NO141892C - PROCEDURE FOR PREPARING 5-FLUORO-2-METHYL-1- (P-METHYLSULPHINYLBENZYLIDE) -INDEN-3-ACETIC ACID - Google Patents

PROCEDURE FOR PREPARING 5-FLUORO-2-METHYL-1- (P-METHYLSULPHINYLBENZYLIDE) -INDEN-3-ACETIC ACID

Info

Publication number
NO141892C
NO141892C NO790360A NO790360A NO141892C NO 141892 C NO141892 C NO 141892C NO 790360 A NO790360 A NO 790360A NO 790360 A NO790360 A NO 790360A NO 141892 C NO141892 C NO 141892C
Authority
NO
Norway
Prior art keywords
methylsulphinylbenzylide
inden
fluoro
methyl
preparing
Prior art date
Application number
NO790360A
Other languages
Norwegian (no)
Other versions
NO790360L (en
NO141892B (en
Inventor
Roger James Tull
Robert Francis Czaja
Richard Ferriss Shuman
Seemon Hayden Pines
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US426864A external-priority patent/US3870753A/en
Priority claimed from US05/486,031 external-priority patent/US3970693A/en
Priority claimed from US05/509,602 external-priority patent/US3944600A/en
Publication of NO790360L publication Critical patent/NO790360L/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO141892B publication Critical patent/NO141892B/en
Publication of NO141892C publication Critical patent/NO141892C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/75—Reactions with formaldehyde
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO790360A 1973-12-20 1979-02-05 PROCEDURE FOR PREPARING 5-FLUORO-2-METHYL-1- (P-METHYLSULPHINYLBENZYLIDE) -INDEN-3-ACETIC ACID NO141892C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US426864A US3870753A (en) 1973-12-20 1973-12-20 Process for preparing indenyl acetic acids
US05/486,031 US3970693A (en) 1974-07-05 1974-07-05 Process for preparing indene acetic acids
US05/509,602 US3944600A (en) 1973-12-20 1974-09-30 Indenylidene-3-acetic acid process for preparing indene acetic acids

Publications (3)

Publication Number Publication Date
NO790360L NO790360L (en) 1975-06-23
NO141892B NO141892B (en) 1980-02-18
NO141892C true NO141892C (en) 1980-05-28

Family

ID=27411527

Family Applications (2)

Application Number Title Priority Date Filing Date
NO744395A NO140857C (en) 1973-12-20 1974-12-05 PROCEDURES FOR THE PREPARATION OF 5-FLUORO-2-METHYL-1- (P-METHYLSULFINYLBENXYLIDENE) -INDEN-3-ACETIC ACID
NO790360A NO141892C (en) 1973-12-20 1979-02-05 PROCEDURE FOR PREPARING 5-FLUORO-2-METHYL-1- (P-METHYLSULPHINYLBENZYLIDE) -INDEN-3-ACETIC ACID

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO744395A NO140857C (en) 1973-12-20 1974-12-05 PROCEDURES FOR THE PREPARATION OF 5-FLUORO-2-METHYL-1- (P-METHYLSULFINYLBENXYLIDENE) -INDEN-3-ACETIC ACID

Country Status (16)

Country Link
JP (1) JPS5331153B2 (en)
AR (2) AR210484A1 (en)
CA (1) CA1044255A (en)
CH (1) CH616152A5 (en)
DD (1) DD116819A5 (en)
DE (1) DE2462380C2 (en)
DK (1) DK140835B (en)
ES (2) ES432921A1 (en)
FI (1) FI62287C (en)
FR (1) FR2255060B1 (en)
GB (1) GB1479519A (en)
IE (1) IE41529B1 (en)
NL (1) NL170534C (en)
NO (2) NO140857C (en)
SE (2) SE426818B (en)
YU (2) YU41017B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732292A (en) * 1970-05-01 1973-05-08 Merck & Co Inc Indenyl compounds
US3822310A (en) * 1971-01-21 1974-07-02 Merck & Co Inc Substituted indenyl acetic acids
NL7200058A (en) * 1971-01-21 1972-07-25

Also Published As

Publication number Publication date
DD116819A5 (en) 1975-12-12
DE2460292B2 (en) 1977-06-16
DE2462380A1 (en) 1977-02-10
SE7415063L (en) 1975-06-23
DK140835C (en) 1980-04-28
DK629674A (en) 1975-08-25
NL7415701A (en) 1975-06-24
NO140857C (en) 1979-11-28
FI62287B (en) 1982-08-31
FI62287C (en) 1982-12-10
CA1044255A (en) 1978-12-12
GB1479519A (en) 1977-07-13
NO790360L (en) 1975-06-23
NO141892B (en) 1980-02-18
JPS5331153B2 (en) 1978-08-31
YU41017B (en) 1986-10-31
FR2255060B1 (en) 1978-07-21
ES432921A1 (en) 1977-03-16
DK140835B (en) 1979-11-26
NO140857B (en) 1979-08-20
FI348974A (en) 1975-06-21
AU7623674A (en) 1976-06-10
NL170534B (en) 1982-06-16
SE440774B (en) 1985-08-19
YU55981A (en) 1982-06-30
IE41529L (en) 1975-06-20
NO744395L (en) 1975-07-14
SE8107702L (en) 1981-12-22
CH616152A5 (en) 1980-03-14
NL170534C (en) 1982-11-16
ES455333A1 (en) 1978-05-01
FR2255060A1 (en) 1975-07-18
DE2460292A1 (en) 1975-06-26
YU331674A (en) 1982-02-28
JPS5095254A (en) 1975-07-29
DE2462380C2 (en) 1982-11-11
AR206334A1 (en) 1976-07-15
AR210484A1 (en) 1977-08-15
SE426818B (en) 1983-02-14
IE41529B1 (en) 1980-01-30

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