phosphate buffer. In a comparison with prior art, which involves a further operation, namely dissolving the tablet-shaped preparation in water, as well as a longer cleaning time, the method according to the present invention is obviously suitable for allowing both a simplified handling and a shortened one. cleaning time.

Därutöver medges en avsevärt förbättrad rengöring av kontaktlin- sarna, med hänsyn till den högre enzymatiska aktiviteten. Till skillnad från tidigare kända medel, så avses sättet enligt före- liggande uppfinning även utnyttjat dagligen, dels för rengöring av linserna, dels även i förebyggande syfte mot större avlagringar av protein och lipider, vilka efter en tid är svåra att avlägsna, samt vilka även påverka linsernas egenskaper.In addition, a considerably improved cleaning of the contact lenses is allowed, taking into account the higher enzymatic activity. Unlike previously known agents, the method according to the present invention is also used daily, partly for cleaning the lenses, partly also for preventive purposes against larger deposits of protein and lipids, which after a time are difficult to remove, and which also affect the properties of the lenses.

De typer av enzymer som kan utnyttjas vid rengöringen, kan sammanfattningsvis anges såsom papain eller bromelain, samt en lipolytisk enzym. Som substrat utnyttjas cystein och polysaccarider.The types of enzymes that can be used in the cleaning can be summarized as papain or bromelain, as well as a lipolytic enzyme. Cysteine and polysaccharides are used as substrates.

Aktiviteten kan anges 1 storleksordningen 100 Tyrosin-enheter 0 per ul/protein (Substrat).The activity can be stated in the order of 100 Tyrosine units 0 per ul / protein (Substrate).

Sättet enligt föreliggande uppfinning medger att äggvitan genom enzymen spjälkas till vattenlösliga peptoner, vilka kan sköljas eller kokas bort i fysiologisk koksaltlösning. 1 Sättet enligt föreliggande uppfinning är givetvis ej endast begränsat till det utföríngsexempel som angivits ovan, i syfte att | underlätta förståelsen för uppfinningen, då angivna lösningar I liksom rengöringsoperationen i övrigt uppenbarligen kan modifieras på ett flertal olika sätt, med bibehållande av uppfinnartanken.The method of the present invention allows the egg whites to be cleaved by the enzymes into water-soluble peptones, which can be rinsed or boiled away in physiological saline. The method according to the present invention is of course not limited only to the exemplary embodiment given above, in order that | facilitate the understanding of the invention, since the stated solutions I as well as the cleaning operation in general can obviously be modified in a number of different ways, while maintaining the inventive idea.

Claims (6)

5 vao#614-1 P A T E N T K R A V5 vao # 614-1 P A T E N T K R A V 1. Sätt att rengöra kontaktlinser; innefattande steget att ut- nyttja enzymatisk spjälkning av förekommande avlagringar, k ä n - n e t e c k n a d a v, att en lösning, innefattande papain eller bromelain, samt därutöver en lipolytisk enzym, droppas på de kontaktlinser som avses rengjorda, varvid förekommande äggviteämnen och lipider spjälkas till vattenlösliga peptoner, vilka medelst efterföljande sköljning, samt kokning, i fysiologisk koksaltlösning, avlägsnas.1. Ways to clean contact lenses; comprising the step of utilizing enzymatic cleavage of existing deposits, characterized in that a solution, comprising papain or bromelain, and in addition a lipolytic enzyme, is dropped on the contact lenses intended to be cleaned, whereby any egg whites and lipids are cleaved into water-soluble peptones. , which are removed by subsequent rinsing, as well as boiling, in physiological saline solution. 2. Sätt enligt patentkravet l, k ä n n e t e c k n a d a v, att aktiviteten är i storleksordningen 100 Tyrosin-enheter per nllpro- teín. '2. A method according to claim 1, characterized in that the activity is in the order of 100 tyrosine units per nll protein. ' 3. Sätt enligt något av patentkraven 1 och 2, k ä n n e t e'c k - n a t av, att det anbringade vätskeformiga enzymerna bringas att verka under en tidsrymd i storleksordningen 15 minuter.3. A method according to any one of claims 1 and 2, characterized in that the applied liquid enzymes are allowed to act for a period of time of the order of 15 minutes. 4. U. Sätt enligt något av patentkraven 1 - 3, k ä n n e t e c k - n a t a v, att efterföljande sköljning och kokning utföres i en fysiologisk koksaltlösning med en partikelstorlek understigande 0,2 micron, isotonisk, pH-värde 7,0 med bufferkapacitet 6-8, samt steril.U. A method according to any one of claims 1 to 3, characterized in that subsequent rinsing and boiling are carried out in a physiological saline solution with a particle size of less than 0.2 microns, isotonic, pH value 7.0 with buffer capacity 6- 8, as well as sterile. 5. Sätt enligt något av patentkraven l - H, k ä n n e t e c k - n a t a v, att den enzymatiska lösningen utgöres av bromelain, mannitol, sorbitol, etylenediaminotetraacetylsyra samt natrium metabisulfat. S5. A method according to any one of claims 1 - H, characterized in that the enzymatic solution consists of bromelain, mannitol, sorbitol, ethylenediaminotetraacetyl acid and sodium metabisulfate. S 6. Sätt enligt något av patentkraven 1 - N, k ä n n e t e c k - n a d a v, att den enzymatiska lösningen utgöres av lipas och fosfat buffer. ANFÖRDA PUBLIKATIONER:6. A method according to any one of claims 1 - N, characterized in that the enzymatic solution consists of lipase and phosphate buffer. MENTIONED PUBLICATIONS:
SE7804614A 1978-04-21 1978-04-21 WAY TO CLEAN SOFT CONTACT LENSES SE411152B (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
SE7804614A SE411152B (en) 1978-04-21 1978-04-21 WAY TO CLEAN SOFT CONTACT LENSES
GB7838873A GB2019721B (en) 1978-04-21 1978-10-02 Method and materials for cleaning soft contact lenses
GB7836972A GB2029225B (en) 1978-04-21 1978-10-02 Method and materials for cleaning soft contact lenses
PCT/SE1979/000097 WO1979000963A1 (en) 1978-04-21 1979-04-20 Methods and materials for cleaning soft contact lenses
JP50072079A JPS55500262A (en) 1978-04-21 1979-04-20
NO791335A NO153107C (en) 1978-04-21 1979-04-20 CLEANING CLEANING FOR CLEANING CONTACT LENSES.
FI791296A FI791296A (en) 1978-04-21 1979-04-20 FARING MATERIAL FOR MATERIAL PUTSNING AV MJUKA KONTAKTLINSER
CH1153779A CH643663A5 (en) 1978-04-21 1979-04-20 DRY SUBSTANCE COMPOSITION AND THEIR USE FOR PRODUCING CLEANING LIQUIDS FOR SOFT CONTACT SHELLS.
EP79850032A EP0005131B1 (en) 1978-04-21 1979-04-23 Methods and materials for cleaning soft contact lenses
DE7979850032T DE2965421D1 (en) 1978-04-21 1979-04-23 Methods and materials for cleaning soft contact lenses
EP79900454A EP0015968A1 (en) 1978-04-21 1979-11-19 Methods and materials for cleaning soft contact lenses
SE7804614A SE407470B (en) 1978-04-21 1979-12-19 MAKE CLEANING SOFT CONTACT LENSES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7804614A SE411152B (en) 1978-04-21 1978-04-21 WAY TO CLEAN SOFT CONTACT LENSES

Publications (2)

Publication Number Publication Date
SE7804614L SE7804614L (en) 1979-10-22
SE411152B true SE411152B (en) 1979-12-03

Family

ID=20334707

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7804614A SE411152B (en) 1978-04-21 1978-04-21 WAY TO CLEAN SOFT CONTACT LENSES
SE7804614A SE407470B (en) 1978-04-21 1979-12-19 MAKE CLEANING SOFT CONTACT LENSES

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE7804614A SE407470B (en) 1978-04-21 1979-12-19 MAKE CLEANING SOFT CONTACT LENSES

Country Status (2)

Country Link
GB (2) GB2019721B (en)
SE (2) SE411152B (en)

Also Published As

Publication number Publication date
SE7804614L (en) 1979-10-22
GB2019721A (en) 1979-11-07
SE7910497L (en) 1979-12-19
SE407470B (en) 1980-03-26
GB2029225A (en) 1980-03-19
GB2019721B (en) 1982-06-30
GB2029225B (en) 1982-06-30

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