NO129500B - - Google Patents
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- NO129500B NO129500B NO470669A NO470669A NO129500B NO 129500 B NO129500 B NO 129500B NO 470669 A NO470669 A NO 470669A NO 470669 A NO470669 A NO 470669A NO 129500 B NO129500 B NO 129500B
- Authority
- NO
- Norway
- Prior art keywords
- monofluorophosphate
- calcium carbonate
- aluminum oxide
- insoluble
- agent
- Prior art date
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 42
- 239000003795 chemical substances by application Substances 0.000 claims description 26
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 21
- 229940074371 monofluorophosphate Drugs 0.000 claims description 18
- 229910052783 alkali metal Inorganic materials 0.000 claims description 16
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims description 13
- 238000005498 polishing Methods 0.000 claims description 12
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical group OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 9
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 239000000551 dentifrice Substances 0.000 description 19
- 239000000606 toothpaste Substances 0.000 description 14
- 229910052782 aluminium Inorganic materials 0.000 description 13
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 13
- 239000000463 material Substances 0.000 description 12
- 229940034610 toothpaste Drugs 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 239000000047 product Substances 0.000 description 7
- 239000002245 particle Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 description 5
- 230000007797 corrosion Effects 0.000 description 5
- 238000005260 corrosion Methods 0.000 description 5
- 229940091249 fluoride supplement Drugs 0.000 description 5
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 5
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 5
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 4
- 230000005484 gravity Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- 239000003349 gelling agent Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 125000005341 metaphosphate group Chemical group 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- UBLAMKHIFZBBSS-UHFFFAOYSA-N 3-Methylbutyl pentanoate Chemical compound CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000206575 Chondrus crispus Species 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- -1 fluoride compound Chemical class 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 241000416162 Astragalus gummifer Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 239000005696 Diammonium phosphate Substances 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000047703 Nonion Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- ROPDWRCJTIRLTR-UHFFFAOYSA-L calcium metaphosphate Chemical compound [Ca+2].[O-]P(=O)=O.[O-]P(=O)=O ROPDWRCJTIRLTR-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- GFIKIVSYJDVOOZ-UHFFFAOYSA-L calcium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Ca+2].[O-]P([O-])(F)=O GFIKIVSYJDVOOZ-UHFFFAOYSA-L 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 229910000388 diammonium phosphate Inorganic materials 0.000 description 1
- 235000019838 diammonium phosphate Nutrition 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- QJLVYSQIYAHNJO-UHFFFAOYSA-L magnesium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Mg+2].[O-]P([O-])(F)=O QJLVYSQIYAHNJO-UHFFFAOYSA-L 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/526—Corrosion inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Dental Preparations (AREA)
- Detergent Compositions (AREA)
Description
Tannpleiemiddel. Tooth care product.
Oppfinnelsen angår et tannpleiemiddel inneholdende et vannopplbselig monofluorfosfåt. The invention relates to a dental care agent containing a water-soluble monofluorophosphate.
Vannopplbselige monofluorfosfater, og spesielt alkalimetall-monofluorfosfater som natriummonofluorfosfat, er blitt anvendt som fluorgivende, aktive bestanddeler i tannpleiemidler. De poleringsmidler som kan anvendes i slike tannpleiemidler, har vært gjenstand for omfattende undersøkelser. Water-soluble monofluorophosphates, and especially alkali metal monofluorophosphates such as sodium monofluorophosphate, have been used as fluorinating, active ingredients in dental care products. The polishing agents that can be used in such dental care products have been the subject of extensive research.
Et tannpleiemiddel inneholdende natriummonofluorfosfat og et poleringsmiddel som er fritt for uopplo.selig fosfatsalt og som i virkeligheten bare består av"kalsiumcarbonat, mister en vesentlig mengde opplost fluor ved henstand. A dentifrice containing sodium monofluorophosphate and a polishing agent which is free of insoluble phosphate salt and which in reality consists only of "calcium carbonate" loses a significant amount of dissolved fluoride on standing.
For å oppnå en maksimal virkning av monofluorfosfatet er det tidligere bare b;li'tt anvendt mindre. mengder, av kalsium sa Lt,.'" som d'i-kalsiumfosfat eller kalsiumcarbonat, eller av magnesiumsalt, og det er som hovedpoleringsmiddel blitt anvendt uopploselig alkalimetallmetafosfat. Det har hittil vært vanlig .praksis å pakke monofluorfosfattannpleiemidler i en med epoxyharpiks foret aluminiumbeholder eller i forede beholdere av andre metaller eller i plastbeholdere da bestanddelene i forskjellige monofluorfosfattannpleiemidler bevirker korrosjon av uforede aluminiumtuber ved lagring. .Det tilveiebringes ved oppfinnelsen et monofluorfosfattannpleiemiddel som byr på spesielle- fordeler sammenlignet med kjente monofluorfosfattannpleiemidler inneholdende kalsiumcarbonat eller uopploselig alkalimetallmetafosfat.- Mer. spesielt unngås ved tannpleiemidlet ifolge oppfinnelsen dé ustabile egenskaper til kjente monofluorfosfattannpleiemidler inneholdende kalsiumcarbonat som er fritt for uopploselig fosfat. Det tilveiebringes ved oppfinnelsen også et monofluorfosfattannpleiemiddel ' som ved lagring ikke i vesentlig grad korroderer uforede aluminiumbeholdere. In order to achieve a maximum effect of the monofluorophosphate, only less has previously been used. amounts, of calcium sa Lt,.'" as d'i-calcium phosphate or calcium carbonate, or of magnesium salt, and insoluble alkali metal metaphosphate has been used as the main polishing agent. It has hitherto been common practice to package monofluorophosphate dentifrices in an epoxy resin-lined aluminum container or in lined containers of other metals or in plastic containers as the components of various monofluorophosphate dentifrices cause corrosion of unlined aluminum tubes during storage. The invention provides a monofluorophosphate dentifrice which offers special advantages compared to known monofluorophosphate dentifrices containing calcium carbonate or insoluble alkali metal metaphosphate. in the dentifrice according to the invention the unstable properties of known monofluorophosphate dentifrices containing calcium carbonate which is free of insoluble phosphate. The invention also provides a monofluorophosphate dentifrice 'which by la gring does not significantly corrode lined aluminum containers.
Oppfinnelsen angår således et tannpleiemiddel inneholdende et vannopplbselig monofluorfosfat og et i j/ann uopploselig, forenelig poleringsmiddel omfattende en blanding av kalsiumcarbonat og uopploselig alkalimetallmetafosfat og eventuelt aluminiumoxyd, og tannpleiemidlet er særpreget ved at forholdet mellom kalsiumcarbonatet og det uoppløselige alkalimetallmetafosfat er 3:1 - 1000:1 og hvis aluminiumoxyd også er tilstede, er forholdet mellom kalsiumcarbonatet og aluminiumoxydet 1:3 - 1000:1. The invention thus relates to a dentifrice containing a water-soluble monofluorophosphate and a water-insoluble, compatible polishing agent comprising a mixture of calcium carbonate and insoluble alkali metal metaphosphate and possibly aluminum oxide, and the dentifrice is characterized by the ratio between the calcium carbonate and the insoluble alkali metal metaphosphate being 3:1 - 1000: 1 and if aluminum oxide is also present, the ratio between the calcium carbonate and the aluminum oxide is 1:3 - 1000:1.
Det kommersielt tilgjengelige natriummonofluorfosfat kan ha en sterkt varierende renhet. Det kan anvendes med en hvilken som helst egnet renhet, med den betingelse at eventuelle forurensnirger ikke i vesentlig grad uheldig påvirker de onskede egenskaper. Den onskede renhet er som regel minst ca. 80%. For oppnåelse av de beste resultater bor den være minst 85, fortrinnsvis minst 90, vekt% natrium-monof luorf osf at idet resten hovedsakelig er forurensninger eller bi-produkter fra fremstillingen, som natriumfluorid og vannopploselig natriumfosfatsalt etc. Uttrykt på en annen måte bor det anvendte natriummonofluorfosfat ha et samlet fluoridinnhold av over 12%, fortrinnsvis over.12,7%, et innhold av ikke over 1,5%, fortrinnsvis ikke over 1,2%, fritt natriumfluorid og et natriummonofluorfosfat-innhold av minst 12%, fortrinnsvis minst 12,1%, alt beregnet som fluor. The commercially available sodium monofluorophosphate can have a widely varying purity. It can be used with any suitable purity, with the condition that any contaminants do not adversely affect the desired properties to a significant extent. The desired purity is usually at least approx. 80%. In order to achieve the best results, it should be at least 85, preferably at least 90, wt% sodium monofluoride, etc., with the rest being mainly impurities or by-products from the manufacture, such as sodium fluoride and water-soluble sodium phosphate salt, etc. Expressed in another way, it should used sodium monofluorophosphate have a total fluoride content of more than 12%, preferably more than 12.7%, a content of not more than 1.5%, preferably not more than 1.2%, free sodium fluoride and a sodium monofluorophosphate content of at least 12%, preferably at least 12.1%, all calculated as fluorine.
Monofluorfosfatet er som regel tilstede i en mengde slik at det oppnås 0,01-1% fluor i tannpleiemidlet. Natriummonofluorfosfatet er således i alminnelighet tilstede i en mengde av 0,05 - 7,6%. The monofluorophosphate is usually present in an amount such that 0.01-1% fluorine is obtained in the dental care agent. The sodium monofluorophosphate is thus generally present in an amount of 0.05 - 7.6%.
Kalsiumcarbonatet i poleringsmidlet kan utgjøres av kritt. Dette anvendes som regel i form av et pulver med en partikkelstorrelse av 1-10 jxm. The calcium carbonate in the polishing agent can be made up of chalk. This is usually used in the form of a powder with a particle size of 1-10 μm.
Det foretrekkes å anvende en kalsiumcarbonatkvalitet med en for-holdsvis hoy tilsynelatende egenvekt av f.eks. 0,9-1,2. Om onskes kan det også anvendes kalsiumcarbonatkvaliteter med en lavere tilsynelatende egenvekt av f.eks. 0,7-0,9. Med "tilsynelatende egenvekt" er ment saltets egenvekt i ustampet tilstand. It is preferred to use a calcium carbonate quality with a relatively high apparent specific gravity of e.g. 0.9-1.2. If desired, calcium carbonate grades with a lower apparent specific gravity of e.g. 0.7-0.9. By "apparent specific gravity" is meant the specific gravity of the salt in the untamped state.
De uoppløselige alkalimetallmetafosfater for anvendelse i det foreliggende tannpleiemiddel er fortrinnsvis de uoppløselige natrium-og kaliumsalter av polymetafosfor syre. Disse materialer er kjente innen denne teknikk, og det uoppløselige natriummetafosfat er blitt foreslått som poleringsmiddel som angitt ovenfor. Slike materialer kan fremstilles på en hvilken som helst egnet måte, som f.eks. angitt i Thorpe's Dictionary of Applied Chemistry, vol, 9 (^. utg.) The insoluble alkali metal metaphosphates for use in the present dentifrice are preferably the insoluble sodium and potassium salts of polymetaphosphoric acid. These materials are known in the art and the insoluble sodium metaphosphate has been suggested as a polishing agent as indicated above. Such materials can be produced in any suitable way, such as e.g. given in Thorpe's Dictionary of Applied Chemistry, vol, 9 (^. ed.)
s. 510-511. De former av uoppløselig natriummetafosfat som er kjente som Madrells salt og Kurrols salt, er ytterligere eksempler på egnede materialer. Disse metafosfatsalter har bare en meget lav opploselighet i vann og betegnes derfor i alminnelighet som uopp-løselige metafosfater. En mindre mengde oppløselig fosfatmateriale er tilstede som forurensninger, som regel av størrelsesordenen et par prosent og inntil ca. h vekt%. Den mengde av det opploselige fosfatmateriale som antas å være et oppløselig natriumtrimetafosfat hva gjelder uoppløselig natriummetafosfat, kan om onskes minskes ved vasking med vann. Det uoppløselige alkalimetallmetafosfat anvendes som regel i form av et pulver med en slik partikkelstbrrelse at ikke over ca. 1% av materialet er storre enn ca. 37 /^m. pp. 510-511. The forms of insoluble sodium metaphosphate known as Madrell's salt and Kurrol's salt are further examples of suitable materials. These metaphosphate salts only have a very low solubility in water and are therefore generally referred to as insoluble metaphosphates. A smaller amount of soluble phosphate material is present as contaminants, usually of the order of a few percent and up to approx. h wt%. The quantity of the soluble phosphate material which is assumed to be a soluble sodium trimetaphosphate in terms of insoluble sodium metaphosphate can, if desired, be reduced by washing with water. The insoluble alkali metal metaphosphate is usually used in the form of a powder with such a particle size that no more than approx. 1% of the material is larger than approx. 37/^m.
Forholdet mellom carbonat og uopploselig alkalimetallmetafosfat er fortrinnsvis 6:1 - 500:1 og helst ca. ^-6,25:1. The ratio between carbonate and insoluble alkali metal metaphosphate is preferably 6:1 - 500:1 and preferably approx. ^-6.25:1.
Med de foretrukne forhold, og spesielt ved anvendelse av for-holdsvis små mengder uopploselig alkalimetallmetafosfat, korroderer praktisk talt uten unntagelse tannpleiemidlets ikke ufBrede aluminiumtuber. Når storre mengder av metafosfatet anvendes innen oppfinnelsens omfang, forårsaker tannpleiemidlet fremdeles ingen vesentlig korrosjon av uforede aluminiumtuber selv om det i unntagelsestil-feller kan forekomme en uheldig innvirkning på aluminiumet. With the preferred conditions, and especially with the use of relatively small amounts of insoluble alkali metal metaphosphate, practically without exception the non-extended aluminum tubes of the dentifrice corrode. When larger quantities of the metaphosphate are used within the scope of the invention, the dentifrice still causes no significant corrosion of unlined aluminum tubes, although in exceptional cases an adverse effect on the aluminum may occur.
Tannpleiemidlets samlede innhold av poleringsmiddel kan variere, men er som regel inntil ca. 95 vekt% av det samlede middel. For en tannkrem vil slike poleringsmidler som regel utgjore 20 - 75%, mens poleringsmidlene i tannpulver som regel vil være tilstede i en storre mengde av f.eks. 70-95%. The toothpaste's overall content of polishing agent can vary, but is usually up to approx. 95% by weight of the total agent. For a toothpaste, such polishing agents will usually make up 20 - 75%, while the polishing agents in tooth powder will usually be present in a larger quantity of e.g. 70-95%.
Ved fremstillingen av tannpulver er det som regel tilstrekkelig mekanisk å blande, f.eks. ved maling, de forskjellige faste bestanddeler i de egnede mengder og med de egnede partikkelstorrelser. In the production of tooth powder, mechanical mixing is usually sufficient, e.g. when painting, the various solid components in the appropriate quantities and with the appropriate particle sizes.
Et hvilket som helst overflateaktivt eller rensende materiale kan anvendes i tannpleiemidlene. Det er onskelig å anvende slike forenelige materialer for å oppnå ytterligere rensende, skummende og antibakterielle egenskaper avhengig av den spesielle type av det overflateaktive materiale, og de velges i overensstemmelse hermedc Disse overflateaktive forbindelser er som regel vannopploselige, organiske forbindelser og kan ha en anionaktiv, ikke-ioneaktiv eller kationaktiv struktur. Det foretrekkes som regel å anvende de vannopploselige, ikke-såpe- eller syntetiske organiske overflateaktive forbindelser. Any surface-active or cleansing material can be used in the dentifrices. It is desirable to use such compatible materials to obtain additional cleansing, foaming and antibacterial properties depending on the particular type of surfactant, and they are selected accordingly. These surfactants are usually water-soluble organic compounds and may have an anionic, non-ion active or cation active structure. As a rule, it is preferred to use the water-soluble, non-soap or synthetic organic surface-active compounds.
De forskjellige overflateaktive materialer kan anvendes i en hvilken som helst egnet mengde, men som regel i en mengde av 0,05- The various surface-active materials can be used in any suitable amount, but as a rule in an amount of 0.05-
10 vekt%, fortrinnsvis 0,5 - 5 vekt%, av tannpleiemidlet. 10% by weight, preferably 0.5 - 5% by weight, of the dental care agent.
Ved fremstilling av tannkrem bor væsker og faste stoffer avpas-ses slik i forhold til hverandre at det oppnås en ekstruderbar krem-lignende masse med onsket konsistens. Væskene i tannkremen vil som regel bestå hovedsakelig av vann, glycerol, sorbitol og propylen-glycol eller blandinger derav. Det er som regel fordelaktig å anvende en blanding av både vann og et fuktemiddel eller bindemiddel, som glycerol eller sorbitol. Det foretrekkes å anvende glycerol. In the production of toothpaste, liquids and solids must be adjusted in relation to each other in such a way that an extrudable cream-like mass with the desired consistency is obtained. The liquids in the toothpaste will usually consist mainly of water, glycerol, sorbitol and propylene glycol or mixtures thereof. It is usually advantageous to use a mixture of both water and a wetting agent or binder, such as glycerol or sorbitol. It is preferred to use glycerol.
Det samlede væskeinnhold vil som regel være 20r-75 vekt% av blandingen. Det foretrekkes også å anvende et geleringsmiddel i tannkremer, som The total liquid content will normally be 20-75% by weight of the mixture. It is also preferred to use a gelling agent in toothpastes, such as
de naturlige og syntetiske gummier cg gummilignende materialer, f.eks. irsk mose, tragantgummi, natriumcarboxymethylcellulose, polyvinyl-pyrolidon og stivelse etc. Irsk mose og natriumcarboxymethylcellulose er spesielt forenelige og er, som vist, foretrukne geleringsmidler. Gummiinnholdet er som regel inntil ca. 10%, fortrinnsvis 0,5-5%, av blandingens vekt. the natural and synthetic rubbers and rubber-like materials, e.g. Irish moss, gum tragacanth, sodium carboxymethylcellulose, polyvinylpyrrolidone and starch, etc. Irish moss and sodium carboxymethylcellulose are particularly compatible and, as shown, are preferred gelling agents. The rubber content is usually up to approx. 10%, preferably 0.5-5%, of the weight of the mixture.
Ifblge oppfinnelsen oppnås onskede lagringsegenskaper dersom According to the invention, desired storage properties are achieved if
en mindre mengde hydratisert aluminiumoxyd anvendes i tannpleiemidlet som en del av poleringsmidlet sammen med kalsiumcarbonatet. Forhol- a smaller amount of hydrated aluminum oxide is used in the dental care product as part of the polishing agent together with the calcium carbonate. Rela-
det mellom kalsiumcarbonatet og aluminiumoxydet er 1:3 - lOOOil. Tannpleiemidler inneholdende små mengder.uopploselig alkalimetallmetafosfat, f.eks,, med et forhold mellom kalsiumcarbonat og metafosfat av over 100:1, har' bedre lagringsegenskaper dersom aluminiumoxyd også er tilstede. that between the calcium carbonate and the aluminum oxide is 1:3 - lOOOil. Dentifrices containing small amounts of insoluble alkali metal metaphosphate, e.g., with a ratio between calcium carbonate and metaphosphate of over 100:1, have better storage properties if aluminum oxide is also present.
En tannkrem med forbedrede fysikalske egenskaper kan fremstilles fra kalsiumcarbonat og uopploselig alkalimetallmetafosfat suspen-dert i en gel omfattende vann, fuktemiddel og geleringsmiddel, sammen med fluoridforbindelsen og den organiske, ikke-såpe, syntetiske overflateaktive forbindelse og hydratisert aluminiumoxyd, idet tannkremen har en pH av 7-9,5. Det hydratiserte aluminiumoxyd kan også ute-lates. Disse tannkremer har en sterkt forbedret lagringsstabilitet over lengre tid og spesielt ved forhoyet temperatur. Aluminiumoxydet virker som stabilisator og modifiseringsmiddel slik at en hvilken som helst tilbbyelighet til separering eller synerese .i tannkremen i den sammenklembare tube elimineres eller hindres. A toothpaste with improved physical properties can be prepared from calcium carbonate and insoluble alkali metal metaphosphate suspended in a gel comprising water, wetting agent and gelling agent, together with the fluoride compound and the organic, non-soap, synthetic surfactant compound and hydrated aluminum oxide, the toothpaste having a pH of 7-9.5. The hydrated aluminum oxide can also be omitted. These toothpastes have a greatly improved storage stability over a longer period of time and especially at elevated temperatures. The aluminum oxide acts as a stabilizer and modifier so that any tendency to separation or syneresis in the toothpaste in the squeezable tube is eliminated or prevented.
Det. foretrukne forhold mellom kalsiumcarbonat og aluminiumoxyd er 3:1 - 100:1 og helst 35:1 - 52:1. The. preferred ratio between calcium carbonate and aluminum oxide is 3:1 - 100:1 and preferably 35:1 - 52:1.
Det er ifolge. oppfinnelsen tilstrekkelig uopploselig alkali-metallmetaf osf at og eventuelt aluminiumoxyd tilstede til sterkt å forlenge den tid monofluorfosfatet holder seg i det vesentlige opp-løselig, f.eks. for å sikre at minst, og fortrinnsvis mer enn, h0% og helst minst 50% av det opprinnelige monofluorfosfatinnhold er opp-loselig efter akselerert lagring av tannpleiemidlet i 9 uker ved ^9°C. It follows. the invention sufficiently insoluble alkali-metal metaphosphate and optionally aluminum oxide present to greatly extend the time the monofluorophosphate remains essentially soluble, e.g. to ensure that at least, and preferably more than, h0% and preferably at least 50% of the original monofluorophosphate content is soluble after accelerated storage of the dentifrice for 9 weeks at ^9°C.
Egnede eksempler på hydratisert aluminiumoxyd som kan anvendes, er de former som er kjent som a- og (3-aluminiumoxydtrihydrat, og blandinger derav. Det anvendes som regel i form av fine partikler med en hvilken som helst bnsket partikkelstbrrelse ved fremstillingen av tannkremen. Det foretrekkes i praksis å anvende a-trihydrat-formen med minst 90% av partiklene med en storrelse av t325 mesh (U.S. standard) og.ikke flere enn 5 vekt% av partiklene med en storrelse under 5 M^. Det har vist seg at det er mest onskelig med hydratisert aluminiumoxyd i en mengde av 0,25 - 10 vekt%, fortrinnsvis 1 vekt%, av tannpleiemidlet. Forskjellige andre materialer kan anvendes i tannpleiemidlet ifolge oppfinnelsen. Eksempler på disse er farve- eller hvitestoffer, konserveringsmidler, siliconer, klorofyllforbindelser, ammoniakkmaterialer som urinstoff, diammonium-fosfat og blandinger derav, og antibakterielle midler og smaks- Suitable examples of hydrated aluminum oxide that can be used are the forms known as α- and (3-aluminum oxide trihydrate, and mixtures thereof. It is generally used in the form of fine particles with any desired particle size in the manufacture of the toothpaste. it is preferred in practice to use the α-trihydrate form with at least 90% of the particles with a size of t325 mesh (U.S. standard) and no more than 5% by weight of the particles with a size below 5 M^. It has been shown that the is most desirable with hydrated aluminum oxide in an amount of 0.25 - 10% by weight, preferably 1% by weight, of the dental care agent. Various other materials can be used in the dental care agent according to the invention. Examples of these are coloring or whitening agents, preservatives, silicones, chlorophyll compounds , ammonia materials such as urea, diammonium phosphate and mixtures thereof, and antibacterial agents and flavoring
eller sotemidler. or sweeteners.
Tannkremene bor ha en for anvendelse praktisk pH. Bn noytral til basisk pH er spesielt onskelig. Et opprinnelig pH-område av 7-9,5, fortrinnsvis 7,5, ansees å være det mest-praktiske for bruk. En henvisning til pH heri gjelder for pH bestemt direkte i tannkremen. Om nddvendig kan basiske materialer tilsettes for efter briske a regulere pH. Toothpastes must have a practical pH for use. A neutral to basic pH is particularly desirable. An initial pH range of 7-9.5, preferably 7.5, is considered to be the most practical for use. A reference to pH herein applies to pH determined directly in the toothpaste. If necessary, basic materials can be added to adjust the pH.
Beholderen for tannpleiemidlet er som regel en tube hvorfra tannkremen kan ekstruderes. Det er en særlig fordel ved tannpleiemidlet ifolge oppfinnelsen omfattende uopploselig alkalimetallmetafosfat at det kan pakkes i en uforet aluminiumbeholder og bevare onskelige kosmetiske og rheologiske egenskaper ved lagring uten å forårsake noen vesentlig lagdannelse eller korrosjon av det alu-minium som det er i kontakt med. The container for the toothpaste is usually a tube from which the toothpaste can be extruded. It is a particular advantage of the dental care agent according to the invention comprising insoluble alkali metal metaphosphate that it can be packed in an unlined aluminum container and preserve undesirable cosmetic and rheological properties during storage without causing any significant layer formation or corrosion of the aluminum with which it is in contact.
De mest onskelige resultater er blitt oppnådd med et tannpleiemiddel inneholdende 0,1-3 vekt% uopploselig alkalimetallmetafosfat og. hh- k- 7 vekt% kalsiumcarbonat. The most desirable results have been obtained with a dentifrice containing 0.1-3% by weight of insoluble alkali metal metaphosphate and. hh- k- 7% by weight calcium carbonate.
For standardiserte undersokelsesformål fremstilles tannpleiemidlene med ca. 0,76% natriummonofluorfosfat med bestemmelse av det opprinnelige monofluorfosfatinnhold som er tilstede ved akselererte lagringsforsok. For standardized examination purposes, the dental care products are produced with approx. 0.76% sodium monofluorophosphate with determination of the initial monofluorophosphate content present in accelerated storage experiments.
Tannpleiemidlene ifolge eksemplene ble fremstilt på vanlig måte, og alle mengder i eksemplene er basert på vekt dersom intet annet er angitt. The dentifrices according to the examples were prepared in the usual way, and all amounts in the examples are based on weight if nothing else is stated.
Eksempel 1 Example 1
Middel A uten noe innhold av fosfatsalt som poleringsmiddel og hvor kalsiumcarbonat var det eneste slipemiddel, og middel' B inneholdende kalsiumcarbonat, aluminiumoxyd og fosfatsalt ble lagret ved 1+9°C, og den prosentuelle mengde tilstedeværende opploseiig monofluorfosfat ble periodevis bestemt som fluorid. 3 ukers lagring under disse betingelser tilsvarte ca. 1 års lagring ved værelses-temperatur. Resultatene er gjengitt i den nedenstående tabell: Agent A without any content of phosphate salt as a polishing agent and where calcium carbonate was the only abrasive, and agent B containing calcium carbonate, aluminum oxide and phosphate salt was stored at 1+9°C, and the percentage amount of soluble monofluorophosphate present was periodically determined as fluoride. 3 weeks of storage under these conditions corresponded to approx. 1 year storage at room temperature. The results are reproduced in the table below:
Det er klart fra disse resultater at en tilsetning av en liten mengde av det uoppløselige metafosfat og aluminiumoxyd sterkt oket midlets B evne til å holde tilbake opploseiig fluor. It is clear from these results that the addition of a small amount of the insoluble metaphosphate and aluminum oxide greatly increased the ability of agent B to retain soluble fluorine.
Ved ifylling av midlet B i en uforet aluminiumtube holdt aluminiumoverflaten i kontakt med tannpleiemidlet seg i det vesentlige korrosjonfri selv i lengre tid, mens middel A ganske snart be-virket korrosjonsangrep på en uforet aluminiumtube. When filling agent B into an unlined aluminum tube, the aluminum surface in contact with the dental care agent remained essentially corrosion-free even for a long time, while agent A very soon caused corrosion attack on an unlined aluminum tube.
Eksempel 2 Example 2
De folgende tannpleiemidler hadde også en hoy tilbakeholdelse av opploseiig fluor og ga ingen vesentlig korrosjon av den aluminium-overf late som de befant seg i kontakt med i uforede aluminiumtuber. The following dentifrices also had a high retention of soluble fluoride and produced no significant corrosion of the aluminum surface with which they were in contact in unlined aluminum tubes.
Eksempex 3 Example 3
De folgende tannpleiemidler ligger også innen oppfinnelsens ramme: The following dental care products are also within the scope of the invention:
Eksempel h Example h
De folgende tannpleiemidler ligger også innen oppfinnelsens ramme: The following dental care products are also within the scope of the invention:
Andre monofluorfosfatsalter enn natriummonofluorfosfat, Na2P0^F, som har tilstrekkelig vannopploselighet til at de kan anvendes ifolge oppfinnelsen, omfatter kalsiummonofluorfosfat, magnesiummonofluor-fosfat og aluminiummonofluorfosfat. Uttrykket "monofluorfosfat" Monofluorophosphate salts other than sodium monofluorophosphate, Na2P0^F, which have sufficient water solubility to enable them to be used according to the invention, include calcium monofluorophosphate, magnesium monofluorophosphate and aluminum monofluorophosphate. The term "monofluorophosphate"
som anvendt heri omfatter ogsa monofluorpolyfosfater, som Na^P309F, \ ?309¥, (NH^P^F, Na^P^F, (NH^NaP^F og Li^P^F. as used herein also includes monofluoropolyphosphates, such as Na^P309F, \?309¥, (NH^P^F, Na^P^F, (NH^NaP^F and Li^P^F.
Claims (3)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78573168A | 1968-12-20 | 1968-12-20 | |
US87824169A | 1969-11-19 | 1969-11-19 |
Publications (1)
Publication Number | Publication Date |
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NO129500B true NO129500B (en) | 1974-04-22 |
Family
ID=27120434
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Application Number | Title | Priority Date | Filing Date |
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NO470669A NO129500B (en) | 1968-12-20 | 1969-11-28 | |
NO494973A NO137811C (en) | 1968-12-20 | 1973-12-27 | DENTAL CARE. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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NO494973A NO137811C (en) | 1968-12-20 | 1973-12-27 | DENTAL CARE. |
Country Status (12)
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BE (1) | BE742639A (en) |
CH (1) | CH548775A (en) |
DE (1) | DE1962143A1 (en) |
DK (1) | DK124920B (en) |
ES (1) | ES374187A1 (en) |
FI (1) | FI50053C (en) |
FR (1) | FR2026643A1 (en) |
GB (1) | GB1265040A (en) |
IE (1) | IE33884B1 (en) |
NL (1) | NL6918636A (en) |
NO (2) | NO129500B (en) |
SE (1) | SE373747C (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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DE2555454A1 (en) * | 1974-12-13 | 1976-06-16 | Colgate Palmolive Co | TOOTHPASTE |
-
1969
- 1969-11-28 NO NO470669A patent/NO129500B/no unknown
- 1969-12-03 ES ES374187A patent/ES374187A1/en not_active Expired
- 1969-12-04 BE BE742639D patent/BE742639A/xx unknown
- 1969-12-11 NL NL6918636A patent/NL6918636A/xx unknown
- 1969-12-11 DE DE19691962143 patent/DE1962143A1/en active Pending
- 1969-12-15 FR FR6943346A patent/FR2026643A1/fr not_active Withdrawn
- 1969-12-15 GB GB1265040D patent/GB1265040A/en not_active Expired
- 1969-12-16 IE IE168069A patent/IE33884B1/en unknown
- 1969-12-16 SE SE6917305A patent/SE373747C/en unknown
- 1969-12-17 CH CH1876769A patent/CH548775A/en not_active IP Right Cessation
- 1969-12-17 DK DK666769A patent/DK124920B/en unknown
- 1969-12-19 FI FI369869A patent/FI50053C/en active
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1973
- 1973-12-27 NO NO494973A patent/NO137811C/en unknown
Also Published As
Publication number | Publication date |
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BE742639A (en) | 1970-05-14 |
FI50053C (en) | 1975-12-10 |
CH548775A (en) | 1974-05-15 |
NO137811B (en) | 1978-01-23 |
FR2026643A1 (en) | 1970-09-18 |
NL6918636A (en) | 1970-06-23 |
SE373747B (en) | 1975-02-17 |
DE1962143A1 (en) | 1970-07-02 |
GB1265040A (en) | 1972-03-01 |
DK124920B (en) | 1972-12-11 |
IE33884L (en) | 1970-06-20 |
SE373747C (en) | 1976-06-14 |
ES374187A1 (en) | 1972-03-16 |
NO137811C (en) | 1978-05-03 |
IE33884B1 (en) | 1974-11-27 |
FI50053B (en) | 1975-09-01 |
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