NO135200B - - Google Patents
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- NO135200B NO135200B NO2077/71A NO207771A NO135200B NO 135200 B NO135200 B NO 135200B NO 2077/71 A NO2077/71 A NO 2077/71A NO 207771 A NO207771 A NO 207771A NO 135200 B NO135200 B NO 135200B
- Authority
- NO
- Norway
- Prior art keywords
- weight
- dental
- agent
- water
- oral care
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 239000003242 anti bacterial agent Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 8
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 7
- 239000008375 oral care agent Substances 0.000 claims description 6
- 239000002324 mouth wash Substances 0.000 claims description 4
- 231100000252 nontoxic Toxicity 0.000 claims description 4
- 230000003000 nontoxic effect Effects 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 229940051866 mouthwash Drugs 0.000 claims description 3
- 229920002959 polymer blend Polymers 0.000 claims 1
- 239000000047 product Substances 0.000 description 17
- 239000000463 material Substances 0.000 description 15
- 239000000606 toothpaste Substances 0.000 description 14
- 229940034610 toothpaste Drugs 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 239000002245 particle Substances 0.000 description 9
- 238000005498 polishing Methods 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 239000007788 liquid Substances 0.000 description 8
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000000600 sorbitol Substances 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- -1 zirconium silicates Chemical class 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000011149 active material Substances 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- 239000001506 calcium phosphate Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000003349 gelling agent Substances 0.000 description 3
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 235000011837 pasties Nutrition 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000013256 coordination polymer Substances 0.000 description 2
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 2
- 229940038472 dicalcium phosphate Drugs 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 2
- 125000005341 metaphosphate group Chemical group 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- QLAJNZSPVITUCQ-UHFFFAOYSA-N 1,3,2-dioxathietane 2,2-dioxide Chemical compound O=S1(=O)OCO1 QLAJNZSPVITUCQ-UHFFFAOYSA-N 0.000 description 1
- UBLAMKHIFZBBSS-UHFFFAOYSA-N 3-Methylbutyl pentanoate Chemical compound CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000206575 Chondrus crispus Species 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910001515 alkali metal fluoride Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 150000003841 chloride salts Chemical class 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910021488 crystalline silicon dioxide Inorganic materials 0.000 description 1
- QWJNFFYFEKXZBF-UHFFFAOYSA-N cyanocyanamide Chemical compound N#CNC#N QWJNFFYFEKXZBF-UHFFFAOYSA-N 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 150000004985 diamines Chemical class 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 229910052909 inorganic silicate Inorganic materials 0.000 description 1
- LIKBJVNGSGBSGK-UHFFFAOYSA-N iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Fe+3].[Fe+3] LIKBJVNGSGBSGK-UHFFFAOYSA-N 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 229910000400 magnesium phosphate tribasic Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical class CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 229940099402 potassium metaphosphate Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Oppfinnelsen angår tann- eller munnpleiemidler, omfattende The invention relates to dental or oral care products, comprehensively
f.eks. tannpastaer eller tannkremer, tannpulvere, munnvann eller skyllevann, dental-tyggegutnmier, dentalfloss, tyggetabletter, sugetabletter og pastiller. e.g. toothpastes or toothpastes, tooth powders, mouthwashes or rinses, dental chewing gums, dental floss, chewable tablets, lozenges and lozenges.
I norsk patentskrift nr. I31A08 er beskrevet tannpleie- In Norwegian patent document no. I31A08, dental care is described
midler som inneholder 1,6-bis-(2-ethylhexyl-biguanido)-hexandi-hydroklorid for å hemme dannelse av tannbelegg og tannstenvagents containing 1,6-bis-(2-ethylhexyl-biguanido)-hexanedihydrochloride to inhibit the formation of plaque and tartar
Det er dessuten tidligere blitt beskrevet at biguanido- It has also previously been described that biguanido-
hexaner, som 1,6-di-(p-klorfenyl-biguanido)-hexan, er antimikrobi- hexanes, such as 1,6-di-(p-chlorophenyl-biguanido)-hexane, are antimicrobial
elle midler som kan innarbeides i tannpastaer. or agents that can be incorporated into toothpastes.
Disse for anvendelse i tannpleietnidler foreslåtte, monomere biguanidohexaner vil i tannpleiemidler uvegerlig fore til reak/ These monomeric biguanidohexanes proposed for use in dental care products will inevitably lead to reactions in dental care products
sjoner mellom biguanidohexankationer og anioner som normalt er tilstede i tannpleiemidler, og bevirke dannelse av bunnfall og nedsatt antibakteriell virksomhet. tions between biguanidohexane cations and anions that are normally present in dentifrices, and cause the formation of precipitates and reduced antibacterial activity.
Det tas ved oppfinnelsen sikte på å tilveiebringe tann- The invention aims to provide dental
eller munnpleiemidler som inneholder et antibakterielt middel, or oral care products containing an antibacterial agent,
men som ikke er beheftet med de ovennevnte ulemper, men tillater tilstedeværelsen i tann- eller munnpleiemidlene av en rekke forskjellige anioner som ville fore til uopploseliggjorelse og ned- but which are not affected by the above-mentioned disadvantages, but allow the presence in the dental or oral care products of a number of different anions which would lead to insolubilization and degradation
satt antibakteriell virksomhet dersom et monomert biguanid var blitt anvendt. set antibacterial activity if a monomeric biguanide had been used.
Dette oppnås ved tann- eller tnunnpleietnidlet Ifolge oppfinnelsen som er særpreget ved at det inneholder et antibakterielt middel bestående av en blanding av de ugiftige polymerer med formelen This is achieved by the tooth or tooth care tool according to the invention, which is characterized by the fact that it contains an antibacterial agent consisting of a mixture of the non-toxic polymers with the formula
hvor Y er eller where Y is or
X er X is
-NH2 -NH2
eller or
og-'h ér et helt tall fra 1-6, eller salter derav, og en med and-'h is a whole number from 1-6, or salts thereof, and one with
midlet forenlig bærer. the agent compatible carrier.
Tann- eller munnpleiemidlet kan dessuten inneholder andre aktive bestanddeler. The dental or oral care product may also contain other active ingredients.
De i tann- eller munnpleiemidlet ifolge oppfinnelsen Those in the dental or oral care product according to the invention
anvendte polymere amino-cyano-diguanider er kationaktive, men forenlige med ahionaktive materialer og andre materialer som er vanlig polymeric amino-cyano-diguanides used are cation-active, but compatible with anion-active materials and other materials commonly
anvendte i raunnpreparater, f.eks. overflateaktive midler, fluorgivende forbindelser og, dersom munn- eller tannpleiemidler inneholder et svakt opploselig poleringsmateriale, den del av poleringsmaterialet som er opploselig i vann eller i spytt. used in round preparations, e.g. surfactants, fluorine-giving compounds and, if oral or dental care products contain a slightly soluble polishing material, the part of the polishing material that is soluble in water or in saliva.
Det anvendte polymere amino-cyano-diguanid kan fremstilles ved en fremgangsmåte lignende den som er beskrevet i Britisk Patentskrift nr. 1.152.2^3» Ved en slik fremgangsmåte omsettes hexamet-hylendiamin, R^NCCR^^NI^, eller et uorganisk salt derav med hexa-methylendiaminsaltet av et dicyanimid med formelen [H^N- (CR^k-NH^l [N(CN)2]. I det minste den forste del av omsetningen utfores som regel i nærvær av et hydroxylisk opplosningsmiddel, som en alifatisk alkohol inneholdende 1 - h carbonatomer, eller helst vann. Det hydroxyliske opplosningsmiddel kan være blandet med mindre mengder av et ikke-hydroxylisk opplosningsmiddel, som toluen. Reaksjonsblan-dingens pH reguleres fortrinnsvis til ca. 6. - 8 med en mineralsyre, som saltsyre, som omdanner det frie diamin til syresaltet, og opp-lesningen oppvarmes til å begynne med til ca. 100° C ved attnosfære-trykk for å destillere av i det minste en del av det hydroxyliske opplosningsmiddel. Reaksjonsblandingen blir deretter oppvarmet til ca. 120 - 170° C i 1 - 8 timer. Deretter kan, om onskes, vann til-settes under avkjoling. Det derved erholdte araino-cyano-polydiguanid kan deretter skilles fra eventuelt tilstedeværende med vann ubland-bart opplosningsmiddel og, om onskes, også isoleres fra den vandige opplosning. The polymeric amino-cyano-diguanide used can be prepared by a method similar to that described in British Patent No. 1.152.2^3» In such a method, hexamethylenediamine, R^NCCR^^NI^, or an inorganic salt is reacted hence with the hexamethylenediamine salt of a dicyanimide of the formula [H^N- (CR^k-NH^l [N(CN)2]. At least the first part of the reaction is usually carried out in the presence of a hydroxylic solvent, which an aliphatic alcohol containing 1 - h carbon atoms, or preferably water. The hydroxylic solvent can be mixed with smaller amounts of a non-hydroxyl solvent, such as toluene. The pH of the reaction mixture is preferably adjusted to about 6 - 8 with a mineral acid, which hydrochloric acid, which converts the free diamine to the acid salt, and the reaction is initially heated to about 100° C. at atmospheric pressure to distill off at least a portion of the hydroxylic solvent. The reaction mixture is then heated to about 120 - 170° C for 1 - 8 hours. Then, if desired, water can be added during cooling. The thus obtained araino-cyano-polydiguanide can then be separated from any water-immiscible solvent present and, if desired, also isolated from the aqueous solution.
Polymerproduktet er en blanding av polymerer med formelen The polymer product is a mixture of polymers with the formula
hvor Y er NH2(CH2)6" eller X er -NH2 eller where Y is NH2(CH2)6" or X is -NH2 or
og and
n er et lavt helt tall, f.eks. fra 2 til 6, gjennomsnittlig ca. h. n is a low integer, e.g. from 2 to 6, average approx. h.
Den gjennomsnittlige molekylvekt til de ved den'ovenstående fremgangsmåte fremstilte polymerer er som regel ca. 1100. The average molecular weight of the polymers produced by the above method is usually approx. 1100.
Som angitt ovenfor, kan ugiftige tilsetningssalter av slike forbindelser anvendes. Disige salter kan være uorganiske, f.eks. fluorid, klorid, nitrat eller sulfat, eller organiske, som succinat, As indicated above, non-toxic addition salts of such compounds may be used. Hazy salts can be inorganic, e.g. fluoride, chloride, nitrate or sulfate, or organic, such as succinate,
i. in.
tartråt, citrat, maleat og .methosulfat. tartrate, citrate, maleate and .methosulphate.
''Visse av <t>ilsetnin<g> skaltene er uoppløselige, som det vannuopp- . ''Certain of the <t>ilsetnin<g> skins are insoluble, such as the water-soluble .
Ibselige -sulfattilsetningssalt. Disse salter kan anvendes i tannpleiemidler i form av. adskilte .partikler som. kan være ..synlige på overflaten av- .opake tannkremer eller inne i .og på overflaten av. klare , dvs. gjen-nomsiktige; eller .gjennomskinnelige geler., Ibselige -sulphate addition salt. These salts can be used in dental care products in the form of separated .particles which. may be ..visible on the surface of- .opaque toothpastes or inside .and on the surface of. clear, i.e. transparent; or .translucent gels.,
"''■• -'Det 'foretrukne 'polymer-produkt 'er 'en- blanding av forskjellige kombinasjoner av X- og Y-gruppené bg forskjellige -mengder av den . The preferred polymer product is a mixture of different combinations of the X and Y groups and different amounts thereof.
gjentatt forekommende enhet recurring entity
Det' er -vanlig å fremstille pblymerproduktet-i form"av dets-' klbridsålt, og'det'forekommer som om polymerproduktétvhovedsakelig-består 'åv ,det lineære ' amino-cyåno-^polyhexaméthylen-diguanid . • .. :■ It is common to prepare the polymer product in the form of its chloride salt, and it appears that the polymer product mainly consists of the linear amino-cyano-polyhexamethylene diguanide.
:' - Polymeren er sterkt . opploselig-i vann og (sp-ytt og er særpreget ved enf.hby antibakteriell aktivitet sammelignet med 1,6-di-. :' - The polymer is strong. soluble in water and saliva and is characterized by an antibacterial activity comparable to that of 1,6-di-.
(p-klorf enylbiguanidhexan)..-Polymeren kan som regel anvendes i en mengde av 0,01 5* vekt^,.fortrinnsvis 0,05 - 1,5 vekt$, av munnpreparatet. (p-chlorophenylbiguanidehexane)..-The polymer can usually be used in an amount of 0.01 5* weight^,.preferably 0.05 - 1.5 weight$, of the oral preparation.
Midlene -ifolge .oppfinnelsen kan være i det vesentlige flytende, f.eks. i form av et munnvann eller skyllevann. I et slikt middel er bæreren som regel en blanding av vann og alkohol. Vektforholdet vann:alkohol er som regel 1:1 - 20:1, fortrinnsvis 3:1 - 20:1, og helst ca. 17:3. Den samlede mengde vann-alkohol i denne type middel er som regel 70 - 99,95 vekt$ av preparatet. Slike flytende midler har som regel en pH av M-,5 - 9, vanligvis 5,5 - 8. The means - according to the invention can be essentially liquid, e.g. in the form of a mouthwash or rinse. In such an agent, the carrier is usually a mixture of water and alcohol. The weight ratio water:alcohol is usually 1:1 - 20:1, preferably 3:1 - 20:1, and preferably approx. 17:3. The total amount of water-alcohol in this type of agent is usually 70 - 99.95% by weight of the preparation. Such liquid agents usually have a pH of M-.5 - 9, usually 5.5 - 8.
,Slike flytende munnpleiemidler kan også inneholde et overflateaktivt middel og/eller en fluorgivende forbindelse.' "Such liquid oral care agents may also contain a surface-active agent and/or a fluorine-giving compound."
Midlene ifolge oppfinnelsen kan dessuten være i det vesentlige faste eller pasta-formige, som et tahnpulver, eller en tannpasta eller tannkrem. Bæreren i slike faste eller pasta-formige midler inneholder et poleringsmateriale. Eksempler på poleringsmaterialer er vannuopploselig natriummetafosfat, kalium-metafosfat, trikalsiumfosfat, dihydratisert dikalsiumfosfat, vannfritt dikalsiumfosfat, kalsiumpyrofosfat, magnesiumorthofosfat, tri-magnesiumfosfat, kalsiumcarbonat, aluminiumoxyd, aluminiumsilieat, zirconiumsilicater, siliciumdioxyd, plaster som polymethylmethacry-lat, bentonitt og blandinger derav. De foretrukne poleringsmaterialer<;>The agents according to the invention can also be essentially solid or paste-like, such as a toothpaste powder, or a toothpaste or toothpaste. The carrier in such solid or pasty agents contains a polishing material. Examples of polishing materials are water-insoluble sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, dihydrated dicalcium phosphate, anhydrous dicalcium phosphate, calcium pyrophosphate, magnesium orthophosphate, tri-magnesium phosphate, calcium carbonate, aluminum oxide, aluminum silicate, zirconium silicates, silicon dioxide, plastics such as polymethyl methacrylate, bentonite and mixtures thereof. The preferred polishing materials<;>
inneholder krystallinsk siliciumdioxyd med partikler med en storrelse inntil 5 en gjennomsnittlig partikkelstbrrelse inntil 1,1 ^ og et contains crystalline silicon dioxide with particles with a size of up to 5 an average particle size of up to 1.1 ^ and a
overflateareal av inntil 50.000 cm 2/g, uopploselig natriummetafosfat, vannfritt dikalsiumfosfat og kalsiumcarbonat som vanligvis er fin-delte med en gjennomsnittlig partikkelstorrelse under 10 /x. surface area of up to 50,000 cm 2 /g, insoluble sodium metaphosphate, anhydrous dicalcium phosphate and calcium carbonate which are usually finely divided with an average particle size below 10 /x.
Aluminiumoxyd, spesielt det hydratiserte aluminiumoxyd som selges under betegnelsen C333 og som har et aluminiumoxydinnhold av 6^,9 vekt$, et siliciumdioxydinnhold av 0,008 vekt#, et jern (III)-oxydinnhold av 0,003 vekt% og et fuktighetsinnhold av 0,37 vekt# ved 110°C og som har en egenvekt av 2,^2 og en slik partikkelstorrelse at 100$ av partiklene har en storrelse under 50 \ l og 8h% av partiklene har en storrelse under 20 ^., er spesielt gunstig. Alumina, in particular the hydrated alumina sold under the designation C333 and having an alumina content of 6^.9% by weight, a silicon dioxide content of 0.008% by weight, an iron (III) oxide content of 0.003% by weight and a moisture content of 0.37% by weight # at 110°C and which has a specific gravity of 2.2 and a particle size such that 100% of the particles have a size below 50 µl and 8% of the particles have a size below 20 µl, is particularly favorable.
Dersom det anvendes klare geler, er det spesielt gunstig med If clear gels are used, it is particularly beneficial
et poleringsmiddel av kolloidalt siliciumdioxyd, som den kvalitet som selges under varemerket "SYL0ID", f.eks. "SYL0ID 72" og "SYL0ID 7^", eller under varemerket "SANT0CEL", f.eks. "SANT0CEL 100", og alkalimetall-aluminiumsilicat-komplekser da disse har brytningsin-' dekser som er nær brytningsindeksene for de i tannpleiemidler vanlig anvendte systemer av geleringsmiddel-væske (omfattende vann og/eller fuktemiddel). a polishing agent of colloidal silicon dioxide, such as the grade sold under the trademark "SYL0ID", e.g. "SYL0ID 72" and "SYL0ID 7^", or under the trademark "SANT0CEL", e.g. "SANT0CEL 100", and alkali metal-aluminium silicate complexes as these have refractive indices which are close to the refractive indices of the gelling agent-liquid systems (comprising water and/or wetting agent) commonly used in dental care products.
En rekke av de såkalte "vannuopploselige" poleringsmaterialer er anionaktive og inneholder dessuten små mengder opploselig materiale. Uopploselig natriummetafosfat kan således være fremstilt.. på en hvilken som helst egnet måte, som beskrevet i Thorpe's Dictio-nary. of Applied Chemistry, V. 9 (^. utgave), s. 510 - 511. De former av uopploselig natriummetafosfat som er kjente som Medrell's salt og Kurrol's salt er ytterligere eksempler på egnede materialer. Disse metafosfatsalter har en meget lav opploselighet i vann og be-tegnes derfor ofte som uopploselige metafosfater. De inneholder en mindre mengde opploselig fosfatmateriale som forurensning, som regel i en mengde av et par prosent, f.eks. inntil h vekt$. Mengden av opploselig fosf atmateriale, som i forbindelse med uopploselig natri--ummetafosfat antaes å være et opploselig natriumtrimetafosfat, kan, om onskes, nedsettes ved vasking med vann. Det uoppløselige alkalimetallmetafosfat- anvendes som regel i form av et pulver med partikler med en slik storrelse at ikke mer enn 1 % av materialet er storre enn 37 U- A number of the so-called "water-insoluble" polishing materials are anion-active and also contain small amounts of soluble material. Insoluble sodium metaphosphate may thus be prepared.. in any suitable manner, as described in Thorpe's Dictio-nary. of Applied Chemistry, V. 9 (^th edition), pp. 510-511. The forms of insoluble sodium metaphosphate known as Medrell's salt and Kurrol's salt are further examples of suitable materials. These metaphosphate salts have a very low solubility in water and are therefore often referred to as insoluble metaphosphates. They contain a small amount of soluble phosphate material as a contaminant, usually in the amount of a few percent, e.g. up to h weight$. The amount of soluble phosphate material, which in connection with insoluble sodium metaphosphate is assumed to be a soluble sodium trimetaphosphate, can, if desired, be reduced by washing with water. The insoluble alkali metal metaphosphate- is usually used in the form of a powder with particles of such a size that no more than 1% of the material is larger than 37 U-
Poleringsmaterialet er som regel tilstede i en mengde av The polishing material is usually present in an amount of
20 - 99 vekt$ av midlet. Det er fortrinnsvis tilstede i en mengde av 20 - 75 % i tannpasta og i en mengde av 70 - 99 % i tann-pulver. 20 - 99% by weight of the agent. It is preferably present in an amount of 20 - 75% in toothpaste and in an amount of 70 - 99% in tooth powder.
Ved fremstilling av tannpulvere er det som regel tilstrekkelig mekanisk å blande, f.eks. i en triolle, de forskjellige faste bestanddeler i egnede mengder og med egnede partikkelstorrelser. In the manufacture of tooth powders, mechanical mixing is usually sufficient, e.g. in a triolle, the various solid components in suitable quantities and with suitable particle sizes.
I pastaformige midler er den antibakterielle digua-nidpolymer forenlig med poleringsmaterialet og andre bestanddeler i preparatet. I en tannpasta kan således den flytende bærer være vann, som regel' i en mengde av 10 - 90 vekt% av preparatet. Glycerol, sorbitol eller propylenglycol kan også være tilstede som fuktemidler eller bindemidler. Spesielt gunstige flytende■bestanddeler omfatter blandinger av vann, glycerol og sorbitol. In pasty preparations, the antibacterial diguanide polymer is compatible with the polishing material and other ingredients in the preparation. In a toothpaste, the liquid carrier can thus be water, usually in an amount of 10 - 90% by weight of the preparation. Glycerol, sorbitol or propylene glycol may also be present as wetting agents or binders. Particularly favorable liquid ■ingredients include mixtures of water, glycerol and sorbitol.
I klare geler hvor brytningsindeksen er av stor betydning, anvendes fortrinnsvis ca. 10 - 30 vekt% vann, 0 - ca. 80 vekt% glycerol og ca. 20 - 80 vekt% sorbitol. Et geleringsmiddel, som natur-lige eller syntetiske gummier eller gummilignende materialer, f.eks. irsk mose, natriumcarboxymethylcellulose, methylcellulose eller hydroxyethylcellulose-, kan ..anvendes. Andre geleringsmidler som kan anvendes, omfatter den syntetiske, ubrganiske silicatleire som selges under varemerket "LAP0NITE", 'f.eks. "LAP0NITE CP" og "LAP0NITE SP" med formelen [SigMg^ jLig 6Hy 6°2h^ ' Na0 6' 'tragan'tgumrai, poly-vinylklorid og stivelse. Disse er som regel tilstede i tannpasta i en mengde av inntil 10 vekt$, fortrinnsvis 0,5-5 vekt$. De foretrukne geleringsmidler er methylcellulose, hydroxyethylcellulose og "LAP0NITE.CP", og helst "LAP0NITE SP". I en tannpasta eller -gel av-passes de forholdsvise mengder av væsker og faste stoffer slik at det fåes en kremlignende eller gelert masse som kan ekstruderes fra en trykkbehoider eller fra en sammenklembar tube av f.eks. aluminium eller bly. In clear gels where the refractive index is of great importance, preferably approx. 10 - 30% by weight water, 0 - approx. 80% by weight glycerol and approx. 20 - 80% by weight sorbitol. A gelling agent, such as natural or synthetic gums or rubber-like materials, e.g. Irish moss, sodium carboxymethylcellulose, methylcellulose or hydroxyethylcellulose-, may be used. Other gelling agents which may be used include the synthetic inorganic silicate clay sold under the trademark "LAP0NITE", e.g. "LAP0NITE CP" and "LAP0NITE SP" of the formula [SigMg^ jLig 6Hy 6°2h^ ' Na0 6' 'tragan'tgumrai, polyvinyl chloride and starch. These are usually present in toothpaste in an amount of up to 10% by weight, preferably 0.5-5% by weight. The preferred gelling agents are methylcellulose, hydroxyethylcellulose and "LAP0NITE.CP", and preferably "LAP0NITE SP". In a toothpaste or gel, the relative quantities of liquids and solids are adjusted so that a cream-like or gelled mass is obtained which can be extruded from a pressure container or from a squeezable tube of e.g. aluminum or lead.
De fasite eller pastaformige midler kan også inneholde et overflateaktivt middel og/eller en fluorgivende forbindelse. The faceted or pasty agents may also contain a surface-active agent and/or a fluorinating compound.
De overflateaktive midler som kan anvendes, er organiske materialer og gir en oket profylaktisk virkning og letter opp-nåelsen av en god og fullstendig dispergering av preparatet i munnhulen. Det organiske overflateaktive materiale kan være anionaktivt, ikke-ionisk, amfolytisk eller kationaktivt, og det foretrekkes som overflateaktivt middel å anvende et rensende materiale som gjor preparatet rensende og skummende. Det foretrekkes å anvende 0,05-5 vekt$ overflateaktivt materiale i munnhulen. The surfactants that can be used are organic materials and provide an increased prophylactic effect and facilitate the achievement of a good and complete dispersion of the preparation in the oral cavity. The organic surface-active material can be anion-active, non-ionic, ampholytic or cation-active, and it is preferred as surface-active agent to use a cleansing material which makes the preparation cleansing and foaming. It is preferred to use 0.05-5 wt.% surface active material in the oral cavity.
En fluorgivende forbindelse kan være tilstede A fluorinating compound may be present
'i tann- eller munnpleiemidlet. Disse forbindelser kan være svakt oppløselige i vann eller fullstendig vannopploselige. En hvilken som helst minste mengde av en slik forbindelse kan anvendes, men det foretrekkes å anvende en tilstrekkelig mengde av forbindelsen til at det vil frigjores 0,005-1 vekt%, fortrinnsvis ca. 0,1 vekt% fluoridion. Alkalimetallfluorid og toverdig tinnfluorid er som regel tilstede i en mengde av inntil 2 vekt%, basert på vekten av preparatet, fortrinnsvis 0,05-1 vekt$. Natriummonofluorfosfat kan være tilstede i en mengde av inntil 7»6 vekt$, som regel 0,76 vekt$. 'in the dental or oral care product. These compounds can be slightly soluble in water or completely water soluble. Any minimum amount of such a compound may be used, but it is preferred to use a sufficient amount of the compound to release 0.005-1% by weight, preferably about 0.1 wt% fluoride ion. Alkali metal fluoride and divalent stannous fluoride are usually present in an amount of up to 2% by weight, based on the weight of the preparation, preferably 0.05-1% by weight. Sodium monofluorophosphate may be present in an amount of up to 7.6% by weight, usually 0.76% by weight.
I et flytende middel, som et munnvann, er den fluorgivende forbindelse som regel tilstede i en tilstrekkelig mengde, til at det vil avgis inntil 0,13 vekt$, fortrinnsvis 6,0013-0,1 vekt$, og helst 0,0013-0,05 vekt%, fluoridion. In a liquid agent, such as a mouthwash, the fluorinating compound is usually present in a sufficient quantity that up to 0.13 wt%, preferably 6.0013-0.1 wt%, and most preferably 0.0013- 0.05% by weight, fluoride ion.
Foruten amino-cyano-diguanid-polymeren. kan' Besides the amino-cyano-diguanide polymer. can'
et ytterligere antibakterielt middel være tilstede i en slik mengde at det samlet fås ca. 5 vekt% antibakterielt middel. a further antibacterial agent be present in such an amount that a total of approx. 5% by weight antibacterial agent.
Den samlede mengde av antibakterielle midler i tann- eller munnpleiemidlet vil som regel være 0,01-5 vekt$, og en hoveddel (dvs. over 50 vekt$)av det antibakterielle middel er fortrinnsvis amino-cyano-diguanidpolymeren mens det ytterligere antibakterielle middel er tilstede i en mindre mengde. The total amount of antibacterial agents in the dental or oral care agent will usually be 0.01-5 wt.$, and a major part (ie over 50 wt.$) of the antibacterial agent is preferably the amino-cyano-diguanide polymer, while the additional antibacterial agent is present in a smaller amount.
Et hvilket som helst egnet smaksmiddel eller sotningsmiddel kan også anvendes. Det er gunstig at den samlede mengde av smaksmiddel og sotningsmiddel er 0,01-5$ eller derover av tann- eller munnpleiemidlet. Any suitable flavoring or sweetening agent may also be used. It is advantageous that the total amount of flavoring agent and sooting agent is 0.01-5$ or more of the dental or oral care agent.
Ved fremstilling av tannpleiemidler er det vanlig å fjerne inneholdt luft fra produktet ved utlufting under vakuum, som regel på et sent trinn under fremstillingen. Det har nu vist seg at i de klare tannpleiemiddelgeler med egnet viskositet forbedrer dispergerte, ubevegelige luftbobler på onsket måte tannpleiemidlets utseende og kan derfor tillates å bli til- In the manufacture of dental care products, it is common to remove contained air from the product by venting under vacuum, usually at a late stage during manufacture. It has now been shown that in the clear toothpaste gels with a suitable viscosity, dispersed, immobile air bubbles improve the appearance of the toothpaste in the desired way and can therefore be allowed to
bake. Luften kan også erstattes med en annen gass i en ugiftig, bake. The air can also be replaced with another gas in a non-toxic,
mengde, som nitrogen eller carbondioxyd. Spesielt kan carbon- quantity, such as nitrogen or carbon dioxide. In particular, carbon-
dioxyd gjore tannpleiemidlet brusende. dioxide make the toothpaste effervescent.
I de nedenstående eksempler ble bestanddelene, blandet på vanlig måte. De i eksemplene angitte prosenter er basert på In the examples below, the components were mixed in the usual way. The percentages given in the examples are based on
vekt, og diguanid-polymereneble fremstilt ved den fremgangsmåte som er beskrevet i Britisk Patentskrift nr. 1.152.2^3 og ut- weight, and the diguanide polymers were prepared by the method described in British Patent No. 1,152,2^3 and ex-
gjordes av diguanid-polymerer hvori n i den ovennevnte formel var h og som hovedsakelig besto av det lineære amino-cyano-polyhexamethylen-diguanid was made of diguanide polymers where n in the above formula was h and which consisted mainly of the linear amino-cyano-polyhexamethylene diguanide
NH9(CH2)^[NH-C-NH-C-NH-(CHC))A]1,-NH-C-NH-C=NNH9(CH2)^[NH-C-NH-C-NH-(CHC))A]1,-NH-C-NH-C=N
it li it li
NH NH2<+>C1" NH2<+>C1" NH NH2<+>C1" NH2<+>C1"
Eksempel 1 Example 1
Eksempel 2 Example 2
Eksempel 3 Eksempel h Example 3 Example h
Eksempel 5 ' : Example 5 ' :
Eksempel 6 Eksempel 7 Example 6 Example 7
De 1 eksemplene anvendte a) "Pluronle 75"» b)"Miranol C2M" og c) "Tween 80" er hhv. a) et pastalignende kondensat av 50 vekt% polyoxyethylen og polyoxypropylen med en molekylvekt på 2050, b) et amfotert, langkjedet, zwitterionisk imidazolin med formelen The 1 examples used a) "Pluronle 75"» b) "Miranol C2M" and c) "Tween 80" are respectively a) a paste-like condensate of 50% by weight polyoxyethylene and polyoxypropylene with a molecular weight of 2050, b) an amphoteric, long-chain, zwitterionic imidazoline of the formula
c) en blanding av oleatestere av sorbitol og sorbitolanhydrider hovedsakelig bestående av monoesteren kondensert med ca. 20 mol c) a mixture of oleate esters of sorbitol and sorbitol anhydrides mainly consisting of the monoester condensed with approx. 20 moles
ethylenoxyd. ethylene oxide.
Claims (3)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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GB2702770 | 1970-06-04 | ||
GB5657670 | 1970-11-27 |
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Publication Number | Publication Date |
---|---|
NO135200B true NO135200B (en) | 1976-11-22 |
NO135200C NO135200C (en) | 1977-03-02 |
Family
ID=26258567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NO2077/71A NO135200C (en) | 1970-06-04 | 1971-06-03 |
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BE (1) | BE767671A (en) |
CA (1) | CA964589A (en) |
CH (1) | CH562032A5 (en) |
DE (1) | DE2126539A1 (en) |
DK (1) | DK127840B (en) |
ES (1) | ES391306A1 (en) |
FR (1) | FR2096772A1 (en) |
IE (1) | IE35249B1 (en) |
IT (1) | IT1040522B (en) |
NL (1) | NL7107747A (en) |
NO (1) | NO135200C (en) |
OA (1) | OA03739A (en) |
PH (1) | PH9243A (en) |
SE (1) | SE376842B (en) |
ZM (1) | ZM6571A1 (en) |
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Publication number | Priority date | Publication date | Assignee | Title |
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DE3928063A1 (en) * | 1989-08-25 | 1991-02-28 | Henkel Kgaa | ANTI-COATING TOOTHPASTE |
US5180577A (en) * | 1990-10-09 | 1993-01-19 | Colgate-Palmolive | Stabilized bis biguanide/anionic active ingredient compositions |
-
1971
- 1971-05-18 ES ES391306A patent/ES391306A1/en not_active Expired
- 1971-05-19 ZM ZM65/71*UA patent/ZM6571A1/en unknown
- 1971-05-19 IE IE630/71A patent/IE35249B1/en unknown
- 1971-05-21 PH PH12489*UA patent/PH9243A/en unknown
- 1971-05-26 BE BE767671A patent/BE767671A/en unknown
- 1971-05-28 DK DK262371AA patent/DK127840B/en unknown
- 1971-05-28 CA CA114,268A patent/CA964589A/en not_active Expired
- 1971-05-28 DE DE19712126539 patent/DE2126539A1/en active Pending
- 1971-06-01 FR FR7119825A patent/FR2096772A1/en active Granted
- 1971-06-01 IT IT50754/71A patent/IT1040522B/en active
- 1971-06-02 CH CH800871A patent/CH562032A5/xx not_active IP Right Cessation
- 1971-06-02 OA OA54268A patent/OA03739A/en unknown
- 1971-06-03 NO NO2077/71A patent/NO135200C/no unknown
- 1971-06-03 SE SE7107204A patent/SE376842B/xx unknown
- 1971-06-04 NL NL7107747A patent/NL7107747A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
SE376842B (en) | 1975-06-16 |
DE2126539A1 (en) | 1971-12-16 |
FR2096772B1 (en) | 1975-07-04 |
ES391306A1 (en) | 1975-01-01 |
NO135200C (en) | 1977-03-02 |
BE767671A (en) | 1971-10-18 |
PH9243A (en) | 1975-07-30 |
ZM6571A1 (en) | 1973-01-22 |
DK127840B (en) | 1974-01-21 |
NL7107747A (en) | 1971-12-07 |
CA964589A (en) | 1975-03-18 |
IE35249B1 (en) | 1975-12-24 |
OA03739A (en) | 1971-12-24 |
IE35249L (en) | 1971-12-04 |
FR2096772A1 (en) | 1972-02-25 |
IT1040522B (en) | 1979-12-20 |
CH562032A5 (en) | 1975-05-30 |
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