NO151007B - PROCEDURE FOR PREPARING 2- (2-TENOYLTIO) -PROPIONYLGYLINE - Google Patents

PROCEDURE FOR PREPARING 2- (2-TENOYLTIO) -PROPIONYLGYLINE Download PDF

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Publication number
NO151007B
NO151007B NO802178A NO802178A NO151007B NO 151007 B NO151007 B NO 151007B NO 802178 A NO802178 A NO 802178A NO 802178 A NO802178 A NO 802178A NO 151007 B NO151007 B NO 151007B
Authority
NO
Norway
Prior art keywords
procedure
formula
tenoyltio
propionylgyline
preparing
Prior art date
Application number
NO802178A
Other languages
Norwegian (no)
Other versions
NO151007C (en
NO802178L (en
Inventor
Rinaldo Del Bono
Original Assignee
Mediolanum Farmaceutici Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Farmaceutici Srl filed Critical Mediolanum Farmaceutici Srl
Publication of NO802178L publication Critical patent/NO802178L/en
Publication of NO151007B publication Critical patent/NO151007B/en
Publication of NO151007C publication Critical patent/NO151007C/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Claims (2)

1. Fremgangsmåte ved fremstilling av 2-(2-tenoyltio)-propionylglycin med formelen (I) karakterisert ved at et salt av tiofen-2-tiolkarboksylsyre (II) med formelen omsettes med (2-halopropionyl)-glycin (III) med formelen hvor M betyr et metall, fortrinnsvis natrium eller kalium, og X betyr halogen, fortrinnsvis brom eller klor, idet om-setningen utføres i et vandig eller vann/alkoholmedium ved en temperatur i området -10°Ctil 100°C, fortrinnsvis ved romtemperatur.1. Procedure for the production of 2-(2-thenoylthio)-propionylglycine with the formula (I) characterized in that a salt of thiophene-2-thiolcarboxylic acid (II) with the formula is reacted with (2-halopropionyl)-glycine (III) with the formula where M means a metal, preferably sodium or potassium, and X means halogen, preferably bromine or chlorine, the reaction being carried out in an aqueous or water/alcohol medium at a temperature in the range -10°C to 100°C, preferably at room temperature. 2. Fremgangsmåte ifølge krav 1, karakterisert ved at saltet (II) anvendes i form av en oppløsning erholdt ved in situ omsetning av tiofen-2-karboksylsyre-klorid med et hydrogenmetallsulfid.2. Method according to claim 1, characterized in that the salt (II) is used in the form of a solution obtained by in situ reaction of thiophene-2-carboxylic acid chloride with a hydrogen metal sulphide.
NO802178A 1979-07-20 1980-07-18 PROCEDURE FOR PREPARING 2- (2-TENOYLTIO) -PROPIONYLGYLINE NO151007C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT24534/79A IT1193195B (en) 1979-07-20 1979-07-20 PROCESS FOR PREPARATION OF 2- (2-TENOILTIO) -PROPIONYLGLYCIN

Publications (3)

Publication Number Publication Date
NO802178L NO802178L (en) 1981-01-21
NO151007B true NO151007B (en) 1984-10-15
NO151007C NO151007C (en) 1985-01-23

Family

ID=11213885

Family Applications (1)

Application Number Title Priority Date Filing Date
NO802178A NO151007C (en) 1979-07-20 1980-07-18 PROCEDURE FOR PREPARING 2- (2-TENOYLTIO) -PROPIONYLGYLINE

Country Status (8)

Country Link
AR (1) AR223715A1 (en)
AT (1) AT374195B (en)
CA (1) CA1153382A (en)
DK (1) DK292880A (en)
ES (1) ES493213A0 (en)
IT (1) IT1193195B (en)
NO (1) NO151007C (en)
SE (1) SE8004966L (en)

Also Published As

Publication number Publication date
CA1153382A (en) 1983-09-06
NO151007C (en) 1985-01-23
AR223715A1 (en) 1981-09-15
IT1193195B (en) 1988-06-02
SE8004966L (en) 1981-01-21
DK292880A (en) 1981-01-21
NO802178L (en) 1981-01-21
IT7924534A0 (en) 1979-07-20
AT374195B (en) 1984-03-26
ATA358980A (en) 1983-08-15
ES8105990A1 (en) 1981-07-01
ES493213A0 (en) 1981-07-01

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