NO130577B - - Google Patents

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Publication number
NO130577B
NO130577B NO6829A NO2968A NO130577B NO 130577 B NO130577 B NO 130577B NO 6829 A NO6829 A NO 6829A NO 2968 A NO2968 A NO 2968A NO 130577 B NO130577 B NO 130577B
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NO
Norway
Prior art keywords
minutes
disinfection
peroxide compounds
sterility
ozonides
Prior art date
Application number
NO6829A
Other languages
Norwegian (no)
Other versions
NO130577C (en
Inventor
R Pine
Original Assignee
Uarco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uarco Inc filed Critical Uarco Inc
Publication of NO130577B publication Critical patent/NO130577B/no
Publication of NO130577C publication Critical patent/NO130577C/no

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B41PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41LAPPARATUS OR DEVICES FOR MANIFOLDING, DUPLICATING OR PRINTING FOR OFFICE OR OTHER COMMERCIAL PURPOSES; ADDRESSING MACHINES OR LIKE SERIES-PRINTING MACHINES
    • B41L1/00Devices for performing operations in connection with manifolding by means of pressure-sensitive layers or intermediaries, e.g. carbons; Accessories for manifolding purposes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T225/00Severing by tearing or breaking
    • Y10T225/30Breaking or tearing apparatus
    • Y10T225/35Work-parting pullers [bursters]

Landscapes

  • Sheets, Magazines, And Separation Thereof (AREA)
  • Separation, Sorting, Adjustment, Or Bending Of Sheets To Be Conveyed (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

Fremgangsmåte for desinfeksjon og desodorisering med organiske peroksydforbindelser. Procedure for disinfection and deodorization with organic peroxide compounds.

Desinfeksjonsmidler for grov- og fin-desinfeksjon fremstilles i dag ikke lengere Disinfectants for coarse and fine disinfection are no longer manufactured today

fra planteråstoffer, men består gjennom-gående av mer eller mindre giftige ufysio-logiske kjemikalier, som med større sikker-het gir den tilstrebede sterilitet. Prøvnin-gen av den hygieniske verdi av dagens from plant raw materials, but consist throughout of more or less toxic non-physiological chemicals, which with greater certainty provide the desired sterility. Testing the hygienic value of today

handelsprodukter gir vel en tilstrekkelig Commercial products probably provide a sufficient one

virkning overfor de fleste sykdomssporer effect against most disease spores

og sopper, men mot Mycobacterium tuberculosis svikter imidlertid nesten alle, og de and fungi, but almost all fail against Mycobacterium tuberculosis, and they

få virkelig virksomme dreper tuberkelbak-teriene først etter lengere innvirkningstid, few really effective ones kill the tubercle bacteria only after a longer exposure time,

hvorved for det meste en beskadigelse av whereby mostly a damage of

huden ikke er til å unngå. the skin cannot be avoided.

Som hittil beste middel ble 70 pst. alkohol med 10 minutters anvendelse er-kjent, altså en tidsperiode som for praksis As the best remedy to date, 70 percent alcohol with 10 minutes of application is known, i.e. a time period that for practice

er uønsket lang og ved hyppig anvendelse is undesirably long and with frequent use

forbundet med beskadigelse av huden, og associated with damage to the skin, and

dessuten drepes på den annen side flere moreover, on the other hand, more are killed

sporedannende stoffer i det hele tatt ikke. spore-forming substances not at all.

Med foreliggende oppfinnelse anvises With the present invention is indicated

nå en ny fremgangsmåte som i løpet av få now a new procedure that within a few

minutter henholdsvis sekunder fører til minutes or seconds leads to

fullstendig drepning av Mycob. tuberc. complete killing of Mycob. tuberc.

bakterier og som på huden danner en fet-tende film, og som også dreper andre sykdomssporer, og ved dette imidlertid bare bacteria and which form a greasy film on the skin, and which also kill other disease spores, and in this case, however, only

lar tilbake stoffer som ved tilsvarende valg leaves back substances as in the corresponding choice

av utgangsstoffene kan resorberes av huden som «fysiologiske bestanddeler», slik of the starting materials can be absorbed by the skin as "physiological components", such

at det ikke kan komme til noen giftig beskadigelse. that no toxic damage can occur.

Som bekjent forekommer mange organiske peroksyder og ozonider i spor også i As is well known, many organic peroxides and ozonides also occur in traces

naturen, således f. eks. i de eteriske oljer og terpener. nature, thus e.g. in the essential oils and terpenes.

Fremgangsmåten etter oppfinnelsen består nå i at peroksydiske forbindelser av organiske alkoholer, aldehyder, etre, ketoner og syrer oppløses i alifatiske enverdige alkoholer med korte kjeder, hvorved even-tuelt også estere og acetaler kan danne seg med oppløsningsmidlet. Disse alkoholiske oppløsninger viser overfor vandig oppløs-ninger på overraskende måte den fordel, at de selv etter en 8-måneders lagring bare bagatellmessig taper sitt aktive oksy-geninnhold med ca. 5 til 10 pst., mens de i vandige oppløsninger langt tidligere avbyg-ges til fettsyrer. Mest fordelaktig går man etter oppfinnelsen slik frem at umettede organiske forbindelser, særlig imidlertid umettede alifatiske kjeder, på kjent måte omdannes i sine ozonider og straks etter ozoniseringen eller også under denne opp-løses i alifatiske enverdige alkoholer med The method according to the invention now consists in dissolving peroxidic compounds of organic alcohols, aldehydes, ethers, ketones and acids in aliphatic monohydric alcohols with short chains, whereby possibly also esters and acetals can be formed with the solvent. Compared to aqueous solutions, these alcoholic solutions surprisingly show the advantage that, even after 8 months of storage, they only marginally lose their active oxygen content by approx. 5 to 10 per cent, while in aqueous solutions they are broken down into fatty acids much earlier. The most advantageous approach according to the invention is that unsaturated organic compounds, especially unsaturated aliphatic chains, are converted in a known manner into their ozonides and immediately after or during ozonization are dissolved in aliphatic monohydric alcohols with

korte kjeder, hvilke også kan inneholde short chains, which may also contain

noe vann, slik at ozoniderne ved hydrolyse eller alkoholyse omdannes til peroksyder. Ved dette er det altså ikke vesentlig, at veien, som fører til peroksydforbindelsen, alltid bare må føre over et ozonid. some water, so that the ozonides are converted into peroxides by hydrolysis or alcoholysis. In this respect, it is therefore not essential that the path leading to the peroxide compound must always only lead over an ozonide.

Såvel oppløsninger, som ble oppbevart 8 måneder ved romtemperatur, som også Both solutions, which were stored for 8 months at room temperature, as well

slike som bare var noen dager gamle, viste ved sin bakteriologiske prøvning, at tuber-kelbakteriene ved kulturforsøk drepes i lø-pet av 10 sekunder (5 pst. ozonid i 70 pst.'s such as were only a few days old, showed in their bacteriological tests that the tubercle bacteria are killed in culture tests in the course of 10 seconds (5 per cent ozonide in 70 per cent

etanol). Tbc-Sputum på linlapper var ste-rile i løpet av 1—2 minutter, eller som det lot seg påvise ved marsvinsprøver etter 6 ethanol). Tbc sputum on linen swabs was sterile within 1-2 minutes, or as was demonstrated by guinea pig samples after 6

måneders iakttagelse. Likeledes ble mate-riesporer meget hurtig drept. months of observation. Likewise, material spores were killed very quickly.

Å benytte organiske ozonider til desinfeksjon er allerede lenge kjent. Således ozoniseres etter de tyske patenter nr. 126.292, 135.898 og 452.227 såpe, benzol og tymol/furfurol i vandige oppløsninger så lenge inntil vannoppløselighet er inntrådt. Bruksverdien av slike preparater var imidlertid liten, da det aktive oksygen ikke lot seg opprettholde lenge. Mere holdbart var imidlertid det av CRONHEIM (J. Am. Pharm. Assoc. Sei. Ed. 36, 247—8 (1947) foreslåtte vann- og oppløsningsmiddelfrie olivenoljeozonid som sårlegemiddel. Dets virkning ble forklart med at denne ozonid i kontakt med serumvann fremkaller aktivt oksygen, som derpå utvikler antibak-terielle egenskaper. Using organic ozonides for disinfection has already been known for a long time. Thus, according to the German patents no. 126,292, 135,898 and 452,227, soap, benzol and thymol/furfurol are ozonized in aqueous solutions until water solubility has occurred. However, the use value of such preparations was small, as the active oxygen could not be maintained for long. More durable, however, was the water- and solvent-free olive oil ozonide proposed by CRONHEIM (J. Am. Pharm. Assoc. Sei. Ed. 36, 247-8 (1947)) as a wound remedy. Its effect was explained by the fact that this ozonide in contact with serum water induces active oxygen, which then develops antibacterial properties.

Egne forsøk, som skulle gi den bak-terieside egenskap for rene ozonider (av linoljefettsyrene) gå, at de på Mycobacterium tuberculosis bakterier i korte tidsfris-ter ikke har noen virkning. Denne inntrer imidlertid straks såsnart alkohol benyttes som oppløsningsmiddel. For å forklare denne overraskende effekt kan anføres at virkningen vel beror på at umettede fettsyrer av bakteriefett (30 pst.) ombygges av de organiske peroksydforbindelser i liten mengde til epoksyder og sluttelig til dioksy- henh. polyoksyfettsyrer og dermed blir bakterienes fettmantel mere gjennom-trengelig for oppløsningsmiddel. Seigtfly-tende ozonider trenger følgelig ikke så raskt inn i tuberkelbakterienes fettmantel, som de alkoholiske oppløsninger av deres hydrolyse- henh. alkoholyseprodukter. Own experiments, which should give the bacteria-side property for pure ozonides (of the linseed oil fatty acids) go, that they have no effect on Mycobacterium tuberculosis bacteria in short periods of time. However, this occurs immediately as soon as alcohol is used as a solvent. To explain this surprising effect, it can be stated that the effect is probably due to unsaturated fatty acids of bacterial fat (30 per cent) being converted by the organic peroxide compounds in small quantities into epoxides and finally into dioxygen. polyoxy fatty acids and thus the bacteria's fat mantle becomes more permeable to solvent. Viscous ozonides consequently do not penetrate the tubercle bacteria's fatty mantle as quickly as the alcoholic solutions of their hydrolysis. alcohololysis products.

Eksempel 1. Example 1.

1 g linolsyre-etylester oppløses i den 10-dobbelte mengde tetraklorcarbon, ozoniseres på kjent måte, avdestilleres oppløs-ningsmidlet i vakuum og erstatte dette med alkohol. 1 g of linoleic acid ethyl ester is dissolved in the 10-fold amount of carbon tetrachloride, ozonized in a known manner, the solvent is distilled off in a vacuum and replaced with alcohol.

Eksempel 2. Example 2.

1 g cykloheksen ozoniseres i 10 cm" alkohol ved temperaturer under 0°. Etter ozonopptagelsen og flere dagers modnings-tid innstilles alkoholinnholdet ved vann-tilsetning på 70 pst. 1 g of cyclohexene is ozonized in 10 cm" of alcohol at temperatures below 0°. After the absorption of ozone and a maturation period of several days, the alcohol content is adjusted to 70 percent by adding water.

Eksempel 3. Example 3.

1 g linolsyre-etylester ozoniseres uten oppløsningsmiddel ved temperaturer under + 10°. Er 70 pst. av det teoretiske ozon-forbruk avbundet, oppløses det dannede ozonid i 70 pst.'s alkohol. Desinfeksjons-midlet kan bringes i handelen som 5 pst.'s oppløsning eller som 20 pst.'s konsentrat. 1 g of linoleic acid ethyl ester is ozonized without solvent at temperatures below + 10°. If 70 per cent of the theoretical ozone consumption is bound, the ozonide formed is dissolved in 70 per cent alcohol. The disinfectant can be sold as a 5% solution or as a 20% concentrate.

Eksempel 4. Example 4.

5 g linolsyre-etylesterozonid oppløses i 50 cm» alkohol og blandes med 35 cm'<1>Dissolve 5 g of linoleic acid-ethylesterozonide in 50 cm» of alcohol and mix with 35 cm'<1>

vann, til hvilket 10 pst. av et emulgeringsmiddel (fettsyre-glukosid) ble tilsatt. Det danner seg en klar gjennomsiktlig oppløs-ning. Uten emulgeringsmiddel vil oppløs-ningen spaltes opp i 2 faser. water, to which 10 percent of an emulsifier (fatty acid glucoside) was added. A clear transparent solution forms. Without an emulsifier, the solution will split into 2 phases.

Forsøksprotokoll Erklæring av tegnene: 1) Mycobacterium tuberculosis. Experimental protocol Declaration of the signs: 1) Mycobacterium tuberculosis.

Tb-suspensj onsf orsøk, Tb suspension assay,

Stamme PAMESKU 2 mg kulturmateriale, kontroll + + + + ved 70 pst.'s metanol drept i løpet av 13 minutter. Strain PAMESKU 2 mg culture material, control + + + + at 70% methanol killed within 13 minutes.

2) Mycrocuccus pyogenes var. sureus. sterilitet. Fenol 1 : 100 etter 7 y2 minutt 2) Mycrocuccus pyogenes var. sure. sterility. Phenol 1 : 100 after 7 y2 minutes

ingen, etter 10 minutter sterilitet. none, after 10 minutes of sterility.

Metanol etter 10 minutter ennå ingeningen, Methanol after 10 minutes still nothing,

3) Bacterium coli. 3) Bacterium coli.

Metanol etter 10 minutter ennå ingen Methanol after 10 minutes still none

sterilitet. Penol 1 : 100, etter 2,5 og 5 minutter ingen, etter 7,5 og 10 minutter sterilitet. sterility. Penol 1 : 100, after 2.5 and 5 minutes none, after 7.5 and 10 minutes sterility.

4) Bacterium Pyocyaneus. Metanol etter 10 minutter ennå ingen sterilitet. Fenol 1 : 100, etter 2,5 og 5 minutter ingen, etter 7,5 og 10 minutter sterilitet. 4) Bacterium Pyocyaneus. Methanol after 10 minutes still none sterility. Phenol 1 : 100, after 2.5 and 5 minutes none, after 7.5 and 10 minutes sterility.

5) Candida albicans. 5) Candida albicans.

Metanol etter 10 minutter ennå ingen Methanol after 10 minutes still none

sterilitet. Fenol 1 : 100, først etter 10 minutter sterilitet. sterility. Phenol 1:100, only after 10 minutes of sterility.

6) Hånddesinfeksjon etter SCUMBURG. 6) Hand disinfection according to SCUMBURG.

Prøvespore: Coli Sample spore: Coli

Den 2,5 pst.'s ozonidoppløsning i alkohol er ved 4 minutters innvirkning anven-delig for hånddesinfeksjon. The 2.5% ozone solution in alcohol is suitable for hand disinfection after 4 minutes of exposure.

Claims (3)

1. Desinfeksjons- og desodoriserings-middel, karakterisert ved at det inneholder1. Disinfection and deodorizing agent, characterized in that it contains organiske peroksydforbindelser som opp-løses i enverdige alifatiske alkoholer med korte kjeder. organic peroxide compounds that dissolve in monovalent aliphatic alcohols with short chains. 2. Desinfeksjons- og desodoriserings-middel som i påstand 1 angitt, karakterisert ved at peroksydforbindelsene finner anvendelse i form av alkoholer, aldehyder, ketoner, etre eller syrer henh. deres estre og acetaler enkeltvis eller i blandinger. 2. Disinfection and deodorizing agent as stated in claim 1, characterized in that the peroxide compounds are used in the form of alcohols, aldehydes, ketones, ethers or acids according to their esters and acetals singly or in mixtures. 3. Desinfeksjons- og desodoriserings-middel soom i påstandene 1 og 2 angitt, karakterisert ved at de inneholder aktivt oksygen, som foreligger i form av organiske peroksydforbindelser henh. ozonider, som ble oppløst i 60—100 pst.'s alifatiske alkoholer med korte kjeder.3. Disinfection and deodorising agent as set out in claims 1 and 2, characterized in that they contain active oxygen, which is present in the form of organic peroxide compounds acc. ozonides, which were dissolved in 60-100 percent aliphatic alcohols with short chains.
NO2968A 1967-07-20 1968-01-04 NO130577C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65483567A 1967-07-20 1967-07-20

Publications (2)

Publication Number Publication Date
NO130577B true NO130577B (en) 1974-09-30
NO130577C NO130577C (en) 1975-01-08

Family

ID=24626433

Family Applications (1)

Application Number Title Priority Date Filing Date
NO2968A NO130577C (en) 1967-07-20 1968-01-04

Country Status (11)

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US (1) US3484031A (en)
AT (1) AT295314B (en)
BE (1) BE708774A (en)
CH (1) CH460819A (en)
DE (1) DE1611775B2 (en)
DK (1) DK121908B (en)
FR (1) FR1552421A (en)
GB (1) GB1172641A (en)
NL (1) NL6801485A (en)
NO (1) NO130577C (en)
SE (1) SE347239B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3727814A (en) * 1970-03-09 1973-04-17 Windmoeller & Hoelscher Tear-off apparatus for successively tearing off a length from the leading end of a moving flattened tubular web of material
US3741451A (en) * 1971-01-04 1973-06-26 Standard Register Co Burster apparatus
US3972283A (en) * 1974-09-16 1976-08-03 Uarco Incorporated Removable imprinter with latch for burster
USRE30398E (en) * 1978-12-14 1980-09-09 American/Durein Company Burster mechanism
US4261497A (en) * 1979-01-18 1981-04-14 Pitney Bowes Inc. Bursting apparatus
US4269341A (en) * 1979-11-05 1981-05-26 Uarco Incorporated Stationery burster
DE3218304A1 (en) * 1982-05-14 1983-11-17 Systemform Datenbelege GmbH, 8210 Prien DEVICE FOR SEPARATING CONTINUOUS FORM SETS OR THE LIKE.
JPS6012466A (en) * 1983-06-30 1985-01-22 Toshiba Corp Breaking device for paper
US4688708A (en) * 1984-01-09 1987-08-25 Pitney Bowes Inc. Bursting machine
GB2248828A (en) * 1990-10-19 1992-04-22 Pitney Bowes Inc Bursting two webs of material
US20020144770A1 (en) 2001-04-06 2002-10-10 Stephane Mabit Carrier-less patch protection including cassette and separation process

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1790680A (en) * 1931-02-03 Manifolding machine
US2252736A (en) * 1939-09-20 1941-08-19 Katherine M Sherman Strip feeding trimmer and bursting machine
US2513093A (en) * 1945-11-07 1950-06-27 Moore Business Forms Inc Strip feeding and severing machine
US2618336A (en) * 1949-11-22 1952-11-18 Standard Register Co Strip burster
US3161335A (en) * 1962-07-19 1964-12-15 Uarco Inc Burster
GB1008152A (en) * 1963-03-13 1965-10-27 Lamson Paragon Ltd Improvements in or relating to paper and the like web severing mechanisms

Also Published As

Publication number Publication date
AT295314B (en) 1971-12-27
DE1611775A1 (en) 1971-01-28
CH460819A (en) 1968-08-15
NO130577C (en) 1975-01-08
GB1172641A (en) 1969-12-03
NL6801485A (en) 1969-01-22
BE708774A (en) 1968-05-02
DE1611775B2 (en) 1977-07-14
FR1552421A (en) 1969-01-03
SE347239B (en) 1972-07-31
DK121908B (en) 1971-12-20
US3484031A (en) 1969-12-16

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