NO137811B - DENTAL CARE. - Google Patents
DENTAL CARE. Download PDFInfo
- Publication number
- NO137811B NO137811B NO494973A NO494973A NO137811B NO 137811 B NO137811 B NO 137811B NO 494973 A NO494973 A NO 494973A NO 494973 A NO494973 A NO 494973A NO 137811 B NO137811 B NO 137811B
- Authority
- NO
- Norway
- Prior art keywords
- monofluorophosphate
- calcium carbonate
- dental care
- aluminum oxide
- agent
- Prior art date
Links
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 39
- 239000003795 chemical substances by application Substances 0.000 claims description 29
- 238000005498 polishing Methods 0.000 claims description 22
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 19
- 229940074371 monofluorophosphate Drugs 0.000 claims description 18
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 9
- 239000000551 dentifrice Substances 0.000 description 22
- 239000000606 toothpaste Substances 0.000 description 14
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 12
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 12
- 238000003860 storage Methods 0.000 description 11
- 229940034610 toothpaste Drugs 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 229940091249 fluoride supplement Drugs 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 8
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 229910052782 aluminium Inorganic materials 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 229910052783 alkali metal Inorganic materials 0.000 description 4
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 4
- -1 fluoride compound Chemical class 0.000 description 4
- 150000002222 fluorine compounds Chemical class 0.000 description 4
- 230000005484 gravity Effects 0.000 description 4
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 4
- 239000011775 sodium fluoride Substances 0.000 description 4
- 235000013024 sodium fluoride Nutrition 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- 239000003349 gelling agent Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- UBLAMKHIFZBBSS-UHFFFAOYSA-N 3-Methylbutyl pentanoate Chemical compound CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 241000206575 Chondrus crispus Species 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 2
- 229960002799 stannous fluoride Drugs 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 239000005696 Diammonium phosphate Substances 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- BLXGLHZAGQSPEQ-UHFFFAOYSA-K [F].[Na+].[Na+].[Na+].[O-]P([O-])([O-])=O Chemical compound [F].[Na+].[Na+].[Na+].[O-]P([O-])([O-])=O BLXGLHZAGQSPEQ-UHFFFAOYSA-K 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- GFIKIVSYJDVOOZ-UHFFFAOYSA-L calcium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Ca+2].[O-]P([O-])(F)=O GFIKIVSYJDVOOZ-UHFFFAOYSA-L 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 239000011538 cleaning material Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- UOCIZHQMWNPGEN-UHFFFAOYSA-N dialuminum;oxygen(2-);trihydrate Chemical compound O.O.O.[O-2].[O-2].[O-2].[Al+3].[Al+3] UOCIZHQMWNPGEN-UHFFFAOYSA-N 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 229910000388 diammonium phosphate Inorganic materials 0.000 description 1
- 235000019838 diammonium phosphate Nutrition 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- QJLVYSQIYAHNJO-UHFFFAOYSA-L magnesium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Mg+2].[O-]P([O-])(F)=O QJLVYSQIYAHNJO-UHFFFAOYSA-L 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/526—Corrosion inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
- Dental Preparations (AREA)
Description
Oppfinnelsen angår et tannpleiemiddel inneholdende et vann-oppløselig monofluorfosfat. The invention relates to a dental care agent containing a water-soluble monofluorophosphate.
Vannoppløselige monofluorfosfater, og spesielt alkalimetall-monofluorfosfater som natriummonofluorfosfat, er blitt anvendt som fluorgivende, aktive bestanddeler i tannpleiemidler. De polerings-midler som kan anvendes i slike tannpleiemidler, har vært gjen- Water-soluble monofluorophosphates, and especially alkali metal monofluorophosphates such as sodium monofluorophosphate, have been used as fluorinating, active ingredients in dentifrices. The polishing agents that can be used in such dental care agents have been re-
stand for omfattende undersøkelser. capable of extensive research.
Et tann<p>leiemiddel inneholdende natriummonofluorfosfat og et poleringsmiddel som er fritt for uppløselig fosfatsalt og som i virkeligheten bare består av kalsiumcarbonat, mister en vesentlig mengde oppløst fluor ved henstand. A dentifrice containing sodium monofluorophosphate and a polishing agent which is free of soluble phosphate salt and which in reality consists only of calcium carbonate, loses a significant amount of dissolved fluoride on standing.
For å oppnå maksimal virkning av monofluorfosfatet er det tid-ligere bare blitt anvendt mindre mengder av kalsiumsalt, som di-kalsiumfosfat eller kalsiumcarbonat, eller magnesiumsalt, og det er som hovedpoleringsmiddel blitt anvendt uoppløselig alkalimetallmetafosfat. Det har hittil vært vanlig praksis å pakke monofluorfosfattannpleiemidler i en med epoxyharpiks foret aluminiumbeholder eller i'forede beholdere av andre metaller eller i plastbeholdere da bestanddelene i forskjellige monofluorfosfattannpleiemidler be-virker korrosjon av uforede aluminiumtuber ved lagring. In order to achieve the maximum effect of the monofluorophosphate, only small amounts of calcium salt, such as dicalcium phosphate or calcium carbonate, or magnesium salt, have previously been used, and insoluble alkali metal metaphosphate has been used as the main polishing agent. Up until now, it has been common practice to pack monofluorophosphate dentifrices in an aluminum container lined with epoxy resin or in lined containers of other metals or in plastic containers, as the ingredients in various monofluorophosphate dentifrices cause corrosion of unlined aluminum tubes during storage.
I US patentskrift nr. 3060098 er beskrevet et tannpleiemiddel som kan inneholde som det samlede poleringsmiddel 60,0-99,9% av en forbindelse som kalsiumcarbonat og 0,1-4 0% kalsinert a-aluminiumoxyd. En fluoridforbindelse kan ifølge patentskriftet være tilstede, men bare enkle, vannoppløselige fluoridforbindelser, som natriumfluorid og toverdig tinnfluorid, er beskrevet. US patentskriftet går ut på å fremstille et tannpleiemiddel med forbedrede poleringsegenskaper ved hjelp av en spesiell kvalitet av vannfritt a-aluminiumoxyd bestående av partikler med en glatt overflate og avrundede kanter og med endel andre spesielle fysikalske parametere som sammen med et supplerende poleringsmiddel som bl.a. kan bestå av kalsiumcarbonat, vil gi den ønskede forbedrede tannpolering. US Patent No. 3060098 describes a dental care agent which can contain as a total polishing agent 60.0-99.9% of a compound such as calcium carbonate and 0.1-40% calcined α-aluminium oxide. According to the patent, a fluoride compound may be present, but only simple, water-soluble fluoride compounds, such as sodium fluoride and divalent stannous fluoride, are described. The US patent is about producing a dental care product with improved polishing properties using a special quality of anhydrous α-aluminum oxide consisting of particles with a smooth surface and rounded edges and with a number of other special physical parameters which together with a supplementary polishing agent such as . may consist of calcium carbonate, will provide the desired improved tooth polishing.
Da det i US patentskrift nr. 3060098 bare er foreslått som fluoridforbindelse å anvende enkle fluoridforbindelser og som aluminiumoxyd å anvende kalsinert a-aluminiumoxyd, vil et tannpleiemiddel som beskrevet i US patentskriftet gi en utilfredsstillende tilbakeholdelse av oppløselig fluorid efter lengre tids lagring av tannpleiemidlet. Since in US patent document no. 3060098 it is only proposed to use simple fluoride compounds as a fluoride compound and as aluminum oxide to use calcined α-aluminum oxide, a dentifrice as described in the US patent document will give an unsatisfactory retention of soluble fluoride after long-term storage of the dentifrice.
I US patentskrift nr. 3119743 er beskrevet et tannpleiemiddel inneholdende kalsiumcarbonat som poleringsmiddel og et alkalimono-fluorfosfat som fluoravgivende forbindelse. Forsøk har imidlertid vist at det fås en meget dårlig tilbakeholdelse av oppløselig fluor i et slikt tannpleiemiddel efter flere ukers lagring. US Patent No. 3119743 describes a dental care agent containing calcium carbonate as a polishing agent and an alkali monofluorophosphate as a fluorine-releasing compound. Experiments have shown, however, that there is a very poor retention of soluble fluoride in such a dental care agent after several weeks of storage.
I US patentskrift nr. 3227618 er beskrevet et tannpleiemiddel som inneholder natriummonofluorfosfat og et i vann uoppløselig, forenlig poleringsmateriale som omfatter en blanding av en hovedsakelig andel av et uoppløselig alkalimetallmetafosfat og en mindre andel av uoppløselige kalsium- eller magnesiumpoleringsmidler. US patent document no. 3227618 describes a dentifrice containing sodium monofluorophosphate and a water-insoluble, compatible polishing material comprising a mixture of a main proportion of an insoluble alkali metal metaphosphate and a minor proportion of insoluble calcium or magnesium polishing agents.
Det er i US patentskriftet uttrykt at poleringsmaterialet bør være fritt for kalsium- og magnesiumpoleringsmidler i en slik mengde at de i vesentlig grad vil fjerne fluorfosfationene fra en vandig oppløsning, og dette må tas som en klar'advarsel mot å anvende natriummonofluorfosfat som fluorgivende forbindelse i tannpleiemidler sammen med store mengder kalsiumcarbonat som poleringsmiddel. It is stated in the US patent that the polishing material should be free of calcium and magnesium polishing agents in such an amount that they will substantially remove the fluorophosphate ions from an aqueous solution, and this must be taken as a clear warning against using sodium monofluorophosphate as a fluorinating compound in dentifrices together with large amounts of calcium carbonate as a polishing agent.
I norsk patentskrift nr. 129499 er beskrevet tannpleiemidler som inneholder natriummonofluorfosfat og a-aluminiumoxydtrihydrat. Det er også i det norske patentskrift angitt at tannpleiemidlet eventuelt kan inneholde en liten mengde av andre vanlige poler-ingsmidler, deriblant kalsiumcarbonat. Det i det norske patentskrift beskrevne tannpleiemiddel inneholder en grov kvalitet av hydratisert aluminiumoxyd med spesielle poleringsegenskaper. Den i det norske paentskrift foreslåtte anvendelse av natriummonofluorfosfat som fluorgivende forbindelse stilles på linje med anvendelse av enkle fluorider, som natriumfluorid og toverdig tinnfluorid. Patentskriftet befatter seg ikke med problemer an-gående en god tilbakeholdelse av oppløselig fluorid i tannpleiemidler efter lengre tids lagring av tannpleiemidlene. In Norwegian patent document no. 129499, dentifrices containing sodium monofluorophosphate and α-aluminium oxide trihydrate are described. It is also stated in the Norwegian patent document that the dental care product may possibly contain a small amount of other common polishing agents, including calcium carbonate. The dentifrice described in the Norwegian patent document contains a coarse grade of hydrated aluminum oxide with special polishing properties. The use of sodium monofluorophosphate as a fluorinating compound proposed in the Norwegian patent is aligned with the use of simple fluorides, such as sodium fluoride and divalent stannous fluoride. The patent does not deal with problems regarding a good retention of soluble fluoride in dental care products after long-term storage of the dental care products.
Det tilveiebringes ved oppfinnelsen et monofluorfosfattannpleiemiddel som byr på spesielle fordeler sammenlignet med kjente monofluorfosfattannpleiemidler inneholdende hydratisert aluminiumoxyd, kalsiumcarbonat eller uoppløselig alkalimetallmetafosfat. The invention provides a monofluorophosphate dentifrice which offers particular advantages compared to known monofluorophosphate dentifrices containing hydrated aluminum oxide, calcium carbonate or insoluble alkali metal metaphosphate.
Mer spesielt unngås ved tannpleiemidlet ifølge oppfinnelsen de ustabile egenskaper til kjente monofluorfosfattannpleiemidler inneholdende hydratisert aluminiumoxyd %ller kalsiumcarbonat som er fritt for uoppløselig fosfat. Det tilveiebringes ved oppfinnelsen også et monofluorfosfattannpleiemiddel som ved lagring ikke i vesentlig grad korroderer uforede aluminiumbeholdere. More particularly, the dentifrice according to the invention avoids the unstable properties of known monofluorophosphate dentifrices containing hydrated aluminum oxide or calcium carbonate which is free of insoluble phosphate. The invention also provides a monofluorophosphate dentifrice which does not significantly corrode unlined aluminum containers during storage.
Oppfinnelsen angår således et tannpleiemiddel inneholdende et vannoppløselig monofluorfosfat og 20-95%, basert på tannpleiemidlet, av et i vann uoppløselig, forenlig poleringsmiddel omfattende en blanding av kalsiumcarbonat og hydratisert alumrniumoxyd, og tannpleiemidlet er særpreget ved at kalsiumcarbonatet utgjør den hovedsakelige bestanddel av poleringsmidlet ocp at forholdet mellom kalsiumcarbonatet og det hydratiserte aluminiumoxyd er 3:1-1000:1. The invention thus concerns a dentifrice containing a water-soluble monofluorophosphate and 20-95%, based on the dentifrice, of a water-insoluble, compatible polishing agent comprising a mixture of calcium carbonate and hydrated aluminum oxide, and the dentifrice is characterized by the fact that the calcium carbonate constitutes the main component of the polish that the ratio between the calcium carbonate and the hydrated aluminum oxide is 3:1-1000:1.
Det kommersielt tilgjengelige natriummonofluorfosfat kan ha en sterkt varierende renhet. Det kan anvendes med en hvilken "som helst egnet renhet, med den betingelse åt eventuelle forurensninger ikke i vesentlig grad uheldig påvirker de ønskede egenskaper.. Den ønskede renhet er som regel minst ca. 80%. For oppnåelse av de beste resultater bør den være minst 85%, fortrinnsvis minst 90 vekt%, natriummonofluorfosfat ■ idet resten hovedsakelig er forurensninger eller biprodukter fra fremstillingen, som natrium-fluorid og vann-oppløselig natriumfosfatsalt etc. Uttrykt på en annen måte bør det anvendte natriummonofluorfosfat ha et samlet fluoridinnhold av over 12%, fortrinnsvis over 12,7%, et innhold av ikke over 1,5%, fortrinnsvis ikke over 1,2%, fritt natriumfluorid og et natrium-monof luorf osf atinnhold av minst 12%, fortrinnsvis minst 12,1% alt beregnet som fluor. The commercially available sodium monofluorophosphate can have a widely varying purity. It can be used with any suitable purity, with the condition that any contamination does not significantly adversely affect the desired properties. The desired purity is usually at least approx. 80%. To achieve the best results, it should be at least 85%, preferably at least 90% by weight, sodium monofluorophosphate ■ with the rest mainly being impurities or by-products from the manufacture, such as sodium fluoride and water-soluble sodium phosphate salt etc. Expressed in another way, the sodium monofluorophosphate used should have a total fluoride content of over 12% , preferably above 12.7%, a content of not more than 1.5%, preferably not more than 1.2%, of free sodium fluoride and a sodium monofluorine phosphate content of at least 12%, preferably at least 12.1% all calculated as fluoride.
Monofluorfosfatet er som regel tilstede i en mengde slik at det oppnås 0,01-1% fluor i tannpleiemidlet. Natriummonofluor-fosfatet er således i alminnelighet tilstede i en mengde av 0,05-7,6%. The monofluorophosphate is usually present in an amount such that 0.01-1% fluorine is obtained in the dental care product. The sodium monofluorophosphate is thus generally present in an amount of 0.05-7.6%.
Kalsiumcarbonatet i poleringsmidlet kan utgjøres av kritt. Dette anvendes som regel i form av et pulver med en partikkel-størrelse av 1-10 um. The calcium carbonate in the polishing agent can be made up of chalk. This is usually used in the form of a powder with a particle size of 1-10 µm.
Det foretrekkes å anvende en kalsiumcarbonatkvalitet med en forholdsvis høy tilsynelatende egenvekt av f.eks. 0,9-1,2. Om ønskes kan det også anvendes kalsiumcarbonatkvaliteter med en It is preferred to use a calcium carbonate quality with a relatively high apparent specific gravity of e.g. 0.9-1.2. If desired, calcium carbonate grades with a
■to■two
lavere tilsynelatende egenvekt'av f.eks. 0,7-0,9. Med "tilsynelatende egenvekt" .-er ment saltewt- s egenvekt i ustampet otilstand. lower apparent specific gravity of e.g. 0.7-0.9. By "apparent specific gravity" is meant the specific gravity of saltewt in the unstamped condition.
o o
Tannpleiemidlets samlede innhold av poleringsmiddel er 20-.95 vekt% av det 'samlede tannpleiemiddel. For en tannkrem vil poleringsmiddelinnholdet_som regel utgjøre 20-75%, mens polerings-O The dental care product's total content of polishing agent is 20-.95% by weight of the total dental care product. For a toothpaste, the polishing agent content_will usually amount to 20-75%, while polishing O
midlene i tannpulver som regel^vil være tilstede i en større mengde av f.eks. 70-95%. the agents in tooth powder will usually be present in a larger quantity of e.g. 70-95%.
Et hvilket som helst ove^flateaktivt eller rensende materiale kan anvendes-i tannpleiemidlene. Det er ønskelig å anvende slike forenlige materialer^oo<r> å oppnå ytterligere rensende, skummende og antibakterielle egenskaper avhengig av den spesielle type av det oyerflateaktive materiAe, og de velges på lignende måte. Disse Any surfactant or cleaning material can be used in the dentifrices. It is desirable to use such compatible materials to obtain additional cleansing, foaming and antibacterial properties depending on the particular type of surface-active material, and they are selected in a similar manner. These
o o
overflateaktive forbindelser er som regel vannoppløselige, organiske forbindelser og kan ha en anionaktiv, ikke-ioneaktiv eller kationaktiv struktur. Det foretrekkes som regel å anvende de vannoppløselige, ikke-såpe eller syntetiske, organiske overflateaktive forbindelser. surface-active compounds are usually water-soluble organic compounds and can have an anion-active, non-ion-active or cation-active structure. It is generally preferred to use the water-soluble, non-soap or synthetic organic surface-active compounds.
De forskjellige overflateaktive materialer kan anvendes i en hvilken som helst egnet mengde, som regel i en mengde av 0,05 - The various surface-active materials can be used in any suitable amount, usually in an amount of 0.05 -
10 vekt%, fortrinnsvis 0,5-5 vekt%, av tannpleiemidlet. 10% by weight, preferably 0.5-5% by weight, of the dental care agent.
Ved fremstilling av tannkrem bør væsker og faste stoffer av-passes slik i forhold til hverandre at det oppnås en ekstruderbar kremlignende masse med ønsket^konsistens. Væskene i tannkremen vil som regel bestå hovedsakelig av vann, glycerol, sorbitol og propylenglycol eller blandinger derav. Det er som regel fordel-aktig å anvende en blanding av både vann og et fuktemiddel eller bindemiddel, som glycerol eller sorbitol. Det foretrekkes å anvende glycerol. Det samlede væskeinnhold vil som regel være 20-75 vekt% av blandingen. Det foretrekkes også å anvende et geleringsmiddel i tannkremer, som de naturlige og syntetiske gummier og gummilignende materialer, f.eks. irsk mose, tragantgummi, natriumcarboxymethylcellulose, polyvinylpyrolidon og stivelse etc. Irsk mose og natriumcarboxymethylcellulose er spesielt forenlig In the production of toothpaste, liquids and solids should be matched in such a way that an extrudable cream-like mass with the desired consistency is obtained. The liquids in the toothpaste will usually consist mainly of water, glycerol, sorbitol and propylene glycol or mixtures thereof. It is usually advantageous to use a mixture of both water and a wetting agent or binder, such as glycerol or sorbitol. It is preferred to use glycerol. The total liquid content will usually be 20-75% by weight of the mixture. It is also preferred to use a gelling agent in toothpastes, such as the natural and synthetic gums and gum-like materials, e.g. Irish moss, gum tragacanth, sodium carboxymethylcellulose, polyvinylpyrrolidone and starch etc. Irish moss and sodium carboxymethylcellulose are particularly compatible
og ér, som vist, foretrukne geleringsmidler. Gummiinnholdet er som regel inntil ca. 10%, fortrinnsvis 0,5-5%, av blandingens vekt. and are, as shown, preferred gelling agents. The rubber content is usually up to approx. 10%, preferably 0.5-5%, of the weight of the mixture.
En tannkrem med forbedrede fysikalske egenskaper kan fremstilles fra kalsiumcarbonat. og hydratisert aluminiumoxyd suspen-dert i en gel omfattende vann, fuktemiddel og geleringsmiddel, sammen med fluor - forbindelsen og den organiske, ikke-såpe, syntetiske overflateaktive forbindelse og hydratisert aluminiumoxyd, idet tannkremen har en pH av 7-9,5. Disse tannkremer har en sterkt forbedret lagringsstabilitet over lengre tid og spesielt ved for-høyet temperatur. Aluminiumoxydet virker som en stabilisator og modifiseringsmiddel slik at en hvilken som helst tilbøyelighet til separering eller synerese i tannkremen i den sammenklembare tube elimineres eller hindres. A toothpaste with improved physical properties can be made from calcium carbonate. and hydrated aluminum oxide suspended in a gel comprising water, wetting agent and gelling agent, together with the fluorine compound and the organic, non-soap, synthetic surfactant compound and hydrated aluminum oxide, the toothpaste having a pH of 7-9.5. These toothpastes have a greatly improved storage stability over a longer period of time and especially at elevated temperatures. The aluminum oxide acts as a stabilizer and modifier so that any tendency to separation or syneresis in the toothpaste in the squeezable tube is eliminated or prevented.
Det foretrekkes at forholdet mellom kalsiumcarbonat og aluminiumoxyd ikke er over 100:1 og at det helst er 35:1 - 52:1. It is preferred that the ratio between calcium carbonate and aluminum oxide is not over 100:1 and that it is preferably 35:1 - 52:1.
Det er ifølge oppfinnelsen tilstrekkelig aluminiumoxyd tilstede til" sterkt å forlenge den tid monofluorfosfatet holder seg i det vesentlige oppløselig, f.eks. for å sikre at minst, og fortrinnsvis mer enn, 40% og helst minst 50% av det opprinnelige monofluorfosfatinnhold er oppløselig efter akselerert lagring av tannpleiemidlet i 9 uker ved 4 9°C. According to the invention, sufficient aluminum oxide is present to greatly extend the time the monofluorophosphate remains essentially soluble, e.g. to ensure that at least, and preferably more than, 40% and preferably at least 50% of the original monofluorophosphate content is soluble after accelerated storage of the dentifrice for 9 weeks at 4 9°C.
Egnede eksempler på hydratisert aluminiumoxyd som kan anvendes, er de former som er kjent som a- og p<->aluminiumoxydtrihydrat, og blandinger derav. Det anvendes som regel i form av fine partikler med en hvilken som helst ønsket partikkelstørrelse ved fremstillingen av tannkremen. Det foretrekkes i praksis å anvende a-trihydratformen med minst 90% av partiklene med en størrelse av -325 mesh (U.S. standard) og ikke flere enn 5 vekt% Suitable examples of hydrated aluminum oxide which can be used are the forms known as a- and p<-> aluminum oxide trihydrate, and mixtures thereof. It is usually used in the form of fine particles with any desired particle size in the manufacture of the toothpaste. It is preferred in practice to use the α-trihydrate form with at least 90% of the particles having a size of -325 mesh (U.S. standard) and no more than 5% by weight
av partiklene med en størrelse under 5 um. Det har vist seg at det er mest ønskelig med hydratisert aluminiumoxyd i en mengde av 0,25-10 vekt%, fortrinnsvis 1 vekt% av tannpleiemidlet. Forskjellige andre materialer kan anvendes i tannpleiemidlet ifølge oppfinnelsen. Eksempler på disse er farve- eller hvitestoffer, konserveringsmidler, siliconer, klorofyllforbindelser, ammoniakk-materialer som urinstoff, diammoniumfosfat og blandinger derav, antibakte-rielle midler og smaks- eller søtemidler. of the particles with a size below 5 µm. It has been shown that it is most desirable to use hydrated aluminum oxide in an amount of 0.25-10% by weight, preferably 1% by weight of the dental care agent. Various other materials can be used in the dental care product according to the invention. Examples of these are coloring or bleaching agents, preservatives, silicones, chlorophyll compounds, ammonia materials such as urea, diammonium phosphate and mixtures thereof, antibacterial agents and flavoring or sweetening agents.
Tannkremene bør ha en for anvendelse praktisk pH. En nøytral til basisk pH er spesielt ønskelig. Et opprinnelig pH-område av 7-9,5, fortrinnsvis 7,5, anses å være det mest praktiske for bruk. En henvisning-til pH heri gjelder for pH bestemt direkte i tannkremen. Om nødvendig kan basiske materialer tilsettes for efter ønske å regulere pH. The toothpastes should have a practical pH for use. A neutral to basic pH is particularly desirable. An initial pH range of 7-9.5, preferably 7.5, is considered to be the most practical for use. A reference to pH herein applies to pH determined directly in the toothpaste. If necessary, basic materials can be added to adjust the pH as desired.
Beholderen for tannpleiemidlet er som regel en tube hvorfra tannkremen kan ekstruderes. Det er en særlig fordel ved tannpleiemidlet ifølge oppfinnelsen at det kan pakkes i en uforet aluminiumbeholder og bevare ønskelige kosmetiske og rheologiske egenskaper ved lagring uten å forårsake noen vesentlig lagdannelse eller korrosjon av det aluminium som det er i kontakt med. The container for the toothpaste is usually a tube from which the toothpaste can be extruded. It is a particular advantage of the dental care agent according to the invention that it can be packed in an unlined aluminum container and preserve desirable cosmetic and rheological properties during storage without causing any significant layer formation or corrosion of the aluminum with which it is in contact.
For standardiserte undersøkelsesformål fremstilles tannpleiemidlene med ca. 0,76% natriummonofluorfosfat med bestemmelse av det opprinnelige monofluorfosfatinnhold som er tilstede, ved akselererte lagringsforsøk. For standardized examination purposes, the dental care products are produced with approx. 0.76% sodium monofluorophosphate with determination of the initial monofluorophosphate content present, by accelerated storage tests.
Tannpleiemidlene ifølge eksemplene ble fremstilt på vanlig måte, og alle mengder i eksemplene er basert på vekt dersom intet annet er angitt. The dentifrices according to the examples were prepared in the usual way, and all amounts in the examples are based on weight if nothing else is stated.
Hvert av tannpleiemidlene ble lagret ved *+9°C, og det pro-sentuelle innhold av monofluorfosfat ble periodevis bestemt som fluorid. 3 ukers lagring under disse betingelser tilsvarte ca. 1 års lagring ved værelsetearperatur. Resultatene er gjengitt i den neden-stående tabell: Each of the dentifrices was stored at *+9°C, and the percentage content of monofluorophosphate was periodically determined as fluoride. 3 weeks of storage under these conditions corresponded to approx. 1 year storage at room temperature. The results are reproduced in the table below:
Det fremgår at mer opploselig fluor ble tilbakeholdt i midlet C enn i midlene A og B. It appears that more soluble fluorine was retained in agent C than in agents A and B.
Eksempel 2 Example 2
Detfolgende tannpleiemiddel ligger også innen oppfinnelsens ramme: The following toothpaste is also within the scope of the invention:
Andre monofluorfosfatsalter enn natriummonofluorfosfat, Na2P0^F, som har tilstrekkelig vannopploselighet til at de kan anvendes' ifolge oppfinnelsen, omfatter kalsiummonofluorfosfat, magnesiummonofluor-fosfat og aluminiummonofluorfosfat. Uttrykket "monofluorfosfat" Monofluorophosphate salts other than sodium monofluorophosphate, Na2P0^F, which have sufficient water solubility to enable them to be used according to the invention, include calcium monofluorophosphate, magnesium monofluorophosphate and aluminum monofluorophosphate. The term "monofluorophosphate"
som anvendt heri omfatter også monofluorpolyfosfater, som NV3°9F' K1+P3°9F» (NVl,P3°9F' Na3KP309F, (NH^NaP^F og Li^P^F. as used herein also includes monofluoropolyphosphates, such as NV3°9F' K1+P3°9F» (NVl,P3°9F' Na3KP309F, (NH^NaP^F and Li^P^F.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78573168A | 1968-12-20 | 1968-12-20 | |
US87824169A | 1969-11-19 | 1969-11-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO137811B true NO137811B (en) | 1978-01-23 |
NO137811C NO137811C (en) | 1978-05-03 |
Family
ID=27120434
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO470669A NO129500B (en) | 1968-12-20 | 1969-11-28 | |
NO494973A NO137811C (en) | 1968-12-20 | 1973-12-27 | DENTAL CARE. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO470669A NO129500B (en) | 1968-12-20 | 1969-11-28 |
Country Status (12)
Country | Link |
---|---|
BE (1) | BE742639A (en) |
CH (1) | CH548775A (en) |
DE (1) | DE1962143A1 (en) |
DK (1) | DK124920B (en) |
ES (1) | ES374187A1 (en) |
FI (1) | FI50053C (en) |
FR (1) | FR2026643A1 (en) |
GB (1) | GB1265040A (en) |
IE (1) | IE33884B1 (en) |
NL (1) | NL6918636A (en) |
NO (2) | NO129500B (en) |
SE (1) | SE373747C (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2555454A1 (en) * | 1974-12-13 | 1976-06-16 | Colgate Palmolive Co | TOOTHPASTE |
-
1969
- 1969-11-28 NO NO470669A patent/NO129500B/no unknown
- 1969-12-03 ES ES374187A patent/ES374187A1/en not_active Expired
- 1969-12-04 BE BE742639D patent/BE742639A/xx unknown
- 1969-12-11 NL NL6918636A patent/NL6918636A/xx unknown
- 1969-12-11 DE DE19691962143 patent/DE1962143A1/en active Pending
- 1969-12-15 GB GB1265040D patent/GB1265040A/en not_active Expired
- 1969-12-15 FR FR6943346A patent/FR2026643A1/fr not_active Withdrawn
- 1969-12-16 IE IE168069A patent/IE33884B1/en unknown
- 1969-12-16 SE SE6917305A patent/SE373747C/en unknown
- 1969-12-17 CH CH1876769A patent/CH548775A/en not_active IP Right Cessation
- 1969-12-17 DK DK666769A patent/DK124920B/en unknown
- 1969-12-19 FI FI369869A patent/FI50053C/en active
-
1973
- 1973-12-27 NO NO494973A patent/NO137811C/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES374187A1 (en) | 1972-03-16 |
FI50053B (en) | 1975-09-01 |
DK124920B (en) | 1972-12-11 |
FR2026643A1 (en) | 1970-09-18 |
DE1962143A1 (en) | 1970-07-02 |
NL6918636A (en) | 1970-06-23 |
NO129500B (en) | 1974-04-22 |
GB1265040A (en) | 1972-03-01 |
SE373747B (en) | 1975-02-17 |
CH548775A (en) | 1974-05-15 |
FI50053C (en) | 1975-12-10 |
BE742639A (en) | 1970-05-14 |
SE373747C (en) | 1976-06-14 |
IE33884B1 (en) | 1974-11-27 |
IE33884L (en) | 1970-06-20 |
NO137811C (en) | 1978-05-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4923684A (en) | Tripolyphosphate-containing anti-calculus toothpaste | |
US3935305A (en) | Toothpaste | |
US4562066A (en) | Astringent dentifrice containing monofluorophosphate | |
US4528181A (en) | Dentifrice containing dual sources of fluoride | |
NO169817B (en) | toothpaste | |
US4022881A (en) | Dentifrice | |
US3937804A (en) | Toothpaste | |
US4160022A (en) | Toothpaste | |
US3943240A (en) | Toothpaste | |
US3935304A (en) | Dental creams | |
GB1569757A (en) | Dentifrices | |
US3864471A (en) | Stable dentifrices containing a monofluorophosphate, an insoluble metaphosphate, and calcium carbonate | |
US4046872A (en) | Dental cream | |
US3937321A (en) | Toothpaste | |
US4581228A (en) | Toothpaste composition and plastic containers containing the same | |
US4075317A (en) | Dental cream composition | |
US3937803A (en) | Flavored dental creams | |
NL8202589A (en) | TOOTHPASTE. | |
NO180706B (en) | Stabilized stannous fluoride preparations for oral care | |
NO132224B (en) | ||
US4412983A (en) | Dentifrices containing amorphous silica | |
US4562065A (en) | Astringent dentifrice | |
DK157728B (en) | PACKAGED DENTAL CARE | |
US3956478A (en) | Dentifrice composition | |
NO137811B (en) | DENTAL CARE. |