NO135852B - - Google Patents
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- NO135852B NO135852B NO3055/73A NO305573A NO135852B NO 135852 B NO135852 B NO 135852B NO 3055/73 A NO3055/73 A NO 3055/73A NO 305573 A NO305573 A NO 305573A NO 135852 B NO135852 B NO 135852B
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- Norway
- Prior art keywords
- gluconate
- lactate
- weight
- solution
- chlorhexidine
- Prior art date
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- 229940050410 gluconate Drugs 0.000 claims description 28
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 25
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 15
- WUJZVKDLOUTNMK-UHFFFAOYSA-N C(CCCCCCCCCCC)[N+](C(C1=CC=CC=C1)(C)C)(Cl)Cl Chemical compound C(CCCCCCCCCCC)[N+](C(C1=CC=CC=C1)(C)C)(Cl)Cl WUJZVKDLOUTNMK-UHFFFAOYSA-N 0.000 claims description 6
- 125000001453 quaternary ammonium group Chemical group 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 5
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical compound CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 claims description 4
- WNBGYVXHFTYOBY-UHFFFAOYSA-N benzyl-dimethyl-tetradecylazanium Chemical compound CCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 WNBGYVXHFTYOBY-UHFFFAOYSA-N 0.000 claims description 4
- 239000000645 desinfectant Substances 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 3
- ULBMBQLPJXAYAG-UHFFFAOYSA-N ethyl-dimethyl-(1-phenyltridecyl)azanium Chemical compound CCCCCCCCCCCCC([N+](C)(C)CC)C1=CC=CC=C1 ULBMBQLPJXAYAG-UHFFFAOYSA-N 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- WJLUBOLDZCQZEV-UHFFFAOYSA-M hexadecyl(trimethyl)azanium;hydroxide Chemical compound [OH-].CCCCCCCCCCCCCCCC[N+](C)(C)C WJLUBOLDZCQZEV-UHFFFAOYSA-M 0.000 claims 1
- 239000000243 solution Substances 0.000 description 25
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 14
- 229960003260 chlorhexidine Drugs 0.000 description 14
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 7
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000002585 base Substances 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- ZFKLWOJJZKGHQW-UHFFFAOYSA-M C(C(O)C)(=O)[O-].C(CCCCCCCCCCC)[N+](C(C1=CC=CC=C1)(C)C)(Cl)Cl Chemical compound C(C(O)C)(=O)[O-].C(CCCCCCCCCCC)[N+](C(C1=CC=CC=C1)(C)C)(Cl)Cl ZFKLWOJJZKGHQW-UHFFFAOYSA-M 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 5
- 244000052616 bacterial pathogen Species 0.000 description 5
- -1 dodecyldimethyldichlorobenzylammonium lactate dodecyldimethylbenzylammonium lactate tetradecyldimethylbenzylammonium lactate dodecyldimethylethylbenzylammonium lactate hexadecyltrimethylammonium Chemical compound 0.000 description 5
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 150000004820 halides Chemical class 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- RLGQACBPNDBWTB-UHFFFAOYSA-N cetyltrimethylammonium ion Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)C RLGQACBPNDBWTB-UHFFFAOYSA-N 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- AKCDSOIBQNVSSJ-UHFFFAOYSA-M [Cl-].C(CCCCCCCCCCC)[N+](C(C1=CC=CC=C1)(C)C)(Cl)Cl Chemical compound [Cl-].C(CCCCCCCCCCC)[N+](C(C1=CC=CC=C1)(C)C)(Cl)Cl AKCDSOIBQNVSSJ-UHFFFAOYSA-M 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 150000002334 glycols Chemical class 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- WTXGYGWMPUGBAL-SQOUGZDYSA-N (3r,4s,5r,6r)-3,4,5,6-tetrahydroxyoxepan-2-one Chemical compound O[C@@H]1COC(=O)[C@H](O)[C@@H](O)[C@@H]1O WTXGYGWMPUGBAL-SQOUGZDYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- DPXJRRNZAUKEHX-UHFFFAOYSA-M hexadecyl(trimethyl)azanium;2-hydroxypropanoate Chemical compound CC(O)C([O-])=O.CCCCCCCCCCCCCCCC[N+](C)(C)C DPXJRRNZAUKEHX-UHFFFAOYSA-M 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
Foreliggende oppfinnelse angår et desinfeksjonsmiddel som i vandig oppløsning som virksomt stoff inneholder salter av klorheksidin (dvs. 1,1<1->heksametylen-bis-[5-(p-klor-fenylbiguanid)]) og salter av en kvaternær ammoniumbase, og midlet karakteriseres ved at begge de virksomme stoffer foreligger som glukonat eller laktat. The present invention relates to a disinfectant which in aqueous solution as active ingredient contains salts of chlorhexidine (i.e. 1,1<1->hexamethylene-bis-[5-(p-chloro-phenylbiguanide)]) and salts of a quaternary ammonium base, and the remedy is characterized by the fact that both active substances are present as gluconate or lactate.
Konsentrasjonen av klorheksidinlaktatet eller -glukonatet utgjør hensiktsmessig 0,1-15 vekt-%, fortrinnsvis 4 vekt-%, og den til laktatet eller glukonatet av den kvaternære ammoniumbase 1-20 vekt-%, fortrinnsvis 5 vekt-%. The concentration of the chlorhexidine lactate or gluconate is suitably 0.1-15% by weight, preferably 4% by weight, and that of the lactate or gluconate of the quaternary ammonium base 1-20% by weight, preferably 5% by weight.
Som kvaternære ammoniumbaser skal f.eks. nevnes følgende forbindelser: dodecyldimetyldiklorbenzylammoniumlaktat dodecyldimetylbenzylammoniumlaktat tetradecyldimetylbenzylammohiumlaktat dodecyldimetyletylbenzylammoniumlaktat heksadecyltrimetylammoniumlaktat As quaternary ammonium bases, e.g. the following compounds are mentioned: dodecyldimethyldichlorobenzylammonium lactate dodecyldimethylbenzylammonium lactate tetradecyldimethylbenzylammonium lactate dodecyldimethylethylbenzylammonium lactate hexadecyltrimethylammonium lactate
dodecyldimetyldiklorbenzylammoniumglukonat dodecyldimetylbenzylammoniumglukonat dodecyldimethyldichlorobenzylammonium gluconate dodecyldimethylbenzylammonium gluconate
tetradecyldimetylbenzylammoniumglukonat dodecyldimetyletylbenzylammoniumglukonat heksadecyltrimetylammoniumglukonat. tetradecyldimethylbenzylammonium gluconate dodecyldimethylethylbenzylammonium gluconate hexadecyltrimethylammonium gluconate.
Klorheksidinglukonat har god virksomhet mot gramnegative kimer, og de kvaternære ammoniumsalter har god virksomhet mot grampositive kimer, spesielt mot Staphylokokkér. Disse virkninger utfyller seg ved kombinasjonen av de to stoffer på fordelaktig måte. Chlorhexidine gluconate has good activity against Gram-negative germs, and the quaternary ammonium salts have good activity against Gram-positive germs, especially against Staphylococcus. These effects are complemented by the combination of the two substances in an advantageous way.
Den minst like gode virksomhet mot gramnegative kimer tilkommer klorheksidinlaktatet. Dette utmerker seg i til- Chlorhexidine lactate has the least equally good activity against Gram-negative germs. This excels in to-
legg ved en spesielt god hudfordragelighet. add a particularly good skin tolerance.
Det, nye klorheksidinlaktat oppnås idet man omsetter melkesyre eller et salt av ,denne syre med klorheksidin eller et salt av denne forbindelse. The new chlorhexidine lactate is obtained by reacting lactic acid or a salt of this acid with chlorhexidine or a salt of this compound.
Det er kjent desinfeksjonsmidler som i oppløst til-stand inneholder de to virksomme stoffer klorheksidinglukonat og et kvaternært ammoniumhalogénid. Disinfectants are known which in a dissolved state contain the two active substances chlorhexidine gluconate and a quaternary ammonium halide.
Disse preparater har dog den store mangel at klor-heksidinet forener seg med halogenidet, spesielt kloridet, i ammoniumbasen, og dette'gir et uoppløselig bunnfall. Derfor er fremstillingen av slike oppløsninger kun mulig med en tilleggs-tilsetning av oppløsningsfremmende stoffer (polyoksyetylenglykoler), og til og med i dette tilfelle kan det kun bringes en liten konsentrasjon (0,15 vekt-%) åv klorheksidinglukonat i oppløsning, hvis oppløsningen skal forbli klar. However, these preparations have the major disadvantage that the chlorhexidine combines with the halide, especially the chloride, in the ammonium base, and this gives an insoluble precipitate. Therefore, the preparation of such solutions is only possible with an additional addition of dissolution-promoting substances (polyoxyethylene glycols), and even in this case only a small concentration (0.15% by weight) of chlorhexidine gluconate can be brought into solution, if the solution is to stay ready.
En ytterligere mangel ligger i at tilsetning av oppløsningsfremmende stoffer (polyoksyetylenglykoler) nedsetter den bioside virksomhet av preparatet. A further shortcoming is that the addition of dissolution-promoting substances (polyoxyethylene glycols) reduces the biocidal activity of the preparation.
Ifølge oppfinnelsen anvendes for første gang i stedet for halogenidet av det kvaternære ammoniumsalt det tilsvarende glukonat henholdsvis laktat. På denne måte kan klorheksidin ikke mer falle ut som halogenid, og oppløsningen forblir klar, uten at det tilsettes dppløsningsfremmende stoffer. According to the invention, the corresponding gluconate or lactate is used for the first time instead of the halide of the quaternary ammonium salt. In this way, chlorhexidine can no longer precipitate as a halide, and the solution remains clear, without the addition of dissolution-promoting substances.
Konsentrasjonen av klorheksidinlaktat henholdsvis The concentration of chlorhexidine lactate respectively
-glukonat slik som nevnt ovenfor utgjør opptil 15 vekt-%. Virksomheten blir ikke nedsatt ved tilsetning av et oppløsnings- fremmende stoff. På grunn av de kvaternære ammoniumsalter gir det seg en hurtig inntreden av virkningen og virksomheten mot grampositive kimer; på grunn av;klorheksidinlaktatet henholdsvis -glukonatet en vedvarende virksomhet og virkning mot gramnegative kimer. Substansen er filmdannende, overflåteaktiv og tåles godt av huden. -gluconate as mentioned above constitutes up to 15% by weight. The business is not reduced by the addition of a dissolution promoting substance. Because of the quaternary ammonium salts, there is a rapid onset of action and activity against gram-positive germs; due to the chlorhexidine lactate and -gluconate a persistent activity and effect against Gram-negative germs. The substance is film-forming, surface-active and well tolerated by the skin.
Fremstillingseksempler: Production examples:
Fremstilling av 1,1<1->heksametylen-bis-[5-(p-klorfenylbiguanid)]-dilaktat. Preparation of 1,1<1->hexamethylene bis-[5-(p-chlorophenylbiguanide)]-dilactate.
En blanding av 5,05 g 1,1r<->heksametylen-bis-[5-(p-klorfenylbiguanid)] og 2,0 g melkesyre (90%-ig) oppløses i 50 ml vann og oppvarmes lett (30°C). A mixture of 5.05 g of 1,1r<->hexamethylene-bis-[5-(p-chlorophenylbiguanide)] and 2.0 g of lactic acid (90%) is dissolved in 50 ml of water and heated slightly (30°C ).
Det filtreres og avkjøles, og man oppnår en klar, bestandig oppløsning av 1,1'-heksametylen-bis-[5-(p-klorfenyl-biguanid) ]dilaktat. It is filtered and cooled, and a clear, stable solution of 1,1'-hexamethylene bis-[5-(p-chlorophenyl-biguanide)]dilactate is obtained.
Fremstilling av dodecyldimetyldiklorbenzylammoniumglukonat. 2 1 av en 20%-ig vandig "Benzalkon B"-oppløsning (dodecyldimetyldiklorbenzylammoniumklorid) lar man flyte over 50 g av den sterkt basiske ionebytter "Merck III". Til den oppnådde oppløsning settes 70 g glukono-6-lakton og pH-verdien innstilles på denne måte til 7,0. Innholdet justeres ved hjelp av vann til 20%. Oppløsningen inneholder under 0,1% klorid. Preparation of dodecyldimethyldichlorobenzylammonium gluconate. 2 1 of a 20% aqueous "Benzalkon B" solution (dodecyldimethyldichlorobenzylammonium chloride) is allowed to flow over 50 g of the strongly basic ion exchanger "Merck III". 70 g of glucono-6-lactone are added to the solution obtained and the pH value is adjusted in this way to 7.0. The content is adjusted using water to 20%. The solution contains less than 0.1% chloride.
Kun på denne måte oppnår man en oppløsning" med tilstrekkelig liten kloridkonsentrasjon. This is the only way to achieve a solution with a sufficiently low chloride concentration.
Det skal fremheves at en behandling med alkali og derpå følgende nøytralisering av "Benzalkon B"-basen med glukon-syre-6-lakton ikke gir det tilstrekkelig lave kloridinnhold. "Benzalkon B"-glukonat som fremstilles ved behandling med alkali osv., ga med klorheksidinglukonat uklare oppløsninger.- It should be emphasized that a treatment with alkali and subsequent neutralization of the "Benzalkon B" base with gluconic acid-6-lactone does not give it a sufficiently low chloride content. "Benzalkon B" gluconate, which is prepared by treatment with alkali, etc., gave with chlorhexidine gluconate cloudy solutions.-
På samme måte kan også de følgende glukonater av kavternære ammoniumbaser fremstilles fra tilsvarende halogenider: dodecyldimetylbenzylammoniumglukonat tetradecyldimetylbenzylammoniumglukonat dodecyldimetyletylbenzylammoniumglukonat og heksadecyltrimetylammoniumglukonat. In the same way, the following gluconates of quaternary ammonium bases can also be prepared from corresponding halides: dodecyldimethylbenzylammonium gluconate tetradecyldimethylbenzylammonium gluconate dodecyldimethylethylbenzylammonium gluconate and hexadecyltrimethylammonium gluconate.
Fremstilling av dodecyldimetyldiklorbenzylammoniumlaktat.. 30 ml av en 20%-ig vandig "Benzalkon B'l<->oppløsning (dodecyldimetyldiklorbenzylammoniumklorid) lar man flyte over 500 g av den sterkt basiske ionebytter "Merck III". Preparation of dodecyldimethyldichlorobenzylammonium lactate.. 30 ml of a 20% aqueous "Benzalkon B'l<-> solution (dodecyldimethyldichlorobenzylammonium chloride) is allowed to flow over 500 g of the strongly basic ion exchanger "Merck III".
Til denne oppnådde oppløsning settes 36 g 90%-ig melkesyre, og pH-verdien innstilles på denne måte til 7,0.. Opp-løsningen inneholder under 0,1% klorid. 36 g of 90% lactic acid is added to this obtained solution, and the pH value is adjusted in this way to 7.0. The solution contains less than 0.1% chloride.
Eksempel 1 Example 1
20% av en 20%-ig klorheksidinglukonatoppløsning og 25 g av en 20%-ig dodecyldimetyldiklorbenzylammoniumglukonat-oppløsning helles sammen. Dertil settes 55 g vann, og det røres godt. 20% of a 20% chlorhexidine gluconate solution and 25 g of a 20% dodecyldimethyldichlorobenzylammonium gluconate solution are poured together. Add 55 g of water to this and stir well.
Man oppnår 100 g av en oppløsning som oppviser et innhold på 4 vekt-% klorheksidinglukonat og 5 vekt-% dodecyldi- 100 g of a solution with a content of 4% by weight of chlorhexidine gluconate and 5% by weight of dodecyl di-
raetyldiklorbenzylammoniumglukonat. raethyldichlorobenzylammonium gluconate.
Analogt fremspilles blandinger av klorheksidinglukonat og følgende kvaternære ammoniumsalter: dodecy.ldimetylbenzy lammoniumglukonat tetradecyldimetylbenzylammoniumglukonat d<p>decyldlmetyletylbenzylammoniumglukonat, og heksadecyltrimetylammoniumglukonat. Analogously, mixtures of chlorhexidine gluconate and the following quaternary ammonium salts are produced: dodecyldimethylbenzylammonium gluconate tetradecyldimethylbenzylammonium gluconate d<p>decyldlmethylethylbenzylammonium gluconate, and hexadecyltrimethylammonium gluconate.
Eksempel 2 Example 2
20 g av en 20%-ig klorheksidinlaktatoppløsning og 25 g av en 20%-ig dodecyldimetyldiklorbenzylammoniumlaktat-oppløsning forenes. 20 g of a 20% chlorhexidine lactate solution and 25 g of a 20% dodecyldimethyldichlorobenzylammonium lactate solution are combined.
Dertil settes 55 g vann pg det omrøres. Man oppnår en oppløsning som.oppviser et innhold på 4 vekt-% klorheksidinlaktat og 5 vekt-% dodecyldimetyldiklorbenzylammoniumlaktat. Add 55 g of water to it and stir. A solution is obtained which has a content of 4% by weight of chlorhexidine lactate and 5% by weight of dodecyldimethyldichlorobenzylammonium lactate.
Analogt fremstilles blandinger av klorheksidinlaktat og følgende kvaternære ammoniumsalter: dodecyldimetylbenzylammoniumlaktat tetradecyldimetylbenzylammoniumlaktat dodecyldimetyletylbenzylammoniumlaktat, <p>g heksadecyltrimetylammoniumlaktat. Analogously, mixtures of chlorhexidine lactate and the following quaternary ammonium salts are prepared: dodecyldimethylbenzylammonium lactate tetradecyldimethylbenzylammonium lactate dodecyldimethylethylbenzylammonium lactate, <p>g hexadecyltrimethylammonium lactate.
Eksempel 3 Example 3
20 g av,en 20%-ig klorheksidindiglukonatoppløsning og 25 g av 20%-ig dodecyldimetyldiklorbenzylammoniumlaktat-oppløsning forénes. Dertil settes 55 g og det omrøres. 20 g of a 20% chlorhexidine digluconate solution and 25 g of a 20% dodecyldimethyldichlorobenzylammonium lactate solution are combined. Add 55 g to it and stir.
Man oppnår 100 g av en oppløsning som oppviser et innhold på 4 vekt-% klorheksidindiglukonat og 5 vekt-% dode-cyldimetyldikiorbenzylammoiirumlaktat. 100 g of a solution is obtained which has a content of 4% by weight of chlorhexidine digluconate and 5% by weight of dodecyldimethyldichlorobenzylammonium lactate.
Eksempel 4 Example 4
20 g av én 20%-ig klorheksidindilaktatoppløsning og 25 g av en 20%-ig dodecyldimetyldiklorbenzylammoniumglukonat-oppløsning forénes. 20 g of a 20% chlorhexidine dilactate solution and 25 g of a 20% dodecyldimethyldichlorobenzylammonium gluconate solution are combined.
Dertil settes 55 g vann og man omrører. Man oppnår 100 g av en oppløsning som oppviser et innhold på 4 vekt-% klorheksidindilaktat og 5 vekt-% dodecyldimetyldiklorbenzylammoniumglukonat. Add 55 g of water and stir. 100 g of a solution is obtained which has a content of 4% by weight chlorhexidine dilactate and 5% by weight dodecyldimethyldichlorobenzylammonium gluconate.
Claims (2)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT659572A AT318152B (en) | 1972-07-31 | 1972-07-31 | Disinfectants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO135852B true NO135852B (en) | 1977-03-07 |
| NO135852C NO135852C (en) | 1977-06-15 |
Family
ID=3587881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO3055/73A NO135852C (en) | 1972-07-31 | 1973-07-30 |
Country Status (13)
| Country | Link |
|---|---|
| AT (1) | AT318152B (en) |
| AU (1) | AU468341B2 (en) |
| BE (1) | BE802957A (en) |
| CA (1) | CA1026232A (en) |
| DD (1) | DD106780A5 (en) |
| FI (1) | FI58424C (en) |
| FR (1) | FR2194448B1 (en) |
| GB (1) | GB1355636A (en) |
| IL (1) | IL42716A (en) |
| NL (1) | NL7306479A (en) |
| NO (1) | NO135852C (en) |
| SE (1) | SE397268B (en) |
| ZA (1) | ZA735201B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE425043B (en) * | 1977-05-10 | 1982-08-30 | Kenogard Ab | FUNGICID COMPOSITION, PREFERRED FOR USE AS A THREE PROTECTIVE, CONTAINING AT LEAST ONE QUARTER OF AMMONIUM SUBSTANCE IN MIXING WITH AN AMINE COMPONENT |
| AT381001B (en) * | 1983-11-28 | 1986-08-11 | Arcana Chem Pharm | METHOD FOR PRODUCING CLEAR AQUEOUS DISINFECTANT SOLUTIONS |
| FR2691325B1 (en) * | 1992-05-21 | 1997-06-06 | Hutchinson | ANTISEPTIC COMPOSITIONS AND THEIR APPLICATIONS. |
| IL100881A (en) * | 1992-02-06 | 1996-06-18 | Porat Michael | Prophylactic lubricating composition and devices and method for using same |
| US6303557B1 (en) | 1999-11-16 | 2001-10-16 | S. C. Johnson Commercial Markets, Inc. | Fast acting disinfectant and cleaner containing a polymeric biguanide |
| WO2010010345A2 (en) * | 2008-07-22 | 2010-01-28 | Polybiotech Limited | Sanitising compositions and methods |
| GB2474017B (en) * | 2009-09-29 | 2015-07-15 | Europ First Aid Ltd | Biocidal solution |
-
1972
- 1972-07-31 AT AT659572A patent/AT318152B/en not_active IP Right Cessation
-
1973
- 1973-03-12 SE SE7303386A patent/SE397268B/en unknown
- 1973-03-14 GB GB1230573A patent/GB1355636A/en not_active Expired
- 1973-05-08 FR FR7316482A patent/FR2194448B1/fr not_active Expired
- 1973-05-09 NL NL7306479A patent/NL7306479A/xx unknown
- 1973-07-11 IL IL42716A patent/IL42716A/en unknown
- 1973-07-27 DD DD172577A patent/DD106780A5/xx unknown
- 1973-07-30 AU AU58699/73A patent/AU468341B2/en not_active Expired
- 1973-07-30 BE BE134004A patent/BE802957A/en unknown
- 1973-07-30 FI FI2389/73A patent/FI58424C/en active
- 1973-07-30 CA CA177,588A patent/CA1026232A/en not_active Expired
- 1973-07-30 NO NO3055/73A patent/NO135852C/no unknown
- 1973-07-31 ZA ZA735201A patent/ZA735201B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO135852C (en) | 1977-06-15 |
| AU468341B2 (en) | 1976-01-08 |
| DD106780A5 (en) | 1974-07-05 |
| CA1026232A (en) | 1978-02-14 |
| SE397268B (en) | 1977-10-31 |
| NL7306479A (en) | 1974-02-04 |
| FI58424B (en) | 1980-10-31 |
| AT318152B (en) | 1974-09-25 |
| IL42716A0 (en) | 1973-10-25 |
| ZA735201B (en) | 1974-09-25 |
| DE2310989B2 (en) | 1975-06-26 |
| DE2310989A1 (en) | 1974-02-14 |
| FI58424C (en) | 1981-02-10 |
| BE802957A (en) | 1973-11-16 |
| FR2194448B1 (en) | 1976-09-17 |
| FR2194448A1 (en) | 1974-03-01 |
| GB1355636A (en) | 1974-06-05 |
| AU5869973A (en) | 1975-01-30 |
| IL42716A (en) | 1976-03-31 |
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