NO137445B - ANALOGICAL PROCEDURES FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE IMIDAZOLE DERIVATIVES - Google Patents
ANALOGICAL PROCEDURES FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE IMIDAZOLE DERIVATIVES Download PDFInfo
- Publication number
- NO137445B NO137445B NO166072A NO166072A NO137445B NO 137445 B NO137445 B NO 137445B NO 166072 A NO166072 A NO 166072A NO 166072 A NO166072 A NO 166072A NO 137445 B NO137445 B NO 137445B
- Authority
- NO
- Norway
- Prior art keywords
- bath
- analogical
- procedures
- preparation
- therapeutically active
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 5
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- AFCIMSXHQSIHQW-UHFFFAOYSA-N [O].[P] Chemical compound [O].[P] AFCIMSXHQSIHQW-UHFFFAOYSA-N 0.000 claims description 7
- 230000002378 acidificating effect Effects 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 claims description 2
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 2
- 150000001450 anions Chemical class 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 16
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 8
- 235000011007 phosphoric acid Nutrition 0.000 description 8
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 5
- AUYOHNUMSAGWQZ-UHFFFAOYSA-L dihydroxy(oxo)tin Chemical compound O[Sn](O)=O AUYOHNUMSAGWQZ-UHFFFAOYSA-L 0.000 description 5
- 239000002253 acid Substances 0.000 description 3
- 238000005282 brightening Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000007747 plating Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KWSLGOVYXMQPPX-UHFFFAOYSA-N 5-[3-(trifluoromethyl)phenyl]-2h-tetrazole Chemical compound FC(F)(F)C1=CC=CC(C2=NNN=N2)=C1 KWSLGOVYXMQPPX-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 125000005037 alkyl phenyl group Chemical group 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 125000005341 metaphosphate group Chemical group 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical class O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 description 1
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical class [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 229910001379 sodium hypophosphite Inorganic materials 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- 150000003606 tin compounds Chemical class 0.000 description 1
- 229910000375 tin(II) sulfate Inorganic materials 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Description
Fremgangsmåte til å hindre kolloidale avleiringer i sure, galvaniske fortinningsbad. Method for preventing colloidal deposits in acidic, galvanic tinning baths.
Oppfinnelsen vedrører en fremgangsmåte til å hindre kolloidale avleiringer i sure, galvaniske fortinningsbad. De kjente galvaniske bad av denne type inneholder tinn i den toverdige form og vanligvis som anionsulfat, sulfonat eller fluoborat og dessuten omtrent alltid et reduksjonsmiddel, for det meste formaldehyd. Dessuten kan badet inneholde en overflateaktiv forbindelse, vanligvis av en ikke ionogen type, samt et glansmiddel. The invention relates to a method for preventing colloidal deposits in acidic, galvanic tinning baths. The known galvanic baths of this type contain tin in the divalent form and usually as anionic sulphate, sulphonate or fluoborate and, furthermore, almost always a reducing agent, mostly formaldehyde. In addition, the bath may contain a surface-active compound, usually of a non-ionic type, as well as a brightening agent.
Den industrielle anvendbarhet av et galvanisk bad- bestemmes også ved om det egner seg til kontinuerlig drift og bekvemt kan rege-nereres ved komplettering av forbrukte bestanddeler. En ulempe ved de tidligere anvendte sure fortinningsbad er at etterhvert dannes hydro-lyseprodukter av de oppløselige tinnforbindelser som er dårlig oppløselige, har en kolloidal natur og således ikke kan fjernes ved filtrering. Fjerning er nødvendig, da disse produkter lett kan inne-sluttes i de galvaniske utfellinger og deres kvalitet kan bli betraktelig dårligere. Levetiden av sure fortinningsbad tilsvarte derfor tidligere ikke de industrielle krav. The industrial applicability of a galvanic bath is also determined by whether it is suitable for continuous operation and can be conveniently regenerated by supplementing consumed components. A disadvantage of the previously used acid tinning baths is that hydrolysis products of the soluble tin compounds are eventually formed which are poorly soluble, have a colloidal nature and thus cannot be removed by filtration. Removal is necessary, as these products can easily be trapped in the galvanic deposits and their quality can be considerably worse. The lifetime of acid tinning baths therefore previously did not correspond to the industrial requirements.
Ifølge oppfinnelsen unngås denne ulempe i betraktelig grad og gjør de sure, galvaniske fortinningsbad likeså godt egnet for kontinuerlig drift som f.eks. de vanlige forniklings- og forkobrings-bad. According to the invention, this disadvantage is avoided to a considerable extent and makes the acid, galvanic tinning baths just as well suited for continuous operation as e.g. the usual nickel-plating and copper-plating baths.
Fremgangsmåten ifølge oppfinnelsen er karakterisert ved at man til det sure, galvaniske fortinningsbad setter en uorganisk fosfor-oksygen-forbindelse. i en mengde av 0,001 - 10 g/l badvæske. The method according to the invention is characterized by adding an inorganic phosphorus-oxygen compound to the acidic, galvanic tinning bath. in an amount of 0.001 - 10 g/l bath liquid.
For dette formål anvendbare fosfor-oksygen-forbindelser er fosforsyre, fosfater, pyrofosfater, metafosfater, fosfiter og hypofos-fiter. Phosphorus-oxygen compounds that can be used for this purpose are phosphoric acid, phosphates, pyrophosphates, metaphosphates, phosphites and hypophosphites.
I den kvalitative, analytiske kjemi er det kjent, for ikke In qualitative, analytical chemistry it is known, for not
å forstyrre påvisning av jordalkaliioner, å fjerne fosforsyre fra en oppløsning av en blanding som skal analyseres ved tilsetning av metatinnsyre. Metatinnsyren dannes i oppløsningen ved tilsetning av ren tinnfolie til den salpetersyreholdige oppløsning. Fosforsyren absor-beres på en eller annen måte på den overskytende metatinnsyre og kan fjernes fullstendig ved filtrering av metatinnsyren. Hydrolyseproduk-tene av tinn i et galvanisk fortinningsbad som sogar kan være av en annen type enn den ovennevnte metatinnsyre, er for det meste til å begynne med tilstede i en liten konsentrasjon og dannes med liten hastighet, hvorved deres kolloidale type befordres. Det faktum at den kolloidale type unngås ved tilsetning av fosforsyre er imidlertid ikke utledbart fra de kjennskaper som foreligger i den analytiske kjemi. to interfere with the detection of alkaline earth ions, to remove phosphoric acid from a solution of a mixture to be analyzed by the addition of metastannic acid. The metastannic acid is formed in the solution by adding pure tin foil to the solution containing nitric acid. The phosphoric acid is absorbed in one way or another on the excess metastannic acid and can be completely removed by filtering the metastannic acid. The hydrolysis products of tin in a galvanic tinning bath, which may even be of a different type than the above-mentioned metastannic acid, are mostly initially present in a small concentration and are formed at a low rate, whereby their colloidal type is promoted. However, the fact that the colloidal type is avoided by adding phosphoric acid cannot be deduced from the knowledge available in analytical chemistry.
De for dette formål tilsatte mengder av fosfor-oksygen-forbindelse utgjør vanligvis bare ca. 0,001 til 0,010 g pr. liter badvæske. , Man tilsetter maksimalt 10'g av fosfor-oksygen-forbindelsen pr. liter badvæske, da ellers fortinningsbadets natur forandres så sterkt og det ikke mere er oppnåelig en tilfredsstillende tinnavleiring. The amounts of phosphorus-oxygen compound added for this purpose usually amount to only approx. 0.001 to 0.010 g per liter bath liquid. , A maximum of 10 g of the phosphorus-oxygen compound is added per liter of bath liquid, as otherwise the nature of the tinning bath changes so strongly and a satisfactory tin deposit is no longer achievable.
Det skal dessuten bemerkes at det er kjent til galvaniske bad, f.eks. galvaniske fortinningsbad, å sette overflateaktive fosforsyre-estere som fukemidler. Denne type av fosfor-oksygen-forbindelser gir imidlertid for behandlingen av fortinningsbad ifølge oppfinnelsen ikke den ønskede virkning og det er for dette formål mere nødvendig å tilsette uorganiske fosfor-oksygen-forbindelser. It should also be noted that galvanic baths are known, e.g. galvanic tinning baths, to use surface-active phosphoric acid esters as wetting agents. However, this type of phosphorus-oxygen compounds does not provide the desired effect for the treatment of the tinning bath according to the invention, and for this purpose it is more necessary to add inorganic phosphorus-oxygen compounds.
Det skal endelig dessuten nevnes at tilsetning av fosforsyre som glansmiddel til galvaniske bad for utfelling av tinnholdig nikkel er kjent. Ved tilsetning til fortinningsbad har imidlertid fosforsyre som glansmiddel ikke den ringeste virkning. Finally, it should also be mentioned that the addition of phosphoric acid as a brightening agent to galvanic baths for the precipitation of tin-containing nickel is known. When added to tinning baths, however, phosphoric acid as a brightening agent does not have the slightest effect.
For nærmere forklaring skal i det følgende forklares anven-delsen av noen fortinningsbad ved et industrielt fortinningsanlegg. Ved hjelp av dette anlegg, hvori 300 liter oppløsning kontinuerlig pumpes rundt gjennom et filter, utfelles gjennomsnittlig pr. time 50 g tinn på jerngjenstander. De forbrukte kjemikalier kompletteres regel-messig . For further explanation, the use of some tinning baths at an industrial tinning plant will be explained in the following. With the help of this facility, in which 300 liters of solution are continuously pumped around through a filter, an average of hour 50 g of tin on iron objects. The used chemicals are regularly replenished.
Et vandig fortinningsbad av følgende sammensetning pr." liter: An aqueous tinning bath of the following composition per liter:
40 g SnSO^40 g of SnSO4
135 g H2S04135 g of H 2 SO 4
40 ml av en 36 $ig formalin-oppløsning 40 ml of a 36 µg formalin solution
2 g "Lissapol N" (en ikke-ioniserende alkylfenyl-polyglykoleter) , og 2 g "Lissapol N" (a non-ionizing alkylphenyl polyglycol ether), and
0,02 g Al,3-dihydro-o-tolylaldehyd, 0.02 g Al,3-dihydro-o-tolylaldehyde,
inneholder etter 300 brukstimer dispergerte forurensninger i en slik mengde at kvaliteten av det utfelte tinn ikke mere er akseptabel. Badet er blitt fullstendig ubrukbart og må fjernes. contains, after 300 hours of use, dispersed contaminants in such a quantity that the quality of the precipitated tin is no longer acceptable. The bathroom has become completely unusable and must be removed.
Blir det til den nysammensatte badvæske hver gang etter 250 timer pr. liter satt 0,1 g eller hver gang etter 50 timer 0,02 g ortofosforsyre eller en tilsvarende mengde fosforsyrling, natriumhypo-fosfit eller kaliumpyrofosfat, så er det angjeldende bad etter 7000 brukstimer under stadig komplettering av forbrukte kjemikalier ennu helt klart og gir ennu tinnavleiringer av samme fortrinnlige kvalitet som det nyfremstilte bad. Will it be the newly formulated bath fluid every time after 250 hours per liter added 0.1 g or every time after 50 hours 0.02 g of orthophosphoric acid or an equivalent amount of phosphoric acid, sodium hypophosphite or potassium pyrophosphate, then the bath in question after 7000 hours of use while constantly replenishing used chemicals is still completely clear and still produces tin deposits of the same excellent quality as the newly manufactured bathroom.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH696771A CH561202A5 (en) | 1971-05-10 | 1971-05-11 | |
| CH425072A CH579072A5 (en) | 1971-05-10 | 1972-03-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO137445B true NO137445B (en) | 1977-11-21 |
| NO137445C NO137445C (en) | 1978-03-01 |
Family
ID=25695022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO166072A NO137445C (en) | 1971-05-11 | 1972-05-10 | ANALOGICAL PROCEDURES FOR THE PREPARATION OF NEW THERAPEUTICALLY ACTIVE IMIDAZOLE DERIVATIVES |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5630352B1 (en) |
| AR (4) | AR194594A1 (en) |
| CS (4) | CS181745B2 (en) |
| CY (1) | CY936A (en) |
| DD (1) | DD97654A5 (en) |
| ES (1) | ES402563A1 (en) |
| FI (1) | FI57407C (en) |
| HK (1) | HK61477A (en) |
| HU (1) | HU164884B (en) |
| IE (1) | IE36319B1 (en) |
| IL (1) | IL39285A (en) |
| KE (1) | KE2796A (en) |
| MY (1) | MY7800118A (en) |
| NO (1) | NO137445C (en) |
| PL (4) | PL92552B1 (en) |
| SU (4) | SU456409A3 (en) |
| YU (6) | YU35878B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010211753B2 (en) * | 2009-02-04 | 2015-11-05 | Otsuka Pharmaceutical Factory, Inc. | Phenylimidazole compounds |
-
1972
- 1972-04-18 FI FI108772A patent/FI57407C/en active
- 1972-04-24 IE IE53772A patent/IE36319B1/en unknown
- 1972-04-24 IL IL39285A patent/IL39285A/en unknown
- 1972-04-28 CY CY93672A patent/CY936A/en unknown
- 1972-05-09 PL PL17650972A patent/PL92552B1/en unknown
- 1972-05-09 PL PL15526372A patent/PL84726B1/en unknown
- 1972-05-09 PL PL17651272A patent/PL92546B1/en unknown
- 1972-05-09 ES ES402563A patent/ES402563A1/en not_active Expired
- 1972-05-09 PL PL17651072A patent/PL92549B1/en unknown
- 1972-05-10 JP JP4555472A patent/JPS5630352B1/ja active Pending
- 1972-05-10 SU SU1783894A patent/SU456409A3/en active
- 1972-05-10 HU HUCI001235 patent/HU164884B/hu unknown
- 1972-05-10 YU YU123372A patent/YU35878B/en unknown
- 1972-05-10 NO NO166072A patent/NO137445C/en unknown
- 1972-05-10 DD DD16286072A patent/DD97654A5/xx unknown
- 1972-05-11 CS CS596076A patent/CS181745B2/en unknown
- 1972-05-11 AR AR24195372A patent/AR194594A1/en active
- 1972-05-11 CS CS316372A patent/CS181711B2/en unknown
- 1972-05-11 CS CS596276A patent/CS181747B2/en unknown
- 1972-05-11 CS CS596176A patent/CS181746B2/en unknown
-
1973
- 1973-03-20 AR AR24713373A patent/AR198658A1/en active
- 1973-03-20 AR AR24713473A patent/AR195910A1/en active
- 1973-03-20 AR AR24713273A patent/AR198820A1/en active
- 1973-11-27 SU SU1971711A patent/SU502605A3/en active
- 1973-11-27 SU SU1971713A patent/SU489330A3/en active
- 1973-11-27 SU SU1971712A patent/SU489329A3/en active
-
1977
- 1977-11-15 KE KE279677A patent/KE2796A/en unknown
- 1977-12-08 HK HK61477A patent/HK61477A/en unknown
-
1978
- 1978-11-14 YU YU264578A patent/YU35880B/en unknown
- 1978-11-14 YU YU264678A patent/YU35881B/en unknown
- 1978-11-14 YU YU264478A patent/YU35879B/en unknown
- 1978-12-30 MY MY7800118A patent/MY7800118A/en unknown
-
1979
- 1979-04-09 YU YU83779A patent/YU35883B/en unknown
-
1980
- 1980-01-23 YU YU17680A patent/YU36165B/en unknown
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